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1.
Medical Journal of Chinese People's Liberation Army ; 47(4):359-366, 2022.
Article in Chinese | EMBASE | ID: covidwho-1939421

ABSTRACT

Objective To analyze the epidemiological and clinical features of coronavirus disease 2019 (COVID-19) infected with the Delta variant of SARS-CoV-2. Methods Retrospectively analyze the epidemiological and clinical features of 138 confirmed cases of COVID-19 infected with the Delta variant of SARS-CoV-2 from October 25, 2021 to November 19, 2021 in Yantan Branch of the Second People's Hospital of Lanzhou City. The epidemiological and demographic information, clinical symptoms, laboratory tests, chest CT, treatment and prognosis data were collected, with a final follow-up date of November 27, 2021. Results As of November 19, 2021, a total of 144 confirmed cases of COVID-19 were reported in Gansu Province, of which 138 cases [65 males (47.1%) and 73 females (52.9%), aged 2-87 (42.7±21.0) years old, with the clinical classification of mainly common type (48.6%, 67/138)] were concentrically treated in the Yantan Branch of the Second People's Hospital of Lanzhou City. The transmission mode of the Delta variant of SARS-CoV-2 is mainly in confined spaces, with obvious tour group and family aggregation;screening the close contacts and community investigation are the main approaches of finding the infected persons;86.2% (119/138) of confirmed patients have been vaccinated with the domestic inactivated COVID-19 vaccine. The most common clinical symptoms are cough (57.2%, 79/138), followed by sore throat (28.3%, 39/138), dry throat (24.6%, 34/138), and expectoration (21.0%, 29/138). Only 20.3% (28/138) of patients have fever, and 4 patients (2.9%) have decreased or lost sense of smell and taste. Laboratory tests showed that serum amyloid A and high-density lipoprotein cholesterol increased significantly. The Ct value of SARS-CoV-2 ORF1ab gene is 26.31±7.63, and N gene is 26.35±7.17. Chest CT fined that 71.3% (72/101) of confirmed patients showed bilateral lung lobes involvement, and the lesions are mostly located in the lower lobes of both lungs;the lesions are mainly flaky and patchy ground-glass opacities. All confirmed cases are treated with integrated traditional Chinese and Western medicine, mainly prone position ventilation and traditional Chinese medicine (TCM) treatment. The TCM treatment rate is 100% for severe cases. On the basis of respiratory support, nutritional support and anticoagulation, immunotherapy such as neutralizing antibodies are combined. Conclusions The main clinical features of COVID-19 infected by the Delta variant of SARS-CoV-2 in Gansu Province are low rate of fever, long time for viral nucleic acid turned to negative, low risk of severe illness after vaccination, the good therapeutic effect, no intubation, no extracorporeal membrane oxygenation (ECMO), and no deaths. "One person, one plan" personalized treatment with integrated Chinese and Western medicine can effectively control the progression of the disease and cure the disease.

2.
18th IEEE/CVF International Conference on Computer Vision (ICCV) ; : 7366-7375, 2021.
Article in English | Web of Science | ID: covidwho-1927512

ABSTRACT

Semi-supervised learning (SSL) algorithms have attracted much attentions in medical image segmentation by leveraging unlabeled data, which challenge in acquiring massive pixel-wise annotated samples. However, most of the existing SSLs neglected the geometric shape constraint in object, leading to unsatisfactory boundary and non-smooth of object. In this paper, we propose a novel boundary-aware semi-supervised medical image segmentation network, named Graph-BAS(3)Net, which incorporates the boundary information and learns duality constraints between semantics and geometrics in the graph domain. Specifically, the proposed method consists of two components: a multi-task learning framework BAS(3)Net and a graph-based cross-task module BGCM. The BAS(3)Net improves the existing GAN-based SSL by adding a boundary detection task, which encodes richer features of object shape and surface. Moreover, the BGCM further explores the co-occurrence relations between the semantics segmentation and boundary detection task, so that the network learns stronger semantic and geometric correspondences from both labeled and unlabeled data. Experimental results on the LiTS dataset and COVID-19 dataset confirm that our proposed Graph-BAS(3) Net outperforms the state-of-the-art methods in semi-supervised segmentation task.

