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1.
Journal of Pure & Applied Microbiology ; 16(4):2961-2967, 2022.
Article in English | Academic Search Complete | ID: covidwho-2156012

ABSTRACT

Acute Invasive Fungal Rhinosinusitis (AIFR) is a serious condition with aggressive course and high mortality rates. There is an upsurge in the incidence of invasive fungal rhinosinusitis in post COVID-19 patients. We have come across 20 AIFR cases in post COVID-19 patients. On retrospective exploration of the patient's records, we found that 30% patients had received steroids and 90% had diabetes. All the patients were managed by administration of Iv amphotericin B and local debridement of infected tissues. The mortality rate was as low as 15 %. We conclude that combined approach of Antifungal therapy with debridement of infected tissues improves the prognosis and survival of AIFR patients. [ FROM AUTHOR]

2.
Journal of Clinical and Diagnostic Research ; 16(9):EC41-EC46, 2022.
Article in English | EMBASE | ID: covidwho-2067190

ABSTRACT

Introduction: Coronavirus Disease 2019 (COVID-19) is an extremely transmissible infectious disease. Detection of coronavirus by Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) requires expert skills and moreover, it is not widely available in all the laboratories. Aim: To evaluate Red Blood Cell (RBC), platelet histogram and White Blood Cell (WBC) scattergram graphic patterns and interpretation of corresponding parameters along with peripheral smear in 500 COVID-19 RT-PCR positive study cases (COVID-19) and to compare them with normal study controls (non COVID-19). Materials and Methods: This was a laboratory-based observational study, conducted at a fully accredited National Accreditation Board for testing and calibration Laboratories’s (NABL) Central Diagnostic Research Laboratory, RL Jalapa Hospital Tamaka, Kolar, Karnataka, India from September 2020 to April 2021. RBC, platelet histogram, WBC scattergram graphic patterns with corresponding parameters were noted in RT-PCR COVID-19 positive patients and compared with controls using (Automated Haematology Analyser XN11500). Cases were further subcategorised into moderate and severe categories. For statistical analysis, Chi-square test or Fisher’s exact test, Independent t test was used for assessing qualitative and quantitative data respectively. Mean and standard deviation were depicted in box plots. Receiver Operating Characteristic (ROC) curve was used for predicting severity. A p-value <0.05 was considered statistically significant. results: Among 500 subjects, males were 359 and females 141 with the mean age 50.5 years. Present study showed a characteristic finding of “sandglass” effect in WBC scattergram which is described as discontinuous cluster of plasmacytoid lymphocytes. RBC histogram and parameters did not show any significant changes. In severe COVID-19 cases among WBC parameters most common finding was neutrophilia. Platelet Lymphocyte Ratio (PLR), Platelet Monocyte Ratio (PMR), Platelet Neutrophil Ratio (PNR) were statistically significant in severe COVID-19 cases (p-value <0.001) corresponding ROC curve for WBC and platelet showed WBC count and PLR as the significant parameter in severe COVID-19 positive cases. conclusion: Current study reported a specific and unique sandglass effect in WBC scattergram in severe COVID-19 subjects which can help the physicians for predicting the severity of disease and to prevent further pro ression of disease

3.
Journal of Clinical and Diagnostic Research ; 16(5):27-31, 2022.
Article in English | EMBASE | ID: covidwho-1863297

ABSTRACT

Introduction: Focus of Blood transfusion services is continuous, judicious and well-timed supply of safe Blood. The Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2) pandemic has caused the major disruption throughout the world and declaration of nationwide lockdown by Government of India from 25th March 2020 to 31st May 2020 to halt the spread of virus has afflicted the blood bank services enormously. Aim: To keep the focal point on approaches implemented for safe blood transfusion services during Coronavirus Disease-2019 (COVID-19) pandemic in rural blood bank and to observe how COVID-19 pandemic has affected blood transfusion services in year 2020 with regards to blood collection, supply and organization of camps as compared to year 2019. Materials and Methods: A retrospective study was done in the Blood Bank in a rural tertiary care hospital in Southern India, from January 2019 to December 2020. Various measures were implemented to increase the donor safety and prevention of spread to community and to increase the number of voluntary donors. Statistical analysis performed using Statistical Package for Social Sciences (SPSS) software version 21.0. All data was entered and tabulated in excel sheet. A two sided t-test was utilized for comparing dual variables and one sided Analysis of Variance (ANOVA) for multiple variables. The p-value <0.05 was considered significant. Results: Mean number of units received during pre-COVID-19 year were significantly higher (4468±4127.2) as compared to COVID-19 year 2020 (2282±1856.4) with significant p-value <0.001. Overall utilisation of Packed Red Blood Cell (PRBC) (0.001), Human Platelets (Single Donor Platelets (SDP)/Random Donor platelets (RDP)) p-value 0.003,Fresh Frozen Plasma) FFP (p-value 0.001) was significantly higher in pre-COVID-19 year as compared to COVID-19 year 2020. Total number of camps conducted in pre-COVID-19 year was 41 as compared to 23 in COVID-19 year 2020. Patients deferred for blood donation were much higher in COVID-19 year 2020 (n=400) with maximum (32.5%) under category of self-deferral due to clinical illness as compared to year 2019 (n=200). Conclusion: As a result of our strict and effective implementation of COVID-19 safety protocols, no donor had complained of post donation COVID related symptoms and none of our blood bank staff had developed any COVID-19 related illness. Hence during the COVID-19 pandemic, our blood bank maintained 100% attendance (with staggered duty hours).

5.
Indian Journal of Hematology and Blood Transfusion ; 37(SUPPL 1):S122, 2021.
Article in English | EMBASE | ID: covidwho-1631513

ABSTRACT

Introduction: Coronavirus disease 2019 (COVID-19) is extremelytransmissible infectious disease caused by severe acute respiratorysyndrome coronavirus 2 (SARS-CoV-2). Detection of Coronavirus byRT-PCR is the primary method which requires expert skills. RT-PCRtest is not widely available in all the laboratories. Cost effectivescreening of COVID-19 could be possible with the automated analysers which may provide a hint for early diagnosis. Histogramanalysis is neglected part of the automated haemogram when interpreted efficaciously has noteworthy capacity to contribute fordiagnostically pertinent information before higher level investigationsare requested.Aims &Objectives: The aim of this study is to evaluate RBC andplatelet histogram graphic patterns, WBC scattergram alongwithplatelet indices in 500 COVID RT-PCR positive cases and comparedwith 500 controls.Materials &Methods: Laboratory Based Observational study.Duration: September 2020 to March 2021. RBC and platelet histogram, WBC scattergram graphic patterns along with platelet indiceswere noted in RT-PCR COVID-19 positive patients and comparedwith normal subjects utilizing automated haematology analyser XN11,500.Result: WBC scattergram and Histogram most of the COVID positivecases showed neutrophilia (96).Conclusions: Interpretation of the alteration in RBC and platelethistogram, WBC scattergram and Platelet indices in SARS-CoV-2infected patients can contribute timely clues for diagnosis and mayhelp in predicting the prognosis.

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