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1.
Digital Twin Driven Service ; : 279-302, 2022.
Article in English | Scopus | ID: covidwho-20245330

ABSTRACT

Tribo-tests play a crucial role in the evaluation of the material performance of tribo-pairs. Traditionally, tribo-tests are performed onsite and tightly depend on experienced human operators. However, some public health emergencies such as covid-19 have a substantial impact on daily human life, including product and service systems. Therefore, this chapter aims to develop a new tribo-test service pattern, that is, digital twin enhanced remote tribo-test. A digital twin enhanced tribo-test service framework is proposed, which includes the modeling stage and the application stage of tribo-test service. A case study is presented to showcase how to implement the proposed framework. © 2022 Elsevier Inc. All rights reserved.

2.
International Journal of Technology Assessment in Health Care ; 38(Supplement 1):S107, 2022.
Article in English | EMBASE | ID: covidwho-2221691

ABSTRACT

Introduction. Multi-criteria decision analysis (MCDA) is a useful tool in complex decision-making situations and has been used in medical fields to evaluate treatment options and drug selection. We aimed to provide valuable insights on the use ofMCDAin health care through examining the research focus of existing studies, major fields, major applications, most productive authors and countries, and most common journals in the domain using a scientometric and bibliometric analysis. Methods. Publications related to MCDA in health care were identified by searching the Web of Science Core Collection on 14 July 2021. Three bibliometric software programs (VOSviewer, Bibliometrix, and CiteSpace) were used to conduct the analysis. Results. A total of 410 publications were identified from 196 academic journals (average yearly growth rate of 32% from 1999 to 2021), with 23,637 co-cited references by 871 institutions from 70 countries or regions. The USA was the most productive country (n=80), while the Universiti Pendidikan Sultan Idris (n=16), Universite de Montreal (n= 13), and Syreon Research Institute (n=12) were the most productive institutions. The biggest nodes in every cluster of author networks were Aos Alaa Zaidan, Mireille Goetghebeur, and Zoltan Kalo. The top journals in terms of number of articles (n=17) and citations (n=1,673) were Value in Health and the Journal of Medical Systems, respectively. The research hotspots mainly included the analytic hierarchy process (AHP), decision-making, health technology assessment, and healthcare waste management. In the recent literature there was more emphasis on coronavirus disease 2019 (COVID-19) and fuzzy Technique for Order Preference by Similarities to Ideal Solution (TOPSIS). Big data, telemedicine, TOPSIS, and the fuzzy AHP, which are well-developed and important themes, may be the trends in future research. Conclusions. This study provides a holistic picture of the MCDArelated literature published in health care. MCDA has a broad application in different topic areas and would be helpful for practitioners, researchers, and decision makers working in health care when faced with complex decisions. It can be argued that the door is still open for improving the role ofMCDAin health care, both in its technologies and its application.

3.
Journal of Nonlinear and Convex Analysis ; 23(10):2383-2393, 2022.
Article in English | Web of Science | ID: covidwho-2156885

ABSTRACT

The traceability of COVID-19 is of great importance for Epidemiological implications. Two robust and non-parametric traceability methods were employed in the study to evaluate COVID-19's traceability for the prevention of epidemics. We first corrected the initial dates for eight countries using Solow and smith's method, and then the OLE method was applied to the corrected dataset for traceability. Our model suggests that the first global case of COVID19 originated on 25 September 2019 (95%CI 23 September) and that the first case emerged in Europe and spread rapidly to neighbouring countries, expanding globally in early January 2021. Our study suggests that the spread of the epidemic may be more rapid and earlier than we thought. The two methods we use can be used in a robust traceability approach for small sample estimates, providing additional explanations for epidemic traceability studies.

