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1.
Aktual'ni Problemy Ekonomiky = Actual Problems in Economics ; - (238):100-109, 2021.
Article in Ukrainian | ProQuest Central | ID: covidwho-2205978

ABSTRACT

У cmammi аналЯуеться важливкть туризму для сощально-економтног системи крагни, а також здтснюеться оцтка тенденцт розвитку сфери туризму за сучасних умов впливу пандемй COVID-19. ОбГрунтовано можливi шляхи подолання наслгдкгв пандемй для туристичног галузi в Украгт та вsновлення ii' позицт на свтовому ринку туристичних послуг.Alternate :В статье анализируется важность туризма для социально-экономической системы страны, а также осуществляется оценка тенденций развития сферы туризма в современных условиях воздействия пандемии COVID-19. Обоснованно возможные пути преодоления последствий пандемии для туристической отрасли в Украине и укрепление ее позиций на мировом рынке туристических услуг.Alternate :The article analyzes the importance of tourism for the socio-economic system of the country, and also evaluates trends in the development of tourism in the current conditions of the impact of the COVID-19 pandemic. Possible ways of overcoming the consequences of the pandemic for the tourism industry in Ukraine and strengthening its position in the world market of tourist services have been substantiated.

3.
Open Forum Infectious Diseases ; 8(SUPPL 1):S15, 2021.
Article in English | EMBASE | ID: covidwho-1746816

ABSTRACT

Background. Given the limited collaborative international studies that evaluated COVID-19 in patients with cancer in comparison to patients without cancer, we aimed to determine the independent risk factors associated with increased 30-day mortality and the impact of novel treatment modalities in a large group of cancer and non-cancer patients with COVID-19 from multiple countries. Methods. We retrospectively collected de-identified data on cancer and non-cancer patients diagnosed with COVID-19 between January and November 2020, at 16 centers in Asia, Australia, Europe, North America, and South America. A logistic regression model was used to identify independent predictors of all-cause mortality within 30 days after COVID-19 diagnosis. Results. Of the total 4015 COVID-19 confirmed patients entered, we analyzed 3966 patients, 1115 cancer and 2851 non-cancer patients. Cancer patients were older than non-cancer patients (median age, 61 vs 50 years;p< 0.0001);more likely to be pancytopenic , had pulmonary disorders, hypertension, diabetes mellitus. In addition, they were more likely to present with higher inflammatory biomarkers (D-dimer, ferritin and procalcitonin), but were less likely to present with clinical symptoms. By multivariable logistic regression analysis, cancer was an independent risk factor for 30-day mortality (OR 1.46;95% CI 1.03 to 2.07;p=0.035). Older age (≥65 years) was the strongest predictor of 30-day mortality in all patients (OR 4.55;95% CI 3.34 to 6.20;p< 0.0001). Remdesivir was the only therapeutic agent independently associated with decreased 30-day mortality (OR 0.58;CI 0.39-0.88;p=0.009). Among patients on lowflow oxygen at admission, patients who received remdesivir had a lower 30-day mortality rate than those who were on high flow oxygen (5.9% vs 17.6%;p=0.03). Patients transfused with convalescent plasma within 1 day of diagnosis had a lower 30-day mortality rate than those transfused later (1% vs 7%, p=0.04). Conclusion. Cancer is an independent risk factor for increased 30-day all-cause mortality from COVID-19. Remdesivir, particularly in patients receiving low-flow oxygen, can reduce 30-day all-cause mortality, as well as convalescent plasma given early after COVID-19 diagnosis.

4.
Int J Mol Sci ; 23(5)2022 Feb 23.
Article in English | MEDLINE | ID: covidwho-1736941

ABSTRACT

The fourth enzymatic reaction in the de novo pyrimidine biosynthesis, the oxidation of dihydroorotate to orotate, is catalyzed by dihydroorotate dehydrogenase (DHODH). Enzymes belonging to the DHODH Class II are membrane-bound proteins that use ubiquinones as their electron acceptors. We have designed this study to understand the interaction of an N-terminally truncated human DHODH (HsΔ29DHODH) and the DHODH from Escherichia coli (EcDHODH) with ubiquinone (Q10) in supported lipid membranes using neutron reflectometry (NR). NR has allowed us to determine in situ, under solution conditions, how the enzymes bind to lipid membranes and to unambiguously resolve the location of Q10. Q10 is exclusively located at the center of all of the lipid bilayers investigated, and upon binding, both of the DHODHs penetrate into the hydrophobic region of the outer lipid leaflet towards the Q10. We therefore show that the interaction between the soluble enzymes and the membrane-embedded Q10 is mediated by enzyme penetration. We can also show that EcDHODH binds more efficiently to the surface of simple bilayers consisting of 1-palmitoyl, 2-oleoyl phosphatidylcholine, and tetraoleoyl cardiolipin than HsΔ29DHODH, but does not penetrate into the lipids to the same degree. Our results also highlight the importance of Q10, as well as lipid composition, on enzyme binding.


