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1.
Journal of the American Academy of Dermatology ; 87(3):AB204, 2022.
Article in English | EMBASE | ID: covidwho-2031397

ABSTRACT

A highly visual practice, dermatology as a field has significant potential to use emerging technology such as mobile applications for research and patient-centered mapping of the disease process. The UCSF team is working to create SkinTracker, a mobile application for patients with skin disease to remotely participate in clinical trials and research studies. The initial iteration of the application focuses on atopic dermatitis. The application includes an enrollment and consent module, validated surveys including the Patient Oriented Eczema Measure (POEM), Dermatology Life Quality Index (DLQI), Numerical Rating Scale (NRS) for itch, link to a wearable device that collects biometric data, a voice diary, and a patient-directed photography module to facilitate physician evaluation of disease. Also included is the ability to report medication use, adverse events, and the ability to chat with the study team. The patient information is available to the research team on a secure online website, where researchers can assess patient photographs to perform Eczema Area and Severity Index (EASI) scoring, note important patient observations from the voice diary, and view quantitative data from both patient surveys and health measures like physical activity, sleep, and environmental factors. We believe this application and website will facilitate patient interest and participation in research, continue research despite in-person restrictions placed during the COVID-19 pandemic, and allow enrollment of more diverse patients for clinical studies who would otherwise be less likely to participate in research due to time or financial constraints.

2.
Front Psychol ; 13:978144, 2022.
Article in English | PubMed | ID: covidwho-2022899

ABSTRACT

The outbreak of the COVID-19 epidemic has promoted the popularity of online learning, but has also exposed some problems, such as a lack of interaction, resulting in loneliness. Against this background, students' attitudes toward peer interaction may have become even more important. In order to explore the impact of attitude toward peer interaction on students' mindset including online learning motivation and critical thinking practice that could affect their problem-solving self-efficacy during the COVID-19 pandemic, we developed and administered a questionnaire, receiving 1,596 valid responses. The reliability and validity of the questionnaire were re-tested, and structural equation modeling was applied. It was found that attitude toward peer interaction could positively predict middle school students' online learning motivation and critical thinking. Learning motivation and critical thinking also positively supported problem-solving self-efficacy. It is expected that the results of this study can be a reference for teachers to adopt student-centered online learning in problem solving courses.

3.
Risk Anal ; 2022.
Article in English | PubMed | ID: covidwho-2019609

ABSTRACT

We theoretically analyze the resilience (efficiency) of health insurance systems and diverse factors including trace and test technology, infection and contagion rates, and social distancing/lockdown policy, in coping with contagious diseases like COVID-19. Our findings can be summarized as follows. First, public insurance is more resilient than market insurance, as the former's investment in test technology is made at the social optimum, whereas the latter's investment is less. The decentralized behavior of competing insurers leads to a less resilient outcome. Second, resilience decreases as the market becomes more competitive because the externality effect becomes more severe. Third, a higher contagion rate, a more cost-efficient test technology or a higher initial infection rate unless it is not too high, leads to a higher test accuracy level. Fourth, the socially optimal social distancing/lockdown policy is determined by comparison between its relative costs and the benefit from contagion reduction.

4.
Infect Dis Poverty ; 11, 2022.
Article in English | PMC | ID: covidwho-2009472

ABSTRACT

Background: The continuous mutation of severe acute respiratory syndrome coronavirus 2 has made the coronavirus disease 2019 (COVID-19) pandemic complicated to predict and posed a severe challenge to the Beijing 2022 Winter Olympics and Winter Paralympics held in February and March 2022. Methods: During the preparations for the Beijing 2022 Winter Olympics, we established a dynamic model with pulse detection and isolation effect to evaluate the effect of epidemic prevention and control measures such as entry policies, contact reduction, nucleic acid testing, tracking, isolation, and health monitoring in a closed-loop management environment, by simulating the transmission dynamics in assumed scenarios. We also compared the importance of each parameter in the combination of intervention measures through sensitivity analysis. Results: At the assumed baseline levels, the peak of the epidemic reached on the 57th day. During the simulation period (100 days), 13,382 people infected COVID-19. The mean and peak values of hospitalized cases were 2650 and 6746, respectively. The simulation and sensitivity analysis showed that: (1) the most important measures to stop COVID-19 transmission during the event were daily nucleic acid testing, reducing contact among people, and daily health monitoring, with cumulative infections at 0.04%, 0.14%, and 14.92% of baseline levels, respectively (2) strictly implementing the entry policy and reducing the number of cases entering the closed-loop system could delay the peak of the epidemic by 9 days and provide time for medical resources to be mobilized;(3) the risk of environmental transmission was low. Conclusions: Comprehensive measures under certain scenarios such as reducing contact, nucleic acid testing, health monitoring, and timely tracking and isolation could effectively prevent virus transmission. Our research results provided an important reference for formulating prevention and control measures during the Winter Olympics, and no epidemic spread in the closed-loop during the games indirectly proved the rationality of our research results. Graphical : Supplementary Information: The online version contains supplementary material available at 10.1186/s40249-022-01019-2.