3.
American Journal of Translational Research ; 14(5):2972-2987, 2022.
Article in English | Web of Science | ID: covidwho-1913290

ABSTRACT

Background: The challenges that viral pneumonia poses to the global public health system remain daunting. In this study, an analysis of publications on viral pneumonia over the past two decades was conducted. Through this work, we hope to provide inspiration for future research on viral pneumonia. Methods: We extracted all of the English publications relevant to viral pneumonia published during 1999-2019 from Web of Science. GraphPad Prism, CiteSpace, and VOSviewer were used to collect and analyze the publication trends in related fields. Results: We identified 2,006 publications with 62,155 citations as of February 16, 2021. The United States accounted for the largest number of publications (34.2%), with the highest number of citations (27,616) and the highest h-index (78). China ranked second in the number of publications. Ctr Dis Control & Prevent proved to be the center of research cooperation. Clinical Infectious Diseases included the most papers published relating to the topic of viral pneumonia. Chan KH published the most papers in this field (25), while an article from Fouchier RAM presented the highest citation frequency (1,275). Conclusions: According to the bibliometric analysis database and related software results, the United States dominates the field of viral pneumonia research. The key term extracted by VOS-viewer has shifted to "Diagnosis and management", indicating a new trend for viral pneumonia research.

4.
Ann Oncol ; 33(8): 836-844, 2022 Aug.
Article in English | MEDLINE | ID: covidwho-1885609

ABSTRACT

BACKGROUND: COVID-19 disproportionately impacted patients with cancer as a result of direct infection, and delays in diagnosis and therapy. Oncological clinical trials are resource-intensive endeavors that could be particularly susceptible to disruption by the pandemic, but few studies have evaluated the impact of the pandemic on clinical trial conduct. PATIENTS AND METHODS: This prospective, multicenter study assesses the impact of the pandemic on therapeutic clinical trials at two large academic centers in the Northeastern United States between December 2019 and June 2021. The primary objective was to assess the enrollment on, accrual to, and activation of oncology therapeutic clinical trials during the pandemic using an institution-wide cohort of (i) new patient accruals to oncological trials, (ii) a manually curated cohort of patients with cancer, and (ii) a dataset of new trial activations. RESULTS: The institution-wide cohort included 4756 new patients enrolled to clinical trials from December 2019 to June 2021. A major decrease in the numbers of new patient accruals (-46%) was seen early in the pandemic, followed by a progressive recovery and return to higher-than-normal levels (+2.6%). A similar pattern (from -23.6% to +30.4%) was observed among 467 newly activated trials from June 2019 to June 2021. A more pronounced decline in new accruals was seen among academically sponsored trials (versus industry sponsored trials) (P < 0.05). In the manually curated cohort, which included 2361 patients with cancer, non-white patients tended to be more likely taken off trial in the early pandemic period (adjusted odds ratio: 2.60; 95% confidence interval 1.00-6.63), and substantial pandemic-related deviations were recorded. CONCLUSIONS: Substantial disruptions in clinical trial activities were observed early during the pandemic, with a gradual recovery during ensuing time periods, both from an enrollment and an activation standpoint. The observed decline was more prominent among academically sponsored trials, and racial disparities were seen among people taken off trial.


Subject(s)
COVID-19 , Neoplasms , COVID-19/epidemiology , Humans , Medical Oncology , Neoplasms/epidemiology , Neoplasms/therapy , Pandemics , Prospective Studies
5.
Pacific Accounting Review ; : 16, 2022.
Article in English | English Web of Science | ID: covidwho-1883104

ABSTRACT

Purpose The COVID-19 global pandemic has caused significant disruptions to the non-profit sector, highlighting the issues that the narrowly focused, traditional conception of governance fails to address. The purpose of this paper is to propose a contingency-based framework with its theoretical underpinnings in the existing literature, in order to support future empirical research on non-profit governance and accountability practices. Design/methodology/approach From a theoretical perspective, this paper synthesizes relevant existing literature and proposes a contingency-based accountability and governance framework in the non-profit sector. This paper draws on Ostrower and Stone's (2010) contingency-based framework on boards and Hyndman and McDonnell's (2009) conception of governance systems. This paper engages with the New Zealand and Australia context while reviewing relevant literature and relevant regulations. Findings The global pandemic has caused severe worldwide disruptions both socially and economically. There have been dramatic changes to the ways in which non-profit organisations (NPOs) operate. There is an urgent need to understand how such changes in the external environment impact on NPOs' governance and accountability practices. In this context, the contingency-based accountability and governance framework proposed in this paper has important implications for non-profit research, while opening up an avenue for future research in this field. Research limitations/implications This paper does not involve empirical analysis. Practical implications This paper contributes by facilitating better understanding on how external contingencies like the COVID-19 global pandemic affect the external and internal environment of an NPO, how they impact on stakeholders and their interplay with an NPO's governance and accountability systems. It also suggests that regulators of the non-profit sector, umbrella support organisations, and funders proactively encourage and guide NPOs to embrace a wider scope of governance and strengthen the level of governance in the sector. Originality/value This paper contributes to the literature by proposing a contingency-based accountability and governance framework in the non-profit sector to support future research in this field. It also sheds light on competing theoretical debates relating to the conceptualisation and operationalization of accountability and governance.

