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1.
Revista Espanola de Salud Publica ; 95(e202105071), 2021.
Article in Spanish | GIM | ID: covidwho-1871379

ABSTRACT

Background: Nursing homes have suffered in a particularly pronounced way from the effects of COVID-19 so it is very convenient to know the evolution in them of the disease and the impact of SARS-CoV2 vaccination The objective of this study was to analyze COVID-19 pandemic evolution from the start of the second wave to the end of the vaccination campaign at the nursing homes. A coordination program between Primary Care and Geriatrics and Public Health services was activated.

2.
Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine ; 32(2):255-264, 2021.
Article in English | Scopus | ID: covidwho-1870986

ABSTRACT

Introduction Blood test alterations are crucial in SARS CoV-2 (COVID-19) patients. Blood parameters, such as lymphocytes, C reactive protein (CRP), creatinine, lactate dehydrogenase, or D-dimer, are associated with severity and prognosis of SARS CoV-2 patients. This study aims to identify blood-related predictors of severe hospitalization in patients diagnosed with SARS CoV-2. Methods Observational retrospective study of all rt-PCR and blood-test positive (at 48 hours of hospitalization) SARS CoV-2 diagnosed inpatients between March-May 2020. Deceased and/or ICU inpatients were considered as severe cases, whereas those patients after hospital discharge were considered as non-severe. Multivariate logistic regression was used to identify predictors of severity, based on bivariate contrast between severe and mild inpatients. Results The overall sample comprised 540 patients, with 374 mild cases (69.26%), and 166 severe cases (30.75%). The multivariate logistic regression model for predicting SARS CoV-2 severity included lymphocytes, C reactive protein (CRP), creatinine, total protein levels, glucose and aspartate aminotransferase as predictors, showing an area under the curve (AUC) of 0.895 at a threshold of 0.29, with 81.5% of sensitivity and 81% of specificity. Discussion Our results suggest that our predictive model allows identifying and stratifying SARS CoV-2 patients in risk of developing severe medical complications based on blood-test parameters easily measured at hospital admission, improving health-care resources management and distribution. © 2021 International Federation of Clinical Chemistry and Laboratory Medicine. All rights reserved.

3.
PubMed; 2021.
Preprint in English | PubMed | ID: ppcovidwho-333728

ABSTRACT

BACKGROUND: There is considerable variability in COVID-19 outcomes amongst younger adults-and some of this variation may be due to genetic predisposition. We characterized the clinical implications of the major genetic risk factor for COVID-19 severity, and its age-dependent effect, using individual-level data in a large international multi-centre consortium. METHOD: The major common COVID-19 genetic risk factor is a chromosome 3 locus, tagged by the marker rs10490770. We combined individual level data for 13,424 COVID-19 positive patients (N=6,689 hospitalized) from 17 cohorts in nine countries to assess the association of this genetic marker with mortality, COVID-19-related complications and laboratory values. We next examined if the magnitude of these associations varied by age and were independent from known clinical COVID-19 risk factors. FINDINGS: We found that rs10490770 risk allele carriers experienced an increased risk of all-cause mortality (hazard ratio [HR] 1.4, 95% confidence interval [CI] 1.2-1.6) and COVID-19 related mortality (HR 1.5, 95%CI 1.3-1.8). Risk allele carriers had increased odds of several COVID-19 complications: severe respiratory failure (odds ratio [OR] 2.0, 95%CI 1.6-2.6), venous thromboembolism (OR 1.7, 95%CI 1.2-2.4), and hepatic injury (OR 1.6, 95%CI 1.2-2.0). Risk allele carriers <= 60 years had higher odds of death or severe respiratory failure (OR 2.6, 95%CI 1.8-3.9) compared to those > 60 years OR 1.5 (95%CI 1.3-1.9, interaction p-value=0.04). Amongst individuals <= 60 years who died or experienced severe respiratory COVID-19 outcome, we found that 31.8% (95%CI 27.6-36.2) were risk variant carriers, compared to 13.9% (95%CI 12.6-15.2%) of those not experiencing these outcomes. Prediction of death or severe respiratory failure among those <= 60 years improved when including the risk allele (AUC 0.82 vs 0.84, p=0.016) and the prediction ability of rs10490770 risk allele was similar to, or better than, most established clinical risk factors. INTERPRETATION: The major common COVID-19 risk locus on chromosome 3 is associated with increased risks of morbidity and mortality-and these are more pronounced amongst individuals <= 60 years. The effect on COVID-19 severity was similar to, or larger than most established risk factors, suggesting potential implications for clinical risk management. FUNDING: Funding was obtained by each of the participating cohorts individually.

