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2.
Geophysical Research Letters ; 48(8):e2021GL093243, 2021.
Article | WHO COVID | ID: covidwho-1201143

ABSTRACT

Abstract During the Lunar New Year Holiday of 2020, China implemented an unprecedented lockdown to fight the COVID-19 outbreak, which strongly affected the anthropogenic emissions We utilized elemental carbon observations (equivalent to black carbon, BC) from 42 sites and performed inverse modeling to determine the impact of the lockdown on the weekly BC emissions and quantify the effect of the stagnant conditions on BC observations in densely populated eastern and northern China BC emissions declined 70% (eastern China) and 48% (northern China) compared to the first half of January In northern China, under the stagnant conditions of the first week of the lockdown, the observed BC concentrations rose unexpectedly (29%) even though the BC emissions fell The emissions declined substantially thereafter until a week after the lockdown ended On the contrary, in eastern China, BC emissions dropped sharply in the first week and recovered synchronously with the end of the lockdown

3.
4.
Environ Sci Technol ; 55(9): 5721-5730, 2021 05 04.
Article in English | MEDLINE | ID: covidwho-1164780

ABSTRACT

Despite the large reduction in anthropogenic activities due to the outbreak of COVID-19, air quality in China has witnessed little improvement and featured great regional disparities. Here, by combining observational data and simulations, this work aims to understand the diverse air quality response in two city clusters, Yangtze River Delta region (YRD) and Pearl River Delta region (PRD), China. Though there was a noticeable drop in primary pollutants in both the regions, differently, the maximum daily 8 h average ozone (O3) soared by 20.6-76.8% in YRD but decreased by 15.5-28.1% in PRD. In YRD, nitrogen oxide (NOx) reductions enhanced O3 accumulation and hence increased secondary aerosol formation. Such an increment in secondary organic and inorganic aerosols under stationary weather reached up to 36.4 and 10.2%, respectively, which was further intensified by regional transport. PRD was quite the opposite. The emission reductions benefited PRD air quality, while regional transport corresponded to an increase of 17.3 and 9.3% in secondary organic and inorganic aerosols, respectively. Apart from meteorology, the discrepancy in O3-VOCs-NOx relationships determined the different O3 responses, indicating that future emission control shall be regionally specific, instead of one-size-fits-all cut. Overall, the importance of regionally coordinated and balanced control strategy for multiple pollutants is highly emphasized.


Subject(s)
Air Pollutants , Air Pollution , Ozone , Air Pollutants/analysis , China , Cities , Communicable Disease Control , Environmental Monitoring , Humans , Ozone/analysis , Seasons
5.
China Rural Economy ; 8:8, 2020.
Article | WHO COVID | ID: covidwho-1151439

ABSTRACT

Rural tourism is an important carrier to promote rural revitalization and an important starting point for poverty alleviation After "all-for-one tourism" has become a national strategy, rural tourism has shown a "blowout" development trend Facing the impact of the Covid-19 outbreak, rural tourism is more urgently required to shift from quantity-oriented development to high-quality development, providing people with a healthier, safer, and better tourism environment This article analyzes the high-quality development of rural tourism with the theory of coordinated development of ecological economy, and summarizes the concept and connotative features of high-quality development of rural tourism Furthermore, it identities key issues to realize the high-quality development of rural tourism from six aspects, namely, the integrity and scientific nature of development planning, resource sustainability, industrial integration, talent team construction, tourism products and services, as well as guarantee measures Based on the analysis, the study puts forward a number of suggestions in order to achieve the high-quality development of rural tourism

