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1.
Germs ; 12(4):507-518, 2022.
Article in English | EMBASE | ID: covidwho-20234801

ABSTRACT

Introduction In this study, we aimed to monitor anti-spike and anti-nucleocapsid antibodies positivity in healthcare workers (HCWs) vaccinated with two doses of inactivated CoronaVac (Sinovac, China) vaccine. Methods Overall, 242 volunteer HCWs were included. Of the participants, 193 were HCWs without history of prior documented COVID-19 (Group 1), while 49 had history of prior documented COVID-19 before vaccination (Group 2). The participants were followed up for SARS-CoV-2 antibodies positivity at four different blood sampling time points (immediately before the second vaccine dose and at the 1st, 3rd months and 141-150 days after the second dose). We investigated the serum IgG class antibodies against SARS-CoV-2 RBD region and IgG class antibodies against SARS-CoV-2 nucleocapsid antigen by chemiluminescent microparticle immunoassay (CMIA) method using commercial kits. Results We found positive serum anti-RBD IgG antibody in 76.4% of the participants (71% in Group 1;98% in Group 2) 28 days after the first dose. When the antibody levels of the groups were compared at the four blood sampling time points, Group 2 anti-RBD IgG levels were found to be significantly higher than those in Group 1 at all follow-up time points. Although anti-RBD IgG positivity persisted in 95.6% of all participants in the last blood sampling time point, a significant decrease was observed in antibody levels compared to the previous blood sampling time point. Anti-nucleocapsid IgG antibody was positive in 12 (6.2%) of participants in Group 1 and 32 (65.3%) in Group 2 at day 28 after the first dose. At the fourth blood sampling time point, anti-nucleocapsid antibodies were found to be positive in a total of 20 (9.7%) subjects, 10 (6.1%) in Group 1 and 10 (23.8%) in Group 2. Conclusions In this study, it was determined that serum antibody levels decreased in both groups after the third month after the second dose in HCWs vaccinated with CoronaVac vaccine.Copyright © GERMS 2022.

2.
Advances in Gerontology ; 11(3):298-304, 2021.
Article in English | Scopus | ID: covidwho-1405217

ABSTRACT

Abstract: COVID-19 pandemic required compulsory social isolation;thus, people have been forced to stay at home for months in the most part of world. The curfew has been specially imposed to people aged 65 and above, who are supposedly most affected by devastating effects of COVID-19 disease in Turkey. However, the curfew could cause negative mental difficulties like depression tendency. We aimed to determine the depression tendency by using depression indicators such as insomnia, poor appetite, despair, weariness, anxiety/fear, dereliction, lack of concentration, anger and trashiness on curfew-imposed older people aged 65 and above during outbreak. The participants (n = 119) were the students of Tazelenme University, the university of third age (U3A), of Antalya Campus. The inter-cluster linkage method and the squared Euclidean distance measurement level were used to construct clusters. Frequency, percentage, t-test, Pearson correlation tests were used for further analysis of the clusters. Two clusters were recovered. Statistically significant differences were found between the two clusters by mean comparison values in relation to age, years of education and household factors. Participants of Cluster 2 (average age 64.40) appeared to be more affected and more tend to be depressive than participants of Cluster 1 (average age 68.61). The results indicated a relationship between curfew and depression tendency. © 2021, Pleiades Publishing, Ltd.

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