5.
SMART DESIGN: Disruption, Crisis, and the Reshaping of Urban Spaces ; : 111-136, 2022.
Article in English | Web of Science | ID: covidwho-2083708
6.
Smart Design: Disruption, Crisis, and the Reshaping of Urban Spaces ; : 1-168, 2021.
Article in English | Scopus | ID: covidwho-1954491

ABSTRACT

This book tackles the emerging smart urbanism to advance a new way of urban thinking and to explore a new design approach. It unravels several urban transformations in dualities: Economic relationality and centrality, technological flattening and polarisation, and spatial division and fusion. These dualities are interdependent;concurrent, coexisting, and contradictory, they are jointly disrupting and reshaping many aspects of contemporary cities and spaces. The book draws on a suite of international studies, experiences, and observations, including case studies in Beijing, Singapore, and Boston, to reveal how these processes are impacting urban design, development, and policy approaches. The COVID-19 pandemic has accelerated many changes already in motion, and provides an extreme circumstance for reflecting on and imagining urban spaces. These analyses, thoughts, and visions inform an urban imaginary of smart design that incorporates change, flexibility, collaboration, and experimentation, which together forge a paradigm of urban thinking. This paradigm builds upon the modernist and postmodernist urban design traditions and extends them in new directions, responding to and anticipating a changing urban environment. The book proposes a smart design manifesto to stimulate thought, trigger debate, and, hopefully, influence a new generation of urban thinkers and smart designers. It will be of interest to scholars, students, and practitioners in the fields of urban design, planning, architecture, urban development, and urban studies. © 2022 Richard Hu.

7.
Disease Surveillance ; 37(1):67-71, 2022.
Article in Chinese | GIM | ID: covidwho-1789474

ABSTRACT

Objective: To analyze the epidemiologic characteristics of common respiratory virus infection in hospitalized children in Wuhan Children's Hospital from January to December 2019, and provide evidence for clinical diagnosis and treatment.

8.
2nd International Conference on Intelligent Computing and Human-Computer Interaction, ICHCI 2021 ; : 139-143, 2021.
Article in English | Scopus | ID: covidwho-1774656

ABSTRACT

As the COVID-19 becomes more prevalent worldwide, many countries take various measures to minimize the spread of infection. Since the main route of transmission of covid-19 is through the air, an analysis of transport, particularly global air traffic nodes, will provide a visual representation of the impact of covid-19 on the worldwide air transport industry. This paper uses publicly available aviation data to model the network and analyze the topology of the world aviation network before and after the COVID-19 outbreak in 2019 and 2020 to analyze the impact of the covid-19 epidemic on the world's aviation industry. First, we successfully visualized the significance of the change in the number of flight routes before and after the outbreak and the different distribution in each region by modeling the worldwide airline traffic network. Then, after a series of analyses and investigations. Second, we collected open-source data showing that the overall number of flights worldwide has been downward following the COVID-19 outbreak. Based on this information, we have chosen to conduct specific studies of countries and regions where there have been significant changes since the outbreak of covid-19, combined with reasonable hypotheses and analysis of local traffic control policies, and deduced that covid-19 had affected people's lives more from a policy rather than a medical perspective. Finally, we built up visual analysis images and tables to base our research using open-source aviation data sites such as open-fight. The results show that the analyzed aviation networks exhibit small-world characteristics, with the total number of flights not changing significantly due to the outbreak. However, the number of routes to the most crucial airport nodes worldwide decreases, and centrality diminishes, and the number of direct flights reductions and the increase of connecting flights. © 2021 IEEE.

9.
Canadian Journal of Surgery ; 64:S93-S94, 2021.
Article in English | ProQuest Central | ID: covidwho-1679151

ABSTRACT

Background: The COVID-19 pandemic necessitated a rapid uptake of video-based interviewing for selection processes in health care. A scoping review was conducted to consolidate the available literature on the benefits and limitations of video-based interviews and to understand the perceived barriers associated with transitioning away from face-to-face interviews. Methods: A search strategy, developed in concert with an academic health sciences librarian, was run on Ovid Medline, Embase, PsycINFO and Cochrane Central. The search was performed on Mar. 31, 2020, and updated on Feb. 21, 2021. Studies that implemented and evaluated the impact of video-based interviewing in health care were included in our study. Review articles, editorials and studies that did not implement a video-based interview were excluded. Results: Forty-three studies were included in our scoping review, of which 17 were conference s and 26 were peer-reviewed manuscripts. The risk of bias was moderate or high in most studies. Both financial costs and opportunity costs were reported to be improved with video-based interviewing, while environmental costs were not well explored. Technical limitations, which were not prevalent, were easily managed during the interview process. There were limited studies that evaluated how nonverbal cues are interpreted in a video-based format. Overall, video-based interviews were well received by both applicants and interviewers, although most participants still reported a preference for face-to-face interviews. Conclusion: While video-based interviewing has become necessary during the COVID-19 era, there are benefits from a financial, opportunistic and environmental point of view that argue for its continued use even after the pandemic. Despite its successful implementation with minimal technical issues, a preference still remains for face-to-face interviews. Reasons for this preference are not clear from the available literature. Future studies on the role of non-verbal communication during the video-based interview process are important to better understand how video-based interviews can be optimized.