7.
BMC Psychiatry ; 21(1): 80, 2021 02 08.
Article in English | MEDLINE | ID: covidwho-1069555

ABSTRACT

BACKGROUND: Coronavirus disease 2019 (COVID-19) has affected more than 5 million people around the world and killed more than 300,000 people; thus, it has become a global public health emergency. Our objective was to investigate the mental health of hospitalized patients diagnosed with COVID-19. METHODS: The PTSD checklist for DSM-5 (PCL-5), Patient Health Questionnaire (PHQ-9), Generalized Anxiety Disorder Scale (GAD-7), Trauma Exposure Scale, abbreviated version of the Connor-Davidson Resilience Scale (CD-RISC-10), Perceived Social Support Scale (PSSS) and Demographic Questionnaire were used to examine posttraumatic stress disorder (PTSD), depression, anxiety, trauma exposure, resilience and perceived social support among 898 patients who were hospitalized after being diagnosed with COVID-19 in China. The data were analyzed with t tests, one-way ANOVA and multivariable logistic regression analysis. RESULTS: The results showed that the prevalence of PTSD, depression and anxiety was 13.2, 21.0 and 16.4%, respectively. Hospitalized patients who were more impacted by negative news reports, had greater exposure to traumatic experiences, and had lower levels of perceived social support reported higher PTSD, depression and anxiety. CONCLUSIONS: Effective professional mental health services should be designed to support the psychological wellbeing of hospitalized patients, especially those who have severe disease, are strongly affected by negative news and have high levels of exposure to trauma.


Subject(s)
Stress Disorders, Post-Traumatic , Anxiety/diagnosis , Anxiety/epidemiology , China/epidemiology , Cross-Sectional Studies , Depression/diagnosis , Depression/epidemiology , Humans , Prevalence , Stress Disorders, Post-Traumatic/diagnosis , Stress Disorders, Post-Traumatic/epidemiology
8.
Curr Eye Res ; : 1-4, 2021 Feb 03.
Article in English | MEDLINE | ID: covidwho-1061052

ABSTRACT

Objective: We documented an older female with Coronavirus(CoV) Disease 2019 (COVID-19) and concomitant acquired monocular blindness. We examined this phenomenon in order to understand COVID-19 better.Methods: We observed an older female with COVID-19 and concomitant acquired monocular blindness. The following indicators were monitored during the course of the disease: ocular examinations, flash visual evoked potential examination, a blood test for COVID-19 IgM antibodies, as well as nasopharyngeal swab and tear sample tests for COVID-19 nucleic acid.Results: The patient's visual acuity for the left eye was NLP and the intraocular pressure was 51 mmHg. Keratic precipitates similar to mutton-fat were spread over the corneal endothelium of the left eye. The funduscopic examination of the patient's left eye revealed severe retinal arterial ischemia, and the color of the retina was off-white. Compared to the right eye, the flash visual evoked potential examination revealed a moderate decrease in P2 wave amplitude for the left eye. A blood test was positive for COVID-19 IgM antibodies, and a nasopharyngeal swab test taken for COVID-19 nucleic acid was positive on May 4, 2020. A sample of the patient's tears was taken, and the nucleic acid test for COVID-19 was still positive two weeks later.Conclusions: Our study was the first to find that acute viral retinitis could occur in patients with COVID-19 and severe blindness could be associated with SARS-CoV-2 infection. Therefore, physicians should consider the possibility of coronavirus infection in patients with an abnormal fundus or suddenly vision loss.

9.
Biosens Bioelectron ; 178: 113041, 2021 Apr 15.
Article in English | MEDLINE | ID: covidwho-1051492

ABSTRACT

The outbreak of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been challenging human health worldwide. Loop-mediated isothermal amplification (LAMP) has been promptly applied to the detection of SARS-CoV-2 owing to its high amplification efficacy and less requirement of the thermal cycler. However, the vast majority of these LAMP-based assays depend on the non-specific detection of LAMP products, which can not discern the undesirable amplificons, likely to yield unreliable results. Herein, a sequence-specific LAMP assay was reported to detect SARS-CoV-2 using proofreading enzyme-mediated probe cleavage (named Proofman), which could realize real-time and visual detection without uncapping. This assay, introducing a proofreading enzyme and the fluorogenic probe to reverse-transcription LAMP (RT-Proofman-LAMP), can specifically detect the SARS-CoV-2 RNA with a detection limit of 100 copies. In addition to the real-time analysis, the assay is capable of endpoint visualization under a transilluminator within 50 min, providing a convenient reporting manner under the setting of point-of-care testing (POCT). In combination with different fluorophores, the one-pot multiplex assay was successfully achieved to detect multiple targets of SARS-CoV-2 and inner control simultaneously. In summary, the development of RT-Proofman-LAMP offers a versatile and highly-specific method for fast field screening and laboratory testing of SARS-CoV-2, making it a promising platform in COVID-19 diagnosis.


