Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 20 de 141
Filter
1.
International Journal of Management in Education ; 16(6):664-680, 2022.
Article in English | Scopus | ID: covidwho-2197261

ABSTRACT

The purpose of this study is to examine the effect of Transformation Leadership (TL) on Work Performance (WP) and mediating role of teaching Faculty Engagement (FE) in Higher Educational Institutions (HEI) in India during the COVID-19 pandemic. The survey method of data collection using Google forms was circulated among teaching faculty working in HEI across major cities in India. We were able to gather 568 valid responses after screening the invalid responses. The outcome of the research indicates that the structural model confirms the positive association between TL and WP. Further, the results confirmed that EE positively mediates the association between TL and WP of teaching faculty in HEI. Thus, transformational leaders in HEI develop the engagement of teaching faculty, which enhances their WP even in the virtual work environment during the COVID-19 pandemic. Copyright © 2022 Inderscience Enterprises Ltd.

2.
Infectious Microbes & Diseases ; 4(4):175-177, 2022.
Article in English | Web of Science | ID: covidwho-2190912

ABSTRACT

Middle East respiratory syndrome coronavirus (MERS-CoV) infection in humans has a high mortality of >30%. Dromedaries are the reservoir of MERS-CoV and the main source of human infections. However, MERS-CoV infections in dromedaries are usually subclinical. Rapid diagnosis of MERS-CoV infection in these animals is important in preventing camel-to-human transmission of the virus. The possible cross-reactivity of a previously reported rapid nucleocapsid protein-based antigen detection assay for MERS-CoV was examined with different CoVs, including Tylonycteris bat CoV HKU4, dromedary camel CoV UAE-HKU23, human CoV-229E, human CoV-OC43, severe acute respiratory syndrome CoV-2 and rabbit CoV HKU14, where none of them showed false-positive results. The assay was further validated using quantitative real-time reverse transcription-polymerase chain reaction-confirmed MERS-CoV-positive and MERS-CoV-negative dromedary nasal samples collected in Dubai, the United Arab Emirates, which showed that the rapid antigen detection assay has a specificity of 100% and sensitivity of 91.7%.

3.
biorxiv; 2023.
Preprint in English | bioRxiv | ID: ppzbmed-10.1101.2023.01.25.524586

ABSTRACT

Cardiovascular sequelae of severe acute respiratory syndrome (SARS) coronavirus-2 (CoV-2) disease 2019 (COVID-19) contribute to the complications of the disease. One potential complication is lung vascular remodeling, but the exact cause is still unknown. We hypothesized that endothelial TLR3 insufficiency contributes to lung vascular remodeling induced by SARS-CoV-2. In the lungs of COVID-19 patients and SARS-CoV-2 infected Syrian hamsters, we discovered thickening of the pulmonary artery media and microvascular rarefaction, which were associated with decreased TLR3 expression in lung tissue and pulmonary artery endothelial cells (ECs). In vitro, SARS-CoV-2 infection reduced endothelial TLR3 expression. Following infection with mouse-adapted (MA) SARS-CoV-2, TLR3 knockout mice displayed heightened pulmonary artery remodeling and endothelial apoptosis. Treatment with the TLR3 agonist polyinosinic:polycytidylic acid reduced lung tissue damage, lung vascular remodeling, and endothelial apoptosis associated with MA SARS-CoV-2 infection. In conclusion, repression of endothelial TLR3 is a potential mechanism of SARS-CoV-2 infection associated lung vascular remodeling and enhancing TLR3 signaling is a potential strategy for treatment.


Subject(s)
Vascular Remodeling , COVID-19 , Severe Acute Respiratory Syndrome , Addison Disease
4.
American Journal of Alzheimer's Disease and Other Dementias Vol 35 2020, ArtID 1533317520976761 ; 35, 2020.
Article in English | APA PsycInfo | ID: covidwho-2156643

