Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 20 de 733
Filter
Add filters

Year range
1.
Acta Medica Philippina ; 56(11):99-102, 2022.
Article in English | Scopus | ID: covidwho-1965204

ABSTRACT

Behcet's disease (BD) is a systemic vasculitis characterized by recurrent acute vascular inflammation. There is currently limited epidemiological data in Southeast Asia. We discuss a 26-year-old woman who came to our institution for recurrent vulvar abscesses for a year. Physical examination showed labial, tongue, and vulvar ulcers. Pathergy test was negative and biopsy done were unremarkable. We diagnosed her clinically as a case of Behcet's disease. We started her on colchicine 0.6 mg once daily and educated her on skin, oral, and perineal hygiene. On follow-up after one month, she noted resolution of her lesions. However, symptoms recurred in the last three months after discontinuing treatment. We used telemedicine to communicate due to the COVID-19 pandemic and lockdown, advising her to continue her medication. Timely diagnosis is essential in order to provide symptomatic relief and enhance patient education. © 2022 University of the Philippines Manila. All rights reserved.

2.
Taiwan Gong Gong Wei Sheng Za Zhi ; 41(3):235-248, 2022.
Article in English | ProQuest Central | ID: covidwho-1964514

ABSTRACT

This presentation is a review and discussion of some of the crucial lessons we are learning from the COVID-19 pandemic and its impact on global public health. How will we in the public health academic community contribute to addressing these challenges through our research, our teaching, and our engagement with policymakers and the public? Is it business as usual or do we "step up our game?" If the latter, what are our goals, and how should we reshape, re-frame and re-energize our three missions (research, education, community engagement) to achieve them? Importantly, what can we in academic public health do to connect ourselves better globally for coming public health challenges?

3.
B.E. Journal of Economic Analysis and Policy ; 2022.
Article in English | Scopus | ID: covidwho-1963077

ABSTRACT

The intensity of the early months of the COVID-19 pandemic were a surprise to many people and functioned as an unexpected disturbance where individuals and businesses were slow to adapt their behavior. This event allows us to explore pre-pandemic structural differences in employment and estimate the public health impacts of these first few months of the pandemic. Novel datasets provided by the Connecticut Department of Health and the Massachusetts Department of Health enable us to link deaths to industry and occupation directly at the individual level. A significant number of working-aged people died from COVID-19, with black and Hispanic populations dying at much higher rates. Linking individual deaths with employment, we find that nearly half of these deaths come from people working non-telework essential jobs. Black and Hispanic non-telework essential workers died at a rate 14-percentage points higher than white individuals employed in these same occupations. © 2022 Walter de Gruyter GmbH, Berlin/Boston 2022.

4.
New waves in social psychology ; : 83-94, 2021.
Article in English | APA PsycInfo | ID: covidwho-1958870

ABSTRACT

If the COVID-19 pandemic sets the tone for our present condition, it is "only" the last revelator of the failure of modern civilization. The "developed" world is facing, in particular, an unprecedented regressive turn: the profound political, ethical, and civilizational setback that we are seeing and living;the destruction of the human in us. From within this civilizational bankruptcy, this essay strives to project an answer to the question (Beckettian question par excellence): How to continue? How can we orient ourselves in thinking and in life from now on, after the ruin of faith in man, postulated by humanisms? A good guide: the correspondence between Freud and Einstein, Why war? This outlines an anamnesis of the assumptions of all humanism. The human constitutively carries within himself "something" that exceeds him and that, as such, is not human. This excess is inescapable;rather, it requires a "work", the "work of culture, Kulturarbeit," a "care", and a "cure" (the cura sui). Outlining a turnaround movement (retournement) from the bankruptcy of modernity, Freud thus opens the way for what really concerns us: a thought of after-humanism. It is here that we find Lacan's seminar on the "Ethics of Psychoanalysis," built around the figure of Antigone-one that does not give up on his desire, which is faithful to unconditional desire. Civil disobedience. Tragic conception of ethics. This essay makes, by the way, some observations on the state delinquency that is devastating Brazil today. And it leaves a question: How to explain, in a Republic, the unbelievable impunity of a notorious genocide and ecocide placed at the top of the state, openly involved with organized crime? What to conclude from this banality of evil? And the lack of consequent indignation of the so-called progressive forces? This attests to the structural lack, in that "psychic apparatus" called "Brazilian civilization", of a true "work of culture". This lack goes perfectly hand in hand with the obscurantist propensity of global neoliberalism in crisis. (PsycInfo Database Record (c) 2022 APA, all rights reserved)

