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2.
Journal of Fashion Marketing and Management ; : 1-19, 2022.
Article in English | Scopus | ID: covidwho-2078114

ABSTRACT

Purpose: The purpose of this study was to understand the impact of the coronavirus disease (COVID-19) pandemic on the global textile and apparel supply chain from the perspectives of industry professionals within the two leading production countries: Bangladesh and China. Design/methodology/approach: Applying the theory of dynamic capabilities, a qualitative research design was employed using interviews with a total of 33 apparel industry practitioners, 15 in Bangladesh and 18 in China. Findings: Findings indicate that four factors primarily impacted the extent to which COVID-19 disrupted a firm's supply chain: firm size, channel diversification, sourcing method and product type. Viewed through the lens of the theory of dynamic capabilities, findings point to the need for firms to address the challenges brought about by supply chain disruptions by creating opportunities. Originality/value: It is important to understand the impact of COVID-19 in real time and within the two largest textile and apparel–producing countries globally, as they have borne much of the brunt of the supply chain disruptions brought on by COVID-19. This empirical study makes contributions to the apparel supply chain literature as it provides an in-depth investigation of what textile and apparel firms in China and Bangladesh have learned from the COVID-19 experience to better prepare for future unexpected global events. © 2022, Emerald Publishing Limited.

3.
Journal of Pharmaceutical Negative Results ; 13:78-83, 2022.
Article in English | Web of Science | ID: covidwho-2072516

ABSTRACT

One of the Indonesian government's efforts to reduce COVID-19 disease is holding vaccinations for all people in Indonesia. The effect of administering the first dose of Sinovac (R) COVID-19 Vaccine occurs after injection, as a result of deep penetration and different needle directions, as well as Unexpected Events (KTD), which are generally mild and temporary. This research aimed to determine attitudes, perceptions, and the effects of the first Sinovac (R) vaccine. The research used an observational study by taking a sample of 130 people who met the inclusion criteria through the purposive sampling technique. The study showed that the most common adverse effects of local injections were itching and pain, as much as 54%, followed by fatigue (tiredness) at 46%, muscle pain at 41%, and a small proportion of joint pain, nausea, and changes in body temperature. Patients who experience symptoms both locally at the injection site and other mild side effects are more likely to be female by up to 60%. General symptoms of negative effects in local injection with ages 18-40 years (54.4%) and 41-50 years (54.9%). The common symptom effects are in the form of fatigue, joint pain, muscle pain, and nausea, with a vulnerable age of 41-50 years (56.9%) predominating. Patients with general symptom effects in the form of fatigue, joint pain, muscle aches, and nausea, with an age range of 41-50 years (56.9%), predominated. Based on the results of the research, it was found that the most effective Sinovac (R) vaccine caused bad effects by local injection. This can be solved by giving an antipathy to reduce the symptoms of the bad effects of local injection that can occur.