ABSTRACT

By incorporating appropriate drug(s) into lipid (biobased) nanocarriers, one obtains a combination therapeutic for dementia treatment that targets certain cell-surface scavenger receptors (mainly class B type I, or "SR-BI") and thereby crosses the blood-brain barrier. The cardiovascular risk factors for dementia trigger widespread inflammation-which lead to neurodegeneration, gradual cognitive/memory decline, and eventually (late-onset) dementia. Accordingly, one useful strategy to delay dementia could be based upon nanotargeting drug(s), using lipid nanocarriers, toward a major receptor class responsible for inflammation-associated (cytokine-mediated) cell signaling events. At the same time, the immune response and excessive inflammation, commonly observed in the very recent human coronavirus (COVID-19) pandemic, may accelerate the progression of brain inflammatory neurodegeneration-which increases the probability of post-infection memory impairment and accelerating progression of Alzheimer's disease. Hence, the proposed multitasking combination therapeutic, using a (biobased) lipid nanocarrier, may also display greater effectiveness at different stages of dementia. (PsycInfo Database Record (c) 2022 APA, all rights reserved)

5.
J Gerontol A Biol Sci Med Sci ; 2022 Mar 02.
Article in English | MEDLINE | ID: covidwho-2151970

ABSTRACT

BACKGROUND: The association of cognitive function with symptoms of psychological distress during the coronavirus 2019 (COVID-19) pandemic or adherence to COVID-19 protective health behaviors is not well understood. METHODS: We examined 2,890 older women from the Women's Health Initiative cohort. Pre-pandemic (i.e., within 12 months prior to pandemic onset) and peri-pandemic global cognitive function scores were assessed with the modified Telephone Interview for Cognitive Status (TICS-m). Anxiety, stress, and depressive symptom severity during the pandemic were assessed using validated questionnaires. We examined adherence to protective behaviors that included safe hygiene, social distancing, mask wearing, and staying home. Multivariable models were adjusted for age, race, ethnicity, education, region of residence, alcohol intake, and comorbidities. RESULTS: Every five-point lower pre-pandemic TICS-m score was associated with 0.33-point mean higher (95% CI, 0.20,0.45) perceived stress, and 0.20-point mean higher (95% CI, 0.07,0.32) depressive symptom severity during the pandemic. Higher depressive symptom severity, but not anxiety or perceived stress, was associated with a 0.69-point (95% CI, -1.13, -0.25) mean decline in TICS-m from the pre- to peri-pandemic period. Every five-point lower peri-pandemic TICS-m score was associated with 12% lower odds (OR, 0.88; 95% CI, 0.80,0.97) of practicing safe hygiene. CONCLUSIONS: Among older women, we observed that: 1) lower pre-pandemic global cognitive function was associated with higher stress and depressive symptom severity during the pandemic; 2) higher depressive symptom severity during the pandemic was associated with cognitive decline; and 3) lower global cognitive function during the pandemic was associated with lower odds of practicing safe hygiene.

6.
Machine Learning and Deep Learning in Medical Data Analytics and Healthcare Applications ; : 39-64, 2022.
Article in English | Scopus | ID: covidwho-2120659

ABSTRACT

Visual representation of intricate anatomical morphology of the human body has great significance in the medical field. Technological advancements in imaging modalities over the past two decades have had a powerful impact on disease diagnosis and treatment. Simultaneously, development of sophisticated mathematical models, image processing, and visualization tools have enabled the emergence of three-dimensional (3D) models which are closer to reality. Three-dimensional visualization of medical image data is finding increasing applications in diagnosis, treatment planning, intraoperative support, and education and research. Medical two-dimensional (2D) images acquired from imaging modalities such as magnetic resonance imaging (MRI), computed tomography (CT), and ultrasound lack in-depth information and they are unable to interpret the complex interrelationship between anatomical spatial structures. Three-dimensional reconstruction is useful for directly displaying 3D structures, especially multiple, spatially interlinked, hollow, branching structures. However, many of the tactual qualities of physical specimen are absent in digital models. So, 3D printing opened up a new way for researchers to present their data. Medical simulation needs 3D reconstruction and 3D printing. Three-dimensional reconstruction is the mathematical process of generating a 3D virtual model of an object from a set of 2D images. Three-dimensional printing is an additive manufacturing technology which converts the digital information from an MRI or computer-aided design into 3D physical, solid model. Three-dimensional printing, the fourth industrial revolution technology, which aims at digital manufacturing and smart production, has the potential of turning dream into reality in the medical field. The aspirational applications of medical 3D printing are in medical education, pre-surgical planning, pharmaceutical drug production, bioprinting, and the customization of implants and prosthetics. This chapter puts forward the technology and software used for 3D reconstruction and provides an overview of various techniques and materials used in medical 3D printing. Furthermore, it discusses the wide range of clinical applications of 3D reconstruction and printing, including its role in the fight against the COVID-19 pandemic. The chapter also discusses the current challenges and barriers to medical 3D reconstruction and printing along with the future directions. © 2022 selection and editorial matter, Om Prakash Jena, Bharat Bhushan, Utku Kose;individual chapters, the contributors.