5.
Computational Approaches for Novel Therapeutic and Diagnostic Designing to Mitigate SARS-CoV-2 Infection ; : 537-557, 2022.
Article in English | EuropePMC | ID: covidwho-1958364

ABSTRACT

The Coronavirus disease 2019 pandemic struck the world at the end of 2019 and, as of 2021, there are no specific drugs available against the causative agent, the severe acute respiratory syndrome-Coronavirus-2 (SARS-CoV-2). From the onset of the pandemic, researchers have been trying to find drugs among the current therapeutic arsenal that could target crucial viral function, and many of these efforts resulted in clinical trials to repurpose a drug for this new indication. In this scenario, artificial intelligence (AI) is of fundamental importance, allowing academia and pharmaceutical companies to accelerate the discovery of biochemical insights from the chemical and biological information available in literature databases. This chapter will cover some AI methods that are being explored to repurpose drugs against SARS-CoV-2. It will be outlined how these methods work followed by a discussion of selected examples applying them to identify promising drugs.

6.
Dissertation Abstracts International Section A: Humanities and Social Sciences ; 83(9-A):No Pagination Specified, 2022.
Article in English | APA PsycInfo | ID: covidwho-1958344

ABSTRACT

While many opine the criticality of leader Emotional Intelligence (EQ) (Goleman et al., 2004;Goleman, 2005;Boyatzis et al. 2011;Boyatzis et al. 2017;Hess & Bacigalupo, 2013;Galen, 2012), this research identified empathy as the sine qua non for leader EQ. Elders serve as the leadership for their congregation. Therefore, their inter-personal skills are crucial for inspiring and influencing followers for Kingdom work (White & Kimmons, 2019). Leaders are evaluated in three distinct skill sets: (1) cognitive, (2) intra-personal, and (3) inter-personal (Boyatzis et al., 2011). These latter two skill sets are the sub-sets of EQ. For the last, although sympathy may be unattached or distant, empathy is connected and may even be close enough to effectively sense, interpret, and understand the thoughts of another (Pavlovich & Krahnke 2012). While religiosity may generally result in higher affective empathy, that enterprise considers the involvement of another's emotions. This research considers how the elder's empathic skills affect followers in the congregation and inspire them for Kingdom work. This research sets forth to consider the impact of the inter-personal skill set on the congregation. This research considers leader emotional intelligence (EQ), empathy, narcissism, and social networks and the relationship to followers. While there is a widening body of research concerning EQ among business leaders, and while some research concerns empathy and its antagonist narcissism, there is little research focused on church (Boyatzis, personal communication, 2019) and non-profit leader EQ or its effect on a volunteer workforce. Similar to efforts in for-profit settings, leaders in non-profit settings exercise influence to affect decisions. Leaders with higher EQ are more likely to assess their skills, and the skills of others, for the best alignment to achieve both organizational goals and promote individual and collective growth amongst followers (Hess & Bacigalupo, 2013). Modern considerations of EQ are based on previous concepts. Social intelligence is a complex pattern of behaviors which demonstrate skills related to personal interaction and adaptability. The individual situations and personal circumstances are all independent variables affecting those interactions (Strang, 1930). Gardner's original work in 1984 developed the construct for personal intelligence (2004). He posited that each of the elements of human learning and ability, including personal intelligence, have a separate lotus within the brain. These abilities become the intellectual aptitudes and problem-solving skills which generate the ability to resolve actual or perceived issues. As tacit knowledge develops, so does the ability to consistently complete a task or series of tasks or reach a goal. Often efforts become more efficient as tacit knowledge increases (Wagner & Sternberg, 1985). (PsycInfo Database Record (c) 2022 APA, all rights reserved)

7.
Dissertation Abstracts International Section A: Humanities and Social Sciences ; 83(9-A):No Pagination Specified, 2022.
Article in English | APA PsycInfo | ID: covidwho-1957956

ABSTRACT

As information and communications technologies continue to evolve, a growing number of global corporations can have their employees work simultaneously around the globe from multiple locations. There have been numerous historical studies on empathy and empathetic leaders, but there was a void regarding studies that examined empathetic communication from organizational leaders and its potential impact on increasing buy-in from geographically separated employees. The purpose of this phenomenological study was to investigate the lived experiences of individuals with substantial experience working in geographically dispersed organizations and understand if empathetic communication from their organizational leadership increased their buy-in to the organization. This study took on increased importance as the world continues to grapple with a global pandemic. This research study included interviewing eleven participants from diverse backgrounds to understand and analyze their lived experiences being geographically separated from their organizational leadership, and answer the research question: Does empathetic communication from organizational leaders increase buy-in from geographically separated employees? After data was collected and verified for accuracy, a thematic analysis was completed to examine any potential trends in the data. The results of this study illustrated five major themes, and a further seventeen subthemes, that supported a direct connection between empathetic communication from organizational leadership and employee buy-in to the organization. Most research participants explicitly stated that empathetic communication from organizational leadership drives increased buy-in to the organization. (PsycInfo Database Record (c) 2022 APA, all rights reserved)