10.
American Journal of Gastroenterology ; 116(SUPPL):S399-S400, 2021.
Article in English | EMBASE | ID: covidwho-1534702

ABSTRACT

Introduction: Upadacitinib (UPA), an oral JAK inhibitor, showed significantly greater efficacy vs placebo (PBO) in induction treatment of patients (pts) with moderately-to-severely active ulcerative colitis (UC) in two phase 3 induction trials, U-ACHIEVE and U-ACCOMPLISH. We evaluated efficacy of UPA in pts who had an inadequate response (IR), loss of response, or intolerance to biologic therapies (Bio-IR) or were non-Bio-IR. Methods: U-ACHIEVE and U-ACCOMPLISH, multicentre, double-blind, placebo (PBO)-controlled trials, randomized pts with moderately to severely active UC to UPA 45 mg QD or PBO for 8 weeks (wks). Randomization was stratified by status of previous biologic failure, ie an inadequate response (IR), loss of response, or intolerance to biologic therapies (Bio-IR or bio-failure) vs non-Bio-IR (nonbio-IR or non-bio-failure), baseline corticosteroid use (yes or no), and baseline adapted Mayo score (≤7 or>7). Efficacy endpoints included primary endpoint of clinical remission (adaptedMayo score) at Wk 8 and ranked secondary endpoints of clinical response (partial adapted Mayo score at Wk 2 and adapted Mayo score at Wk 8), endoscopic improvement (Mayo endoscopic subscore 0 or 1), endoscopic remission (Mayo endoscopic subscore 0) and histologic-endoscopic mucosal improvement at Wk 8 (HEMI;endoscopic subscore ≤1 and Geboes score ≤3.1). Results using non-responder imputation incorporating multiple imputation for missing data due to COVID-19 are reported. Results: In both studies, approximately half the pts were Bio-IR (Table 1). In both Bio-IR and non-Bio-IR pts, significantly higher proportion of pts receiving UPA achieved primary endpoint of clinical remission versus PBO;the magnitude of clinical remission at Wk 8 was greater in non-Bio-IR pts (UPA, 35% vs PBO, 9%;treatment difference [95% CI]: 26.0% [16.0, 36.1]) versus Bio-IR (UPA, 18% vs PBO, 0%;17.5% [11.4, 23.6]) in U-ACHIEVE and non-Bio-IR (UPA, 38% vs PBO, 6%;31.6% [22.8, 40.5]) versus Bio-IR (UPA, 30% vs PBO, 2%;27.1% [19.6, 34.7];Table 1) in U-ACCOMPLISH. Results were generally similar for ranked secondary endpoints (Table 1). UPA 45 mg QD was well-tolerated and no new safety signals were observed. Conclusion: UPA 45 mg QD is an effective induction treatment for pts with moderately to severely active UC. A significantly higher proportion of pts in both Bio-IR and non-Bio-IR groups receiving UPA achieved primary and secondary endpoints versus PBO. The magnitude of difference was greater among pts who were non-Bio-IR versus Bio-IR.

