ABSTRACT
Background: COVID-19 is still changing problem for pediatric rheumatologist, not only related with multisystem inflammatory syndrome. SARS-CoV- 2 can damage blood vessel endothelium through direct invasion, immune system dysregulation (hyperproduction of pro-inflammatory cytokines, interferonopathy) and hypercoagulation, and in this way triggers vasculitis. There are some data in the literature about skin vasculitis, central nervous system vasculopathy, associated with COVID-19 in children, but data are scarce. The aim of our study was to describe the cases, associated with COVID-19 in children. Method(s): in the retrospective-prospective case series study we included information about five children with COVID-19 associated vasculitis. In every case we have morphological description and the etiology was confirmed by RT-PCR in tissue biopsy. Result(s): The patients' demography, type of SARS-CoV- 2 identification, disease characteristics are in the tables 1-2. All patients required systemic corticosteroids and immunosuppression to control inflammation and recovering tissue damage.
ABSTRACT
Multisystem inflammatory syndrome in children and adolescents associated with SARS-CoV-2 (MBS-D) is a new challenge for pediatricians around the world. Scientific data is updated daily and patient treatment regimens are developed. The involvement of the heart in the inflammatory process complicates the course of the disease and further rehabilitation of patients. The article describes 12 patients with heart disease in the structure of MVS-D, who underwent laboratory tests and instrumental studies, including MRI of the heart, and also provides detailed descriptions of three clinical cases and a review of literature data. © 2021, Pediatria Ltd.. All rights reserved.