8.
The Judges' Journal ; 61(3):37-39, 2022.
Article in English | ProQuest Central | ID: covidwho-1957919

ABSTRACT

In 2021, the U.S. Federal Trade Commission received over 5.7 million reports of fraud, identity theft, and other consumer protection issues, accounting for $5.9 billion in fraud losses.3 Of people ages 20-29 reporting fraud to the FTC, 41 percent lost money to the schemes perpetrated, compared to only 18 percent of those in the 70-79 age range reporting fraud.4 The most common types of fraud and their median losses vary by age group. The top categories for fraud losses for the 20-29-year-old category are $2,000 for fake check scams, $1,821 for job scams, and $1,000 for government imposter scams.5 For the 80 and over age group, the highest median losses are $7,650 for romance scams;$6,000 for prizes, sweepstakes, and lottery scams;and $4,975 for family and friend imposter scams.6 Scammers Understand Their Potential Targets There is little doubt that scammers target the unsuspecting, but be advised that scammers also target professionals, businesspeople, and other "sophisticated" groups. According to a psychology professor who has studied scams, scammers are amateur psychologists.7 They understand that people respond to social influences and authority figures. Once the therapist provided the fake deputy sheriff with the Visa card numbers and the PINs, the final step of the scam involved his advising the therapist that she should put the cards in an envelope with his name and badge number and deposit the envelope in a special mailbox (which was a regular, public

9.
Preprint in English | bioRxiv | ID: ppbiorxiv-503400

ABSTRACT

The SARS-CoV-2 Omicron variant, with 15 mutations in Spike receptor binding domain (Spike-RBD), renders virtually all clinical monoclonal antibodies against WT SARS-CoV-2 ineffective. We recently engineered the SARS-CoV-2 host entry receptor, ACE2, to tightly bind WT-Spike-RBD and prevent viral entry into host cells ("receptor traps"). Here we determine cryo-EM structures of our receptor traps in complex with full length Spike. We develop a multi-model pipeline combining Rosetta protein modeling software and cryo-EM to allow interface energy calculations even at limited resolution and identify interface side chains that allow for high affinity interactions between our ACE2 receptor traps and Spike-RBD. Our structural analysis provides a mechanistic rationale for the high affinity (0.53 - 4.2nM) binding of our ACE2 receptor traps to Omicron-RBD confirmed with biolayer interferometry measurements. Finally, we show that ACE2 receptor traps potently neutralize Omicron- and Delta-pseudotyped viruses, providing alternative therapeutic routes to combat this evolving virus.

12.
Journal of Plastic Film & Sheeting ; 38(3):339-340, 2022.
Article in English | Academic Search Complete | ID: covidwho-1951011
13.
Frontiers in immunology ; 13, 2022.
Article in English | EuropePMC | ID: covidwho-1939959

ABSTRACT

The SARS-CoV-2 pandemic has had a social and economic impact worldwide, and vaccination is an efficient strategy for diminishing those damages. New adjuvant formulations are required for the high vaccine demands, especially adjuvant formulations that induce a Th1 phenotype. Herein we assess a vaccination strategy using a combination of Alum and polyinosinic:polycytidylic acid [Poly(I:C)] adjuvants plus the SARS-CoV-2 spike protein in a prefusion trimeric conformation by an intradermal (ID) route. We found high levels of IgG anti-spike antibodies in the serum by enzyme linked immunosorbent assay (ELISA) and high neutralizing titers against SARS-CoV-2 in vitro by neutralization assay, after two or three immunizations. By evaluating the production of IgG subtypes, as expected, we found that formulations containing Poly(I:C) induced IgG2a whereas Alum did not. The combination of these two adjuvants induced high levels of both IgG1 and IgG2a. In addition, cellular immune responses of CD4+ and CD8+ T cells producing interferon-gamma were equivalent, demonstrating that the Alum + Poly(I:C) combination supported a Th1 profile. Based on the high neutralizing titers, we evaluated B cells in the germinal centers, which are specific for receptor-binding domain (RBD) and spike, and observed that more positive B cells were induced upon the Alum + Poly(I:C) combination. Moreover, these B cells produced antibodies against both RBD and non-RBD sites. We also studied the impact of this vaccination preparation [spike protein with Alum + Poly(I:C)] in the lungs of mice challenged with inactivated SARS-CoV-2 virus. We found a production of IgG, but not IgA, and a reduction in neutrophil recruitment in the bronchoalveolar lavage fluid (BALF) of mice, suggesting that our immunization scheme reduced lung inflammation. Altogether, our data suggest that Alum and Poly(I:C) together is a possible adjuvant combination for vaccines against SARS-CoV-2 by the intradermal route.

