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1.
The Journal of craniofacial surgery ; 33(5):1300-1302, 2021.
Article in English | EuropePMC | ID: covidwho-1939919

ABSTRACT

: To report 2 successfully managed cases of graft rejection with acellular porcine corneal stroma (APCS) transplantation in patients with fungal corneal ulcer. Two patients were diagnosed with fungal corneal ulcer and received APCS transplantation. Graft rejection developed due to the lost follow-up during the period of coronavirus disease 2019 outbreak. Amniotic membranes transplantation and cauterization of neovascularization was performed, respectively. The graft failure resolved successfully after the procedure. To the best of our knowledge, amniotic membranes transplantation and cauterization of new vessels are the firstly reported in treating APCS graft failure. Amniotic membranes transplantation or cauterization of neovascularization appear to be a safe and costeffective method for treating graft failure.

2.
Polymers (Basel) ; 14(14)2022 Jul 21.
Article in English | MEDLINE | ID: covidwho-1938950

ABSTRACT

Meltblown (MB) nonwovens as air filter materials have played an important role in protecting people from microbe infection in the COVID-19 pandemic. As the pandemic enters the third year in this current global event, it becomes more and more beneficial to develop more functional MB nonwovens with special surface selectivity as well as antibacterial activities. In this article, an antibacterial polypropylene MB nonwoven doped with nano silicon nitride (Si3N4), one of ceramic materials, was developed. With the introduction of Si3N4, both the average diameter of the fibers and the pore diameter and porosity of the nonwovens can be tailored. Moreover, the nonwovens having a single-side moisture transportation, which would be more comfortable in use for respirators or masks, was designed by imparting a hydrophobicity gradient through the single-side superhydrophobic finishing of reactive organic/inorganic silicon coprecipitation in situ. After a nano/micro structural SiO2 precipitation on one side of the fabric surfaces, the contact angles were up to 161.7° from 141.0° originally. The nonwovens were evaluated on antibacterial activity, the result of which indicated that they had a high antibacterial activity when the dosage of Si3N4 was 0.6 wt%. The bacteriostatic rate against E. coli and S. aureus was up to over 96%. Due to the nontoxicity and excellent antibacterial activity of Si3N4, this MB nonwovens are promising as a high-efficiency air filter material, particularly during the pandemic.

3.
Med Sci Educ ; 32(3): 657-677, 2022 Jun.
Article in English | MEDLINE | ID: covidwho-1930628

ABSTRACT

Healthcare education providers are eager to apply technologies in teaching and learning activities; however, students are the consumers in higher education, and their opinion and experience should be considered. We performed a meta-synthesis of qualitative studies to help inform our understanding of Southeast Asian healthcare students' perceptions and experience of technology-based teaching and learning in their education. Our search strategy located 1599 articles from a dozen electronic research databases. Articles were analyzed for quality using the Hawker's Evidence Appraisal Tool, and 23 qualitative studies were included in the final meta-synthesis. Technologies investigated largely involved online or blended learning, with fewer exploring virtual reality, simulations, telehealth, game-based learning, and videos. Three overarching themes were synthesized: (i) culture does matter in the implementation of technology-based learning; (ii) the values and limitations of technology used for learning; and (iii) technology is part of daily life and creates new challenges in education. Technology is an asset to enhance the learning experience, but educators must be aware of its limitations. Pre-coronavirus disease 2019 (COVID-19) studies were more focused on technology and product, and were optimistically reported, whereas COVID-19-spanning studies focused on life experience and paid more attention to reporting on the inherent challenges. The educational approaches, theories, cultural aspects, and availability of facilities all play a vital role in steering successful technology use in learning.

4.
BMC Med Educ ; 22(1): 535, 2022 Jul 11.
Article in English | MEDLINE | ID: covidwho-1928177

ABSTRACT

The COVID-19 pandemic and Movement Control Order have restricted learning activities from traditional face-to-face classrooms attendance shifted to full online learning in the student's environment. The present study is aimed to explore pertaining issues on full online learning among nursing students and offer a contingency solution. Nursing students from one Malaysian public institution were recruited. The sessions were conducted online via teleconference and were recorded. The data were analysed using thematic analysis with the assistance of QDA Miner Lite software. Twenty-one students participated, resulting in four focus group discussions and three in-depth interviews. Three themes with a total of ten sub-themes were generated: (i) Full online learning has ramifications on life (it is about life; blurred division on education life and personal life; non-conducive environment for learning; health and well-being; human is an adaptable being while the transition takes time), (ii) full online learning is a medium of teaching and learning delivery but with several concerns (the boon and bane of fully online learning; challenges associated with full online learning; coping strategy in handling full online learning), and (iii) Foundation in teaching and learning is the key (role of the educator; teaching and learning approaches; motivation and regulation). A model of practice for full online learning was developed, consisting of some modifications to create a conducive and healthy learning environment. This study embarks on a more structured and standard online learning practice for making the Internet of Things and Industrial Revolution 4.0 concept a contemporary and mainstream education practice.