Subject(s)
/methods , /virology , Molecular Diagnostic Techniques/methods , Nucleic Acid Amplification Techniques/methods , /isolation & purification , Biosensing Techniques/methods , Biosensing Techniques/statistics & numerical data , Humans , Limit of Detection , Molecular Diagnostic Techniques/statistics & numerical data , Multiplex Polymerase Chain Reaction/methods , Multiplex Polymerase Chain Reaction/statistics & numerical data , Nucleic Acid Amplification Techniques/statistics & numerical data , Pandemics , Point-of-Care Systems/statistics & numerical data , RNA, Viral/analysis , RNA, Viral/genetics , Sensitivity and Specificity
10.
Geophysical Research Letters ; n/a(n/a):e2020GL090542, 2020.
Article in English | WHO COVID | ID: covidwho-1003290

ABSTRACT

Abstract Anthropogenic emissions were greatly constrained during COVID-19 lockdown in China Nevertheless, observations still showed high loadings of fine particles (PM2 5) over northern China with secondary aerosols increasing by 15 ?g/m3 yet a ?10% drop in light-absorbing black carbon (BC) Such a chemical transition in aerosol composition tended to make the atmosphere more scattering, indicated by satellite retrieved aerosol absorption optical depth falling by 60% Comparison between weather forecast and radiosonde observations illustrated that, without upper-level heating induced by BC, the stabilized stratification diminished, which was conducive for PBL mixing and thus near-surface pollution dispersion Furthermore, coulped dynamic-chemistry simulations estimated that emission reduction during the lockdown weakened aerosol-planetary boundary layer (PBL) interaction and thus a reduction of 25 ?g/m3 (?50%) in PM2 5 enhancement Based on the unique natural experiment, this work observationally-confirmed and numerically-quantified the importance of BC-induced meteorological feedback, further highlighting the priority of BC control in haze mitigation

11.
Atmospheric and Oceanic Science Letters ; : 100015, 2020.
Article in English | WHO COVID | ID: covidwho-973822

ABSTRACT

The explosive spread of the 2019 novel coronavirus (COVID-19) provides a unique chance to rethink the relationship between human activity and air pollution Though related studies have revealed substantial reductions in primary emissions, obvious differences do exist in the responses of secondary pollutants, like ozone (O3) pollution However, the regional disparities of O3 responses and their causes have still not been fully investigated To better elucidate the interrelationship between anthropogenic emissions, chemical production, and meteorological conditions, O3 responses caused by lockdowns over different regions were comprehensively explored at a global scale Observational signals of air-quality change were derived from multi-year surface measurements and satellite retrievals With similar substantial drops in nitrogen dioxide (NO2), ozone shows rising signals in most areas of both East Asia and Europe, even up to ∼14 ppb, while a non-negligible declining signal exists in North America, by about 2–4 ppb Furthermore, the drivers behind the different O3 responses are discussed based on meteorological analysis and O3 sensitivity diagnosis On the one hand, O3 responses to NO2 declines can be affected by the primary dependence on its precursors On the other hand, it is also highly dependent on meteorological factors, especially temperature Our study further highlights the great importance of taking into consideration both the regional disparities and synergistic effects of precursor reductions and meteorological influence for scientific mitigation of O3 pollution 摘要: 疫情期间全球各地一次排放大幅削减, 而臭氧等二次污染的响应则存在着区域间差异 结合地面和卫星观测发现, 同在氮氧化物大幅下降的情况下,臭氧在东亚和欧洲呈现出可达14ppb的上升信号, 而北美则下降为主 (约2-4ppb) 我们结合气象分析和臭氧敏感性进一步讨论了臭氧响应差异性的原因, 一方面受臭氧与前体物间关系的影响;另一方面来自于气象, 尤其是温度 研究明晰了人为排放,化学和气象三者的内在关联, 强调了在臭氧控制过程中考虑前体物削减和气象条件协同的重要性