5.
Journal of the ASEAN Federation of Endocrine Societies ; 37:8, 2022.
Article in English | EMBASE | ID: covidwho-2006564

ABSTRACT

Introduction The management of teenagers with diabetes during the COVID-19 pandemic has become more challenging with the negative psychosocial impact brought upon by the pandemic. Methodology We embarked on a cross-sectional study to identify the factors influencing glycaemic control (HbA1c) among teenagers with diabetes during the COVID-19 pandemic. Interviews regarding lifestyle changes were conducted among teenagers with type 1 (T1DM) and type 2 diabetes mellitus (T2DM), followed by the administration of the Depression, Anxiety, and Stress Scale (DASS-21). Results A total of 59 adolescents with T1DM (32 males, 54.2%) and 31 patients with T2DM (10 males, 32.3%) were recruited. Overall, the HbA1c worsened from 9.13% before the COVID-19 pandemic to 9.33% during the pandemic (p-value 0.039). Significant factors which negatively influenced glycaemic control were male sex, puberty, prolonged screen time, presence of symptoms of anxiety/stress, and T2DM. However, skipping breakfast, sleep adequacy and physical activity did not directly influence the HbA1c. About one-third of the participants suffered from some form of mental disturbance (31.1% of patients had depressive symptoms, 38.9% of patients had anxiety symptoms, and 23.3% of patients experienced stress). The incidence of depression was higher among participants with T2DM, while anxiety and stress were higher among those with T1DM. Male gender, good glycaemic control pre-pandemic, and prepubertal status were associated with depressive symptoms during the pandemic. Conclusion Besides the disruption of daily routine, glycaemic control worsened among diabetic adolescents during the COVID-19 pandemic. A holistic management plan is needed to address the psychosocial concerns of this group to ensure optimal mental well-being and appropriate glycaemic control.

6.
JMIR Mental Health ; 9(8):e38600, 2022.
Article in English | MEDLINE | ID: covidwho-2002418

ABSTRACT

BACKGROUND: The COVID-19 pandemic required mental health services around the world to adapt quickly to the new restrictions and regulations put in place to reduce the risk of transmission. As face-to-face contact became difficult, virtual methods were implemented to continue to safely provide mental health care. However, it is unclear to what extent service provision transitioned to telemental health worldwide. OBJECTIVE: We aimed to systematically review the global research literature on how mental health service provision adapted during the first year of the pandemic. METHODS: We searched systematically for quantitative papers focusing on the impact of the COVID-19 pandemic on mental health services published until April 13, 2021, in the PubMed, Embase, medRxiv, and bioXriv electronic bibliographic databases, using the COVID-19 Open Access Project online platform. The screening process and data extraction were independently completed by at least two authors, and any disagreement was resolved by discussion with a senior member of the team. The findings were summarized narratively in the context of each country's COVID-19 Stringency Index, which reflects the stringency of a government's response to COVID-19 restrictions at a specific time. RESULTS: Of the identified 24,339 records, 101 papers were included after the screening process. Reports on general services (n=72) showed that several countries' face-to-face services reduced their activities at the start of the pandemic, with reductions in the total number of delivered visits and with some services forced to close. In contrast, telemental health use rapidly increased in many countries across the world at the beginning of the pandemic (n=55), with almost complete virtualization of general and specialistic care services by the end of the first year. Considering the reported COVID-19 Stringency Index values, the increased use of virtual means seems to correspond to periods when the Stringency Index values were at their highest in several countries. However, due to specific care requirements, telemental health could not be used in certain subgroups of patients, such as those on clozapine or depot treatments and those who continued to need face-to-face visits. CONCLUSIONS: During the pandemic, mental health services had to adapt quickly in the short term, implementing or increasing the use of telemental health services across the globe. Limited access to digital means, poor digital skills, and patients' preferences and individual needs may have contributed to differences in implementing and accessing telemental health services during the pandemic. In the long term, a blended approach, combining in-person and virtual modalities, that takes into consideration the needs, preferences, and digital skills of patients may better support the future development of mental health services. It will be required to improve confidence with digital device use, training, and experience in all modalities for both clinicians and service users.

