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1.
Medical Science ; 26(122):8, 2022.
Article in English | Web of Science | ID: covidwho-1887480

ABSTRACT

COVID-19 (Coronavirus infectious disease 2019) denotes an ever changing and varied disease which has crippled the health care systems throughout the world. There have been studies conducted across the globe to establish the important factors for severity and mortality associated with COVID-19. We tried to study the effect of chronic obstructive pulmonary disease (COPD) on the severity as well as outcome of COVID-19. Material and methods: A total of 180 patients with COVID-19 were enrolled in this study and were then screened for history of COPD. There were 49 patients with history of COPD and 131 patients with no history of COPD. Inflammatory markers and HRCT scores were assessed for all the patients and they were followed up to study the outcome. Result: COPD was significantly associated HRCT Score, inflammatory markers and outcome. The mean HRCT Score for patients with COPD was more in COPD group (15.39 +/- 4.65) when compared with Non-COPD group (9.39 +/- 3.98). Mortality was also significantly higher in patients with COPD (67.3%) when compared to the patients without COPD (3.3%). Conclusion: We conclude that COPD is an important factor which has to be considered while treating the patients of COVID-19 especially in the rural India where lockdown restrictions and lack of knowledge have provided hinderance in achieving optimal follow up as there is increased severity and mortality associated with it.

2.
Journal of Clinical and Diagnostic Research ; 16(2):OE01-OE03, 2022.
Article in English | EMBASE | ID: covidwho-1677770

ABSTRACT

Coronavirus Disease 2019 (COVID-19), caused by the coronavirus, since its start in Wuhan a city in China has spread like a wild fire and created havoc all over the globe. Initially, the disease was thought to be causing only respiratory complication, but gradually it was found to be causing multiorgan complication. Due to the hypercoagulable property of coronavirus, it has shown neurological, cardiological and endocrine complication. Recently, the effect of the virus on endocrine system has also been noted. Evidence has shown that COVID-19 can hamper the hypothalamo-pituitary axis resulting in altered adrenal response to stress. The immune-mediated damage to the endocrine glands results in subacute thyroiditis. The presence of Angiotensin Converting Enzyme 2 (ACE 2) receptors on various tissues could be the cause of this immune mediated damage. COVID-19 has also precipitated hyperglycaemia and in few cases, uncovered the insulin resistance in previously undiagnosed cases. It is crucial to have knowledge about the impact of endocrine system, as it is the powerhouse of the body.

3.
Journal of Medicine (Bangladesh) ; 22(2):150-154, 2021.
Article in English | EMBASE | ID: covidwho-1666969

ABSTRACT

With increasing incidence of Severe Acute Respiratory Distress Virus 2(SARS -CoV -2) in India, there has been growing reports of super infections in post covid 19 period. Long COVID refers to persistence of COVID19 symptoms for weeks to months. While most common manifestation of long COVID is fatigue and ill health, it may lead to development of life-threatening complications like Pulmonary Mucormycosis. We report a case of 54 year young, non-diabetic previously healthy male who had moderate COVID19 treated with low dose steroids and recovered completely, only to present with hemoptysis 3 months later on High Resolution Computed Tomography Scan of the Chest and Rhizopus fungi on bronchoalveolar lavage confirming Post Covid Pulmonary Mucormycosis in non-immunocompromised host. Patient was managed with dual antifungal therapy intravenous Liposomal Amphotericin B and Posaconazole for 3 weeks, followed by oral Posaconazole.

4.
Medical Science ; 25(116):2524-2528, 2021.
Article in English | Web of Science | ID: covidwho-1553268

ABSTRACT

Since 2019, The Coronavirus Disease (COVID19) has emerged as a global health concern. Various kinds of disorders like the vascular involvement along with neurological complications continue to be reported worldwide. In this case report we describe the case of a 28 year old Female who was antenatal (6.5 months) presented with Genereliazed Tonic Clonic Convulsions of duration more than 30 minutes which upon investigations turned out to be a case of subdural bleed and upon Nasopharyngeal swab testing revealed to be COVID19 positive case. Though the patient underwent urgent craniotomy and evacuation of hematoma was done, the patient ultimately succumbed leading to maternal mortality. Thus, this case report is an attempt to draw attention towards the maternal mortality caused due to COVID19 which we tend to overlook.

5.
Medical Science ; 25(114):1910-1914, 2021.
Article in English | Web of Science | ID: covidwho-1372264

ABSTRACT

Antibodies against Dengue virus (DENV) have been postulated to act against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV 2) which might reduce the severity of COVID19 in a patient who previously had dengue fever. However, we report a case of 30 year old male who presented with dengue shock syndrome two months after contracting COVID19. The patient had no history of dengue fever in the past and had no IgG antibodies against Dengue Virus whereas he tested positive for IgG SARS CoV 2 antibodies. Therefore, we highlight a rare case of Antibody Dependent Enhancement of Dengue fever as a result of antibodies against SARS CoV2 in a young male which proved to be fatal. In our knowledge this is the first case in the world to report dengue shock syndrome as a result of SARS CoV2 antibodies.

6.
Medical Science ; 25(113):1507-1512, 2021.
Article in English | Web of Science | ID: covidwho-1335719

ABSTRACT

Deadly secondary infections caused by Rhizopus species leading to mucormycosis have taken the world by storm. Most common presenting features of COVID-19 remain congectival congestion, headache and blurring of vision. However mucormycosis with a fistula manifesting as the primary symptom of COVID-19 is rare and this is the first case report of its kind to best of our knowledge. We report a case of 61 year old female who presented with a pus draining fistula on right side of her face. A Nasopharyngeal swab came positive for COVID-19 by Reverse Transcriptase polymerase chain reaction method. MRI para nasal sinus was suggestive of fungal sinusitis. Debriedment was done for the same and a swab was sent which showed growth of Rhizopus species on culture.