4.
Degenhardt, F.; Ellinghaus, D.; Juzenas, S.; Lerga-Jaso, J.; Wendorff, M.; Maya-Miles, D.; Uellendahl-Werth, F.; ElAbd, H.; Rühlemann, M. C.; Arora, J.; Özer, O.; Lenning, O. B.; Myhre, R.; Vadla, M. S.; Wacker, E. M.; Wienbrandt, L.; Ortiz, A. B.; de Salazar, A.; Chercoles, A. G.; Palom, A.; Ruiz, A.; Garcia-Fernandez, A. E.; Blanco-Grau, A.; Mantovani, A.; Zanella, A.; Holten, A. R.; Mayer, A.; Bandera, A.; Cherubini, A.; Protti, A.; Aghemo, A.; Gerussi, A.; Ramirez, A.; Braun, A.; Nebel, A.; Barreira, A.; Lleo, A.; Teles, A.; Kildal, A. B.; Biondi, A.; Caballero-Garralda, A.; Ganna, A.; Gori, A.; Glück, A.; Lind, A.; Tanck, A.; Hinney, A.; Nolla, A. C.; Fracanzani, A. L.; Peschuck, A.; Cavallero, A.; Dyrhol-Riise, A. M.; Ruello, A.; Julià, A.; Muscatello, A.; Pesenti, A.; Voza, A.; Rando-Segura, A.; Solier, A.; Schmidt, A.; Cortes, B.; Mateos, B.; Nafria-Jimenez, B.; Schaefer, B.; Jensen, B.; Bellinghausen, C.; Maj, C.; Ferrando, C.; de la Horra, C.; Quereda, C.; Skurk, C.; Thibeault, C.; Scollo, C.; Herr, C.; Spinner, C. D.; Gassner, C.; Lange, C.; Hu, C.; Paccapelo, C.; Lehmann, C.; Angelini, C.; Cappadona, C.; Azuure, C.; Bianco, C.; Cea, C.; Sancho, C.; Hoff, D. A. L.; Galimberti, D.; Prati, D.; Haschka, D.; Jiménez, D.; Pestaña, D.; Toapanta, D.; Muñiz-Diaz, E.; Azzolini, E.; Sandoval, E.; Binatti, E.; Scarpini, E.; Helbig, E. T.; Casalone, E.; Urrechaga, E.; Paraboschi, E. M.; Pontali, E.; Reverter, E.; Calderón, E. J.; Navas, E.; Solligård, E.; Contro, E.; Arana-Arri, E.; Aziz, F.; Garcia, F.; Sánchez, F. G.; Ceriotti, F.; Martinelli-Boneschi, F.; Peyvandi, F.; Kurth, F.; Blasi, F.; Malvestiti, F.; Medrano, F. J.; Mesonero, F.; Rodriguez-Frias, F.; Hanses, F.; Müller, F.; Hemmrich-Stanisak, G.; Bellani, G.; Grasselli, G.; Pezzoli, G.; Costantino, G.; Albano, G.; Cardamone, G.; Bellelli, G.; Citerio, G.; Foti, G.; Lamorte, G.; Matullo, G.; Baselli, G.; Kurihara, H.; Neb, H.; My, I.; Kurth, I.; Hernández, I.; Pink, I.; de Rojas, I.; Galván-Femenia, I.; Holter, J. C.; Afset, J. E.; Heyckendorf, J.; Kässens, J.; Damås, J. K.; Rybniker, J.; Altmüller, J.; Ampuero, J.; Martín, J.; Erdmann, J.; Banales, J. M.; Badia, J. R.; Dopazo, J.; Schneider, J.; Bergan, J.; Barretina, J.; Walter, J.; Quero, J. H.; Goikoetxea, J.; Delgado, J.; Guerrero, J. M.; Fazaal, J.; Kraft, J.; Schröder