6.
American Journal of Respiratory and Critical Care Medicine ; 205:2, 2022.
Article in English | English Web of Science | ID: covidwho-1880715
7.
8.
Journal of Heart and Lung Transplantation ; 41(4):S374-S374, 2022.
Article in English | Web of Science | ID: covidwho-1848718
9.
Clinical Cancer Research ; 27(6 SUPPL 1), 2021.
Article in English | EMBASE | ID: covidwho-1816924

ABSTRACT

Introduction: Patients with thoracic malignancies are susceptible to severe outcomes from coronavirus disease 2019 (COVID-19). The aim of this study was to evaluate the disruption to care of patients with thoracic malignancies during the COVID-19 pandemic. Methods: The COVID-19 and Cancer Outcomes Study (CCOS) is a multicenter prospective cohort study comprised of adult patients with a current or past history of hematological malignancy or invasive solid tumor who had an outpatient medical oncology visit on the index week between March 2 and March 6, 2020 at the Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai in New York, NY (MSSM) or the Dana-Farber Cancer Institute in Boston, MA (DFCI). An electronic data capture platform was used to collect patient-, cancer-, and treatment-related variables during the three months prior to the index week (the baseline period) and the following three months (the pandemic period). Two-by-three contingency tables with Fisher's exact tests were computed. All tests were two-tailed and considered statistically significant for p<0.05. All analyses were done in the R statistical environment (v3.6.1). Results: The overall cohort included 2365 patients, of which 313 had thoracic malignancies, 1578 had other solid tumors, and 474 had hematological malignancies. At a median follow-up of 84 days (95% confidence interval, 82-84), 13 patients with thoracic malignancies (4.1%) had developed COVID-19 (vs. other solid: 63 [4.0%] and hematological: 52 [11.0%];p<0.001). When comparing data from the pandemic period to the baseline period, patients with thoracic malignancies had a decrease in the number of in-person outpatient visits (thoracic: 209 [66.8%] vs. other solid: 749 [47.5%] vs. hematological: 260 [54.9%];p<0.001) and an increase in the number of telehealth visits (thoracic: 126 [40.3%] vs. other solid: 465 [29.5%] vs. hematological: 168 [35.4%];p<0.001). During the pandemic period, 33 (10.5%) patients with thoracic malignancies experienced treatment delays due to the pandemic (vs. other solid: 127 [8.0%] and hematological: 79 [16.7%];p<0.001), and 26 (8.3%) patients with thoracic malignancies experienced delays in cancer imaging or diagnostic procedures (vs. other solid: 63 [4.0%] and hematological: 26 [5.5%];p=0.003). Discussion: In this prospective cohort study, patients with thoracic malignancies were not at increased risk of developing COVID-19 compared to patients with other cancers, but experienced significant cancer care disruption during the COVID-19 pandemic with a higher likelihood of decreased in-person visits and increased telehealth visits compared to patients with other malignancies. Focused efforts to ensure continuity of care for this vulnerable patient population are warranted.

