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Journal of Drug Delivery and Therapeutics ; 12(4-s):101-111, 2022.
Article in English | CAB Abstracts | ID: covidwho-2056786


In-silico Computer-Aided Drug Design (CADD) often comprehends virtual screening (VS) of datasets of natural pharmaco-active compounds for drug discovery protocols. Plant Based Natural Products (PBNPs) still, remains to be a prime source of pharmaco-active compounds due to their unique chemical structural scaffolds and functionalities with distinct chemical characteristic feature from natural source that are much acquiescent to drug metabolism and kinetics. In the Post-COVID-Era number of publications pertaining to PBNPs and publicly accessible plant based natural product databases (PBNPDBs) has significantly increased. Moreover, PBNPs are important sources of inspiration or starting points to develop novel therapeutic agents. However, a well-structured, indepth ADME/Tox profile of PBNPs has been limited or lacking for many of such compounds, this hampers the successful exploitation of PBNPs by pharma industries. Absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties play key roles in the discovery/ development of drugs, pesticides, food additives, consumer products, and industrial chemicals. In the present study, ADMET-informatics of Tetradecanoic Acid (Myristic Acid) from ethyl acetate fraction of Moringa oleifera leaves to predict drug metabolism and pharmacokinetics (DMPK) outcomes has been taken up. This work contributes to the deeper understanding of Myristic acid as major source of drug from commonly available medicinal plant - Moringa oleifera with immense therapeutic potential. The data generated herein could be useful for NP based lead generation programs.

Journal of Drug Delivery and Therapeutics ; 12(3):138-157, 2022.
Article in English | CAB Abstracts | ID: covidwho-1975615


Revitalization of local health traditions (RLHT) has become an inevitable aspect of human wellbeing in the post COVID era. An ethnobotanical survey was carried out to collect information on local health traditions and cultural reflections associate with the age old use of wild edible fruits (WEFs) from common plants in Melur Region of Madurai district, TamilNadu, India as the habit of consuming WEFs is quite common among people in this region and has not been completely abandoned in particular among the age old people. Information presented in this paper has been gathered from local people using an integrated approach of botanical collections, group discussions and interviews with questionnaires during the period from Apr 2021 to Mar 2022. As much as 29 informants were interviewed, among the informants 6 were local health-care practitioners (Vidiyars). Studies on the use of WEFs from common plants in Melur resulted in collection and documentation of information on a total of 34 ethnomedicinal plant species distributed across 20 families. Medicinal plants used by local people are listed with scientific name, family, local name, plant part(s) used, mode of consumption and preparation and medicinal uses. Data collected during the study clearly indicates that fresh parts of the plant (Fruit (Ripe/ Unripe)) were more preferred in general for the preparation of medicinal formulations by the local health practitioners. Documented ethnomedicinal plants were mostly used to cure long term complications associated with diabetics, gastrointestinal disorders, skin diseases, poison bites and nervous disorders. Howsoever, results of this study is clear record to the claim that the local people still depend on medicinal plants to overcome situations like COVID pandemic as fruits from most of the plants documented serve as natural source of immune boosters. Further, in-depth studies (both In-silico and Pre Clinical trials) are expected to bring to limelight the hidden quantum of bioactive compounds in the fruits these medicinal plants and their therapeutic potential.

Journal of Drug Delivery and Therapeutics ; 12(2):87-99, 2022.
Article in English | CAB Abstracts | ID: covidwho-1841785


Plant Based Natural Products (PBNPs) have been subject of interest since ancient time due to their use in food, industrial and biomedical applications. Research attention has further augmented to explore their phytochemical composition, properties, and potential application in the post-COVID era. In the present study phytochemical screening has been carried out with Methanolic Leaf Extracts of Moringa oleifera (MLEMO) followed by Gas Chromatography-Mass Spectrometry (GCMS) analysis. Phytochemical analysis of MLEMO revealed the presence of Alkaloids, Carbohydrates, Coumarins, Flavonoids, Glycosides, Phenol, Proteins, Quinones, Saponins, Steroids, Tannins and Terpenoids. Further, GCMS analysis revealed the presence of 41 compounds of which Dihydroxyacetone;Monomethyl malonate;4H-Pyran-4-one,2,3-dihydro- 3,5-dihydroxy-6-methyl;1,3-Propanediol, 2-ethyl-2-(hydroxymethyl);Propanoic acid, 2- methyl-, octyl ester;3-Deoxy-d-mannoic lactone;Sorbitol;Inositol;Cyclohexanemethanol, alpha-methyl-4-(1-methylethyl), Hexadecanoic acid, Methyl palmitate;n-Hexadecanoic acid (Palmitic acid);9-Octadecenoic acid, methyl ester;Phytol;9,12,15-Octadecatrienoic acid;Octadecanoic acid;9-Octadecenamide were prominent. Most of the compounds in the list are bioactive and possess medicinal properties that are expected to serve as a baseline lead for the development of therapeutic agents.

Journal of Drug Delivery and Therapeutics ; 11(4-s):119-126, 2021.
Article in English | CAB Abstracts | ID: covidwho-1744443


Neem (Azadirachta indica) a member of Meliaceae plays an immense role in human health and disease which is attributed to its composition of Bioactive Secondary Metabolites (BASM). It has been widely used in Indian Traditional Systems of Medicine that includes Ayurveda, Siddha, Unani, Homeopathy and other Folklore Systems of Medicine practiced in the Indian Subcontinent for the treatment and prevention of various diseases. Current global health perspectives and medical practice in the post COVID era has no other way but to seek to merge alternative systems of medicine with evidence-based therapeutic aspects for a better understanding of the metabolic process and its effects in the human body. The studies based on animal model established that neem and its chief constituents play pivotal role in anticancer management through the modulation of various molecular pathways including p53, pTEN, NF-B, PI3K/Akt, Bcl-2, and VEGF. Besides, NEEM plays a vital role in the management of diabetics and its associated long term complication through ROS scavenging and ameliorative potentials to restore oxidative injury/inhibit enzymes linked to. Overall NEEM is considered as GRAS medicinal plant that modulates metabolic inflammations without side effects. Though it has been confirmed that neem and its constituents play role in the scavenging of free radical and prevention of disease pathogenesis, a clear scientific basis of its pharmacoinformatics is still lacking. Gas Chromatography-Mass Spectroscopy (GC-MS) analysis of the fractions revealed the presence of 62 metabolites.

Journal of Drug Delivery and Therapeutics ; 11(5-s):77-84, 2021.
Article in English | CAB Abstracts | ID: covidwho-1603047


Quercetin (3,3',4',5,7-Pentahydroxyflavone) is the one among the bioactive secondary metabolite (BASM) in neem seed of Azadirachta indica A. Juss. Quercetin (Que) and its derivatives hold promising pharmacological effects. Antidiabetic, anti-inflammatory, antioxidant, antimicrobial, anti-Alzheimer's, antiarthritic, cardiovascular, and wound-healing effects of Que have been extensively investigated, recently lot of work has been carried out on its anticancer activity against different cancer cell lines. Recently, in silico/in vitro studies have demonstrated that Que interferes with different stages of coronavirus entry and replication cycle (PLpro, 3CLpro, and NTPase/helicase). Due to its pleiotropic effects in human health and disease and lack of systemic toxicity, Que and its derivatives could be tested for their efficacy on human target system in future clinical trials. In the present study, an attempt has been made to evaluate the physicochemical, druggable properties of Que from A. indica to prospect its ADMET properties.