Subject(s)
COVID-19 , Education, Distance , Education, Nursing, Baccalaureate , Students, Nursing , Education, Nursing, Baccalaureate/methods , Humans , Pandemics
5.
Int J Endocrinol ; 2022: 9838923, 2022.
Article in English | MEDLINE | ID: covidwho-1923359

ABSTRACT

[This corrects the article DOI: 10.1155/2022/9322332.].

6.
Biomedicine (Taipei) ; 12(2): 40-46, 2022.
Article in English | MEDLINE | ID: covidwho-1897355

ABSTRACT

Objectives: This study examined analytical sensitivity, specificity, and the clinical performance in detecting SARS-CoV-2 of the Cobas SARS-CoV-2 Test based on the high-throughput Cobas 6800 system and the Cobas SARS-CoV-2 & Flu A/B Test based on the point-of-care cobas Liat system. Methods: The commercial reagents containing SARS-CoV-2 RNA subgenomes were diluted for assessing the sensitivity of the RT-qPCR assay. 385 nasopharyngeal swab specimens taken from contacts of COVID-19 cases were tested for the SARS-CoV-2 detection with both Cobas SARS-CoV-2 Tests. Results: In analytical sensitivity assays, the Cobas SARS-CoV-2 & Flu A/B Test on the Liat system had a lower limit of detection (12.5-25 copies/mL) than the cobas SARS-CoV-2 Test on the cobas 6800 system (25-50 copies/mL). In clinical performance assays, the cobas SARS-CoV-2 Test demonstrated 89.36% (42 out of 47) PPA (positive percent agreement) and 98.82% (334 out of 338) NPA (negative percent agreement) compared to the results of the Cobas SARS-CoV-2 & Flu A/B test. Among five discordant specimens, four had the positive result of the cobas SARS-CoV-2 test, but the negative result of the cobas SARS-CoV-2 & Flu A/B Test. Moreover, these discordant specimens had the Ct values of greater than 33 for the cobas SARS-CoV-2 Test, implying a very small number of virions in the samples. Remarkably, four specimens with a presumptive positive result of the cobas SARS-CoV-2 test had been confirmed by the Cobas SARS-CoV-2 & Flu A/B Test. Next, the scatter plots of the Ct values showed a highly positive correlation between cobas SARS-CoV-2 & Flu A/B Test and the cobas SARS-CoV-2 Test (R-squared value = 0.954-0.962). Conclusions: Both SARS-CoV2 tests of the cobas 6800 and Liat systems produce reliable high throughput and point-of-care assays respectively for the early virus detection and the personal care decision-making during COVID-19 pandemic.

7.
Psychol Res Behav Manag ; 15: 823-837, 2022.
Article in English | MEDLINE | ID: covidwho-1855210

ABSTRACT

Background: The COVID-19 pandemic motivated people to stay at home to reduce the risk of COVID-19 infection and community transmission, but limited research has investigated the behavioral mechanisms underlying home quarantine. Methods: Based on the theory of planned behavior (TPB), this study explored the mediating role of intention toward home quarantine and the moderating role of nationality among attitude, subjective norms, and perceived behavioral control. A total of 827 college students from the United States and China were recruited to complete an online survey. Results: The results of structural equation modeling showed that antecedents (ie, attitude, subjective norms, and perceived behavioral control) could predict actual home-quarantine behavior through the role of intention. Notably, the relation between both attitude and intention and perceived behavioral control and intention were moderated by nationality. Specifically, attitude was a stronger predictor of intention for American participants than for Chinese participants; however, perceived behavioral control was a stronger predictor of intention for Chinese participants. Conclusion: These findings reveal the internal mechanism of home-quarantine behavior and the heterogeneous explanations attributed to cultural diversity during the pandemic, which not only expands the application of TPB but also provides a reference for infectious disease mitigation in the field of public health policy.