4.
Chest ; 162(4):A674-A675, 2022.
Article in English | EMBASE | ID: covidwho-2060664

ABSTRACT

SESSION TITLE: Critical Care Management of COVID-19 SESSION TYPE: Original Investigations PRESENTED ON: 10/17/2022 01:30 pm - 02:30 pm PURPOSE: To compare the incidence of hospital acquired infections (HAI) in patients treated with systemic corticosteroids (dexamethasone or equivalent alternative corticosteroid) with high (> 10 mg/day) vs low (6 mg/day) dose for COVID-19 related acute hypoxemic failure METHODS: Observational cohort study of COVID-19 patients from July 25 and Oct 1, 2021 at a tertiary care hospital. 227 hospitalized patients were positive for COVID-19. 168 patients were included in the analysis. Corticosteroid type and dose was analyzed. Comparison of high vs low dose cohorts was done. Primary outcome measure was incidence of HAI in each group. Bloodstream Infections (BSI), Hospital Acquired Pneumonia (HAP) and Urinary Tract Infections (UTI) were included. Secondary measures were number of patients requiring intubation, length of ICU stay and inpatient mortality. Descriptive statistics were used to compare variables between cohorts including body mass index (BMI), severity of illness (SOFA and modified SOFA scores) and glucose control RESULTS: Of 168 patients: 68 (40%) received high dose (> 10 mg dexamethasone) & 100 patients (60%) received low dose (6 mg dexamethasone) corticosteroids. High vs Low dose: Demographics: Age (57 vs. 64 years;p 0.21), sex (51% vs. 57% female;p 0.77) & chronic comorbidities including BMI (29.2 vs 33.1;p 0.45). Severity of illness scores at day of corticosteroid use were similar (SOFA 4.7 vs 4.1;p 0.71 & mSOFA 2.6 vs 2.3;p 0.07) despite difference in rates of patients that required intubation (56% vs 18%;p<0.001). 45% of intubated died in high dose compared to 18% in low dose group. Overall mortality was 29.4% vs 11%;p 0.011. Glucose control (insulin > 50 u/day) was worse in high dose group (35% vs 14%;p<0.01). Baricitinib or tocilizumab used in 60% vs 44% of intubated;p0.62). HAI data: BSI- High dose 18/68 (26.5 %) vs low dose group 13/10 (13%);p 0.07. UTI-High dose 4/68 (6%) vs low dose group 5/100 (5%);p 1.00. HAP-High dose 27/68 (39.7%) vs low dose group 11/100 (11%);p <0.001. High dose group HAP > 1 organism: 15/27 (MSSA 44%, Aspergillus 18%, MRSA 18%, Streptococcus 26%, Pseudomonas 18%, rest were Enterobacter, H Influenzae, Acinetobacter, Serratia, E coli, Klebsiella, Providencia and Citrobacter species at 3% each). Low dose group HAP > 1 organism: 2/11 (Streptococcus 36%, MSSA 27%, H Influenzae 18%, rest were pseudomonas, E coli, stenotrophomonas and acinetobacter species) CONCLUSIONS: In hospitalized COVID-19 patients with acute respiratory failure, high dose dexamethasone use was associated with significantly higher HAP rates compared to low dose dexamethasone. Moreover the high dose group had higher BSI, worse glucose control, higher intubations and deaths in the intubated cohort despite similar severity of illness in either group CLINICAL IMPLICATIONS: High dose dexamethasone may increase susceptibility to HAIs and negatively impact outcomes in COVID-19 associated hypoxemic failure DISCLOSURES: No relevant relationships by Beenish Bhutta No relevant relationships by Rosalyn Chi No relevant relationships by Jason Graf No relevant relationships by mohsin iqbal No relevant relationships by Rajat Kapoor No relevant relationships by Rachel Kruer No relevant relationships by Connor Parker No relevant relationships by Omar Rahman No relevant relationships by James Skinner

5.
Journal of Clinical Oncology ; 40(16), 2022.
Article in English | EMBASE | ID: covidwho-2009641

ABSTRACT

Background: Prognosis of COVID-19 is poor in the setting of immunosuppression. Casirivimab/imdevimab (REGEN-COV), bamlanivimab, and sotrovimab are investigational monoclonal antibodies (MoAbs) authorized for treatment of mild/moderate COVID-19 for patients (pts) 12 years or older and who are at high-risk for progression to severe COVID-19. These neutralizing antibodies, against SARS-CoV-2 spike proteins, have been shown to decrease risk of progression to severe disease. Recipients of allogeneic stem cell transplants (allo-SCT) or chimeric antigen T cell therapy (CAR T cell) represent a high risk population. However, treatment outcomes with these MoAbs in these pts are not well described. Methods: This retrospective study included 33 consecutive adult pts who developed mild/moderate COVID-19 and received anti-spike SARS-CoV-2 MoAbs between December 2020 and November 2021. Allo-SCT (N=27) or CAR T cell (N=6) recipients were included, and outcomes were analyzed separately. Pts received REGEN-COV (N=19), bamlanivimab (N=11), or sotrovimab (N=1), missing (N=2). Results: In the allo-SCT cohort (N=27), median age at time of COVID-19 was 55 (23-76) years. Median time from allo-SCT to COVID-19 was 31 (22-64) months. Two pts received CAR T-cell therapy prior to allo-SCT. Diagnoses included leukemia or myeloid diseases (82%), lymphoma (11%), or myeloma (7%). Transplant characteristics are summarized (Table). Thirteen pts were vaccinated against SARS-CoV-2 prior to breakthrough COVID-19. Events considered included hospitalization due to COVID- 19, disease progression, or death from any cause. The 6-month event-free and overall survivals were 81% and 91%, respectively. In the CAR T cell recipients cohort (N=6), 4 pts received axicabtagene ciloleucel for diffuse large B-cell or follicular lymphoma and 2 received brexucabtagene autoleucel for mantle cell lymphoma. The median follow-up was 8 (1-11) months. Two pts received autologous SCT prior to COVID-19. Median time from CAR T cell therapy to COVID-19 was 10 (3-24) months. Three pts were vaccinated prior to COVID-19. Only 1 pt was hospitalized due to severe COVID- 19 requiring mechanical ventilation leading to death. Conclusions: These results show a potential benefit of MoAbs in high-risk pts, namely allo-SCT or CAR T cell recipients. Future studies should evaluate the role of prophylactic use MoAbs in these populations. A comparative analysis with a matched control cohort (who did not receive MoAbs) will be provided at the meeting.