7.
Journal of Neurocritical Care ; 15(1):65-68, 2022.
Article in English | Scopus | ID: covidwho-1955222

ABSTRACT

Background: Ischemic stroke is one of the serious neurological complications of coronavirus disease 2019 (COVID-19). However, ischemic stroke can develop secondary complications after cardiac involvement in COVID-19. Case Report: We report the case of a 22-year-old patient who presented with malignant cerebral infarction 10 months after COVID-19-related myocarditis. A 22-year-old woman was referred to the emergency room because of abnormal mental status changes. She developed heart failure and arrhythmia after COVID-19-related myocarditis. Brain magnetic resonance imaging (MRI) revealed high signal intensity on diffusion-weighted imaging that was indicative of acute cerebral infarction in the left middle cerebral artery (MCA) and left anterior cerebral artery (ACA) territory. In addition, occlusion of both the left MCA and ACA was observed on brain MRI. Craniectomy with therapeutic hypothermia was performed to treat the cerebral edema. Conclusion: This case suggests that caution is needed in survivors with secondary complications after COVID-19. © 2022 The Korean Neurocritical Care Society.

8.
Contemporary Educational Research Quarterly ; 30(1):119-147, 2022.
Article in Chinese | Scopus | ID: covidwho-1912066

ABSTRACT

During the outbreak of the new coronavirus disease COVID-19 (Coronavirus Disease 2019) epidemic, online learning has changed the traditional learning model. The purpose of this research was to explore how the antecedent of self-directed learning approach and attitudes of online learning can affect participants’ perceptions of cognitive fatigue and immersion during online learning that reflect their perceptions of the learning ineffectiveness of online learning. Design/methodology/approach This research adopted convenience sampling to collect data. During the period of the COVID-19 epidemic, the target participants were higher education students who adopted distance learning in the lockdown area of China. A questionnaire was posted on the Tencent questionnaire system for participants to fill out. The sample data of 155 college students were validly collected and subjected to test reliability and structural equation modeling using the SmartPLS 3.0 software to verify the research model proposed in this study. Findings/results The study found that self-directed learning attitudes were negatively related to online learning cognitive fatigue, but were positively related to cognitive presence;the self-directed learning approach was negatively related to online learning cognitive fatigue, but was positively related to cognitive presence. Moreover, online learning cognitive fatigue was positively related to perceived learning ineffectiveness, whereas cognitive presence was negatively related to perceived learning ineffectiveness. Originality/value In the new learning mode under the threat of the COVID-19 epidemic, this study explored the interaction between students' selfdirected learning, focused learning, and cognitive fatigue during the online learning process. Although there is no in-depth discussion on related research that affects learners’ perception of their learning outcomes, based on TAT (Trait activation theory), this study first divided self-directed learning into two categories: approach and attitude, and found how self-directed learning traits can predict online learning mental state, such as deactivator-cognitive fatigue and activator–immersion that affected the perceived effectiveness of online learning during the COVID-19 epidemic. Suggestions/implications The results of this study divided self-directed learning into approach and attitudes and indicated that both approach and attitudes of self-directed learning should be promoted by school teachers. Moreover, to design good distance learning programs, it is necessary to stimulate students’ mental state to learn and explore actively. Teachers can design interactive prompts or a reminding service in the teaching process to promote students’ cognitive presence and reduce their Internet cognitive fatigue, and to strengthen the overall learning effect. © 2022. Contemporary Educational Research Quarterly.All Rights Reserved