7.
Journal of Pharmaceutical Negative Results ; 13:1186-1190, 2022.
Article in English | Web of Science | ID: covidwho-2111699

ABSTRACT

COVID-19 has forced several companies to swiftly switch to remote working. The Information Technology (IT) industry responded early by adopting a remote working model. It is now clear that, remote working is here to stay. This model will be an integral part of the working world more than ever. IT organisations have been able to make this migration considerably well in a short span of time. However, it is important to realise that implementation of remote working is a much broader subject. Organizations expect the new joiners to integrate into the organization in a manner similar to a plug and play device. New joiners take time to adapt to a new work environment. Those who joined during the pandemic missed the opportunity to get a first hand experience of their organization due to the remote onboarding. We studied two groups of employees, those who joined in their respective offices in 2019 and those who joined remotely in 2020. We tried to understand and compare the sense of belongingness amongst these two group of employees. The survey approach was adopted for analysis, and a total of 144 employees participated from 27 IT Companies across India. A One Way ANOVA was performed to compare the means and the outcome of the survey. The result was conclusive and corroborated the fact that, the sense of belonging in virtual workers stands low. Some of the significant reasons were due to the lack of regular connect with managers, irregular performance feedback and the dearth of instant recognition for work done. As remote working is going to be a part of future work strategy, it is important to bring the sense of belongingness early on amongst new joiners. Recommendations to address the belongingness gap were provided based on our discussion with a group of HR Managers.

8.
Indian Journal of Rheumatology ; 17(3):289-293, 2022.
Article in English | Web of Science | ID: covidwho-2110467

ABSTRACT

Multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19 is a rare but often life-threatening clinical entity that presents 3-6 weeks after SARS-CoV-2 infection with high fever, organ dysfunction, and strongly elevated markers of inflammation. Unlike MIS-C, where SARS-CoV-2 infection and multisystem inflammation occur in the same subject, maternal SARS-CoV-2 infection may cause a similar hyperinflammatory syndrome in neonates called multisystem inflammatory syndrome in neonates (MIS-N) due to transplacental transfer of antibodies. The clinical profile of these babies remains obscure due to a lack of published literature. Our case highlights the need for practicing pediatricians to be vigilant and to have a high index of clinical suspicion of MIS-N in all critically ill neonates irrespective of antenatal COVID-19 status of mother.

9.
Clin Chem Lab Med ; 2022 Nov 11.
Article in English | MEDLINE | ID: covidwho-2117922

ABSTRACT

OBJECTIVES: Many biomarkers have been studied to assist in the risk stratification and prognostication of patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Procalcitonin (PCT), a circulating precursor of the hormone calcitonin, has been studied with mixed results as a predictor of severe coronavirus disease 2019 (COVID-19) in the general population; however, to date, no studies have focused on the utility of PCT in predicting disease severity and death from COVID-19 in the cancer population. METHODS: We conducted a retrospective study of cancer patients hospitalized with COVID-19 at a comprehensive cancer center over a 10-month period who had PCT recorded on admission. We assessed associations between variables of clinical interest and the primary outcomes of progression of COVID-19 and death during or within 30 days of hospitalization using univariable and multivariable logistic regression. RESULTS: The study included 209 unique patients. In the univariate analysis, elevated PCT on admission was associated with higher odds of progression of COVID-19 or death (Odds ratio [OR] 1.40, 95% CI 1.08-1.93) and mortality alone (OR 1.53, 95% CI 1.17-2.11). In multivariate regression, PCT remained significantly associated with progression or death after holding chronic kidney disease (CKD) status constant (OR 1.40, 95% CI: 1.08, 1.93, p=0.003). Similarly, the association of PCT and death remained significant after adjusting for age (OR 1.54, 95% CI: 1.17-2.15). CONCLUSIONS: In hospitalized COVID-19 patients with underlying cancer, initial PCT levels on admission may be associated with prognosis, involving higher odds of progression of COVID-19 and/or mortality.