10.
Journal of Bio-X Research ; 5(1):27-34, 2022.
Article in English | EMBASE | ID: covidwho-1816311

ABSTRACT

Objective: The coronavirus disease 2019 (COVID-19) epidemic resulting from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has still spread globally. The occurrence of the Delta variant, which is more infectious and spreads faster than earlier forms of the virus that causes COVID-19, makes infection prevention more challenging. Therefore, this study aimed to gain a comprehensive insight into the transmission routes of SARS-CoV-2 for curbing the propagation of SARS-CoV-2 in human populations. Methods: We studied a prospective cohort of 576 patients admitted consecutively to the First Affiliated Hospital of Guangzhou Medical University from January 21 to June 8, 2020. These patients were chosen based on their similar clinical phenotypes or imaging findings. There were 21 (3.6%) laboratory-confirmed COVID-19 patients (16 severe and 5 mild cases) and 555 non-COVID-19 patients. The antibody response and routes and duration of viral shedding were systematically evaluated in serial clinical specimens. Moreover, SARS-CoV-2 RNA was also detected in a mouth rinse, urine, and tear samples. This study was approved by the Medical Ethical Committee of The First Affiliated Hospital of Guangzhou Medical University (approval No. 2020-77). Results: SARS-CoV-2 mainly existed in sputum, nasal and throat swabs, and feces samples. Virus latency was longer in sputum and feces samples than in nasopharyngeal samples. IgG antibody response in respiratory samples was related to disease severity. Although droplets and aerosols are the major transmission routes for COVID-19, covert routes of transmission from asymptomatic patients, contaminated surfaces, and wastewater are also of interest. Conclusion: Our findings provide a solid foundation for developing prophylactic measures against SARS-CoV-2.

11.
Journal of East Asian Studies ; 2022.
Article in English | Scopus | ID: covidwho-1805488

ABSTRACT

How can authoritarian regimes effectively control information to maintain regime legitimacy in times of crisis? We argue that media framing constitutes a subtle and sophisticated information control strategy in authoritarian regimes and plays a critical role in steering public opinion and cultivating an image of competent government during a tremendous crisis. Using structural topic models (STM), we conduct a textual analysis of more than 4,600 news reports produced by seven Chinese media outlets during the COVID-19 pandemic. We find that Chinese media, instructed by the propaganda authorities, used a heroism frame to feature frontline medics' sacrifices when saving others in need and resorted to a contrast frame to highlight the poor performance of the United States in the fight against COVID-19. We also show that both state and commercial media outlets used these two frames, though the tone of commercial media coverage was generally more moderate than the state media version. © 2022 Cambridge University Press. All rights reserved.

12.
Infectious Microbes and Diseases ; 3(1):32-40, 2021.
Article in English | Scopus | ID: covidwho-1795002

ABSTRACT

Coronavirus disease 2019 (COVID-19) has spread throughout China. However, information about COVID-19 in cities and regions outside Wuhan is limited and the indicators that predict the length of hospital stay for patients with COVID-19 are unclear. Therefore, we collected clinical data from 47 patients with COVID-19 in Quanzhou City. The median age was 38 years [interquartile range (IQR): 31-50 years], and 24 (51%) were male. There were 8 mild, 36 moderate, and 3 severe/critical cases. The median interval from exposure to disease onset was 13 days (IQR: 8-18 days). The incidence of severe/critical cases was 33% (3/10) in patients with hypertension. Common symptoms included fever (83%), cough (77%), fatigue (40%), a sore, dry throat (28%), and diarrhea (21%). One patient (2%) developed respiratory distress syndrome on day 13 of inpatient treatment. Six patients had leukopenia, 17 had elevated C-reactive protein (CRP), and 8 had lymphocytopenia and elevated lactate dehydrogenase (LDH). The median length of hospitalization was 22 days (IQR: 16-30 days). Dynamic monitoring of LDH, CRP, and neutrophil-lymphocyte ratio predicted whether length of hospitalization would exceed 21 days. Most patients presented with mild and moderate disease. Patients with hypertension were more likely to become severe or critical. Dynamic monitoring of LDH, CRP, and neutrophil-lymphocyte ratio levels can help predict delayed discharge from the hospital. © 2022 Lippincott Williams and Wilkins. All rights reserved.

13.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation ; 41(4):S374-S374, 2022.
Article in English | EuropePMC | ID: covidwho-1781969

