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Journal of Medical Pest Control ; 38(2):160-163, 2022.
Article in Chinese | Scopus | ID: covidwho-2056260

ABSTRACT

Objective To analyze the transmission characteristics of family clustering of Corona Virus Disease 2019 (COVID-19) in a town in Tianjin, and to study new epidemiological investigation method applied for the epidemic. Methods The field epidemiological method was applied to investigate confirmed, suspected cases and close contacts of COVID-19, and this clustering epidemic was analyze;and real-time fluorescence PCR (RT-PCR) assay was used for 2019-nCoV nucleic acid testing. Results A total of 11 confirmed cases and 1 suspected case, with three generations of transmission and median generation interval of 6 (2-26) days were involved in current clustering epidemic, the confirmed cases were infectious at the end of the incubation period, the recurrence rate within the families was 33. 33% (19/57), and the epidemiological investigation information acquired through case narration were deviated compared with the trace investigated by police force and the information provided by close contacts. Conclusion The COVID-19 can cause the family clustering spread, and it may infectious at the end of the incubation period. It is necessary to strengthen the trace and management of close contacts during clustering epidemics, and multiple methods adopted making for acquiring epidemiological investigation information. © 2022, Editorial Department of Medical Pest Control. All rights reserved.

2.
Advanced Functional Materials ; 2022.
Article in English | Web of Science | ID: covidwho-1995522

ABSTRACT

With the rapid progress in nanomaterials and biochemistry, there has been an explosion of interest in biomolecule-modified quantum dots (QDs) for biomedical applications. Metal chalcogenide quantum dots (MCQDs), as the most widely studied QDs, have attracted tremendous attention in the biomedical field on account of their unique and excellent optical properties and the ease of biomolecular modifications. Herein, important advances in MCQDs over recent years are reviewed, from materials design to biomedical applications. Especially, this review focuses on the challenges encountered in the applications of MCQDs in biomedical fields and how these problems can be solved by rational design of synthesis methods and modifications, which have opened a universal route to develop the functionalized MCQDs. Moreover, recent processes in bioimaging, biosensing, and cancer therapy based on MCQDs are examined, including the rapid detection and diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This review provides broad insights into MCQDs in the biomedical field and will inspire material researchers to develop MCQDs in the future.

3.
European Review for Medical and Pharmacological Sciences ; 25(23):7585-7597, 2021.
Article in English | Web of Science | ID: covidwho-1576100

ABSTRACT

OBJECTIVE: Coronavirus disease 2019 (COVID-19) spread around the world in 2020. Abnormal pulmonary function and residual CT abnormalities were observed in COVID-19 patients during recovery. Appropriate rehabilitation training is around the corner. The correlation between spirometric impairment and residual CT abnormality remains largely unknown. PATIENTS AND METHODS: A cross-sectional study conducted on the pulmonary function of 101 convalescent COVID-19 patients before discharge. Multivariate analysis was used to establish a scoring system to evaluate the spirometric abnormality based on residual chest CT. RESULTS: Lung consolidation area >25% and severe-type COVID-19 were two independent risk factors for severe pulmonary dysfunction. Besides, a scoring system was established. People scoring more than 12 points have more chances (17 times) to get severe pulmonary function impairment before discharge. CONCLUSIONS: For the first time, a chest CT characteristics-based grading system was suggested to predict the pulmonary dysfunction of COVID-19 patients during convalescence in this study. This study may provide suggestions for pulmonary rehabilitation.

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