10.
J Gen Intern Med ; 37(13): 3495-3497, 2022 10.
Article in English | MEDLINE | ID: covidwho-2075546
11.
Trauma Care ; 2(4):550-555, 2022.
Article in English | MDPI | ID: covidwho-2071788

ABSTRACT

We report the case of a 20-year-old male who developed severe HO of the left hip secondary to a prolonged course of COVID-19 pneumonia. Upon extubation, he was found to have debilitating left hip pain and significant functional deficits with regard to his range of motion and functional status. There are numerous known causes of heterotopic ossification (HO), including trauma, surgery, and traumatic brain or spinal cord injuries. An increased incidence of HO has also been reported in patients who undergo prolonged intubation. While the COVID-19 virus has many known respiratory and medical complications, it has also resulted in unforeseen complications that present long-term challenges for patients. When treating patients with coronavirus, physicians should be aware of HO as a possible complication and consider it as a cause of musculoskeletal pain.

12.
Indian Journal of Rheumatology ; 17(3):289-293, 2022.
Article in English | Scopus | ID: covidwho-2055742

ABSTRACT

Multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19 is a rare but often life-threatening clinical entity that presents 3-6 weeks after SARS-CoV-2 infection with high fever, organ dysfunction, and strongly elevated markers of inflammation. Unlike MIS-C, where SARS-CoV-2 infection and multisystem inflammation occur in the same subject, maternal SARS-CoV-2 infection may cause a similar hyperinflammatory syndrome in neonates called multisystem inflammatory syndrome in neonates (MIS-N) due to transplacental transfer of antibodies. The clinical profile of these babies remains obscure due to a lack of published literature. Our case highlights the need for practicing pediatricians to be vigilant and to have a high index of clinical suspicion of MIS-N in all critically ill neonates irrespective of antenatal COVID-19 status of mother. © 2022 Wolters Kluwer Medknow Publications. All rights reserved.

13.
JAMA Netw Open ; 5(10): e2234585, 2022 10 03.
Article in English | MEDLINE | ID: covidwho-2047380

ABSTRACT

This cross-sectional study compares the author and journal characteristics of retracted articles on COVID-19 with retracted articles from other topics.


Subject(s)
COVID-19 , Scientific Misconduct , Humans , Journal Impact Factor
15.
Journal of Camel Practice and Research ; 27(2):207-208, 2020.
Article in English | CAB Abstracts | ID: covidwho-2040330

ABSTRACT

MERS-CoV was isolated from nasal swabs for 10 days from an adult female camel which displayed clear nasal discharge from both nostrils. When MERS-CoV ELISA antibodies appeared in the camel's blood, the virus was no longer present in its nasal cavities.

16.
PLoS One ; 17(9): e0274330, 2022.
Article in English | MEDLINE | ID: covidwho-2039412

ABSTRACT

IMPORTANCE: The Coronavirus Disease (COVID-19) pandemic has significantly impacted mental health outcomes. While the frequency of anxiety and depressive symptoms has increased in the whole population, the relationship between COVID-19 and new psychiatric diagnoses remains unclear. OBJECTIVE: To compare the population incidence rate of emergence of de novo psychiatric disorders in 2020 compared to the previous years, and to compare the incidence rate of new psychiatric disorder diagnoses between people with vs without COVID-19. DESIGN, SETTING, AND PARTICIPANTS: This study utilized administrative claims data from the Clinformatics® Data Mart database, licensed from Optum®. The study is a cross-sectional analysis that compared the incidence rate of new psychiatric disorders in 2020 vs. 2018 and 2019 in the entire insured population database. Subsequently, the incidence of new psychiatric disorders in people with vs. without COVID-19 during 2020 was analyzed. EXPOSURE: The exposures included diagnosis and severity of COVID-19 infection. MAIN OUTCOMES MEASURES: The dependent variables of interest were the incidence rates of new psychiatric disorders, specifically schizophrenia spectrum disorders, mood disorders, anxiety disorders, and obsessive-compulsive disorder. RESULTS: The population studied included 10,463,672 US adults (mean age 52.83, 52% female) who were unique people for the year of 2020. Incidence of newly diagnosed psychiatric disorders per 1,000 individuals in the 2020 whole population were 28.81 (CI: 28.71, 28.92) for anxiety disorders, 1.04 (CI: 1.02, 1.06) for schizophrenia disorders, 0.42 (CI: 0.41, 0.43) for OCD and 28.85 (CI: 28.75, 28.95) for mood disorders. These rates were not significantly higher than 2018 or 2019. When comparing incidence rates between COVID-19 vs. non-COVID-19 populations in 2020, the rates were significantly higher in the COVID-19 population: 46.89 (CI: 46.24, 47.53) for anxiety, 49.31 (CI: 48.66, 49.97) for mood disorders, 0.57 (CI: 0.50, 0.65) for OCD, and 3.52 (CI: 3.34, 3.70) for schizophrenia. COVID-19 severity was significantly associated with new diagnoses of schizophrenia, anxiety and mood disorders in multivariate analyses. CONCLUSIONS: Compared to 2018 and 2019, in 2020 there was no increased incidence of new psychiatric disorders in the general population based on insurance claims data. Importantly, people with COVID-19 were more likely to be diagnosed with a new psychiatric disorder, most notably disorders with psychosis, indicating a potential association between COVID-19 and mental/brain health.