12.
J Ultrasound Med ; 2020 Nov 11.
Article in English | MEDLINE | ID: covidwho-917097

ABSTRACT

OBJECTIVES: Coronavirus disease 2019 (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic, raising widespread public health concerns. Our team treated hospitalized patients with COVID-19 in Wuhan, where the outbreak first began, and we suspected that SARS-CoV-2 may cause testicular infection in male patients. We conducted this study to explore that observation. METHODS: We enrolled male patients with a confirmed diagnosis of COVID-19 and performed a bedside ultrasound (US) examination of the scrotum, focused on findings of acute inflammation such as tunica albuginea thickening, enlargement and heterogeneous echogenicity of the testis, epididymis, or both, an abscess, scrotal wall edema, and hydrocele. Then we compared the proportions of observed epididymo-orchitis in patients from different age groups and COVID-19 severity groups. RESULTS: A total of 142 patients with COVID-19 were enrolled in our study, and 32 (22.5%) patients had acute orchitis, epididymitis, or epididymo-orchitis on scrotal US imaging, according to the diagnosis criteria. The observed risk of acute scrotal infection increased with age, with the incidence reaching 53.3% in men older than 80 years. We also observed that men with severe COVID-19 had a significantly higher possibility of epididymo-orchitis compared to the nonsevere COVID-19 group (P = .037). CONCLUSIONS: This study shows US imaging evidence that SARS-CoV-2 may cause infection of the testis or epididymis, and the risk is worthy of the attention of clinicians.

13.
Front Oncol ; 10: 1272, 2020.
Article in English | MEDLINE | ID: covidwho-853981

ABSTRACT

Background: A recent outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), which began in Wuhan, China, with a high level of human-to-human transmission has been reported. There are limited data available on Coronavirus Disease 2019 (COVID-19) patients with hematological malignancies with more than 60 days of follow-up. This study describes the clinical characteristics, including multiple recurrences of COVID-19, in a patient with chronic lymphocytic leukemia (CLL) during 69 days of follow-up. Case Presentation: A 72-year-old female was admitted to hospital isolation after being infected with COVID-19 as part of a family cluster on January 30, 2020. Apart from SARS-Cov-2 virus infection, laboratory results revealed lymphocytosis of uncertain etiology and abnormal distribution of T lymphocytes. On blood smears, small blue lymphocytes with scant cytoplasm were observed, and the presence of high levels of circulating clonal B cells was also demonstrated by flow cytometry. The patient was diagnosed with COVID-19 and CLL. Among her family members, she had the highest viral loads and the fastest progression on lung injury and developed severe pneumonia. Serological results showed she had both 2019-nCoV-specific IgM and IgG antibodies; however, only IgG antibodies were detected in her husband's plasma. Results: A combination regimen of antiviral therapy and high-dose intravenous immunoglobulin (IVIG) in the early stage seemed to be effective for treating CLL and SARS-Cov-2 infection. Because of the low humoral immune response, the CLL patient could not effectively clear the SARS-Cov-2 infection and suffered from recurrence twice during the 69-day follow-up. Conclusion: In CLL, a neoplastic antigen-specific B-cell clone proliferates, and the progeny cells accumulate and outgrow other B cells, leading to immune deficiency. Considering the low humoral immune response and ineffective clearance of SARS-Cov-2 in CLL patients, the follow-up and home quarantine period should be extended. We need further studies to clarify suspending or continuing CLL therapy during COVID infection. For those patients who are prone to progression to severe disease, administering humoral immunity therapies can help to prevent disease progression and quickly meet the cure criteria.

14.
Journal of Chemical Education ; 97(9):2439-2447, 2020.
Article | WHO COVID | ID: covidwho-805808

ABSTRACT

In Spring 2020, we began a study focused on the development of inclusive teaching practices in an undergraduate chemistry lecture course for non-STEM students In the wake of the COVID-19 pandemic and ensuing educational disruptions, we changed the design of our study to focus on the learning and teaching experiences of students and instructors Here, we conducted student surveys before and after the emergency transition to remote teaching and analyzed data on student participation in the online setting We observed that student engagement was likely negatively impacted by the emergency transition We also found that lectures engaged students less after the transition By contrast, course activities that did not heavily rely on a physical classroom, such as students blogging about their research of chemistry literature and crafting an independent research paper about a chemical question, were more effective in retaining student engagement after the transition We also analyze student utilization of synchronous and asynchronous learning opportunities (for example, recorded lectures) We contextualize student engagement in the course relative to policies adopted by the educational institution, notably a mandatory universal pass/fail grading policy Finally, we communicate thematic reflections from students, undergraduate peer tutors, graduate student teaching fellows, and the course instructor about learning chemistry and teaching non-STEM undergraduates in the time of COVID-19 On the basis of these studies, we recommend seven instructional strategies for teaching chemistry during sustained educational disruptions

