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1.
Med Hypotheses ; 143: 109866, 2020 Oct.
Article in English | MEDLINE | ID: covidwho-1386296

ABSTRACT

Zinc Iodide and Dimethyl Sulfoxide compositions are proposed as therapeutic agents to treat and prevent chronic and acute viral infections including SARS-CoV-2 infected patients. The therapeutic combinations have a wide range of virucidal effects on DNA and RNA containing viruses. The combinations also exhibit anti-inflammatory, immunomodulating, antifibrotic, antibacterial, antifungal and antioxidative effects. Given the fact that Zinc Iodide has been used as an oral antiseptic agent and DMSO has been already proven as a safe pharmaceutical solvent and therapeutic agent, we hypothesize that the combination of these two agents can be applied as an effective, safe and inexpensive treatment for SARS-CoV-2 and other viral infection. The therapeutic compound can be applied as both etiological and pathogenesis therapy and used as an effective and safe antiseptic (disinfectant) for human and animals as well.


Subject(s)
Coronavirus Infections/drug therapy , Dimethyl Sulfoxide/administration & dosage , Disinfectants/administration & dosage , Iodides/administration & dosage , Pneumonia, Viral/drug therapy , Zinc Compounds/administration & dosage , Animals , Anti-Inflammatory Agents/administration & dosage , Antioxidants/administration & dosage , Antiviral Agents/administration & dosage , Betacoronavirus , COVID-19 , Drug Therapy, Combination , Humans , Inflammation , Pandemics , SARS-CoV-2 , Solvents , Virus Diseases/drug therapy
2.
J Glob Antimicrob Resist ; 23: 256-262, 2020 12.
Article in English | MEDLINE | ID: covidwho-899142

ABSTRACT

Coronaviruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza viruses increase oxidative stress in the body leading to cellular and tissue damage. To combat this, administration of high-dose vitamin C (ascorbic acid or ascorbate), in addition to standard conventional supportive treatments, has been shown to be a safe and effective therapy for severe cases of respiratory viral infection. Morbidity, mortality, infectiveness and spread of infectious diseases are dependent on the host-pathogen relationship. Given the lack of effective and safe antiviral drugs for coronaviruses, there should be more attention in supporting host immune defence, cytoprotection and immunoregulation. Implementation of high-dose vitamin C therapy could dramatically reduce the need for high doses of corticosteroids, antibacterials and antiviral drugs that may be immunosuppressive, adrenal depressive and toxic, complicating the disease course. In order to effectively fight the novel SARS-CoV-2 virus, medical professionals should explore readily available pharmaceutical and nutritional therapeutic agents with proven antioxidant, anti-inflammatory and immunosupportive properties. Supplemental vitamin C may also provide additional benefits for the prevention of viral infections, shorten the disease course and lessen complications of the disease.


Subject(s)
Ascorbic Acid/administration & dosage , Coronavirus Infections/drug therapy , Coronavirus Infections/prevention & control , Anti-Inflammatory Agents/administration & dosage , Antioxidants/administration & dosage , Antiviral Agents/administration & dosage , Antiviral Agents/adverse effects , COVID-19/drug therapy , COVID-19/immunology , COVID-19/prevention & control , COVID-19/virology , Coronavirus Infections/immunology , Coronavirus Infections/virology , Host-Pathogen Interactions/drug effects , Host-Pathogen Interactions/immunology , Humans , Oxidative Stress/drug effects , SARS-CoV-2/drug effects
3.
Med Hypotheses ; 145: 110333, 2020 Dec.
Article in English | MEDLINE | ID: covidwho-813777

ABSTRACT

Zinc and the combination with zinc ionophore have been reported in basic research and several clinical investigations as a potentially viable and economical preventive and therapeutic options for COVID-19 treatment. Zinc is a vital microelement that actively supports respiratory epithelium barrier integrity, innate and adaptive immune functions, and inflammatory regulations. Moreover, zinc may also prevent viral entry, suppress viral replication, and mitigate the damages due to oxidative stress and hyperinflammatory reaction in patients with respiratory infections. Hinokitiol (ß-thujaplicin) is a natural monoterpenoid and is considered as a safe zinc ionophore to help zinc transport into cells. It has been widely used in skin and oral care, and therapeutic products for its potent antiviral, antimicrobial, antifungal, anti-inflammatory, and anticancer applications. The ongoing COVID-19 pandemic and the significant morbidity and mortality exist in the high-risk group of patients associated with other respiratory infections such as influenza, respiratory syncytial virus, and dengue fever. There is an urgent need for the development of inexpensive, safe, and effective therapeutics to prevent and treat these viral infections. Considering that hydroxychloroquine (HCQ), the most studied zinc ionophore drug for COVID-19, is linked to potentially serious side effects, we propose the implementation of hinokitiol as a zinc ionophore and anti-infective agent for the prevention and treatment of COVID-19 and other viral infections.


Subject(s)
Anti-Infective Agents/therapeutic use , COVID-19/drug therapy , COVID-19/prevention & control , Ionophores/therapeutic use , Monoterpenes/therapeutic use , Tropolone/analogs & derivatives , Zinc/chemistry , Antiviral Agents/therapeutic use , Homeostasis , Humans , Hydroxychloroquine/pharmacology , Models, Theoretical , Risk , Tropolone/therapeutic use
4.
J Infect Public Health ; 13(12): 1811-1817, 2020 Dec.
Article in English | MEDLINE | ID: covidwho-753247

ABSTRACT

The pandemic of novel coronavirus caused COVID-19 had resulted in a high number of hospitalizations and deaths and caused a devastating toll on human and society health. The symptoms of the infected patients vary significantly, from life-threatening to mild or even asymptomatic. This clinical observation led to hypothesize on the critical role of host innate immunity in the disease development and progression. As the first defense barrier against microorganisms, the innate immune reaction determines not only the viral infection rate but also immune-mediated response. Therefore, promote healthy behaviors to enhance innate immunity with functional food and nutritional agents may be a rational strategy for minimizing damages caused by viruses to global health.


Subject(s)
COVID-19/immunology , Functional Food , SARS-CoV-2 , Humans , Immunity, Innate
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