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Virology ; 562: 63-73, 2021 10.
Article in English | MEDLINE | ID: covidwho-1275757


We aimed to describe SARS-CoV-2 strains in Iranians from nine distributed cities infected during two months expanding late 2020 and early 2021 by genotyping known informative single nucleotide in five PCR amplicons. Two variants associated with haplotype H1 (clade G) and nine additional variants associated with other haplotypes were genotyped, respectively, in RNA isolates of 244 and 85 individuals. The variants associated with the H1a (GR) and H1b (GH) haplotypes were most prevalent, indicating a significant change in infection pattern with passage of time. The most important findings were that recombinant genomes and co-infection, respectively, were surmised in 44.7% and 12.9% of the samples extensively genotyped. Partners of many of the recombinations were relatively common strains. Co-existing viruses were among those currently circulating in Iran. In addition to random mutations, co-infection with different existing strains and recombination between their genomes may significantly contribute to the emergence of new SARS-CoV-2 strains.

COVID-19/virology , Genetic Variation , Genome, Viral , Recombination, Genetic , SARS-CoV-2/genetics , Coinfection/genetics , Evolution, Molecular , Genotyping Techniques , Haplotypes , Humans , Mutation , Phylogeny , RNA, Viral/genetics , SARS-CoV-2/isolation & purification
J Neurovirol ; 27(2): 348-353, 2021 04.
Article in English | MEDLINE | ID: covidwho-1111382


This study was designed to evaluate whether severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) can directly target the central nervous system (CNS). We present four patients suffering from the loss of consciousness and seizure during the clinical course of COVID-19 infection. In addition to positive nasopharyngeal swab tests, SARS-CoV-2 has been detected in their cerebrospinal fluid. This report indicates the neuroinvasive potential of SARS-CoV-2, suggesting the ability of this virus to spread from the respiratory tract to the CNS.

COVID-19/complications , Cerebrospinal Fluid/virology , SARS-CoV-2/isolation & purification , Seizures/virology , Severe Acute Respiratory Syndrome/virology , Aged , Female , Humans , Male , Middle Aged , Young Adult