7.
Medical Science ; 25(113):1517-1521, 2021.
Article in English | Web of Science | ID: covidwho-1335696

ABSTRACT

Features of unilateral cranial nerve 7th lower motor neuron palsy and same sided 6th nerve involvement without hemiplegia or hemiparesis is a rare clinical entity in itself, which is referred to as Facial Colliculus Syndrome. This presentation was noticed in a patient of Covid 19 positive status and mucormycosis not on prolonged steroid treatment. This is a case report of an 80-year old female patient who was admitted to the medical ward of our hospital with presenting complaints of breathlessness and fever of 5 days duration. Later during course of the disease on followup in hospital she developed left sided 6th and 7th cranial nerve involvement. This case report highlights the case of an elderly female patient presenting with cranial nerve involvement with mucormycosis with covid 19 superinfection on follow-up after home quarantine.

8.
Medical Science ; 25(112):1402-1406, 2021.
Article in English | Web of Science | ID: covidwho-1292514

ABSTRACT

Since 2019, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV2) has led to major impact on both the physical as well as mental health. Although the health care facilities aim to provide treatment for the respiratory, cardiovascular as well as neurological manifestations, its huge impact on the mental wellness of patients is somewhat neglected. Perinatal depression is a commonly encountered psychological disorder. Various factors can aggravate or trigger post-partum depression. COVID-19 is one of such triggers. There is microglial cell activation leading to neuroinflammation along with Hypothalmo-pituitary Axis Dysfunction in COVID-19 leading to neuropsychiatric manifestations. Also similarity in genes for Angiotensin Convertase Enzyme 2 and Dopa Decarboxylase leads to reduction in Dopamine and Serotonin in COVID-19 patients leading to Depression. While complications like HELLP Syndrome and Intra Uterine Death remain well reported in association with COVID-19, Post-Partum Depression remains an underreported post COVID sequalae. Thus, we report a case series of COVID-19 positive pregnant patients who suffered from postpartum depression later as a Post COVID sequalae and were successfully treated with antidepressants and cognitive behavioral therapy preventing any complications.

9.
Medical Science ; 25(112):1326-1330, 2021.
Article in English | Web of Science | ID: covidwho-1292513

ABSTRACT

Platypnea -orthodexia syndrome is a rare syndrome which is described as breathlessness during the upright posture which is relieved in supine position. Its causes range from cardiac causes to pulmonary causes with few non cardiopulmonary etiologies. COVID-19 can have a wide range of pulmomonary manifestations ranging from acute respiratory distress syndrome to fibrosis of the lung. It is a rare finding of COVID-19. Here, we describe a case of 32 year old male who had respiratory distress due to COVID-19 infection and later suffered from platypneaorthodexia syndrome during his recovery phase. He was managed with chest physiotherapy along with oxygen support with which he improved and was discharged in stable condition. Platypnea Orthodexia is hence a rare manifestation of COVID-19 which must be diagnosed in time so that it can be managed in time with supportive therapy.

10.
Medical Science ; 25(112):1291-1294, 2021.
Article in English | Web of Science | ID: covidwho-1292512

ABSTRACT

Cardiovascular manifestations of COVID-19 are of paramount importance. Given the increasing load of COVID-19 patients there has been an increase in the thromboembolic events as well as arrhythmias. Though the relationship of COVID-19 with arrhythmias is well studied, Sinus Bradycardia as a presentation of COVID-19 is rare. Here, we report a case of 45- year-old female who tested positive for COVID-19 following exposure to COVID and was completely asymptomatic with bradycardia. The patient later developed features like fever, cough and hypoxia indicating this bradycardia to be a premonition of inflammatory cytokine storm.

11.
Medical Science ; 25(112):1417-1421, 2021.
Article in English | Web of Science | ID: covidwho-1292471

ABSTRACT

Since the December of 2019 there has been an increase in reporting of cerebrovascular events in patients infected with COVID-19. Though it is a common complication which is encountered mostly in the old age it is rare to witness the same in young patient in the absence of prior risk factors. We report a rare case of a young patient with COVID-19 postivie status who presented with a hyper acute infarct in left caudate nucleus, Lenti from nucleus, internal capsule, insular cortex, temporal lobe, parieto-occipital region, focal areas in frontal region and was immediately posted for thrombectomy. The patient improved drastically post procedure. Therefore we highlight the importance of contemplating the differential of stroke induced by COVID-19 even in young patients who present with symptoms consistent with a stroke in the ongoing pandemic.

12.
Medical Science ; 25(112):1281-1285, 2021.
Article in English | Web of Science | ID: covidwho-1265279

ABSTRACT

COVID-19 has increased incidence of thrombotic incidents due to its pro thrombotic state. Ever since the initiation of this pandemic in 2020, there has been an increased mortality due to complications arising due to COVID-19 infection. One of the leading causes of mortality in COVID-19 patients besides the respiratory distress has been myocardial infarction. In the discussion of Acute Myocardial Infarction, posterior wall myocardial infarction has always been difficult to diagnose. It is a challenging to diagnose as well as manage Posterior Wall myocardial infarction which is often missed on routine electrocardiogram in the emergency department. We report a case of a young female aged 32 year old who presented with COVID-19 induced Posterior Wall myocardial infarction. Though the cases of myocardial infarction in people with prior comorbidities and in older age group are common this a rare case report show casing a young female who developed myocardial infarction which later turned out to be posterior wall myocardial infarction induced by COVID-19.

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