6.
Kesmas-National Public Health Journal ; 17(1):22-29, 2022.
Article in English | Web of Science | ID: covidwho-2006644

ABSTRACT

The rapidly growing global Coronavirus Disease 2019 (COVID-19) pandemic crisis affects the labor-intensive mining industry. The industry is characterized by high worker mobility and 24-hour operations;thus, this continuous, mobile workforce increases the transmission risk of COVID-19 and has been a challenge for the mining industry during the pandemic. PT X, one of the largest mineral mining locations in Mimika District, Central Papua Province, Indonesia, was challenged to face the COVID-19 pandemic crisis. Therefore, this qualitative study aimed to analyze the COVID-19 handling efforts by PT X Concentrating Division using a descriptive-analytical method to describe the completion of PT X. The assessment aimed to examine nine critical factors formulated by the International Labour Organization and evaluated as practical steps to prevent and mitigate the virus spread in the division. Furthermore, an analysis was con-ducted on data related to COVID-19 handling. The results showed that the nine critical factors had an average value of 89.41%. These results indicated that the pandemic handling efforts in the division had been implemented well.

7.
Fractal and Fractional ; 6(8):456, 2022.
Article in English | MDPI | ID: covidwho-1997559

ABSTRACT

Fractional-order systems have proved to be accurate in describing the spread of the COVID-19 pandemic by virtue of their capability to include the memory effects into the system dynamics. This manuscript presents a novel fractional discrete-time COVID-19 model that includes the number of vaccinated individuals as an additional state variable in the system equations. The paper shows that the proposed compartment model, described by difference equations, has two fixed points, i.e., a disease-free fixed point and an epidemic fixed point. A new theorem is proven which highlights that the pandemic disappears when an inequality involving the percentage of the population in quarantine is satisfied. Finally, numerical simulations are carried out to show that the proposed incommensurate fractional-order model is effective in describing the spread of the COVID-19 pandemic.

8.
Pakistan Journal of Public Health ; 11(4):279-289, 2022.
Article in English | CAB Abstracts | ID: covidwho-1975795

ABSTRACT

This paper aims to assess the effectiveness of strategies adopted by national health systems across the globe in different 'geographical regions' in the Northern Hemisphere to combat COVID-19 pandemic. Data is included since the first case was reported in November 2019 till mid-April 2020. Sources of information are COVID-19 case repositories, official country websites, university research teams' perspectives, official briefings, and available published research articles to date. We triangulated all data to formulate a comprehensive illustration of COVID-19 situation in each country included. It has been found that the 2002-2004 SARS outbreak experienced in China, Taiwan, and South Korea saw better strategies adopted by leadership to combat COVID-19 pandemic containment as compared to Iran, Italy, and the United States of America. Saudi Arabia has so far been successful in the implementation of containment strategies as there is no large outbreak in major cities or confined areas as prisons. The situation has yet to unfold in India and Pakistan, which exhibit their own weaknesses in policy formulation or implementation in response to health crises. This review provides conclusive evidence that timely travel bans, early detection of COVID-19 spread through exhaustive and reliable testing, and the establishment of a central, fully authorized body to foresee health trends and implement appropriate containment measures are essential to contain the spread of the virus.