Subject(s)
/chemistry , Escherichia coli/enzymology , Lipid Bilayers/metabolism , Ubiquinone/metabolism , Cardiolipins/metabolism , Escherichia coli Proteins/chemistry , Escherichia coli Proteins/metabolism , Humans , Hydrophobic and Hydrophilic Interactions , Models, Molecular , Phosphatidylcholines/metabolism , Protein Conformation , Protein Domains
5.
Rheumatology (United Kingdom) ; 60(SUPPL 1):i40-i41, 2021.
Article in English | EMBASE | ID: covidwho-1266165

ABSTRACT

Background/AimsIndividuals on immunosuppressive therapies were among thoseidentified by the UK Department of Health and Chief Medical Officeras clinically extremely vulnerable to COVID-19. Advice on shieldingfrom infection was disseminated by NHS England, primary care andNHS hospital trusts to those identified at highest risk. The BritishSociety for Rheumatology (BSR) developed further risk stratificationguidance specifically focused on autoimmune rheumatic disease. As the UK entered a period of nationwide lockdown on 23rd March 2020, the clinically highly vulnerable group were asked to shield frominfection by staying at home and avoiding any face-to-face contact foran initial period of 12 weeks. The implications of social isolation, disruption to planned medical care and economic consequencesbecame increasingly recognised. This work aimed to understand theexperience and wellbeing of this patient group during week 5 -6 of UKLockdown, as a guide to how we might best adapt services andaddress the needs of this group.MethodsShort semi-structured telephone interviews were conducted with 141patients during week five and six of UK lockdown, between 20th Apriland 1st May 2020. Participants were sampled systematically from thedepartmental biologic therapy database at Wexham Park Hospital, ageneral hospital providing services to a diverse population ofapproximately 450, 000 people in Berkshire and SouthBuckinghamshire.ResultsTelephone interview was conducted with 141 patients prescribedbiologic therapy. Written advice on risk and shielding was received byover 90%. Sixty four percent of respondents were female with amedian age of 56 years. Thirty-nine percent of those interviewed fellwithin highest BSR risk category for whom full shielding was highlyrecommended, yet at the time of interview 51.1% of respondentsreported they had committed to full shielding. Four percent ofrespondents self-identified as key workers and had continued theirusual commitments. Amongst those interviewed, 35% reportedsignificant adverse impact on their emotional and mental wellbeingwithin the first six weeks of UK lockdown. Isolation, uncertainty, limitedphysical exercise and cancellations to planned appointments werecommon themes. Twenty-eight percent of respondents felt theirdisease control had significantly deteriorated during the ongoingpandemic. Due to prevailing anxiety about the impact of immunosuppression on COVID-19 risk, 5% of patients had adjusted theirprescribed therapies without the direct supervision or clinical advice.ConclusionThis study gives initial insights into the behaviours and concerns ofpatients with autoimmune and inflammatory disease on biologictherapy during the first wave of COVID-19 in the UK. Wellbeing anddisease management have considerably suffered for many individuals.Further understanding patient experience may help guide restructuringof rheumatology services in next phase of the UK pandemic.

6.
Lebanese Medical Journal ; 68(1/2):47-51, 2020.
Article in English | GIM | ID: covidwho-995477

ABSTRACT

Background: The first cases of novel coronavirus (2019-ncov) infected patients occurred in Lebanon in February 2020 and March 2020. Rafic Hariri University Hospital was the first hospital in Lebanon that rapidly responded to this crisis through the effective use of scarce resources and the swift arrangement of departments as part of the contingency plan. It was able to mitigate the impact of the first COVID-19 wave in Lebanon through active management and proper preparedness. We analyzed data on the first 63 confirmed cases of COVID-19 to determine their epidemiological and clinical characteristics.

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