ABSTRACT

Introduction As of April 2021, 78 lung transplants (LTx) were performed for a diagnosis of COVID-19: 50 for COVID-19 ARDS and 28 for pulmonary fibrosis. Bilateral LTx has been recommended as many patients develop significant pulmonary hypertension. Additionally, native lung explants may include cavitary areas of pneumonia, which could serve as a nidus for infection. Single LTx (SLTx) can be considered in patients who have chronic pulmonary fibrosis secondary to COVID-19 with a short window to receive a transplant, or who would otherwise be considered for a single lung. There have been no published cases of a single lung transplant for COVID-19 pulmonary fibrosis. We present a case of a patient with pulmonary fibrosis from COVID-19 who underwent SLTx. Case Report A 70yo male with O+ blood type was hospitalized 8/2020 to 10/2020 with COVID-19 pneumonia, treated with Remdesivir and Tocilizumab. He had hypoxia but never required intubation. His course was complicated by bilateral pneumothoraces requiring chest tubes. He developed pulmonary fibrosis requiring 6 L of oxygen at rest. CT scan of his chest showed multifocal, peripheral prominent ground glass opacities and interlobal septal thickening with traction bronchiectasis. Ventilation-perfusion scan demonstrated 22% perfusion to the left lung and 78% to the right lung. Right heart catheterization showed pulmonary artery pressures of 36/12 mmHg. His pulmonary function test was suggestive of restrictive disease (FEV 0.81 L [30%], FVC 0.96 L [27%], and FEV1/FVC 85%) that had worsened over time. He was presented at multidisciplinary review board with recommendation to list for left SLTx, which was activated August 2021. The patient was admitted in September 2021 and underwent left single lung transplant via left anterolateral thoracotomy, off cardiopulmonary bypass. Total ischemia time was 3:54. Explant pathology showed end stage pulmonary fibrosis. The patient was extubated on postoperative day 1 with an uneventful postoperative course. He was discharged to skilled nursing facility on postoperative day 26 for rehabilitation. Summary SLTxp is safe and feasible for COVID-19 related pulmonary fibrosis in well-selected patients who have a short window to receive a transplant.

14.
2nd Geo Congress - Advances in Monitoring and Sensing, Embankments, Slopes, and Dams, Pavements, and Geo-Education ; 336:453-462, 2022.
Article in English | Web of Science | ID: covidwho-1777229

ABSTRACT

Georgia Institute of Technology's (Georgia Tech's) response to the COVID-19 pandemic included ensuring students gained equitable exposure to hands-on learning. Instructors of the introductory geotechnical engineering lab course developed At-Home Lab Kits that contained materials for students to gather data at home to learn different geotechnical engineering concepts. An end-of-semester survey was distributed for students to share their experiences and for instructors to observe the effectiveness of the virtual lab instruction method. Overall, 90.5% of students responded that labs with hands-on tests were more beneficial than labs that only involved data analysis. Among the topics presented, students were most confident in their understanding of grain size distribution and hydraulic conductivity;they were least confident in their understanding of Atterberg limits, the only instruction topic that did not include hands-on experimentation. Results indicate that at-home lab experiments are a beneficial substitution for in-class lab procedures when in a virtual pedagogy.

15.
PubMed; 2022.
Preprint in English | PubMed | ID: ppcovidwho-331504

ABSTRACT

Background: Disparate COVID-19 outcomes have been observed between Hispanic, Non-Hispanic Black, and White patients. The underlying causes for these disparities are not fully understood.

16.
Journal of Virology ; 96(1):11, 2022.
Article in English | Web of Science | ID: covidwho-1756184

ABSTRACT

Over the past 20 years, the severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome CoV (MERS-CoV), and SARS-CoV-2 emerged, causing severe human respiratory diseases throughout the globe. Developing broad-spectrum drugs would be invaluable in responding to new, emerging coronaviruses and to address unmet urgent clinical needs. Main protease (Mpro;also known as 3CL(pro)) has a major role in the coronavirus life cycle and is one of the most important targets for anti-coronavirus agents. We show that a natural product, noncovalent inhibitor, shikonin, is a pan-main protease inhibitor of SARS-CoV-2, SARS-CoV, MERS-CoV, human coronavirus (HCoV)-HKU1, HCoV-NL63, and HCoV-229E with micromolar half maximal inhibitory concentration (IC50) values. Structures of the main protease of different coronavirus genus, SARS-CoV from the betacoronavirus genus and HCoV-NL63 from the alphacoronavirus genus, were determined by X-ray crystallography and revealed that the inhibitor interacts with key active site residues in a unique mode. The structure of the main protease inhibitor complex presents an opportunity to discover a novel series of broad-spectrum inhibitors. These data provide substantial evidence that shikonin and its derivatives may be effective against most coronaviruses as well as emerging coronaviruses of the future. Given the importance of the main protease for coronavirus therapeutic indication, insights from these studies should accelerate the development and design of safer and more effective antiviral agents. IMPORTANCE The current pandemic has created an urgent need for broad-spectrum inhibitors of SARS-CoV-2. The main protease is relatively conservative compared to the spike protein and, thus, is one of the most promising targets in developing anticoronavirus agents. We solved the crystal structures of the main protease of SARSCoV and HCoV-NL63 that bound to shikonin. The structures provide important insights, have broad implications for understanding the structural basis underlying enzyme activity, and can facilitate rational design of broad-spectrum anti-coronavirus ligands as new therapeutic agents.