9.
Eur Rev Med Pharmacol Sci ; 26(13): 4926-4946, 2022 07.
Article in English | MEDLINE | ID: covidwho-1955409

ABSTRACT

OBJECTIVE: The COVID-19 outbreak was first reported in Wuhan City, China in early December 2019. It was declared a pandemic by WHO in March 2020. This study aimed at assessing the knowledge, awareness, and attitudes of the general population in Saudi Arabia towards COVID-19, as well as its adherence to preventive measures and its willingness to take the vaccine. PATIENTS AND METHODS: This descriptive cross-sectional study involved an online sample of 7,188 participants (from five regions of Saudi Arabia) who completed a self-administered online-based questionnaire. They were recruited from 23 November 2020 to 29 November 2020 based on the nonprobability convenience sampling method. The self-administered questionnaire comprised four main sections: gathering information about participants' demographics, knowledge and awareness of COVID-19, participants' practices (hygiene and other) against infection, and vaccine acceptability. RESULTS: More than half of the study participants were knowledgeable about COVID-19. The mean scores were 10.4 (SD=3.44, range: 0-18 - with high scores indicating better knowledge or awareness) for knowledge and 6.1 (SD=2.26, range: 0-11) for awareness, indicating a need for more educational campaigns to improve the level of knowledge and awareness among the Saudi Arabian population about COVID-19. The mean score for attitude was 5 (SD=1.67, range: 0-8 - from 0=very pessimistic to 8=very optimistic), indicating moderate optimism. As for practices, the mean score was 7.8 (SD=1.57, range: 0-10), indicating good practices to prevent or control infection. Concerning acceptability of the COVID-19 vaccine, 63.8% of the participants agreed to take the vaccine if it was proven to be 95% effective. CONCLUSIONS: The findings of this study can help us designing effective measures against COVID-19 infections. Our results highlight the best practices adopted by the Saudi Arabian population, as well as those areas requiring improvement, including knowledge, attitudes, and practices against this disease.


Subject(s)
COVID-19 , COVID-19/epidemiology , COVID-19/prevention & control , COVID-19 Vaccines , Cross-Sectional Studies , Health Knowledge, Attitudes, Practice , Humans , Pandemics/prevention & control , SARS-CoV-2 , Saudi Arabia/epidemiology , Surveys and Questionnaires
10.
Indian Journal of Transplantation ; 16(2):216-219, 2022.
Article in English | EMBASE | ID: covidwho-1939187

ABSTRACT

Introduction: Remdesivir has shown broad-spectrum antiviral activity. This drug is approved by the Food and Drug Administration for coronavirus disease 2019 (COVID-19) management. Other than a few case series and case reports, not much information is available on its use in kidney transplant recipients (KTRs). Materials and Methods: We describe our experience of seven KTRs with COVID-19. All the patients were hypoxemic. High-resolution computed tomography (CT) chest was done in all the patients. Injection remdesivir 200 mg on day 1 followed by 100 mg daily was given for a maximum of 5 days irrespective of estimated glomerular filtration rate (eGFR). Observations and Results: Mean age of patients was 46.28 ± 10.41 years and one patient was female. Mean CT severity score was 15. In our study, 2 patients who required mechanical ventilation expired. None of our patient had worsening of acute kidney injury (AKI) or new-onset AKI after institution of remdesivir. Discussion: Optimal management for this patient population remains unknown, therefore, treatment of COVID-19 in KTRs varies from center to center. The studies on remdesivir use in KTRs with COVID-19 are not extensive. Our series does indicate safety of remdesivir in KTRs. Conclusion: We observed that remdesivir can be used in KTRs with COVID-19 with hypoxemia irrespective of eGFR. We suggest that large-scale studies should be done to substantiate these findings.