14.
Nurse Educ Pract ; 64: 103419, 2022 Jul 21.
Article in English | MEDLINE | ID: covidwho-1937036

ABSTRACT

AIM: To determine the parsimonious model of the interrelationships of personal resilience, social support, loneliness and quality of life (QoL) and to identify the mediating effect of loneliness among nursing students amidst the pandemic. BACKGROUND: The coronavirus 2019 (COVID-19) pandemic led to control measures which increased loneliness among students due to disrupted social connections and sudden shift to virtual learning. During these changes, resilience and social support can significantly influence how learners deal with pandemic-related stresses thus, minimizing loneliness and enhancing QoL. Although studies posited the influence of resilience and social support with loneliness and QoL, these were conducted prior the COVID-19 pandemic wherein loneliness and feelings of isolation play a crucial part. DESIGN: Correlational, theory testing using covariance-based structural equation modeling METHODS: A total of 550 nursing students from a comprehensive university in Manila, Philippines were recruited from September to October 2021 and answered four standardized, validated scales. RESULTS: A good and parsimonious model (x2/df = 2.84, RMSEA = 0.058, GFI = 0.999, CFI = 0.999, PNFI = 0.048) highlighted the mediating effect of loneliness between social support, personal resilience and QoL. While personal resilience positively influenced the physical and psychological domains of QoL, social support positively affected the social relationships and environmental domains. Loneliness was a strong, negative predictor of the psychological and social domains of QoL and had a moderate, negative effect on the physical domain. Personal resilience also mediated the influence of social support on loneliness and QoL. CONCLUSION: Social support and personal resilience positively affected QoL, while loneliness had a negative effect. Through the mediation of loneliness, the effects of social support on QoL decreases. However, the mediation of resilience further decreases loneliness and improves QoL. The presented model assists nurse educators and administrators in developing strategies to enhance social support, resilience and QoL among students while mitigating the negative effects loneliness during the pandemic. TWEETABLE ABSTRACT: Loneliness and Resilience are mediators of student nurses' quality of life during COVID-19 pandemic. Social support is the common predictor.

15.
International Journal of Information and Education Technology ; 12(8):756-761, 2022.
Article in English | Scopus | ID: covidwho-1934791

ABSTRACT

—Information and Communications Technology Self-efficacy is an essential factor in promoting technopreneurial interest and fostering technopreneurial competence. This study focuses on the impact of Information and Communications Technology Self-Efficacy on technopreneurial Intention, which technopreneurial Learning mediates. The researchers used an explanatory survey as the research method and gathered 200 selected participants from engineering students in the Philippines during COVID-19 Pandemic. The collected data was analyzed using Structural Equation Modelling (SEM). The results show that Information and Communications Technology Self Efficacy has a positive and significant effect on both technopreneurial Intention and technopreneurial Learning. Additionally, this study established that technopreneurial Learning mediates the relationship between Information and Communications Technology Self Efficacy and technopreneurship Intention. The result indicates that boosting Information and Communications Technology Self-Efficacy and technopreneurship Intention Learning will be more successful in improving technopreneurship Intention. © 2022 by the authors.

16.
Sustainability ; 14(13):7919, 2022.
Article in English | ProQuest Central | ID: covidwho-1934243

ABSTRACT

Several studies have explored the effects of restrictive policies in different case-use instances;however, studies focusing on restrictive agricultural policies and their effects on major stakeholders are scarce. While the Philippines has been increasing its support for biotech-related technologies in agriculture, such as the recent approval of Golden Rice and Bt (Bacillus thuringiensis) eggplant for cultivation, the years prior to 2020 have not been as lenient in the acceptance of biotech crops. This paper explored the perceptions and attitudes of biotech corn farmers on the Philippine Supreme Court’s ban on biotech crops in 2015 and discussed how this restrictive agricultural policy could affect rural Filipino communities. A bifurcation was observed regarding the farmers’ ban perception, with almost half indicating that implementing the ban was an incorrect decision. The effects of the decision-making stages and influential factors on farmers’ perceived correctness of the ban were modeled using ordinal logistic regression and Spearman correlation. It was observed that while farmers’ initial instinct is directly related to their ban perception, succeeding decision-making stages enforce the notion of a pragmatic point of view leading to innate resistance effects towards the ban. Furthermore, internal factors (such as income and satisfaction) and external family-related factors perturb their ban perception. This information can offer guidance on how future restrictive agricultural policies may be framed to avoid conflicting interests between policymakers and stakeholders. This also highlights the need to understand farmer perspectives and attitudes to gain critical information regarding technology adoption and development.

