ABSTRACT
The COVID-19 causes strong spillover effects between financial markets. This paper explores the dynamic spillover effects among cryptocurrency, clean energy and oil during the COVID-19 by employing TVP-VAR extended joint connectedness approach. The empirical results show that clean energy and oil markets appear to be the net receivers of spillovers, whereas cryptocurrency market appears to be a net transmitter of spillovers. The dynamic total connectedness experiences a rapid increase in March 2020 when the COVID-19 spreads around the world. © 2022 The Authors. Published by Elsevier B.V.
ABSTRACT
Visible-infrared cross-modality person re-identification (VI-ReID) is currently a prevalent but challenging research topic in computer vision, since it can remedy the poor performance of existing single-modality ReID models under insufficient illumination, thus enabling the 24/7 surveillance systems. Although extensive research efforts have been dedicated to VI-ReID, a systematic and comprehensive literature review is still missing. Considering that, in this paper, a comprehensive review of VI-ReID approaches is provided. First, we clarify the importance, definition and challenges of VI-ReID. Secondly and most importantly, we elaborately analyze the motivations and the methodologies of existing VI-ReID methods. Accordingly, we will provide a comprehensive taxonomy, including 4 categories with 8 sub-items, for those state-of-the-art (SOTA) VI-ReID models. After that, we elaborate on some widely used datasets and evaluation metrics. Next, comprehensive comparisons of SOTA methods are made on the benchmark datasets. Based on the results, we point out the limitations of current methods. At last, we outline the challenges in this field and future research trends.
ABSTRACT
T1 Figure 1ConclusionsOverall, this largest paediatric single cell COVID-19 study to date showed significant differences in response to SARS-CoV-2 between children and adults, reflecting the changes of the immune landscape over developmental time, which in children are dominated by naïve and innate responses.
ABSTRACT
Currently, Coronavirus Disease 2019 (COVID-19)-a respiratory contagion spreading through expiratory droplets-has evolved into a global pandemic, severely impacting the public health. Importantly, the emerging of immune evasion SARS-CoV-2 variants and the limited effect of current antivirals against SARS-CoV-2 in clinical trials suggested that alternative strategies in addition to the conventional vaccines and antivirals are required to successfully control the COVID-19 pandemic. Here, we propose to use liquid-repellent coatings to prevent the spread of the disease in the absence of effective vaccines, antimicrobial agents, or therapeutics, wherein the deposition and penetration of pathogen droplets are prohibited. We use SARS-CoV-2 as a model pathogen and find that SARS-CoV-2 remnants are reduced by seven orders of magnitude on coated surfaces, yielding a repelling efficacy far outperforming the inactivation rate of disinfectants. The SARS-CoV-2 remnant scales exponentially with the liquid/solid adhesion, uncovering the mechanism and effective means for minimizing pathogen attachment. The antipathogen coating that both repels and inactivates pathogens is demonstrated by incorporating the super-liquid-repellent coating with antipathogen additives. Together with its versatility over a wide range of substrates and pathogens, the novel antipathogen coating is of considerable value for infection control in everyday life as well as during pandemics.
ABSTRACT
Human challenge trial (HCT) is a test in which human volunteers are intentionally infected with pathogens in order to evaluate the efficacy of candidate preventive or therapeutic drugs. During the COVID-19 pandemic, the HCT of vaccines has aroused people's attention due to its significant advantages over clinical trial. This paper introduces the concept, development and application of HCT, the advantages and limitations of HCT for vaccine evaluation, and the consideration of future HCT of COVID-19 vaccine in China.
Subject(s)
COVID-19 , Vaccines , COVID-19 Vaccines , Humans , Pandemics , SARS-CoV-2ABSTRACT
The spread of COVID-19 around the world has profoundly affected the process of world development, making significant changes in people's behavior, government operations, and business operations. The spread of COVID-19 is a complex process, closely related to isolation patterns, population risk perception, geospatial and other factors, and simulation of the spread of covid-19 under the prevention and control policy is an important method to test the effectiveness of prevention and control measures. Using the MAS-SEIR-II model to carry out scenario analysis, the results we got show that establishing a cubicle hospital for rapid isolation of susceptible populations, flattening grassroots prevention and control organizations, and establishing a modern emergency logistics system are effective prevention and control measures. © 2020 ACM.
ABSTRACT
The SARS (severe acute respiratory syndrome) outbreak was caused by a coronavirus (CoV) named the SARS-CoV. SARS pathology is propagated both by direct cytotoxic effects of the virus and aberrant activation of the innate immune response. Here, we identify several mechanisms by which a SARS-CoV open reading frame (ORF) activates intracellular stress pathways and targets the innate immune response. We show that ORF8b forms insoluble intracellular aggregates dependent on a valine at residue 77. Aggregated ORF8b induces endoplasmic reticulum (ER) stress, lysosomal damage, and subsequent activation of the master regulator of the autophagy and lysosome machinery, Transcription factor EB (TFEB). ORF8b causes cell death in epithelial cells, which is partially rescued by reducing its ability to aggregate. In macrophages, ORF8b robustly activates the NLRP3 inflammasome by providing a potent signal 2 required for activation. Mechanistically, ORF8b interacts directly with the Leucine Rich Repeat domain of NLRP3 and localizes with NLRP3 and ASC in cytosolic dot-like structures. ORF8b triggers cell death consistent with pyroptotic cell death in macrophages. While in those cells lacking NLRP3 accumulating ORF8b cytosolic aggregates cause ER stress, mitochondrial dysfunction, and caspase-independent cell death. FAU - Shi, Chong-Shan