Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 3 de 3
Embase; 2022.
Preprint in English | EMBASE | ID: ppcovidwho-333275


The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron subvariant BA.2 has spread in many countries, replacing the earlier Omicron subvariant BA.1 and other variants. Here, using a cell culture infection assay, we quantified the intrinsic sensitivity of BA.2 and BA.1 compared with other variants of concern, Alpha, Gamma, and Delta, to five approved-neutralizing antibodies and antiviral drugs. Our assay revealed the diverse sensitivities of these variants to antibodies, including the loss of response of both BA.1 and BA.2 to casirivimab and of BA.1 to imdevimab. In contrast, EIDD-1931 and nirmatrelvir showed a more conserved activities to these variants. The viral response profile combined with mathematical analysis estimated differences in antiviral effects among variants in the clinical concentrations. These analyses provide essential evidence that gives insight into variant emergence’s impact on choosing optimal drug treatment.

2021 IEEE International Conference on Industrial Engineering and Engineering Management, IEEM 2021 ; : 1082-1086, 2021.
Article in English | Scopus | ID: covidwho-1730994


IT (Information technology) has been rapidly growing. Until early 2000s, IT mainly exists for IT industry. However, IT expands their fields into the outer fields of IT industry such as medical and agricultural industries. It means that the cutting-edge technologies have increased to a level that humanity cannot grasp all. It is difficult for even industrial leaders and followers to grasp all. Thus, in order to grasp and create the cutting-edge technologies, this research provide the latest states from keynotes of some events. These text data for this analysis could be gained because a lot of events have shifted from in-person to online by the impact of COVID-19 (the coronavirus disease 2019). Consequently, this analysis measured the closeness between industries that have available data and found that the changes of topics become more frequent after COVID-19. This analysis is to evaluate the potential in order to compare with confidential data and to discover the gap between international trends and in-company competences in the future. © 2021 IEEE.

Jaids-Journal of Acquired Immune Deficiency Syndromes ; 87(2):E182-E187, 2021.
Article in English | Web of Science | ID: covidwho-1688416


Background: During the COVID-19 outbreak, facility capacity for HIV testing has been limited. Furthermore, people may have opted against HIV testing during this period to avoid COVID-19 exposure. We investigated the influence of the COVID-19 pandemic on HIV testing and the number of reported HIV cases in Japan. Methods: We analyzed quarterly HIV/AIDS-related data from 2015 to the second quarter of 2020 using an anomaly detection approach. The data included the number of consultations, the number of HIV tests performed by public health centers or municipalities, and the number of newly reported HIV cases with and without an AIDS diagnosis. We further performed the same analysis for 2 subgroups: men who have sex with men (MSM) and non-Japanese persons. Results: The number of HIV tests (9,584 vs. 35,908 in the yearbefore period) and consultations (11,689 vs. 32,565) performed by public health centers significantly declined in the second quarter of 2020, whereas the proportion of new HIV cases with an AIDS diagnosis (36.2% vs. 26.4%) significantly increased after removing the trend and seasonality effects. HIV cases without an AIDS diagnosis decreased (166 vs. 217), but the reduction was not significant. We confirmed similar trends for the men who have sex with men and non-Japanese subgroups. Conclusions: During the COVID-19 pandemic, the current HIV testing system in Japan seems to have missed more cases of HIV before developing AIDS. Continuously monitoring the situation and securing sufficient test resources by use of self-testing is essential to understand the clear epidemiological picture of HIV incidence during the COVID-19 pandemic.