9.
Journal of Research in Education Sciences ; 66(4):1-33, 2021.
Article in Chinese | Scopus | ID: covidwho-1876094

ABSTRACT

Background and Purpose of Research Adolescents use their smartphones for various purposes, for example, following distance/online learning, especially during the COVID-19 pandemic, staying in touch with friends, having fun using social media tools. According to the social ecological model, risk behaviors, like substance consumption, are regarded as behavior problems. Relatively, etiology is derived of youths’ embeddedness surrounded by their social networks, mainly throughout sensitive development periods (Bishop et al., 2020). Given the prevalence of smartphone addiction among young students, previous studies have explored the relationships between smartphone addiction and students’ learning and indicated there is negative outcomes of smartphone resulting from overuse of mobile phones, including poor sleep quality. However, there some antecedents of smartphone addiction which has not extendedly studied, for example, parenting style, thus, the present study aimed to explore the correlates between parenting styles, academic achievement and smartphone addiction. Parenting that reflects a combination of support and behavioral control has been linked to numerous indices of academic well-being and live functioning from early childhood through adolescence. In regarding the term helicopter parenting indicated that parents involve hovering behaviors and are potentially over-involved in the lives of their child or in their academic work (Padilla-Walker & Nelson, 2012). But empirical research has not adequately used these two construct from other controlling parenting practices to predict children’s smartphone addiction, thus, the present study applied two types of helicopter parenting: Live hovering and academic hovering of parenting for of emerging adults, to explain the prediction of children’s smartphone addiction. According to Bronfenbrenner (1979) micro ecological system that discusses the association between person-process-content (PPC), who described “person-process-context model” (PPCM) that occurs variability in development procedure as considered in this paper as a functional context (mobile phone usage), person (parenting styles) and process (academic achievement). Not only has cultural ecology be likely to pursue its complications in issues originating from social and cultural topics, but intricate schools of understanding of culture-nature relationship have developed for certain risk behavior. For example, helicopter parenting is more obvious in Chinese families than Western ones, even though the parents want their children to grow up to be independent and think for themselves. Particularly, Chinese parents are more concerned about their children’s schoolwork when they are teenagers, which leads to increased helicopter parenting problems, exacerbating issues such as lack of independence, lack of control, and not knowing how to self-manage smartphone use, which can in turn lead to smartphone addiction. If parents are in constant hovering of their children’s lives or schoolwork, children develop dependent behaviors. Some studies have indicated that a child’s dependent behaviors result in lower motivation to learn and reduced academic achievement. In line with this, drawn on PPCM to understanding the role of academic hovering and live hovering affect participants’ smartphone addiction mediated by academic achievement, hypotheses are proposed as follows. Hypotheses (1) Live hovering has a negative effect on academic achievement. (2) Academic hovering has a negative effect on academic achievement. (3) Academic achievement has a negative effect on smartphone addiction. (4) Live hovering has a positive effect on smartphone addiction. (5) Academic hovering has a positive effect on smartphone addiction. Methodology Questionnaire was designed by adapting and translated from previous researched and gave to domain experts to ensure the content validity. Afterward, a purposive sampling was adapted in this study, a total of 400 questionnaires were distributed to 4 vocational senior high schools located in Taipei City. 354 of which were collected, resulting in a questionnaire collection rate of 88.5%. After 64 invalid questionnaires were excluded, 290 valid questionnaires remained, resulting in a valid questionnaire collection rate of 81.92%. Factor analysis was conducted on the valid questionnaires. Results First, helicopter parenting, live and academic hovering had a negative association with academic achievement, with an explanatory power of 20.8%. Second, academic achievement had a negative association with smartphone addiction, with an explanatory power of 38.6%. Third, helicopter parenting had a negative association with smartphone addiction. Fourth, academic hovering had a negative association with smartphone addiction mediated by academic achievement, with an explanatory power of 20.8%. The results of the study thus indicate that young people who are not independent in life or schoolwork tend to rely on their parents, are less able to control their smartphone use, and are more likely to develop smartphone addiction. By contrast, young people who are independent in life and schoolwork and do not need to rely on their parents have control over their smartphone use and are less likely to develop smartphone addiction. Conclusions and Recommendations The results of this study demonstrate that if vocational senior high school students are overly dependent on their parents in life or schoolwork, they may have lower academic achievement and therefore, they are not motivated to achieve strong academic results and will not restrain their desire to spend time on using smartphone, resulting in a tendency toward smartphone addiction. However, when vocational senior high school students do not have to rely on their parents to a great extent in life or schoolwork, they are able to act independently, attain high academic achievement, determine what they want to achieve, and arrange how they will accomplish their goals. Therefore, they have the ability to control the time they spend using their phones and will not develop smartphone addiction. This study suggests that parents should let their children learn to be independent and autonomous, which should help to effectively reduce the problem of smartphone addiction. Finally, conducting this study highlighted possibilities for future research. Some studies suggest that fathers and mothers do not necessarily share the same parenting style, and hence, it is suggested that in a questionnaire survey, the hovering styles of fathers and mothers could be differentiated and then analyzed through a differential analysis. In addition, some smartphone use can be designed with time of use to control using time (e.g., Chinese government limited the hours for children to use smartphone). However, how is the effect of the regulation to students’ smartphone addiction should be further studied. © 2021, National Taiwan Normal University. All rights reserved.