11.
Eur Rev Med Pharmacol Sci ; 25(20): 6411-6424, 2021 Oct.
Article in English | MEDLINE | ID: covidwho-1503073

ABSTRACT

OBJECTIVE: The heterogeneity of clinical manifestations and mortality rates in Coronavirus disease 2019 (COVID-19) patients may be related to the existence of molecular subtypes in COVID-19. To improve current management, it is essential to find the hub genes and pathways associated with different COVID-19 subtypes. MATERIALS AND METHODS: The whole-genome sequencing information (GSE156063, GSE163151) of nasopharyngeal swabs from normal subjects and COVID-19 patients were downloaded from the Gene Expression Omnibus (GEO) database. The molecular subtypes of patients with COVID-19 were classified using the "consistent clustering" method, and the specific genes associated with each subtype were found. Differentially expressed genes (DEGs) were screened between normal subjects and COVID-19 patients; the Weighted gene co-expression network analysis (WGCNA) method was used to find the key module genes of COVID-19 patients. Subtype-specific, differentially expressed and module-related genes were collected and intersected. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were carried out and protein-protein interaction (PPI) networks were generated. The pathways enriched in COVID-19 subtypes were analyzed by gene set variation analysis (GSVA). RESULTS: Patients with COVID-19 were divided into three subtypes, and there was no significant difference in gender and age distribution between subtypes. 82 differential gene pathways were screened between Subtypes I and II, 131 differential gene pathways were screened between Subtypes I and III, and 107 differential gene pathways were screened between Subtypes II and III. Finally, 44 differentially expressed key genes were screened, including 11 hub genes (RSAD2, IFIT1, MX1, OAS1, OAS2, BST2, IFI27, IFI35, IFI6, IFITM3, STAT2). CONCLUSIONS: There are significant differences in gene activation and pathway enrichment among different molecular subtypes of COVID-19, which may account for the heterogeneity in clinical presentation and the prognosis of patients.


Subject(s)
Biomarkers, Tumor/genetics , COVID-19/genetics , Oligonucleotide Array Sequence Analysis , COVID-19/diagnosis , Genetic Variation/genetics , Humans
12.
37th International Symposium on Automation and Robotics in Construction: From Demonstration to Practical Use - To New Stage of Construction Robot, ISARC 2020 ; : 735-742, 2020.
Article in English | Scopus | ID: covidwho-1310395

ABSTRACT

Aging society is not only a crisis in the developed world but also a severe challenge in some emerging economies. However, the awareness of population aging and gerontechnology is far from sufficiently addressed in the architectural design education in universities. Therefore, an interdisciplinary approach in design education is urgently needed to raise the awareness of the aging crisis among the future architects, interior designers, and beyond. This article introduces a novel model of a design seminar offered by a German University, addressing population aging issues in the architecture department. The syllabus, formality, and the expected results of the seminar are revealed in detail. The participants are encouraged to apply interdisciplinary knowledge such as barrier-free architecture, mechanical engineering, electrical engineering, robotics, medicine, psychology, and business to achieve the goals of the seminar. Based on the originality and degree of completion, several students' works are selected and reported, targeting a variety of diseases or syndromes related to aging, such as dementia, immobility, and tremors. Overall, participants of this seminar are motivated and have positive feedback on this seminar, oftentimes claiming that they have seldom studied similar topics in previous architecture education. This enables students from architecture as well as other fields to be better prepared to tackle the upcoming challenges such as labor shortages and infectious diseases in a rapidly aging world. Furthermore, the seminar creates novel concepts that serve as a win-win "honeypot" for both students and their instructors, potentially sparking research topics and start-ups with concepts fostered in this seminar. © 2020 Proceedings of the 37th International Symposium on Automation and Robotics in Construction, ISARC 2020: From Demonstration to Practical Use - To New Stage of Construction Robot. All rights reserved.