8.
Math Biosci Eng ; 19(7): 6469-6488, 2022 04 25.
Article in English | MEDLINE | ID: covidwho-1855918

ABSTRACT

As we all know, vaccination still does not protect people from novel coronavirus infections, and wearing masks remains essential. Research on mask attention is helpful to understand the public's cognition and willingness to wear masks, but there are few studies on mask attention in the existing literature. The health belief model used to study disease prevention behaviors is rarely applied to the research on mask attention, and the research on health belief models basically entails the use of a questionnaire survey. This study was purposed to establish a health belief model affecting mask attention to explore the relationship between perceived susceptibility, perceived severity, self-efficacy, perceived impairment, action cues and mask attention. On the basis of the establishment of the hypothesis model, the Baidu index of epidemic and mask attention, the number of likes and comments on Weibo, and the historical weather temperature data were retrieved by using software. Keyword extraction and manual screening were carried out for Weibo comments, and then the independent variables and dependent variables were coded. Finally, through binomial logistic regression analysis, it was concluded that perceived susceptibility, perceived severity and action cues have significant influences on mask attention, and that the accuracy rate for predicting low attention is 93.4%, and the global accuracy is 84.3%. These conclusions can also help suppliers make production decisions.


Subject(s)
COVID-19 , Epidemics , COVID-19/epidemiology , COVID-19/prevention & control , Epidemics/prevention & control , Humans , Masks , SARS-CoV-2
10.
Medical science educator ; : 1-21, 2022.
Article in English | EuropePMC | ID: covidwho-1824374

ABSTRACT

Healthcare education providers are eager to apply technologies in teaching and learning activities;however, students are the consumers in higher education, and their opinion and experience should be considered. We performed a meta-synthesis of qualitative studies to help inform our understanding of Southeast Asian healthcare students’ perceptions and experience of technology-based teaching and learning in their education. Our search strategy located 1599 articles from a dozen electronic research databases. Articles were analyzed for quality using the Hawker’s Evidence Appraisal Tool, and 23 qualitative studies were included in the final meta-synthesis. Technologies investigated largely involved online or blended learning, with fewer exploring virtual reality, simulations, telehealth, game-based learning, and videos. Three overarching themes were synthesized: (i) culture does matter in the implementation of technology-based learning;(ii) the values and limitations of technology used for learning;and (iii) technology is part of daily life and creates new challenges in education. Technology is an asset to enhance the learning experience, but educators must be aware of its limitations. Pre-coronavirus disease 2019 (COVID-19) studies were more focused on technology and product, and were optimistically reported, whereas COVID-19–spanning studies focused on life experience and paid more attention to reporting on the inherent challenges. The educational approaches, theories, cultural aspects, and availability of facilities all play a vital role in steering successful technology use in learning.

11.
Preprint in English | medRxiv | ID: ppmedrxiv-22274029

ABSTRACT

Comprehensive analyses showed that SARS-CoV-2 infection caused COVID-19 and induced strong immune responses and sometimes severe illnesses. However, cellular features of recovered patients and long-term health consequences remain largely unexplored. In this study, we collected peripheral blood samples from recovered COVID-19 patients (average age of 35.7 years old) from Hubei province, China, 3 months after discharge; and carried out RNA-seq and whole-genome bisulfite sequencing (WGBS) to identify hallmarks of recovered COVID-19 patients. Our analyses showed significant changes both in expression and DNA methylation of genes and transposable elements (TEs) in recovered COVID-19 patients. We identified 639 misregulated genes and 18516 differentially methylated regions (DMRs) in total. Genes with aberrant expression and DMRs were found to be associated with immune responses and other related biological processes, implicating prolonged overreaction of the immune system in response to SARS-CoV-2 infection. Notably, a significant amount of TEs were aberrantly activated and TE activation was positively correlated with COVID-19 severity. Moreover, differentially methylated TEs may regulate adjacent gene expression as regulatory elements. Those identified transcriptomic and epigenomic signatures define and drive the features of recovered COVID-19 patients, helping determine the risks of long COVID-19, and providing guidance for clinical intervention.