, J.; Risnes, K.; Banasik, K.; Müller, K. E.; Gaede, K. I.; Garcia-Etxebarria, K.; Tonby, K.; Heggelund, L.; Izquierdo-Sanchez, L.; Bettini, L. R.; Sumoy, L.; Sander, L. E.; Lippert, L. J.; Terranova, L.; Nkambule, L.; Knopp, L.; Gustad, L. T.; Garbarino, L.; Santoro, L.; Téllez, L.; Roade, L.; Ostadreza, M.; Intxausti, M.; Kogevinas, M.; Riveiro-Barciela, M.; Berger, M. M.; Schaefer, M.; Niemi, M. E. K.; Gutiérrez-Stampa, M. A.; Carrabba, M.; Figuera Basso, M. E.; Valsecchi, M. G.; Hernandez-Tejero, M.; Vehreschild, M. J. G. T.; Manunta, M.; Acosta-Herrera, M.; D'Angiò, M.; Baldini, M.; Cazzaniga, M.; Grimsrud, M. M.; Cornberg, M.; Nöthen, M. M.; Marquié, M.; Castoldi, M.; Cordioli, M.; Cecconi, M.; D'Amato, M.; Augustin, M.; Tomasi, M.; Boada, M.; Dreher, M.; Seilmaier, M. J.; Joannidis, M.; Wittig, M.; Mazzocco, M.; Ciccarelli, M.; Rodríguez-Gandía, M.; Bocciolone, M.; Miozzo, M.; Ayo, N. I.; Blay, N.; Chueca, N.; Montano, N.; Braun, N.; Ludwig, N.; Marx, N.; Martínez, N.; Cornely, O. A.; Witzke, O.; Palmieri, O.; Faverio, P.; Preatoni, P.; Bonfanti, P.; Omodei, P.; Tentorio, P.; Castro, P.; Rodrigues, P. M.; España, P. P.; Hoffmann, P.; Rosenstiel, P.; Schommers, P.; Suwalski, P.; de Pablo, R.; Ferrer, R.; Bals, R.; Gualtierotti, R.; Gallego-Durán, R.; Nieto, R.; Carpani, R.; Morilla, R.; Badalamenti, S.; Haider, S.; Ciesek, S.; May, S.; Bombace, S.; Marsal, S.; Pigazzini, S.; Klein, S.; Pelusi, S.; Wilfling, S.; Bosari, S.; Volland, S.; Brunak, S.; Raychaudhuri, S.; Schreiber, S.; Heilmann-Heimbach, S.; Aliberti, S.; Ripke, S.; Dudman, S.; Wesse, T.; Zheng, T.; Bahmer, T.; Eggermann, T.; Illig, T.; Brenner, T.; Pumarola, T.; Feldt, T.; Folseraas, T.; Cejudo, T. G.; Landmesser, U.; Protzer, U.; Hehr, U.; Rimoldi, V.; Monzani, V.; Skogen, V.; Keitel, V.; Kopfnagel, V.; Friaza, V.; Andrade, V.; Moreno, V.; Albrecht, W.; Peter, W.; Poller, W.; Farre, X.; Yi, X.; Wang, X.; Khodamoradi, Y.; Karadeniz, Z.; Latiano, A.; Goerg, S.; Bacher, P.; Koehler, P.; Tran, F.; Zoller, H.; Schulte, E. C.; Heidecker, B.; Ludwig, K. U.; Fernández, J.; Romero-Gómez, M.; Albillos, A.; Invernizzi, P.; Buti, M.; Duga, S.; Bujanda, L.; Hov, J. R.; Lenz, T. L.; Asselta, R.; de Cid, R.; Valenti, L.; Karlsen, T. H.; Cáceres, M.; Franke, A..
Embase; 2021.
Preprint in English | EMBASE | ID: ppcovidwho-330452

