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Indian Journal of Hematology and Blood Transfusion ; 37(SUPPL 1):S121, 2021.
Article in English | EMBASE | ID: covidwho-1638488

ABSTRACT

Introduction: COVID-19, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has spread across the globe,causing > 100,000 deaths in India in the first wave. The second wavewith its atypical undetected genetic mutation brings new trends indisease morbidity and significant variation in target organs, blood andblood components, especially new and some significant trends in thecoagulation parameters. The coagulopathy associated with COVID-19is characterized by thrombocytopenia, prolongation of the prothrombin time, high levels of D-dimer, elevated levels of fibrinogenand APTT. The levels of D-dimer correlate with disease severity andpredict the risk of thrombosis.Aims &Objectives: Predicting the severity and prognosis ofCOVID-19 patients in the Second Wave of the Pandemic by evaluating the coagulation markers like D-dimer (DD), Prothrombin Time(PT), Activated Partial Thromboplastin Time (APTT), and Fibrinogen(Fb) in them.Materials &Methods: A total of 110 confirmed COVID 19 patientsduring the Second wave who were admitted at DR PRABHAKARKORE HOSPITAL, JNMC, BELAGAVI between March 2021 andJuly 2021 were categorized into mild, moderate and severe based onCO-RADS SCORE. The dynamic changes of DD, PT, APTT, and Fbwere studied and correlated with clinical findings and prognosis.Result: Coagulation variations occurred at the early stage of COVID-19 infection, with 79(71.81%) patients having significant increase inDD, 70(63.63%) patients having significant Fb increase, 53(48.18%)in PT and 57(51.81%) in APTT. In mild to moderate cases significantvariation of coagulation parameters was found in the first week ofadmission whereas in severe and critically ill cases the variationswere more in the last week of their hospital stay. Gender variation isnot significant in the study population. The above 50 yrs age grouphad poorer prognosis with higher variation and higher levels of all theparameters studied as compared to the age group below 50 yrs.Conclusions: Coagulation parameters could be used as significantindicators in predicting the severity and prognosis of COVID-19patients in the Second Wave.

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