12.
Pulm Circ ; 12(2): e12081, 2022 Apr.
Article in English | MEDLINE | ID: covidwho-1782687

ABSTRACT

The aim of this study is to provide evidence for the influencing factors of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) virus mutation by determining the impact of geographical and meteorological factors on SARS-CoV-2 transmission, and the different impacts of SARS-CoV-2 variant strains. From January 20 to March 10, 2020, we collected a number of daily confirmed new cases and meteorological factors in all cities and regions in China and Italy affected by the Alpha "variants of concern" (VOC). We also collected the daily confirmed cases of the Delta VOC infection in China and Italy from May 21 to November 30, 2021. The relationships between daily meteorological data and daily verified new cases of SARS-CoV-2 transmission were then investigated using a general additive model (GAM) with a log link function and Poisson family. The results revealed that latitude was substantially connected with daily confirmed new instances of the Alpha VOC, while there was no such correlation with Delta VOC transmission. When visibility is greater than 7 m, the propagation of the Alpha and Delta VOCs in Italy and China can be controlled. Furthermore, greater temperatures and increased wind speed reduce the transmission of the Alpha and Delta VOCs. In conclusion, geographical and meteorological factors play an important role in SARS-CoV-2 transmissibility and should be considered in virus mitigation strategies.

13.
Int J Environ Res Public Health ; 19(6)2022 03 21.
Article in English | MEDLINE | ID: covidwho-1753498

ABSTRACT

The utilization of pharmacy services in response to the threat of COVID-19 infection remains unclear in areas suffering from air pollution, and little is known regarding the effects of knowledge and attitude (KA) toward COVID-19 on this preventive behavior. This study aimed to explore how the residents perceived and reacted to the new threats of the epidemic and how KA may affect the correlation. Based on the health belief model (HBM), this research took the pharmacy service utilization (PSU) as an example to explain the preventive behavior. The samples were 375 respondents recruited from five districts near the industrial parks. T-test, ANOVA, and regression analyses of SPSS 22.0 were used to analyze the data. Test results show that self-efficacy was the strongest predictor, followed by the net perceived benefit. KA moderated the association of perceived threat and PSU intention. The levels of air pollution of a district may not be a good predictor for the preventive behavior against COVID-19.


Subject(s)
Air Pollution , COVID-19 , Community Pharmacy Services , Air Pollution/prevention & control , COVID-19/epidemiology , Humans , Intention , Surveys and Questionnaires
14.
BMC Psychol ; 10(1): 49, 2022 Mar 03.
Article in English | MEDLINE | ID: covidwho-1724574

ABSTRACT

INTRODUCTION: Medical schools throughout the world were forced to modify their programming during the COVID-19 pandemic. In Malaysia, virtual learning plans were implemented for non-clinical programming, while clinical posting modifications were designed to meet local SOPs. The prolonged enforcement of these modifications to undergraduate medical education will have affected student experiences, including well-being. Since these feelings can relate to perceived relatedness, autonomy, and competence, it is important to identify any potential factors that may lead to reduced intrinsic motivation in students. It is also important to consider how demographic features may contribute to student perspectives, which can be studied using the unique diversity represented by Malaysian students. METHODS: A quantitative survey was distributed to Malaysian medical students to assess their overall wellbeing, autonomy in educational decision making, student experiences, and position on changes to graduation timing. Intrinsic components were identified using Principal Component Analysis and were aligned with the three needs for self-determination, namely relatedness, autonomy, and competence. Finally, trends in responses for participants from various sub-populations were assessed using ANOVA testing. RESULTS: Responses were collected from 442 students representing 23 accredited Malaysian medical schools. Upon validation and reliability testing, eight components were identified with themes relating to: mental health, social concerns, communication, timing of modifications, depth of learning, and student-centred learning. Of these, gender was related to mental health, student-centred learning, and delayed graduation, while stage was related to student-centred learning and delayed graduation in addition to concerns about depth of learning and timing of modifications. Interestingly, ethnicity was related to differences in opinions about delayed graduation and income was related to social concerns. CONCLUSION: The results of this study indicate that, while students were satisfied in general with the content and delivery of their programmes given the circumstances, there is evidence to suggest negative effects on emotional wellbeing and expression of student voice, due to the modifications that were made. Additionally, these feelings related to the three motivational needs, suggesting that students were experiencing a dampened motivational profile during the pandemic. Further, motivational profiles were distinct between student sub-groups, providing insight for developing appropriate and inclusive accommodations moving forward.