ABSTRACT

Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we describe an extended GWAS meta-analysis of a well-characterized cohort of 3,260 COVID-19 patients with respiratory failure and 12,483 population controls from Italy, Spain, Norway and Germany/Austria, including stratified analyses based on age, sex and disease severity, as well as targeted analyses of chromosome Y haplotypes, the human leukocyte antigen (HLA) region and the SARS-CoV-2 peptidome. By inversion imputation, we traced a reported association at 17q21.31 to a highly pleiotropic ~0.9-Mb inversion polymorphism and characterized the potential effects of the inversion in detail. Our data, together with the 5th release of summary statistics from the COVID-19 Host Genetics Initiative, also identified a new locus at 19q13.33, including NAPSA, a gene which is expressed primarily in alveolar cells responsible for gas exchange in the lung.

5.
Urban Book Series ; : 235-248, 2021.
Article in English | Scopus | ID: covidwho-1626462

ABSTRACT

During periods of social crisis, city governance and resilience become critical factors to manage the emergency. In terms of a health and economic crisis, the importance of such terms is even more meaningful. This chapter explores the case of Mexico City during the COVID-19 emergency. The study uses a multilevel framework of city governance and resilience (Lazarus JV, Binagwaho A, El-Mohandes AA, Fielding JE, Larson HJ, Plasència A, … Ratzan SC, Nat Med 26(7):1005–1008, 2020) to make sense of the empirical findings. The evidence from the case study suggests that the reactions from the largest healthcare organization in Mexico (IMSS), the federal, and the local government differed from each other in a variety of ways. Such contradictions between organizations and governments led to confusion and contradictory strategies. The findings contrast with the current understanding of city governance and resilience, which calls for communication and collaboration between government levels. This paper contributes to a better understanding of city governance and resilience during an emergency. © 2021, The Author(s), under exclusive license to Springer Nature Switzerland AG.

7.
United European Gastroenterology Journal ; 9(SUPPL 8):624, 2021.
Article in English | EMBASE | ID: covidwho-1490997

ABSTRACT

Introduction: Background: Irritable bowel syndrome (IBS) has a global prevalence of 11.2%. The current diagnosis is based on Rome IV Criteria, and it is recognized as a gut-brain axis disorder in which biopsychosocial factors, currently affected by the global pandemic of COVID-19, play a major role. Aims & Methods: Objective: To analyze biopsychosocial factors related to IBS during COVID-19. Methods: Observational study using an online survey. The survey combined questions of two validated questionnaires of Rome IV and the Hospital Anxiety and Depression Score Scale, as well as other items related to psychosocial areas affected by COVID-19. Data was collected and a Binary Logistic Regression Analysis was performed. Results: 2487 participants were divided according to the Rome IV criteria in IBS (N=678) and control (N=1809). IBS had a prevalence of 27% and was more prevalent in females (OR=2.81, IC 95% 2.12-3.7), healthcare workers (OR=2.33, IC 95% 1.92-2.82), and was linked to symptoms of anxiety and depression (OR=3.6, IC 95% 2.95-4.41) (OR=2.09, IC 95% 1.75-2.50), respectively. The factors associated with symptoms of anxiety and depression were, healthcare worker (OR=2.01, IC 95% 1.71-2.36) (OR=1.44, IC 95% 1.22-1.70), psychological violence (OR=3.72 IC 95% 2.85-4.8) (OR=2.95 IC 95% 2.35-3.72), time >3 hours/day searching for COVID-19 information (OR=2.36 IC 95% 1.81-2.98) (OR=1.91 IC 95% 1.52-2.41), and worrying about the current pandemic (OR=2.79, IC 95% 2.18-3.58) (OR=2.20, IC 95% 1.68-2.86). Conclusion: There are important associations between IBS prevalence, anxiety, depression and other factors in the environment created by the COVID-19 pandemic.