10.
Korean Chemical Engineering Research ; 60(2):282-288, 2022.
Article in Korean | Web of Science | ID: covidwho-1870102

ABSTRACT

Facial masks have become indispensable in daily life to prevent infection and spread through respiratory droplets in the era of the corona pandemic. To understand how effective two different types of masks (i.e., KF-94 mask and dental mask) are in blocking respiratory droplets, i) we preferentially analyze wettability characteristics (e.g., contact angle and contact angle hysteresis) of filters consisting of each mask, and ii) subsequently observe the dynamic behaviors of microdroplets impacting at high velocities on the filter surfaces. Different wetting properties (i.e., hydrophobicity and hydrophilicity) are found to exhibit depending on the constituent materials and pore sizes of each filter. In addition, the pneumatic conditions for stably and uniformly dispensing microdroplets with a certain volume and impacting behaviors associated with the impacting velocity and filter type change are systematically explored. Three distinctive dynamics constituting the masks and droplet impact velocity. The present experimental results not only provide very useful

11.
4th IEEE Global Conference on Life Sciences and Technologies, LifeTech 2022 ; : 303-304, 2022.
Article in English | Scopus | ID: covidwho-1840261

ABSTRACT

A descriptive time series study of casualties from motorcycle accidents in Taiwan between 2016 and 2020. The data on casualties were obtained from the road safety information system provided by the Ministry of Transportation and Communications. Between 2016 and 2020 the casualties increased from 2,571 to 3,191 (an increase of 241% in casualty rates during the period studied). High casualty rates in 2020 were observed in Taiwan. There was a significant increase in motorcycle accident casualty rates for the country as a whole during the studied period. © 2022 IEEE.

12.
PubMed; 2021.
Preprint in English | PubMed | ID: ppcovidwho-334725

ABSTRACT

With the emergence of SARS-CoV-2 variants, there is urgent need to develop broadly neutralizing antibodies. Here, we isolate two V H H nanobodies (7A3 and 8A2) from dromedary camels by phage display, which have high affinity for the receptor-binding domain (RBD) and broad neutralization activities against SARS-CoV-2 and its emerging variants. Cryo-EM complex structures reveal that 8A2 binds the RBD in its up mode and 7A3 inhibits receptor binding by uniquely targeting a highly conserved and deeply buried site in the spike regardless of the RBD conformational state. 7A3 at a dose of a5 mg/kg efficiently protects K18-hACE2 transgenic mice from the lethal challenge of B.1.351 or B.1.617.2, suggesting that the nanobody has promising therapeutic potentials to curb the COVID-19 surge with emerging SARS-CoV-2 variants. ONE-SENTENCE SUMMARY: Dromedary camel ( Camelus dromedarius ) V H H phage libraries were built for isolation of the nanobodies that broadly neutralize SARS-CoV-2 variants.