Subject(s)
COVID-19 , Education, Medical, Undergraduate , Students, Medical , COVID-19/epidemiology , COVID-19/psychology , Clinical Competence , Education, Medical, Undergraduate/methods , Humans , Malaysia/epidemiology , Mental Health , Motivation , Pandemics , Personal Autonomy , Reproducibility of Results , SARS-CoV-2 , Students, Medical/psychology , Surveys and Questionnaires
15.
Anal Chem ; 94(10): 4522-4530, 2022 03 15.
Article in English | MEDLINE | ID: covidwho-1721381

ABSTRACT

Positive controls made of viral gene components are essential to validate the performance of diagnostic assays for pathogens like severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, most of them are target-specific, limiting their application spectrum when validating assays beyond their specified targets. The use of an inactivated whole-virus RNA reference standard could be ideal, but RNA is a labile molecule that needs cold chain storage and transportation to preserve its integrity and activity. The cold chain process stretches the already dwindling storage capacities, incurs huge costs, and limits the distribution of reference materials to low-resource settings. To circumvent these issues, we developed an inactivated whole-virus SARS-CoV-2 RNA reference standard and studied its stability in silk fibroin matrices, i.e., silk solution (SS) and silk film (SF). Compared to preservation in nuclease-free water (ddH2O) and SS, SF was more stable and could preserve the SARS-CoV-2 RNA reference standard at room temperature for over 21 weeks (∼6 months) as determined by reverse transcription polymerase chain reaction (RT-PCR). The preserved RNA reference standard in SF was able to assess the limits of detection of four commercial SARS-CoV-2 RT-PCR assays. In addition, SF is compatible with RT-PCR reactions and can be used to preserve a reaction-ready primer and probe mix for RT-PCR at ambient temperatures without affecting their activity. Taken together, these results offer extensive flexibility and a simpler mechanism of preserving RNA reference materials for a long time at ambient temperatures of ≥25 °C, with the possibility of eliminating cold chains during storage and transportation.


Subject(s)
COVID-19 , RNA, Viral , COVID-19/diagnosis , Humans , RNA, Viral/analysis , RNA, Viral/genetics , Reverse Transcriptase Polymerase Chain Reaction , SARS-CoV-2/genetics , Sensitivity and Specificity , Silk
16.
Clin Kidney J ; 15(3): 569-570, 2022 Mar.
Article in English | MEDLINE | ID: covidwho-1704405
17.
Medicina (Kaunas) ; 58(2)2022 Feb 18.
Article in English | MEDLINE | ID: covidwho-1701226

ABSTRACT

A coronavirus outbreak caused by a novel virus known as SARS-CoV-2 originated towards the latter half of 2019. COVID-19's abrupt emergence and unchecked global expansion highlight the inability of the current healthcare services to respond to public health emergencies promptly. This paper reviews the different aspects of human life comprehensively affected by COVID-19. It then discusses various tools and technologies from the leading domains and their integration into people's lives to overcome issues resulting from pandemics. This paper further focuses on providing a detailed review of existing and probable Artificial Intelligence (AI), Internet of Things (IoT), Augmented Reality (AR), Virtual Reality (VR), and Blockchain-based solutions. The COVID-19 pandemic brings several challenges from the viewpoint of the nation's healthcare, security, privacy, and economy. AI offers different predictive services and intelligent strategies for detecting coronavirus signs, promoting drug development, remote healthcare, classifying fake news detection, and security attacks. The incorporation of AI in the COVID-19 outbreak brings robust and reliable solutions to enhance the healthcare systems, increases user's life expectancy, and boosts the nation's economy. Furthermore, AR/VR helps in distance learning, factory automation, and setting up an environment of work from home. Blockchain helps in protecting consumer's privacy, and securing the medical supply chain operations. IoT is helpful in remote patient monitoring, distant sanitising via drones, managing social distancing (using IoT cameras), and many more in combating the pandemic. This study covers an up-to-date analysis on the use of blockchain technology, AI, AR/VR, and IoT for combating COVID-19 pandemic considering various applications. These technologies provide new emerging initiatives and use cases to deal with the COVID-19 pandemic. Finally, we discuss challenges and potential research paths that will promote further research into future pandemic outbreaks.


