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2.
Lancet ; 399(10324): 519-520, 2022 02 05.
Article in English | MEDLINE | ID: covidwho-1665561

Subject(s)
COVID-19 , SARS-CoV-2 , Humans
5.
Science ; 373(6558)2021 08 27.
Article in English | MEDLINE | ID: covidwho-1376452

ABSTRACT

The COVID-19 pandemic has revealed critical knowledge gaps in our understanding of and a need to update the traditional view of transmission pathways for respiratory viruses. The long-standing definitions of droplet and airborne transmission do not account for the mechanisms by which virus-laden respiratory droplets and aerosols travel through the air and lead to infection. In this Review, we discuss current evidence regarding the transmission of respiratory viruses by aerosols-how they are generated, transported, and deposited, as well as the factors affecting the relative contributions of droplet-spray deposition versus aerosol inhalation as modes of transmission. Improved understanding of aerosol transmission brought about by studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection requires a reevaluation of the major transmission pathways for other respiratory viruses, which will allow better-informed controls to reduce airborne transmission.


Subject(s)
Air Microbiology , COVID-19/transmission , Respiratory Tract Infections/transmission , SARS-CoV-2 , Virus Diseases/transmission , Virus Physiological Phenomena , Aerosols , COVID-19/virology , Disease Transmission, Infectious , Humans , Microbial Viability , Particle Size , Respiratory System/virology , Respiratory Tract Infections/virology , SARS-CoV-2/isolation & purification , SARS-CoV-2/physiology , Viral Load , Virus Diseases/virology , Viruses/isolation & purification
6.
Environ Sci Technol ; 55(16): 11176-11182, 2021 08 17.
Article in English | MEDLINE | ID: covidwho-1333867

ABSTRACT

Possible links between the transmission of COVID-19 and meteorology have been investigated by comparing positive cases across geographical regions or seasons. Little is known, however, about the degree to which environmental conditions modulate the daily dynamics of COVID-19 spread at a given location. One reason for this is that individual waves of the disease typically rise and decay too sharply, making it hard to isolate the contribution of meteorological cycles. To overcome this shortage, we here present a case study of the first wave of the outbreak in the city of Buenos Aires, which had a slow evolution of the caseload extending along most of 2020. We found that humidity plays a prominent role in modulating the variation of COVID-19 positive cases through a negative-slope linear relationship, with an optimal lag of 9 days between the meteorological observation and the positive case report. This relationship is specific to winter months, when relative humidity predicts up to half of the variance in positive case count. Our results provide a tool to anticipate possible local surges in COVID-19 cases after events of low humidity. More generally, they add to accumulating evidence pointing to dry air as a facilitator of COVID-19 transmission.


Subject(s)
COVID-19 , Humidity , Cities , Humans , SARS-CoV-2 , Temperature
9.
Indoor Air ; 31(2): 314-323, 2021 03.
Article in English | MEDLINE | ID: covidwho-796060

ABSTRACT

During the 2020 COVID-19 pandemic, an outbreak occurred following attendance of a symptomatic index case at a weekly rehearsal on 10 March of the Skagit Valley Chorale (SVC). After that rehearsal, 53 members of the SVC among 61 in attendance were confirmed or strongly suspected to have contracted COVID-19 and two died. Transmission by the aerosol route is likely; it appears unlikely that either fomite or ballistic droplet transmission could explain a substantial fraction of the cases. It is vital to identify features of cases such as this to better understand the factors that promote superspreading events. Based on a conditional assumption that transmission during this outbreak was dominated by inhalation of respiratory aerosol generated by one index case, we use the available evidence to infer the emission rate of aerosol infectious quanta. We explore how the risk of infection would vary with several influential factors: ventilation rate, duration of event, and deposition onto surfaces. The results indicate a best-estimate emission rate of 970 ± 390 quanta/h. Infection risk would be reduced by a factor of two by increasing the aerosol loss rate to 5 h-1 and shortening the event duration from 2.5 to 1 h.


Subject(s)
COVID-19/epidemiology , COVID-19/transmission , Singing , Ventilation/methods , Fomites/virology , Humans , SARS-CoV-2 , Time Factors , Washington/epidemiology
10.
Environ Int ; 142: 105832, 2020 09.
Article in English | MEDLINE | ID: covidwho-381748

ABSTRACT

During the rapid rise in COVID-19 illnesses and deaths globally, and notwithstanding recommended precautions, questions are voiced about routes of transmission for this pandemic disease. Inhaling small airborne droplets is probable as a third route of infection, in addition to more widely recognized transmission via larger respiratory droplets and direct contact with infected people or contaminated surfaces. While uncertainties remain regarding the relative contributions of the different transmission pathways, we argue that existing evidence is sufficiently strong to warrant engineering controls targeting airborne transmission as part of an overall strategy to limit infection risk indoors. Appropriate building engineering controls include sufficient and effective ventilation, possibly enhanced by particle filtration and air disinfection, avoiding air recirculation and avoiding overcrowding. Often, such measures can be easily implemented and without much cost, but if only they are recognised as significant in contributing to infection control goals. We believe that the use of engineering controls in public buildings, including hospitals, shops, offices, schools, kindergartens, libraries, restaurants, cruise ships, elevators, conference rooms or public transport, in parallel with effective application of other controls (including isolation and quarantine, social distancing and hand hygiene), would be an additional important measure globally to reduce the likelihood of transmission and thereby protect healthcare workers, patients and the general public.


Subject(s)
Air Microbiology , Coronavirus Infections/prevention & control , Coronavirus Infections/transmission , Pandemics/prevention & control , Pneumonia, Viral/prevention & control , Pneumonia, Viral/transmission , Aerosols , Betacoronavirus , COVID-19 , Crowding , Disinfection/instrumentation , Filtration , Humans , Inhalation Exposure , SARS-CoV-2 , Ventilation
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