13.
Kidney International Reports ; 6(4):S359, 2021.
Article in English | EMBASE | ID: covidwho-1198739

ABSTRACT

Introduction: Working with The International Society of Nephrology (ISN), Kim Solez and J Stewart Cameron created the Video Legacy Project (VLP) in 1990 to document the lives of the key figures that founded Kidney Medicine and highlight the history of Kidney Medicine within the medical community. These recordings were made on VHS tapes, but it became obvious that digitization of the material was essential, and this also was undertaken as the 21st century began. Transplantation and transplant pathology were important parts of the project. It is hard to imagine a medical subspecialty without any video history at all, but that fate almost befell kidney medicine when funding was removed from the ISN Video Legacy Project in 2007. During the ISN council meeting of 2006, the idea of making the interviews freely available on the Internet was proposed but this did not actually happen. A major feature of the project was not to impose a standard format but allow subjects to talk in an unscripted manner and for as long they wanted. For a time, 3 of the 45 video interviews were accessible on the ISN website, but then the site was restructured and for 8 years none of the videos were accessible. We need to be reminded of the inconsistency of a rolling present through understanding of how present hypotheses, concepts and treatment recommendations came about. Despite a strong movement amongst professional historians to downgrade the role of “great men” in the progress of ideas, these ideas in sum came from an endless series of talented individuals. Hearing directly on video from this series of such men and women, almost all of whom have now passed away, not only gives a vivid idea of their characters but also an insight into how their minds worked. Methods: The videotapes recorded between 1990 and 2007 were kept in temperature-controlled storage until the difficult Canadian winter of 2017-18 when they languished in the senior author's unheated garage. Conventional wisdom held that the information on the tapes was fugitive and that by this time they would all be unreadable. On a whim, we submitted them for conversion to mp4 video files in April-June 2018 and every tape was readable! We combined the footage with the Pioneers of European Nephrology series obtained by ERA-EDTA and today there is a collection of 177 videos on the Nephrology Video Legacy playlist and 82 videos on the Nephrology Pioneers playlist both of which can be found on the YouTube Channel of Kim Solez. Some videos recorded in 2019 were reduced to audio-only with the devastating effects of the COVID-19 pandemic on Europe in 2020. http://www.youtube.com/user/kimsolez. Results: Top videos included: Homer Smith Comical Film About Function of the Kidney from 1950s, Wilhelm Kolff Video Legacy Interview 1995, Donald W Seldin Video Legacy Interview 1997, Resurrecting Video Legacy Project Apr 19 2018, Robert H Heptinstall Video Legacy Interview October 1995 Conclusions: Many of the people interviewed such as Homer Smith, Robert Heptinstall, J Stewart Cameron, John Dirks, and Gabriel Richet had an important influence on the senior author’s direction of the Banff Transplant Pathology Meetings and the spirit and philosophy of those meetings. George Orwell wrote “The most effective way to destroy people is to deny and obliterate their own understanding of their history.” It is comforting that in the end this did not happen to nephrology. No conflict of interest

14.
Kidney International Reports ; 6(4):S357, 2021.
Article in English | EMBASE | ID: covidwho-1198737

ABSTRACT

Introduction: The story began in January 2009 when General Internal Medicine Resident 1 expressed an interest in kidney medicine and began working on Nephrology research tasks with the last author as an undergraduate student. This all emerged unintentionally, not conceived of as an experiment until the present first author began doing similar Nephrology research tasks in January 2018 as a premed student and decided to test this immersion approach to learning kidney medicine and kidney pathology before medical school, after receiving the required privacy training. This method stands out as distinct from the usual stepwise acquisition of knowledge in classical medical education in medical school because it allows the student to be fully “immersed” into the world of nephrology without yet having adequate background in medicine in general. Methods: Just like other immersive education, nephrology immersion was established by the inclusion of premedical students in a renal pathology and nephrology lab. The student had the opportunity to work with pathologists and clinicians on a daily basis, gaining knowledge of the specialty by attending weekly nephrology/pathology rounds, regularly studying renal biopsies from the hospital, and completing online and in-person curricula meant for nephrology trainees (eg. the American Society of Nephrology Kidney Week Early Program ‘Fundamentals of Renal Pathology’). Results: The student demonstrated a good understanding of kidney pathology and nephrology material in several ways: through successful completion of standardized curricula, weekly preparation and presentation of kidney biopsy cases at pathology/nephrology rounds, and training new pathology fellows. Conclusions: A necessary component of the nephrology immersion program is that the students must suspend belief that they have truly mastered the subject until they are in medical school and learn the surrounding context of related subjects necessary to fully understand nephrology. However, once that happens the students are very likely to choose a career in Nephrology because they have already been exposed to the specialized knowledge in the field. Standardized curricula make it easy to assess the knowledge of such immersion students and they perform at a level comparable to current nephrology fellows, despite lacking full “medical” understanding of the subjects. Immersion is an effective education technique in many other areas of human endeavor and represents an additional innovative approach to kidney medicine education, which is something the International Society of Nephrology (ISN) is seeking in several of its programs. In the pandemic era it may make sense to delay entry into medical school until such time as more face to face experiences are available. Meanwhile we are proving it is possible to learn selected aspects of medicine before medical school. We would emphasize that we are not advocating a return to the apprenticeship approach to medical training which preceded the Flexner Report. Mastery of the information and skills of medicine is key, and some of that is only attainable through medical school. No conflict of interest