Subject(s)
COVID-19 , Pandemics , Artificial Intelligence , Humans , SARS-CoV-2 , Technology
18.
EuropePMC; 2021.
Preprint in English | EuropePMC | ID: ppcovidwho-321365

ABSTRACT

The ongoing global pandemic of Coronavirus Disease 2019 (COVID-19) poses a serious threat to public health and the economy. Rapid and accurate diagnosis of COVID-19 is crucial to prevent the further spread of the disease and reduce its mortality. Chest Computed tomography (CT) is an effective tool for the early diagnosis of lung diseases including pneumonia. However, detecting COVID-19 from CT is demanding and prone to human errors as some early-stage patients may have negative findings on images. Recently, many deep learning methods have achieved impressive performance in this regard. Despite their effectiveness, most of these methods underestimate the rich spatial information preserved in the 3D structure or suffer from the propagation of errors. To address this problem, we propose a Dual-Attention Residual Network (DARNet) to automatically identify COVID-19 from other common pneumonia (CP) and healthy people using 3D chest CT images. Specifically, we design a dual-attention module consisting of channel-wise attention and depth-wise attention mechanisms. The former is utilized to enhance channel independence, while the latter is developed to recalibrate the depth-level features. Then, we integrate them in a unified manner to extract and refine the features at different levels to further improve the diagnostic performance. We evaluate DARNet on a large public CT dataset and obtain superior performance. Besides, the ablation study and visualization analysis prove the effectiveness and interpretability of the proposed method.

19.
EuropePMC; 2021.
Preprint in English | EuropePMC | ID: ppcovidwho-317641

ABSTRACT

SARS-CoV-2, the causative agent of coronavirus disease 19 (COVID 19), is responsible for the ongoing pandemic but still lacks approved antivirals. Repurposing pre-existing FDA approved drugs presents a rapid approach for new therapeutic options. In the present study, we report that three pre-existing FDA-approved drugs, i.e., vapreotide, grazoprevir, and simeprevir, inhibit the replication of SARS-CoV-2 in cells. The E50 values of vapreotide, grazoprevir, and simeprevir against SARS-CoV-2 in Vero E6 cells was 3.98 ± 0.35 μM, 2.08 ± 0.13 μM, and 1.41 ± 0.12 μM, respectively. In vitro biochemical experiments further revealed that vapreotide, grazoprevir, and simeprevir efficiently inhibits the unwinding activity of the Nsp13 helicase of SARS-CoV-2 with IC50 values of ⁓10, ⁓2.5, and ⁓1.25 µM, respectively, providing signs for understanding their antiviral mechanism of action. Given their good safety profiles in their original indications, our study offices new insights in repurposing these drugs alone or in combination with other antivirals in the global fighting against SARS-CoV-2.Funding: This work was financially supported by the Youth Innovation Promotion Association CAS (to H.Y.), and the National Natural Science Foundation of China (No. 31770192 and No. 32070187 to H.Y.).Conflict of Interest: The authors declare no competing interests.

20.
EuropePMC; 2020.
Preprint in English | EuropePMC | ID: ppcovidwho-315193

ABSTRACT

Objective: To evaluate the role of high-resolution computed tomography (HRCT) in the diagnosis of 2019 novel coronavirus (2019-nCoV) pneumonia and to provide experience in the early detection and diagnosis of 2019-nCoV pneumonia. Methods: : 72 patients confirmed to be infected with 2019-nCoV from multiple medical centers in western China were retrospectively analyzed, including epidemiologic characteristics, clinical manifestations, laboratory findings and HRCT chest features. Results: : All patients had lung parenchymal abnormalities on HRCT scans, which were mostly multifocal in both lungs and asymmetric in all patients, and were mostly in the peripheral or subpleural lung regions in 52 patients (72.22%), in the central lung regions in sixteen (22.22%), and in both lungs, with "white lung "manifestations in four (5.56%). Subpleural multifocal consolidation was predominant abnormality in 38 patients (52.78%). Ground-glass opacity was seen in 34 patients (47.22%). Interlobular septal thickening was found in 18patients, of which eight had only generally mild thickening with no zonal predominance. Reticulation was seen in 8 patients (11.11%), in all of whom it was mild and randomly distributed. In addition, both lungs of 28 patients had two or three CT imaging features. Out of these 72 patients, 36 were diagnosed as early stage, 32 patients as progressive stage and 4 patient as severe stage pneumonia. Moreover, the diagnostic accuracy of HRCT features combined with epidemiological history was not significantly different from the detection of viral nucleic acid (all P >0.05). Conclusion: The HRCT features of 2019-nCoV pneumonia are characteristic to a certain degree, which when combined with epidemiological history yield high clinical value in the early detection and diagnosis of 2019-nCoV pneumonia.Authors Hong-Wei Li, Li-Hua Zhuo, Gao-Wu Yan contributed equally to this work.

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