Predicting the Pre-release Success of a Web Series' Season

With the onset of COVID-19, OTT platforms have become popular. With this added popularity, many production companies tend to release their content on platforms like Netflix, Amazon Prime, Disney + Hotstar, etc. Through this research work, we tend to check the impact of different classical factors like genre, age certification, time of release, the platform of release, etc. as well as various social factors like the sentiment of the audience around the trailer, songs, and success of the previous season in predicting the success of the pre-release season of an English web series by creating our dataset. This will enhance the business strategies that production houses can use to improve their profits. We have trained different classification models like Decision Tree, Support Vector Machine, Multinomial Naive Bayes, and hyper tuned the parameters of Random Forest and K-Nearest Neighbours. We have also created a Multi-Layer Perceptron model and an ensemble classifier and trained them on our dataset. The best accuracy of 76.66% was achieved by the Hard Voting type ensemble classifier. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.

A retrospective review to assess the clinical outcome of rhino-orbito-cerebral mucormycosis patients with COVID-19 infection and its association with glycaemic control

Introduction: The coronavirus disease 2019 (COVID-19) pandemic in India, having caused 29 500 000 confirmed cases and 374 000 deaths as of June 14, 2021, continues to have devastating consequences, including a large epidemic of COVID-19-associated mucormycosis (COVID-Mucor), manifesting as rhino-orbito-cerebral mucormycosis (ROCM), which has worsened the morbidity among vulnerable populations (JHU, 2021) 1. Reports have shown a much larger surge in the incidence of COVID-Mucor during the second wave in 2021 than during the first wave (Patel et al., 2021, Moorthy et al., 2021) 2, 3. This rapid rise in COVID-Mucor is probably caused by several factors. For patients with diabetes mellitus, lockdowns, travel restrictions, and restricted access to medical care have worsened glycaemic control, the central risk factor for ROCM in India (Chakrabarti et al., 2006) 4. Addressing these could reduce morbidity and mortality among vulnerable populations. Material(s) and Method(s): A Retrospective chart review was conducted in Department of General medicine Dr S N Medical College Jodhpur among population included all rhinoorbito-cerebral mucormycosis patients with Covid-19 infection who were admitted in Mucormycosis ward, Dr S N Medical College Jodhpur from Oct. 2020 to Sept 2021. Bed head tickets of all these patients were reviewed. The final outcome was noted from the bed head ticket, the outcome was correlated with random blood sugar and HbA1c level at admission. Conclusion(s): Mucormycosis is angioinvasive fungal disease with significant morbidity and mortality. The disease has risen dramatically due to interplay of COVID 19 pandemic, uncontrolled diabetes and inappropriate corticosteroid use leading to pathogenic invasion and adverse outcomes. The treatment involves early detection, surgical debridement and antifungal drugs for better survival. Our study revealed an evident role of hyperglycemia as major risk factor for mucormycosis infection. Those patients who had HbA1c> 10 could not survive inspite of best treatment and those patients who survived their hospital stay was directly proportional to their HbA1c level. All those patients who had cerebral involvement could not be saved. Hence, we suggest that closely tracking the levels of blood sugar in COVID-19 patients is a valuable tool to stratify the risk that a patient will have mucormycosis. Copyright © 2022 Ubiquity Press. All rights reserved.

Sudden loss of smell and taste: clinical predictors of coronavirus disease 2019 infection.

OBJECTIVES: This study aimed: to evaluate the association between coronavirus disease 2019 infection and olfactory and taste dysfunction in patients presenting to the out-patient department with influenza-like illness, who underwent reverse transcription polymerase chain reaction testing for coronavirus; and to determine the sensitivity, specificity, and positive and negative predictive values of olfactory and taste dysfunction and other symptoms in these patients. METHODS: Patients presenting with influenza-like illness to the study centre in September 2020 were included in the study. The symptoms of patients who tested positive for coronavirus on reverse transcription polymerase chain reaction testing were compared to those with negative test results. RESULTS: During the study period, 909 patients, aged 12-70 years, presented with influenza-like illness; of these, 316 (34.8 per cent) tested positive for coronavirus. Only the symptoms of olfactory and taste dysfunction were statistically more significant in patients testing positive for coronavirus than those testing negative. CONCLUSION: During the pandemic, patients presenting to the out-patient department with sudden loss of sense of smell or taste may be considered as positive for coronavirus disease 2019, until proven otherwise.

The role of ace2 receptor and its age related immunity in covid-19

World is facing the Coronavirus pandemic, which is resulting in large number of deaths and economic burden to the society. SARS-CoV-2 is the causative agent for COVID-19 infection. SARS-CoV-2 is a single stranded RNA molecule which enters the human through ACE2 receptor. ACE2 is widely expressed in the human tissues, primarily in the heart, kidney and testis and secondarily in the lungs, blood vessels and colon. Therefore, SARS-CoV-2 can infect the lungs and other organs as well leading to multiple organ damage. ACE2 receptor regulates the Renin Angiotensin System (RAS). Therefore, increasing SARS-CoV-2 infection decreases ACE2 receptor and results in dysfunction of RAS, imbalance of blood pressure and inflammation of airways. This provide direct link between the ACE2 receptor and COVID-19 infection. ACE2 expression and immune response may fluctuate throughout the life of human which accounts for variation of disease severity. ACE2 level decreases with age i.e. children have higher expression of ACE2 as compared to the older people and children also possess strong innate immunity leading to early control of the infection comparing to older people. Hence, children are found to be less susceptible to COVID19 infection then the older ones. The difference in ACE2 expression and host immune response to SARS-CoV-2 infection can explain the severity of disease progression in different age, gender and race.