Subject(s)
COVID-19 , Obsessive-Compulsive Disorder , Adult , COVID-19/epidemiology , Cross-Sectional Studies , Female , Humans , Incidence , Male , Middle Aged , Obsessive-Compulsive Disorder/epidemiology , Obsessive-Compulsive Disorder/psychology , SARS-CoV-2
17.
World J Orthop ; 13(8): 693-702, 2022 Aug 18.
Article in English | MEDLINE | ID: covidwho-2025125

ABSTRACT

BACKGROUND: In the Spring of 2020, residency programs across the country experienced rapid and drastic changes to their application process as a result of the coronavirus disease 2019 (COVID-19) pandemic. In response, residency programs shifted to virtual events and began harnessing social media to communicate with applicants. AIM: To analyze the changes in social media usage by orthopaedic surgery programs in response to the COVID-19 pandemic. METHODS: Based on the 2019 residency and fellowship electronic database, accredited US orthopaedic surgery programs were reviewed for social media presence on Instagram and Twitter. Approximately 47000 tweets from 2011-2021 were extracted through the Twitter application programming interface. We extracted: Total number of followers, accounts following, tweets, likes, date of account creation, hashtags, and mentions. Natural language processing was utilized for tweet sentiment analysis and classified as positive, neutral, or negative. Instagram data was collected and deemed current as of August 11, 2021. The account foundation date analysis was based on the date recognized as the start of the COVID-19 outbreak in the United States, before or after March 1, 2020. RESULTS: A total of 85 (42.3%) orthopaedic surgery residency program Twitter handles were identified. Thirty-five (41.2%) programs joined Twitter in the nine months after the 2020 covid outbreak. In 2020, there was a 126.6% increase in volume of tweets by orthopaedic surgery residency accounts as compared to 2019. The median number of followers was 474.5 (interquartile range 205.0-796.5). The account with the highest number of tweets was Hospital for Special Surgery (@HSpecialSurgery) with 13776 tweets followed by University of Virginia (@UVA_Ortho) with 5063 and Yale (@OrthoAtYale) with 899. Sentiment analysis before 2020 revealed 30.4% positive, 60.8% neutral, and 8.8% negative sentiments across tweets. Interestingly, the positive sentiment percentage increased in 2020 from 30.4% to 34.5%. Of the 201 ACGME-accredited orthopaedic residency programs on Fellowship and Residency Electronic Interactive Database, 115 (57.2%) participate on Instagram, with 101 (87.8%) identified as "resident"-managed vs 14 (12.2%) identified as "department"-managed. Over three quarters (77.4%) of Instagram accounts were created after March 1, 2020. The average number of followers per account was 1089.5 with an average of 58.9 total posts. CONCLUSION: Our study demonstrates a substantial growth of Instagram and Twitter presence by orthopaedic surgery residency programs during the COVID-19 pandemic. These data suggest that orthopaedic residency programs have utilized social media as a new way to communicate with applicants and showcase their programs in light of the challenges presented by the pandemic.