16.
Int J Environ Res Public Health ; 17(18)2020 09 09.
Article in English | MEDLINE | ID: covidwho-760921

ABSTRACT

BACKGROUND: Since December 2019, China has been affected by a severe outbreak of coronavirus disease 2019 (COVID-19). Frontline medical workers experienced difficulty due to the high risk of being infected and long and distressing work shifts. The current study aims to evaluate psychological symptoms in frontline medical workers during the COVID-19 epidemic in China and to perform a comparison with the general population. METHODS: An online survey was conducted from 14 February 2020 to 29 March 2020. A total of 899 frontline medical workers and 1104 respondents in the general population participated. Depression, anxiety, insomnia, and resilience were assessed via the Patient Health Questionnaire (PHQ-9), Generalized Anxiety Disorder Scale (GAD-7), Insomnia Severity Index (ISI), and abbreviated Connor-Davidson Resilience Scale (CD-RISC-10), respectively. RESULTS: Overall, 30.43%, 20.29%, and 14.49% of frontline medical workers in Hubei Province and 23.13%, 13.14%, and 10.64% of frontline medical workers in other regions reported symptoms of depression, anxiety, and insomnia, respectively. In addition, 23.33%, 16.67%, and 6.67% of the general population in Hubei Province and 18.25%, 9.22%, and 7.17% of the general population in other regions reported symptoms of depression, anxiety, and insomnia, respectively. The resilience of frontline medical staff outside Hubei Province was higher than that of the general population outside Hubei Province. CONCLUSION: A large proportion of frontline medical workers and the general public experienced psychological symptoms during the COVID-19 outbreak. Psychological services for frontline medical workers and the general public are needed.


Subject(s)
Anxiety/etiology , Coronavirus Infections/psychology , Coronavirus , Depression/etiology , Health Personnel/psychology , Pneumonia, Viral/psychology , Sleep Initiation and Maintenance Disorders/etiology , Sleep Initiation and Maintenance Disorders/psychology , Anxiety/epidemiology , Betacoronavirus , China/epidemiology , Coronavirus Infections/epidemiology , Cross-Sectional Studies , Depression/epidemiology , Female , Humans , Male , Mental Health , Pandemics , Pneumonia, Viral/epidemiology , Prevalence , Surveys and Questionnaires
17.
Med Microbiol Immunol ; 209(6): 657-668, 2020 Dec.
Article in English | MEDLINE | ID: covidwho-734093

ABSTRACT

The magnitude of SARS-CoV-2 infection, the dynamic changes of immune parameters in patients with the novel coronavirus disease (COVID-19) and their correlation with the disease severity remain unclear. The clinical and laboratory results from 154 confirmed COVID-19 patients were collected. The SARS-CoV-2 RNA levels in patients were estimated using the Ct values of specific RT-PCR tests. The lymphocyte subsets and cytokine profiles in the peripheral blood were analyzed by flow cytometry and specific immunoassays. 154 confirmed COVID-19 patients were clinically examined up to 4 weeks after admission. The initial SARS-CoV-2 RNA Ct values at admission varied, but were comparable in the patient groups classified according to the age, gender, underlying diseases, and disease severity. Three days after admission, significant higher Ct values were found in severe cases. Significantly reduced counts of T cells and T cell subsets were found in patients with old age and underlying diseases at admission and were characteristic for the development of severe COVID-19. Severe COVID-19 developed preferentially in patients with underlying compromised immunity and was not associated with initial virus levels. Higher SARS-CoV-2 RNA levels in severe cases were apparently a result of impaired immune control associated with dysregulation of inflammation.


Subject(s)
Betacoronavirus/genetics , Coronavirus Infections/immunology , Coronavirus Infections/virology , Pneumonia, Viral/immunology , Pneumonia, Viral/virology , RNA, Viral/analysis , T-Lymphocytes/immunology , Adult , Aged , Betacoronavirus/immunology , Biomarkers/blood , China/epidemiology , Cohort Studies , Coronavirus Infections/blood , Female , Humans , Inflammation Mediators/blood , Lymphocyte Count , Lymphocyte Subsets , Male , Middle Aged , Pandemics , Pneumonia, Viral/blood , Prognosis , RNA, Viral/genetics , Retrospective Studies , Viral Load
18.
Int J Biol Sci ; 16(13): 2464-2476, 2020.
Article in English | MEDLINE | ID: covidwho-695855