15.
Eur Rev Med Pharmacol Sci ; 25(5): 2409-2414, 2021 03.
Article in English | MEDLINE | ID: covidwho-1148418

ABSTRACT

The COVID-19 (Corona Virus Disease 2019) outbreak, which seriously affected people's lives across the world, has not been effectively controlled. Previous studies have demonstrated that SARS-COV-2 (Severe acute respiratory syndrome coronavirus 2) infecting host cells mainly rely on binding to receptor proteins, namely ACE2 and TMPRSS2. COVID-19 transmission is faster than the severe acute respiratory syndrome (SARS) pneumonia outbreak in 2002. This is mainly attributed to the different pathways of virus-infected host cells, coupled with patients' atypical clinical characteristics. SARS-CoV-2 is mainly transmitted through respiratory droplets and contact, infecting lung tissues before damaging other body organs, such as the liver, brain, kidney and heart. The present study identified potential target genes for SARS-COV-2 receptors, ACE2 and TMPRSS2, in normal human lung tissue. The findings provide novel insights that will guide future drug development approaches for treatment of COVID-19.


Subject(s)
Angiotensin-Converting Enzyme 2/genetics , COVID-19/genetics , Receptors, Virus/genetics , Serine Endopeptidases/genetics , Angiotensin-Converting Enzyme 2/biosynthesis , Angiotensin-Converting Enzyme 2/metabolism , COVID-19/metabolism , COVID-19/virology , Correlation of Data , Gene Expression , Humans , Receptors, Virus/biosynthesis , Receptors, Virus/metabolism , SARS-CoV-2/isolation & purification , SARS-CoV-2/metabolism , Serine Endopeptidases/biosynthesis , Serine Endopeptidases/metabolism
16.
Proc. - IEEE Int. Conf. Mach. Learn. Appl., ICMLA ; : 669-676, 2020.
Article in English | Scopus | ID: covidwho-1142799

ABSTRACT

The emergence of COVID-19 has engendered a new wave of online hate speech in social media platforms such as Twitter. Its widespread effects range from acts of cyber-harassment towards certain ethnic communities (e.g., the Asian community), to targeting older people belonging to age groups correlated with higher mortality rates (termed infamously as Boomer Remover). Thus, an urgent need arises for a timely mitigation of this new wave of online hate speech. In this work, we aim to discover the hate-related keywords linked to COVID-19 in hateful tweets posted on Twitter so that users posting such keywords can be asked to reconsider posting them. We first collect a new dataset of tweets targeting older people supplementing with a dataset targeting the Asian community. Then, we develop an approach to analyze the datasets with BERT (a transformer-based model) attention mechanism and discover 186 novel keywords targeting the Asian community and 100 keywords targeting older people. Based on our study, we then propose a control mechanism wherein a user can be asked to reconsider using certain sensitive words identified by our approach. We further perform an exploratory analysis of BERT attention mechanism and find that the most high-impact, long distance attentions are learned in the earlier or later layers of the model depending on the underlying data distribution. Our study indicates that the BERT model in some cases uses a hate keyword and an associated group or individual to make predictions, a finding that is inline with existing hate-speech research, which suggests that hate-speech is often aimed at certain groups or individuals. © 2020 IEEE.

17.
Eur Rev Med Pharmacol Sci ; 25(3): 1724-1731, 2021 Feb.
Article in English | MEDLINE | ID: covidwho-1102758

ABSTRACT

The outbreak of COVID-19 seriously affected people's life and safety, and it has not been effectively controlled all over the world at present. The binding of S protein of SARS-COV-2 virus to ACE2 receptor requires the assistance of Transmembrane Serine Protease 2 (TMPRSS2), which can activate the S protein on the surface of virus and promote its binding to the ACE2 receptor. With the continuous accumulation of experience in the treatment of COVID-19 patients and the experimental studies of a large number of scientific researchers, it was found that COVID-19 patients had a higher mortality rate in patients with underlying diseases. Therefore, for COVID-19 patients with tumors, the mortality rate may be significantly higher than other people. Clinical studies had found that some patients were complicated with cytokine storm in clinical treatment, which was also the direct cause of death for some patients. The infiltration of immune cells and the release of a variety of cytokines were important factors causing cytokine storm. Therefore, for COVID-19 patients with tumors, it was of great clinical significance to explore the relationship between COVID-19 virus receptor ACE2, TMPRSS2 and immune cell infiltration, which can help clinicians to make some more appropriate treatment plans.