19.
Asia Pacific Journal of Health Management ; 16(4):196-204, 2021.
Article in English | Web of Science | ID: covidwho-2011677

ABSTRACT

OBJECTIVES: The current research focussed to explore the association of daily spiritual experience on the mental well- being of international students hails from Africa and pursuing studies in various higher education institutions in India. The research also tried to explore whether age and gender plays a significant role in the mental well- being of the respondents. DESIGN: The study is an exploratory cross-sectional in nature. The research tool comprised of the Daily Spiritual Experience Scale (DSES) and Warwick-Edinburgh Mental Well-being Scale (WEMWBS) along with the demographic details. Post reliability and validity tests established scales are used to study the variable in the research. The data was analysed using Smart PLS SEM 3.3.2. SETTING: The respondents comprise of international students hails from Africa and pursuing various undergraduate, post graduate and PhD courses from various institutions at Bhopal, Delhi, Mumbai and Rajasthan in India. The respondents include a cohort of 102 respondents who gave consent to be part of the study during first week of July to first week of August 2021 and were selected through purposive sampling technique. MAIN OUTCOME MEASURES: The research measures the association of daily spiritual experience and mental well- being during pandemic and also the coping strategies used by the respondents. FINDINGS: The research report shows an insignificant relation of gender to the mental well-being whereas age reported a significant association. A significant association is reported between daily spiritual experience and mental wellbeing of the respondents amidst pandemic situation. CONCLUSION: Pandemic outbreaks influences the mental well-being of individuals specially when they are away from the social support system. Hence counselling services and other interventions to cater to the needs of students requires a serious deliberation at the policy level.

20.
Annals of the Rheumatic Diseases ; 81:208-209, 2022.
Article in English | EMBASE | ID: covidwho-2009182

ABSTRACT

Background: Pausing methotrexate (MTX) for two to four weeks, improved immunogenicity of infuenza vaccination in patients with rheumatoid arthritis (RA), albeit a risk of disease fare (1). This guided the framing of guidelines on MTX withdrawal for COVID-19 vaccination (2). However, evidence for MTX withdrawal for COVID-19 vaccination is limited to observational studies only. Objectives: To compare the efficacy and safety of holding MTX after each (MIVAC 1) and only after the second dose (MIVAC II) of the ChAdOx1 vaccine versus continuation of MTX in two randomized controlled trials (RCTs). Methods: Two single centre, investigator-blinded, RCTs were conducted in patients with RA or Psoriatic arthritis (PsA) on stable doses of MTX without prior COVID-19 (CTRI reg. no. MIVAC I: CTRI/2021/07/03463 & MIVAC II: CTRI/2021/07/035307). In MIVAC I, unvaccinated patients were randomised (1:1) to hold or continue MTX for two weeks after each dose of the vaccine. MIVAC II included patients who had continued MTX during the frst dose of ChA-dOx1 and were randomised (1:1) to hold or continue MTX for 2 weeks after the second vaccine dose. The primary outcome for both the trials was the anti-Receptor Binding Domain (RBD) antibody titres measured four weeks after the second vaccine dose (per protocol analysis). Secondary outcome was the fare rate, defned as an increase in disease activity scores (DAS28/cDAPSA) or physician intent to hike DMARDs. Results: 250 patients were randomized for MIVAC 1 and 178 for MIVAC II and after due exclusions, 158 and 157 were eligible for analysis respectively (Figure 1). In MIVAC I, median anti-RBD titres were signifcantly high in the MTX hold group [2484 (1050-4388) versus 1147(433-2360), p=0.001] but the fare rate was higher in the hold group [20 (25%) versus 6(8%) p=0.005] compared to continue group. In MIVAC II median anti-RBD titres were signifcantly high for the MTX hold group [2553 (1792-4823) versus 990 (356-2252), p=0.001] when compared to continue group but there was no difference in the fare rate between the groups [9(11.8%) and 4(7.9%), p=0.15] (Table 1). Since both were parallel studies in similar population, MTX hold arms across both the trials were compared for anti-RBD titres and fare. There was no difference in the anti-RBD titres [p=0.2] between the groups. In MIVAC I, 29(36.25%) patients had reported fare (19 in either frst or second dose, 10 for both doses) when compared to MIVAC II where only 9(11.84%) patients had reported fare after the second dose (P <0.001). Conclusion: Holding MTX after both the doses or only after the second dose of ChAdOx1 yields higher anti-RBD antibody titres as compared to continuing MTX. Comparing across the trials, holding MTX only after the second dose appears to be non-inferior to holding MTX after both doses of the vaccine with a lesser risk of fare.

SELECTION OF CITATIONS
SEARCH DETAIL