ABSTRACT

In 2020, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused infections worldwide. However, the correlation between the immune infiltration and coronavirus disease 2019 (COVID-19) susceptibility or severity in cancer patients remains to be fully elucidated. ACE2 expressions in normal tissues, cancers and cell lines were comprehensively assessed. Furthermore, we compared ACE2 expression between cancers and matched normal tissues through Gene Expression Profiling Interactive Analysis (GEPIA). In addition, we performed gene set enrichment analysis (GSEA) to investigate the related signaling pathways. Finally, the correlations between ACE2 expression and immune infiltration were investigated via Tumor Immune Estimation Resource (TIMER) and GEPIA. We found that ACE2 was predominantly expressed in both adult and fetal tissues from the digestive, urinary and male reproductive tracts; moreover, ACE2 expressions in corresponding cancers were generally higher than that in matched healthy tissues. GSEA showed that various metabolic and immune-related pathways were significantly associated with ACE2 expression across multiple cancer types. Intriguingly, we found that ACE2 expression correlated significantly with immune cell infiltration in both normal and cancer tissues, especially in the stomach and colon. These findings proposed a possible fecal-oral and maternal-fetal transmission of SARS-CoV-2 and suggested that cancers of the respiratory, digestive or urinary tracts would be more vulnerable to SARS-CoV-2 infection.


Subject(s)
Computational Biology , Coronavirus Infections/immunology , Neoplasms/immunology , Pneumonia, Viral/immunology , Adult , Betacoronavirus , Coronavirus Infections/complications , Enterocytes/metabolism , Epithelial Cells/metabolism , Female , Gene Expression Profiling , Gene Expression Regulation, Neoplastic , Gene Expression Regulation, Viral , Genotype , Goblet Cells/metabolism , Hepatocytes/metabolism , Humans , Immune System , Kidney Tubules/embryology , Male , Neoplasms/complications , Pandemics , Peptidyl-Dipeptidase A/metabolism , Pneumonia, Viral/complications , Prognosis , RNA-Seq , Signal Transduction
19.
Blood Purif ; : 1-5, 2020 Jul 28.
Article in English | MEDLINE | ID: covidwho-690598

ABSTRACT

It is of crucial importance to diagnose patients in a timely and clear manner during the outbreak of COVID-19. Different causes of pneumonia makes it difficult to differentiate COVID-19 from others. Hemodialysis patients are a special group of people in this outbreak. We present a successfully treated case of a patient with maintenance hemodialysis from acute eosinophilic pneumonia for using meropenem when treating bacterial pneumonia, avoiding possible panic and waste of quarantine materials in dialysis centers.

20.
Acad Radiol ; 27(10): 1363-1372, 2020 10.
Article in English | MEDLINE | ID: covidwho-644090

ABSTRACT

RATIONALE AND OBJECTIVES: Chest CT is not suitable for critically ill patients with COVID-19 and lung ultrasound (LUS) may play an important role for these patients. In this study, we summarized the findings of LUS and explore the value of semiquantitative LUS scores in evaluation and follow-up of COVID-19 pneumonia. MATERIALS AND METHODS: Retrospectively studied the LUS and chest CT imaging of 128 critically ill patients with COVID-19. The imaging data were reviewed to acquire the LUS and CT scores. The correlation between LUS scores and CT scores were made to evaluate the accuracy of LUS. A cut-off point of LUS score was calculated to distinguish critical-type patients from severe-type patients. LUS follow-up of 72 patients were compared with the gold standard chest CT. RESULTS: The most common LUS features of COVID-19 pneumonia were crowded or coalescent B-lines with multifocal small consolidations in multi-zone. The mean LUS score was 8.1 points in severe-type patients and 15.7 points in critical-type patients (P<0.05). The correlation between LUS scores and CT scores was high (r=0.891, p<0.01) and it was higher in critical-type patients than that in severe-type patients. The LUS score higher than 10.5 points had a 97.4% sensitivity and 75.0% specificity to distinguish critical-type patients. The consistency of LUS and chest CT in follow-up was 0.596, with higher consistency in diagnosis of lesion progression (Kappa values was 0.774). CONCLUSION: Our scoring system provides a more quantitative use of LUS findings and accurate evaluation of lung damage for critically ill patients with COVID-19.


Subject(s)
Betacoronavirus , Coronavirus Infections , Critical Illness , Pandemics , Pneumonia, Viral , Aged , Coronavirus Infections/diagnostic imaging , Female , Follow-Up Studies , Humans , Lung , Male , Middle Aged , Pneumonia, Viral/diagnostic imaging , Retrospective Studies , Ultrasonography
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