14.
Cancer Research ; 82(4 SUPPL), 2022.
Article in English | EMBASE | ID: covidwho-1779465

ABSTRACT

Background: During the SARS-CoV-2 pandemic in 2020, the use of routine screening mammography (SM) and diagnostic mammography (DM) was limited for several months in order to reduce patient exposure and redeploy medical personnel. Previous studies suggest such delays result in more late-stage breast cancer diagnoses. We hypothesized that this impact would vary between institutions depending on regional variations in shutdown periods and the ability and willingness of patients to resume screening. Methods: Patients diagnosed with invasive breast cancers from 2016-2020 were identified using the Beth Israel Deaconess Medical Center (BIDMC) and the Duke University Medical Center (DUMC) cancer registries. Rates of mammography were ascertained from billing data. Baseline patient characteristics, demographics, and clinical information were gathered and cross-referenced with the electronic medical record. Late-stage was defined as Anatomic Stage III-IV disease (AJCC 8th edition). Chi-squared analysis was used to examine monthly distributions in stage at presentation for diagnosis in 2016-2019 compared to in 2020 at each institution. Results: There were 5907 patients diagnosed with invasive breast cancer between 2016-2019 (1597 at BIDMC and 4310 at DUMC) and 1075 in 2020 (333 and 742, respectively). Mammography was limited from 3/16/20-6/8/20 at BIDMC and from 3/16/20-4/20/20 Sa t DUMC. There were fewer SM at each institution during their respective shutdown periods in 2020 than in the same months in 2019: BIDMC 1713 versus 8566 (80% reduction) and at DUMC 1649 versus 5698 (71% reduction). Following the pandemic shutdown, SM volume increased in July-December 2020 compared to July-December 2019 (108% at BIDMC and 116% at DUMC). The proportion of patients diagnosed with late-stage disease at BIDMC was greater in 2020 than in 2016-2019, at 12.6% and 6.6%, respectively (p < 0.001);86% of late-stage diagnoses and 68% of all diagnoses in 2020 at BIDMC occurred from July-December following the initial shutdown period. The proportion of patients diagnosed with late-stage disease at DUMC in these two cohorts were 14.3% in 2020 and 16.2%% in 2016-2019 (p = 0.1);50% of late-stage diagnoses and 51% of all diagnoses in 2020 at DUMC occurred in the period following the initial shutdown from July-December. Conclusion: We identified variation between two large academic medical centers in the impact of the SARS-CoV-2 pandemic shutdown on the proportion of late-stage breast cancer diagnoses. These dissimilar outcomes may be the result of differences in referral patterns as well as regional differences in the approach to SM during the pandemic. In particular, a shorter closure time and substantial increase in SM volume following the initial shutdown period in the Southeast region may have prevented an increase in late-stage diagnoses. Further information and analysis may help suggest additional strategies to minimize adverse effects of reduced cancer screening in future public-health emergencies.

15.
Measurement Science and Technology ; 33(6):21, 2022.
Article in English | Web of Science | ID: covidwho-1769098

ABSTRACT

The coronavirus disease (COVID-19) pandemic has spread to nearly every corner of the globe, significantly impacting economies and societies. Despite advances in detection technologies that target viral pathogens, all countries are facing an unprecedented need to perform biosensing in a rapid, sensitive, selective, and reliable way to deal with global and urgent problems. To date, the reverse transcription-polymerase chain reaction has been the gold-standard method for COVID-19 diagnosis. However, it requires complex facilities and elaborate training and is hampered by limited testing capacity and delayed results. Herein, we review state-of-the-art research into point-of-care biosensors for early severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection. We include a general description of the nanotechnological techniques used to develop biosensors, along with the latest research into various biosensors for SARS-CoV-2 detection and a summary of their limitations for practical use. Finally, we discuss future perspectives and directions. This critical review offers the biosensor community insight into how to progress the present research, which may streamline the removal of the problems facing rapid and large-scale SARS-CoV-2 screening.

16.
2021 IEEE International Conference on Image Processing, ICIP 2021 ; 2021-September:235-239, 2021.
Article in English | Scopus | ID: covidwho-1735796

ABSTRACT

Face recognition now requires a large number of labelled masked face images in the era of this unprecedented COVID-19 pandemic. Unfortunately, the rapid spread of the virus has left us little time to prepare for such dataset in the wild. To circumvent this issue, we present a 3D model-based approach called WearMask3D for augmenting face images of various poses to the masked face counterparts. Our method proceeds by first fitting a 3D morphable model on the input image, second overlaying the mask surface onto the face model and warping the respective mask texture, and last projecting the 3D mask back to 2D. The mask texture is adapted based on the brightness and resolution of the input image. By working in 3D, our method can produce more natural masked faces of diverse poses from a single mask texture. To compare precisely between different augmentation approaches, we have constructed a dataset comprising masked and unmasked faces with labels called MFW-mini. Experimental results demonstrate WearMask3D1produces more realistic masked faces, and utilizing these images for training leads to state-of-the-art recognition accuracy for masked faces. © 2021 IEEE

