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1.
Indian Journal of Biochemistry & Biophysics ; 59(7):777-785, 2022.
Article in English | Web of Science | ID: covidwho-2068249

ABSTRACT

Coronavirus disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that has resulted in global pandemic and crisis in health care system. Several studies have focused only on hospitalized patients with 30 to 90 days after one cycle of illness but post-acute sequelae of COVID-19 existing even after a year remains unclear. Moreover, long-term sequelae in outpatients have not been documented and henceforth myriad clinical sequelae in long haulers continue to evolve. In this study, we report three cases represents a single family presenting several post-acute sequelae one after the other extending beyond one year of recovery. To our knowledge such a case series has not been reported in earlier studies. Herein, we present the sequelae in various organs namely neuropsychiatric (tinnitus, anxiety, depression, insomnia, and posttraumatic stress disorder, cognitive decline), cardiovascular (tachycardia, bradycardia), gastrointestinal (appendicitis) and Dermatologic (erythematous rash and acne) besides ophthalmic manifestations (conjunctivitis and dry eyes) in Long-COVID-19 and recommend management strategies.

2.
Indian Journal of Biochemistry and Biophysics ; 59(7):777-785, 2022.
Article in English | Scopus | ID: covidwho-1989897

ABSTRACT

Coronavirus disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that has resulted in global pandemic and crisis in health care system. Several studies have focused only on hospitalized patients with 30 to 90 days after one cycle of illness but post-acute sequelae of COVID-19 existing even after a year remains unclear. Moreover, long-term sequelae in outpatients have not been documented and henceforth myriad clinical sequelae in long haulers continue to evolve. In this study, we report three cases represents a single family presenting several post-acute sequelae one after the other extending beyond one year of recovery. To our knowledge such a case series has not been reported in earlier studies. Herein, we present the sequelae in various organs namely neuropsychiatric (tinnitus, anxiety, depression, insomnia, and posttraumatic stress disorder, cognitive decline), cardiovascular (tachycardia, bradycardia), gastrointestinal (appendicitis) and Dermatologic (erythematous rash and acne) besides ophthalmic manifestations (conjunctivitis and dry eyes) in Long-COVID-19 and recommend management strategies. © 2022, National Institute of Science Communication and Information Resources. All rights reserved.

3.
Advances in Protein Molecular and Structural Biology Methods ; : 405-437, 2022.
Article in English | Scopus | ID: covidwho-1859219

ABSTRACT

Structure-based drug discovery (SBDD) utilizes the three-dimensional (3D) structure of a target protein to identify the lead compounds. This medium is then considered a viable solution based on its availability and correlation with a particular disease. In the case of pandemics like COVID 19, shortening drug development time can save millions of people worldwide;for such a task, classical drug discovery methods will take a long time. Hence, researchers worldwide actively incorporated machine learning (ML) into the drug discovery process, particularly in SBDD, to minimize the lead optimization time. ML uses statistical methods to make a computer perform tasks, take a critical decision, and automate this entire process without being explicitly programmed. With this, the computer can discover new insights about data and unknown patterns crucial to decide the therapeutic use of lead compounds as drugs. The use of ML in the drug discovery field is not new, and it spans an ample research space. By integrating artificial intelligence with ML techniques, viable targets can be found using data clustering, regression, and classification from vast omics databases and sources. In this chapter, we will discuss the methods and applications of ML in SBDD. © 2022 Elsevier Inc. All rights reserved.

4.
Indian Journal of Biochemistry & Biophysics ; 57(4):370-381, 2020.
Article | WHO COVID | ID: covidwho-724199

ABSTRACT

Prior to COVID-19 lockdown in our country, the air around us was highly polluted due to emission of greenhouse gases for over centuries. Melting of glaciers and rising of the sea levels were evidenced as the alarming signs of Global warming. Environmental degradation was observed rapidly due to depletion and exploitation of natural resources like soil, water and air. But there are few changes observed in the environment after the country's lockdown due to coronavirus pandemic. The effects of lockdown are also entwined with human and political effects such as uncontrollable public mobility, poor access to health care due to lack of sufficient medical facilities, unemployment, migrants' crisis, starvation and prevailing poverty. However, apart from sufferings of entire country especially the people by social, economic and psychologic effects in day-to-day life, this lockdown has given to the nature the most optimistic scenarios in environment especially with enhanced air quality, cleaner water and undisturbed pristine forest. The present review brings out the actual picture of the eco-processes that reduced man-made pollution in air and water as well as disposal of domestic or biological waste along with societal implications after imposing lockdown in the state of Tamil Nadu.

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