11.
Rawal Medical Journal ; 47(2):434-437, 2022.
Article in English | EMBASE | ID: covidwho-1925376

ABSTRACT

Objective: To study the impact of covid-19 on medical education and anxiety level of medical students. Methodology: This prospective cross sectional study was done at Shifa College of mMedicine, Islamabad, Pakistan from 1st October 2020 to 15th November 2020. Medical students were randomly selected and a preformed questionnaire was circulated among them via Online Google forums. We used GAD-7 scale. Data were analyzed using SPSS version 23. Results: Out of 122 respondents, 69 (56.5%) were female. Mean age was 22.1 ± 1.7 years. Almost all students had online education during COVID-19, however, 64 (52.4%) of them faced communication problems during online education. Only 32 (26.2%) were satisfied with this method. In this study, 46 (37.7%) respondents had anxiety;38.0% had moderate to severe and 27.0% had mild anxiety. Most of the anxious respondents were significantly younger (21.6 vs. 22.5 years, p = 0.01). Females were significantly more anxious (69.6% vs. 30.4%) than males (p < 0.03). Conclusion: During Covid-19 pandemic, anxiety and stress levels have increased among medical student.

12.
J Mater Chem B ; 10(28): 5323-5343, 2022 07 20.
Article in English | MEDLINE | ID: covidwho-1921742

ABSTRACT

The world has been suffering from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, and millions of people have been infected through human-to-human transmission and lost their lives within months. Although multidisciplinary scientific approaches have been employed to fight against this deadly pandemic, various mutations and diverse environments keep producing constraints in treating SARS-CoV-2. Indeed, the efficacy of the developed vaccines has been limited, and inoculation with the vaccines does not guarantee complete protection even though multiple doses are required, which is a frustrating process. Historically, coinage metals (Cu, Ag, and Au) have been well-known for their effectiveness in antiviral action as well as good biocompatibility, binding receptor inhibition, reactive oxygen species, and phototherapy properties. Thus, this review highlights the diagnostic and therapeutic mechanisms of SARS-CoV-2 using the antivirus ability and mode of action of coinage metals such as viral entry mechanisms into host cells and the NP-inhibition process, which are explained in detail. This article also draws attention to coinage metal nanomaterial-based approaches to treat other contagious viruses. In addition, coinage metal-based biosensors and an overview of some other biocompatible metal-based nanomaterials to fight against SARS-CoV-2 variants are discussed. Finally, the advantages, perspectives and challenges of coinage metal nanoparticles are given to fight against viral infections in the future.


Subject(s)
COVID-19 , Nanostructures , Antiviral Agents/chemistry , Antiviral Agents/pharmacology , Antiviral Agents/therapeutic use , COVID-19/drug therapy , Humans , Nanostructures/therapeutic use , SARS-CoV-2
13.
Annals of Data Science ; 2022.
Article in English | Scopus | ID: covidwho-1920411

ABSTRACT

K-means algorithm is one of the well-known unsupervised machine learning algorithms. The algorithm typically finds out distinct non-overlapping clusters in which each point is assigned to a group. The minimum squared distance technique distributes each point to the nearest clusters or subgroups. One of the K-means algorithm’s main concerns is to find out the initial optimal centroids of clusters. It is the most challenging task to determine the optimum position of the initial clusters’ centroids at the very first iteration. This paper proposes an approach to find the optimal initial centroids efficiently to reduce the number of iterations and execution time. To analyze the effectiveness of our proposed method, we have utilized different real-world datasets to conduct experiments. We have first analyzed COVID-19 and patient datasets to show our proposed method’s efficiency. A synthetic dataset of 10M instances with 8 dimensions is also used to estimate the performance of the proposed algorithm. Experimental results show that our proposed method outperforms traditional kmeans++ and random centroids initialization methods regarding the computation time and the number of iterations. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

14.
Pakistan Journal of Medical and Health Sciences ; 16(6 Jun):56-58, 2022.
Article in English | EMBASE | ID: covidwho-1918388