17.
Educational Technology and Society ; 25(1):142-154, 2022.
Article in English | Scopus | ID: covidwho-1728221

ABSTRACT

With the outbreak of COVID-19, more online learning has been adopted for distance learning. However, the effectiveness of online learning for those students engaged in it for the first time has not been discussed. This study aims to investigate perceived ineffectiveness of online learning and its antecedents related to cognitive and affective factors. Internet self-efficacy (ISE) and Self-efficacy of interacting with learning content (SEILC) were hypothesized to have a correlation with perceived ineffectiveness of online learning (PIOL) mediated by participants’ Internet cognitive fatigue (ICF) and mind-unwandered, while ICF was hypothesized to have a correlation with mind-unwandered. Data of 251 students collected from high schools in China during the lockdown period of COVID-19 were subjected to confirmatory factor analysis via AMOS. Results indicated that participants’ ISE and SEILC were positively related to mind-unwandered, but negatively related to ICF during online learning, while ICF was positively associated with PIOL. On the other hand, mind-unwandered was negatively associated with PIOL. Furthermore, students’ ISE and SEILC indirectly affected their PIOL mediated by ICF. Findings suggest that an enhancement of learners’ ISE and SEILC could have reduced the level of PIOL the first time that online learners experienced under the COVID-19 lockdown to promote their learning effectiveness. This understanding will be useful in case of another pandemic outbreak. © 2022, Educational Technology and Society. All rights reserved.

18.
Nano Energy ; 93, 2022.
Article in English | Scopus | ID: covidwho-1575646

ABSTRACT

Because of the COVID-19 pandemic, the number of bicycle users has increased, raising concerns regarding bicycle safety. Although various small electronic devices have been used to ensure bicycle safety, such devices require an external battery, which introduces certain limitations such as recharging requirements. Several researchers have investigated methods to sustainably harvest energy from bicycles. Triboelectric-generator-based solutions, which can utilize the mechanical motion of a rolling tire can serve as the auxiliary power source of small electronics or self-powered sensors. However, research on practical and reliable bicycle-related triboelectric nanogenerators is limited. In this study, a triboelectric bicycle tire (TBT) was developed, considering the actual material/structure of commercial bicycle tires, and the novel electricity-generation mechanism was clarified. As the TBT system had a fully inserted (packaged) structure, it could generate extremely stable electrical output for 120,000 cycles. The electrical performance was quantitatively analyzed depending on the design parameters and riding situation. The findings demonstrated that the TBT system can be effectively used to enhance bicycle safety;according to the peak magnitude and waveform data, the TBT system can function as a self-powered bicycle pressure sensor. Second, the freestanding-mode TBT system can be utilized as a self-powered bicycle safety light in real time, demonstrated by its ability to power LEDs. © 2021

19.
PUBMED; 2021.
Preprint in English | PUBMED | ID: ppcovidwho-292966

ABSTRACT

With the emergence of SARS-CoV-2 variants, there is urgent need to develop broadly neutralizing antibodies. Here, we isolate two V H H nanobodies (7A3 and 8A2) from dromedary camels by phage display, which have high affinity for the receptor-binding domain (RBD) and broad neutralization activities against SARS-CoV-2 and its emerging variants. Cryo-EM complex structures reveal that 8A2 binds the RBD in its up mode and 7A3 inhibits receptor binding by uniquely targeting a highly conserved and deeply buried site in the spike regardless of the RBD conformational state. 7A3 at a dose of a5 mg/kg efficiently protects K18-hACE2 transgenic mice from the lethal challenge of B.1.351 or B.1.617.2, suggesting that the nanobody has promising therapeutic potentials to curb the COVID-19 surge with emerging SARS-CoV-2 variants. One-Sentence Summary: Dromedary camel ( Camelus dromedarius ) V H H phage libraries were built for isolation of the nanobodies that broadly neutralize SARS-CoV-2 variants.

20.
Journal of Clinical Oncology ; 39(15):3, 2021.
Article in English | Web of Science | ID: covidwho-1533309
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