17.
9th International Conference on Orange Technology, ICOT 2021 ; 2021.
Article in English | Scopus | ID: covidwho-1752401

ABSTRACT

Hosting weddings, graduation dinners, teacher appreciation banquets, family banquets and other activities at hotels are very popular in mainland China, the income of banquets and weddings has been considered as a major revenue generator for the hotels. With the high demand for weddings, Yixing Hotel opened three new banquet halls in 2018 and started to use outsourcing employees to assist in serving wedding banquets. This study collected the history data of hotel internal employee surveys and wedding customer surveys to identify the impact of wedding banquet labor outsourcing on customers and internal employees in terms of happiness and satisfaction. The primary data was conducted monthly from October 2018 to March 2021 through SINOTRUST, a consulting company. From February to April of 2020 were not considered in the analysis because these three months had no wedding banquet due to the COVID-19 pandemic. Therefore, a total amount of 26 cases were sorted out in the sample. To test the hypotheses, this study used the classic linear regression model and empirical model and conducted the factor analysis and the regression analysis. The results of this study identified that outsourcing activities affected the happiness and satisfaction of wedding banquet customers;the outsourcing activity has a negative effect on internal employees' happiness and job satisfaction through three dimensions-colleague relationships, job security, and reasonableness of work assignments. Through the case study, the managerial implications and theoretical implications are provided to Yixing and similar-Type hotels regarding the aforementioned dimensions. © 2021 IEEE.

18.
Embase;
Preprint in English | EMBASE | ID: ppcovidwho-327005

ABSTRACT

Highly transmissible SARS-CoV-2 Omicron variant has posted a new crisis for COVID-19 pandemic control. Within a month, Omicron is dominating over Delta variant in several countries probably due to immune evasion. It remains unclear whether vaccine-induced memory responses can be recalled by Omicron infection. Here, we investigated host immune responses in the first vaccine-breakthrough case of Omicron infection in Hong Kong. We found that the breakthrough infection rapidly recruited potent cross-reactive broad neutralizing antibodies (bNAbs) against current VOCs, including Alpha, Beta, Gamma, Delta and Omicron, from unmeasurable IC50 values to mean 1:2929 at around 9-12 days, which were higher than the mean peak IC50 values of BioNTech-vaccinees. Cross-reactive spike- and nucleocapsid-specific CD4 and CD8 T cell responses were detected. Similar results were also obtained in the second vaccine-breakthrough case of Omicron infection. Our preliminary findings may have timely implications to booster vaccine optimization and preventive strategies of pandemic control.

19.
Embase;
Preprint in English | EMBASE | ID: ppcovidwho-326959

ABSTRACT

Background: Nearly 4 billion doses of the BioNTech-mRNA and Sinovac-inactivated vaccines have been administrated globally, yet different vaccine-induced immunity against SARS-CoV-2 variants of concern (VOCs) remain incompletely investigated. Methods: We compare the immunogenicity and durability of these two vaccines among fully vaccinated Hong Kong people. Findings: Standard BioNTech and Sinovac vaccinations were tolerated and induced neutralizing antibody (NAb) (100% and 85.7%) and spike-specific CD4 T cell responses (96.7% and 82.1%), respectively. The geometric mean NAb IC50 and median frequencies of reactive CD4 subsets were consistently lower among Sinovac-vaccinees than BioNTech-vaccinees. Against VOCs, NAb response rate and geometric mean IC50 against B1.351 and B.1.617.2 were significantly lower for Sinovac (14.3%, 15 and 50%, 23.2) than BioNTech (79.4%, 107 and 94.1%, 131). Three months after vaccinations, NAbs to VOCs dropped near to detection limit, along with waning memory T cell responses, mainly among Sinovac-vaccinees. Interpretation: Our results indicate that Sinovac-vaccinees may face higher risk to pandemic VOCs breakthrough infection.

20.
Eur J Nucl Med Mol Imaging ; 47(9): 2220, 2020 08.
Article in English | MEDLINE | ID: covidwho-1640818

ABSTRACT

The authors P. Orellana and N. El-Haj were inadvertently deleted in the original paper.

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