8.
Journal of Clinical Oncology ; 39(15 SUPPL), 2021.
Article in English | EMBASE | ID: covidwho-1375336

ABSTRACT

Background: 615 fellows began training in American combined hematology/oncology fellowship programs in July 2020. These new fellows face a steep learning curve. The coronavirus pandemic has significantly affected how we learn, with programs having to convert most collective learning to a completely virtual format. Research on the efficacy of introductory lecture series in academic hematology/oncology programs is limited especially regarding virtual formats. We introduced a virtual introductory lecture series with the goal of increasing the clinical confidence and knowledge base of first- year fellows. Methods: A once weekly remotelydelivered two-hour primer series was designed with lectures given by both third-year fellows and faculty from July-August 2020. Fellows were asked to complete pre & post-test evaluations of each lecture. Evaluations included a combination of knowledge-based questions & self-reported confidence assessment. Results:14 fellows were assigned pre- and post-tests in the study. 1 fellow was excluded due to lack of participation. A total of 123 paired pre and post-tests were compared. Data analysis was performed with SPSS v 24.0 using the paired samples t-test. Pre and post-tests were graded on a scale of 0-100. The pre to post mean difference compares the mean test result of the post tests to that of the corresponding pretests. Questions were divided into 2 groups. The 1st group tested the fellow's medical knowledge regarding the pathology while the 2nd group tested the comfort in the management, diagnosis and treatment. In the statistical analysis, these questions were defined as 'Knowledge' and 'Comfort' accordingly, the sum as 'Complete'. A statistically significant improvement in post-test knowledge for fellows of all years was noted with a pre to post test mean difference of 12.52, P <.0001. The difference was more pronounced among 1st year fellows with a pre to post test mean difference of 16.84, P <.0001. A similar improvement was seen for the comfort in management questions. The post-test comfort pre to post test mean difference was 10.48, P <.0001 for fellows of all years and 6.70, P <.0001 for first year fellows. Conclusions: A remotely-delivered introductory lecture series for fellows in a hematology/oncology training program increases both clinical knowledge and clinical confidence in fellows of all years of training.

9.
Ejifcc ; 32(2):255-264, 2021.
Article in English | MEDLINE | ID: covidwho-1368242

ABSTRACT

Introduction: Blood test alterations are crucial in SARS CoV-2 (COVID-19) patients. Blood parameters, such as lymphocytes, C reactive protein (CRP), creatinine, lactate dehydrogenase, or D-dimer, are associated with severity and prognosis of SARS CoV-2 patients. This study aims to identify blood-related predictors of severe hospitalization in patients diagnosed with SARS CoV-2. Methods: Observational retrospective study of all rt-PCR and blood-test positive (at 48 hours of hospitalization) SARS CoV-2 diagnosed inpatients between March-May 2020. Deceased and/or ICU inpatients were considered as severe cases, whereas those patients after hospital discharge were considered as non-severe. Multivariate logistic regression was used to identify predictors of severity, based on bivariate contrast between severe and mild inpatients. Results: The overall sample comprised 540 patients, with 374 mild cases (69.26%), and 166 severe cases (30.75%). The multivariate logistic regression model for predicting SARS CoV-2 severity included lymphocytes, C reactive protein (CRP), creatinine, total protein levels, glucose and aspartate aminotransferase as predictors, showing an area under the curve (AUC) of 0.895 at a threshold of 0.29, with 81.5% of sensitivity and 81% of specificity. Discussion: Our results suggest that our predictive model allows identifying and stratifying SARS CoV-2 patients in risk of developing severe medical complications based on blood-test parameters easily measured at hospital admission, improving health-care resources management and distribution.

11.
Acta Haematologica Polonica ; 52(1):68-71, 2021.
Article in English | EMBASE | ID: covidwho-1270207
12.
Revista Espanola de Salud Publica ; 95:11, 2021.
Article in Spanish | MEDLINE | ID: covidwho-1222442

ABSTRACT

OBJECTIVE: Nursing homes have suffered in a particularly pronounced way from the effects of COVID-19 so it is very convenient to know the evolution in them of the disease and the impact of SARS-CoV2 vaccination The objective of this study was to analyze COVID-19 pandemic evolution from the start of the second wave to the end of the vaccination campaign at the nursing homes. A coordination program between Primary Care and Geriatrics and Public Health services was activated. METHODS: 2,668 seniors were followed at 39 nursing homes. Data from new cases, active cases, mortality and place of treatment of COVID-19 were collected. A descriptive analysis was performed with the measurement of the absolute number of positive SARS-CoV-2 cases and the frequency distribution. RESULTS: Between August 7th 2020 and February 26th 2021, 30 outbreaks occurred at 21 nursing homes. 300 people tested positive for SARS-CoV-2 (11% of total residents). The daily average of active cases was 27,166 were hospitalized (55%). 66 patients died (22% of those infected), 54 of them (78%) at the hospital. 1,984 PCR tests were performed. The temporary profile of new cases did not follow a distribution "in waves" as in the community. Thirty-seven days after the start of the second dose of vaccination, there were no active cases until March 1st, when new cases were under study for possible vaccine leakage. CONCLUSIONS: The incidence of COVID-19 at nursing homes after the first wave of the pandemic has apparently been lower. The transmission in these centers has followed a different distribution than at community. Mass vaccination has achieved the practical disappearance of the disease.

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