ABSTRACT

Background: Fever, myalgia or fatigue, pneumonia, and complicated dyspnea are all signs of COVID-19. Chest physiotherapy can be utilized in these situations to minimize the time of stay on a mechanical ventilator and in the ICU, as well as to prevent ventilator-associated pneumonia. Aim: To determine the psychological distress and anxiety among physiotherapists in intensive care unit while performing chest physiotherapy in covid-19 patients. Methods: 176 physiotherapists were enrolled in this study, Data collected by purposive sampling technique through an online survey from physiotherapist in Lahore. The Scoring GAD-7 Anxiety Severity and Kessler Psychological Distress Scale(K10) were used. Data entered to SPSS for further statistical analysis. Results: Among 176 participants, 143(81.25%) were males and 33 (18.75%) were females.meanagewas35.11±3.752years. Psychological Distress, moderate disorder was among 26(14.6%), server disorder was among 150(85.2%). Anxiety was mild among 9(5.1%) moderate 43(24.4%) and severe 124(70.5%). P value was<0.05. Conclusion: Psychological distress and anxiety were present among physiotherapists in ICU while performing chest physiotherapy in covid-19 patients. Covid-19 affects their mental health. Most of the Physiotherapists were feeling severe anxiety and have a severe psychological Distress.

15.
Mathematics ; 10(13):2224, 2022.
Article in English | MDPI | ID: covidwho-1911460

ABSTRACT

During the broadcast of Coronavirus across the globe, many mathematicians made several mathematical models. This was, of course, in order to understand the forecast and behavior of this epidemic's spread precisely. Nevertheless, due to the lack of much information about it, the application of many models has become difficult in reality and sometimes impossible, unlike the simple SIR model. In this work, a simple, novel fractional-order discrete model is proposed in order to study the behavior of the COVID-19 epidemic. Such a model has shown its ability to adapt to the periodic change in the number of infections. The existence and uniqueness of the solution for the proposed model are examined with the help of the Picard Lindelöf method. Some theoretical results are established in view of the connection between the stability of the fixed points of this model and the basic reproduction number. Several numerical simulations are performed to verify the gained results.

16.
Journal of Physics: Conference Series ; 2243(1):012110, 2022.
Article in English | ProQuest Central | ID: covidwho-1901012

ABSTRACT

Coronavirus disease or COVID-19 is a virus from the Coronaviridae family that has caused pandemics throughout the world since the end of 2019. The virus spreads ten times faster through human interaction than SARS-CoV. The RNA sequence of COVID-19 has a 79.5% similarity with SARS-CoV. Fast and specific detection of COVID-19 is needed so that patient detection can be done quickly and accurately. One method that can be developed as a COVID-19 biosensor is aptamers-based biosensors. The aptamer is an artificial oligo nucleic acid that can specifically bind to target molecules. The aptamer is easily and chemically modifiable for increasing stability and reducing toxicity. It shows a comparable affinity for the target virus and better thermal stability than monoclonal antibodies. This advantage makes aptamer a promising candidate in diagnostic and detection applications. The goal of this research is to use an RNA aptamer as the specific recognition element in a portable surface plasmon resonance (SPR) biosensor for the detection of COVID-19 in humans. An aptamer RNA 1 COVID-19 was designed using the COVID-19 sequence from GISAID using the in silico method. End of 3’ aptamer RNA 1 was modified with dithiol. And Then, the aptamer was immobilized on the gold nanoparticle sensor surface via Cysteine-dithiol binding. The RNA solution, that had been extracted from swab samples, was diluted ten times before being used as a sample. The immobilized aptamer RNA 1 captured COVID-19 in RNA solution, causing an increase in refraction index (r.u). An aptamer RNA 1 was found to bind RNA virus of COVID-19 where the positive sample of COVID-19 has refraction index (r.u) between 3 r.u – 10 r.u for various Ct values.