Subject(s)
Angiotensin-Converting Enzyme 2/genetics , COVID-19/immunology , Neoplasms/immunology , SARS-CoV-2 , Serine Endopeptidases/genetics , COVID-19/complications , COVID-19/genetics , Gene Expression Regulation, Neoplastic , Humans , Neoplasms/complications , Neoplasms/genetics , Protein Binding , Spike Glycoprotein, Coronavirus/genetics
19.
Archives of Hellenic Medicine ; 37:89-92, 2020.
Article | Web of Science | ID: covidwho-806191

ABSTRACT

If there can be "love in the time of cholera", then there can be history of kidney medicine in the time of COVID-19. In our article, we celebrate the history of nephrology, which unites curious young minds with the legacy built by senior figures of the discipline. Notably, technological advances such as the Internet have made nephrology history more accessible to a wide range of audiences, including young students and physicians in training. The interest that continues to prevail for the field ensures that the future of kidney medicine is bright and bound to expand in new directions. We can treat the past and the future with equal precision and rigor under the umbrella of history. One can describe a symmetrical timeline with 193 years back to Richard Bright's book in 1827, and 193 years forward to 2213 the point when some expect that human consciousness will be routinely uploaded to inorganic substrates. But for now, we shall seek to excavate the past to have a better idea of where we're going and how to achieve desired outcomes, which is especially important in a time of global health emergency, where we are all fighting a single enemy, COVID-19.

20.
Zhonghua Fu Chan Ke Za Zhi ; 55(3): 166-171, 2020 Mar 25.
Article in Chinese | MEDLINE | ID: covidwho-5911

ABSTRACT

Objective: To study the effect of COVID-19 on pregnancy outcomes and neonatal prognosis in Hubei Province. Method: s A retrospective comparison of the pregnancy outcomes was done between 16 women with COVID-19 and 45 women without COVID-19. Also, the results of laboratory tests, imaging examinations, and the 2019 novel coronavirus (2019-nCoV) nucleic acid test were performed in 10 cases of neonatal delivered from women with COVID-19. Result: s (1) Of the 16 pregnant women with COVID-19, 15 cases were ordinary type and 1 case was severe type. No one has progressed to critical pneumonia.The delivery method of the two groups was cesarean section, and the gestational age were (38.7±1.4) and (37.9±1.6) weeks,there was no significant difference between the two groups (P>0.05). Also, there wee no significant differences in the intraoperative blood loss and birth weight of the newborn between the two groups (all P>0.05). (2) Ten cases of neonates delivered from pregnant women with COVID-19 were collected. The 2019-nCoV nucleic acid test were all negative.There were no significant differences in fetal distress, meconium-stained amniotic fluid, preterm birth, and neonatal asphyxia between the two groups (all P>0.05).(3) In the treatment of uterine contraction fatigue, carbetocin or carboprost tromethamine was used more in cesarean section for pregnant women with COVID-19 (1.3±0.6), compared with Non-COVID-19 group (0.5±0.7),the difference was statistically significant (P=0.001). Conclusions: If there is an indication for obstetric surgery or critical illness of COVID-19 in pregnant women, timely termination of pregnancy will not increase the risk of premature birth and asphyxia of the newborn, but it is beneficial to the treatment and rehabilitation of maternal pneumonia. Preventive use of long-acting uterotonic agents could reduce the incidence of postpartum hemorrhage during surgery. 2019-nCoV infection has not been found in neonates delivered from pregnant women with COVID-19.


Subject(s)
Coronavirus Infections/complications , Coronavirus , Pandemics , Pneumonia, Viral/complications , Pregnancy Complications, Infectious/prevention & control , Pregnancy Outcome , Betacoronavirus , COVID-19 , Cesarean Section , Coronavirus Infections/epidemiology , Coronavirus Infections/prevention & control , Coronavirus Infections/transmission , Disease Outbreaks , Female , Humans , Infant, Newborn , Pandemics/prevention & control , Pneumonia, Viral/epidemiology , Pneumonia, Viral/prevention & control , Pneumonia, Viral/transmission , Pregnancy , Pregnancy Complications, Infectious/epidemiology , Pregnancy Complications, Infectious/virology , Premature Birth , Retrospective Studies , SARS-CoV-2
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