17.
Dissertation Abstracts International Section A: Humanities and Social Sciences ; 83(9-A):No Pagination Specified, 2022.
Article in English | APA PsycInfo | ID: covidwho-1929536

ABSTRACT

Leaders play an important role in guiding organizations through periods of disruptive change. With accelerating changes in technology, globalization, and the environment, leaders face significant challenges. Disruptive change places stress on employees and organizational cultures. Change situations have historically occurred due to diversity, increases or decreases in profitability, changes in management or leadership, or strategy changes. Change also takes place during growth or boundary expansion. Firms fail to survive following disruptive change due to their reactions at the point of disruptive change. This study was focused on determining leadership tenets that are effective based on the lived experiences of individuals who have led an organization through disruptive change. A qualitative case study using convenience sampling methods was used to explore the lived experiences of 9 individuals who led a hospital through a period of disruptive change due to Covid-19. Dealing with Covid-19 created negative emotions among staff members and the collective reaction to the human grieving process. Empathy, listening, foresight, and communication skills were required for leaders to assist staff members to overcome and eliminate these emotional challenges so they could operate effectively within the environment. Learning what these individuals found effective and ineffective can suggest developmental opportunities needed to improve practice. (PsycInfo Database Record (c) 2022 APA, all rights reserved)

18.
Asia-Pacific Social Science Review ; 22(1):78-91, 2022.
Article in English | Scopus | ID: covidwho-1929389

ABSTRACT

One fundamental healthcare issue brought to the fore by the current COVID-19 pandemic concerns the scope and nature of the right to healthcare. Given our increasing need for the usually limited healthcare resources, to what extent can we demand provision of these resources as a matter of right? One philosophical way of handling this issue is to clarify the nature of this right. Using the challenges of COVID-19 in the Philippines as the context of analysis, we argue for the view that regards the right to healthcare as fundamentally moral in kind, which should thereby guide its legal and contractual appropriations. In particular, we respond to objections against this view stemming from issues concerning the universality and satisfiability of the right’s correlative duty. We deal with such issues by invoking the relative degree of incumbency of moral rights and the capability-relativity of positive duties. We further contend that as these factors define the scope of the moral right to healthcare, they thus constrain what we can demand as a matter of right to meet our healthcare needs in this time of the pandemic. © 2022 by De La Salle University.

19.
Contemporary OB/GYN ; 67(7):3-3, 2022.
Article in English | CINAHL | ID: covidwho-1929325

ABSTRACT

The author discusses how events like the COVID-19 pandemic can intervene and cause patients to miss or skip yearly cancer screenings, thus losing an opportunity to detect an abnormality early. Topics covered include decrease in breast and cervical cancer screenings between 2018 and 2020, screening volumes among minorities, and how misdiagnosis can alter treatment.

20.
Preprint in English | bioRxiv | ID: ppbiorxiv-501169

ABSTRACT

Omicron BA.1 variant isolates were previously shown to replicate less effectively in interferon-competent cells and to be more sensitive to interferon treatment than a Delta isolate. Here, an Omicron BA.2 isolate displayed intermediate replication patterns in interferon-competent Caco-2-F03 cells when compared to BA.1 and Delta isolates. Moreover, BA.2 was less sensitive than BA.1 and similarly sensitive as Delta to betaferon treatment. Delta and BA.1 displayed similar sensitivity to the approved anti-SARS-CoV-2 drugs remdesivir, nirmatrelvir, EIDD-1931 (the active metabolite of molnupiravir) and the protease inhibitor aprotinin, whereas BA.2 was less sensitive than Delta and BA.1 to EIDD-1931, nirmatrelvir and aprotinin. Nirmatrelvir, EIDD-1931, and aprotinin (but not remdesivir) exerted synergistic antiviral activity in combination with betaferon, with some differences in the extent of synergism detected between the different SARS-CoV-2 variants. In conclusion, even closely related SARS-CoV-2 (sub)variants can differ in their biology and in their response to antiviral treatments. Betaferon combinations with nirmatrelvir and, in particular, with EIDD-1931 and aprotinin displayed high levels of synergism, which makes them strong candidates for clinical testing. Notably, effective antiviral combination therapies are desirable, as a higher efficacy is expected to reduce resistance formation.

SELECTION OF CITATIONS
SEARCH DETAIL