17.
Oral Oncology ; 118:14, 2021.
Article in English | EMBASE | ID: covidwho-1735115

ABSTRACT

Introduction: Head and neck cancer (HNC) is a heterogeneous group of subsites, with differing natural histories. Its management is complex and it may have a long-term effect on patients’ quality of life (QOL). The purpose of this survey was to assess patients’ preferences using a validated 12 point ‘Priority Assessment Tool’ developed by Sharp et al [1]. Materials and Methods: Sixty consecutive HNC patients being treated with radiotherapy at our centre were approached. Patients were asked to rank their priorities from 1 to 12 (1 = very important, 12 = least important). Results: 45 patients (75%) completed the survey. The most important, overwhelming priority for the cohort as a whole, was ‘being cured of my cancer’ which was first priority in 73% patients and within first three priorities for 96% of patients. Similarly, ‘living as long as possible’ was within the first three priorities for 67% of patients although for 13% patients, living longer was, surprisingly the least priority. For more than two third of patients (69%), ‘having no pain’ was within the first four important priorities. There is next, a group of six QOL priorities (voice, speech, chewing, swallowing, taste/smell, moist mouth), which have a much wider range and vary considerably in importance to individual patients, being very important to some and much less important to others. There then remains a group of three priorities that have a relatively low importance to patients, not absolutely, but in relation to their other priorities, with ‘keeping appearance unchanged’, being the lowest priority chosen by 40% patients. The other two least priorities were ‘returning to activities as soon as possible’ and ‘having a normal amount of energy’. Conclusions: Our survey has shown that most HNC patients markedly prioritise survival over function and other QOL measures. Having such information is crucial, to being able to make a valid decision with regard to the treatment options and the trade-offs between increased probability of cure or extending survival and loss of function, and late morbidity. This makes shared decision-making even more important in the present COVID-19 era, so that added information about the risks of infection and potential changes in risk benefit ratio may alter patients’ priorities and preferred outcomes.

18.
Pakistan Armed Forces Medical Journal ; 71:S479-S483, 2021.
Article in English | Scopus | ID: covidwho-1732700

ABSTRACT

Objective: To assess audiometry investigations in patients having complaint of tinnitus, vertigo or hearing impairment after recovery from COVID-19 disease, having no external or middle ear diseases. Study Design: Cross-sectional study. Place and Duration of Study: United Medical and Dental College, Creek General hospital, Korangi, Karachi Pakistan, from March to May 2021. Methodology: A total of 60 patients were included in this study who had recovered from the primary COVID-19 infection and reported with the complaints of tinnitus, vertigo and hearing loss. Pure tone audiogram was assessed for sensori-neural deafness, its severity and frequencies affected. Pearson Chi square test was used to see the relation of symptoms with severity of hearing loss. Results: There were 42 (70%) males and 18 (30%) female patients with age range from 18-50 years with mean age of 28.4 ± 8.1 years. Tinnitus was the most common complaint (83.3%) followed by hearing loss (28.3%) and vertigo (23.3%) patients. None of the patients with complaint of hearing loss had normal pure tone audiogram in either right or left ear (p=0.000). Patients with all the three complaints had more hearing impairment where majority had moderate or severe hearing loss (p=0.000). All patients with isolated complaint of vertigo (9 patients) had normal audiogram in both ears (p=0.000). Conclusion: Auditory and vestibular system involvement in reasonably common in COVID-19 patients. Tinnitus is the most frequent symptom and it should be investigated with full audiological investigations. © 2021, Army Medical College. All rights reserved.

20.
7th Geoinformation Science Symposium 2021 ; 12082, 2021.
Article in English | Scopus | ID: covidwho-1705490

ABSTRACT

The term of Mudik (in Bahasa) is often interpreted as the return of migrants from foreign areas to their hometowns, or largely known as massive mobility among regions that especially carried out annually during the Eid al-Fitr holiday in Indonesia. However, due to the COVID-19 pandemic occurred in 2020 and 2021, restrictions were placed on mudik during the Eid holiday. This study was conducted to see the extent of the effectiveness of the mudik restrictions carried out by the Indonesian government. This study was conducted by reviewing the levels of NO2 and CO in the months before and during the Eid al-Fitr holiday through spatiotemporal processing of images retrieved from Google Earth Engine. The data used is Sentinel-5p images to map air pollution levels from NO2 values and CO values in January-June 2019-2021. The study area includes two districts in DKI Jakarta Province and two districts in Central Java Province. The statistical tests are useful to see the trend of data that is obtained from the zonal analysis process. The statistical tests were carried out using the Mann-Kendall Test method to detect trends and the results were equipped with Sen's Slope analysis to measure the magnitude of the changes that occurred. According to the trend of NO2 and CO values obtained, the values in 2019 are higher than in 2021, and the values in 2021 are higher than in 2020. Thus, the policy of mudik restrictions in 2020 is assumed more effectively than in 2021. The trend in the levels of NO2 and CO in the air is more significant a month before the Eid al-Fitr holiday than in the Eid al-Fitr holiday. It can illustrate that the production of NO2 and CO from motor vehicles continues to increase before there are restrictions. © 2021 SPIE.

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