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1.
Open Access Macedonian Journal of Medical Sciences ; 10:1698-1705, 2022.
Article in English | EMBASE | ID: covidwho-2066674

ABSTRACT

BACKGROUND: The rapid worldwide spread of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) or COVID-19 pandemic from its epicenter;Wuhan was first reported in December 2019. Egypt reported its first COVID-19 case on February 14, 2020. Thereafter, Egypt scaled-up preventive measures, with a partial lockdown starting on March 25. Several therapeutic agents along with convalescent plasma transfusion (CPT) are under investigation and data from CPTs have been receiving a lot of attention, after Emergency approvals from the Food and Drug Administration suggesting that it may provide a clinical effect in the treatment of SARS-COV-2. IMPORTANCE: Early and effective treatment of COVID-19 is vital for control of SARS-CoV-2 infection. METHODS: Designs: An interventional, single-arm, and non-randomized clinical trial conducted in Egypt from April 15 to July 21, 2020. Settings: This was a multi-center study conducted in three hospitals in Egypt. Participants: A total of 94 COVID-19 laboratory-confirmed patients using quantitative real-time polymerase chain reaction were enrolled in the study. Intervention: All patients were administered with two plasma units (each unit is 200 cc). The volume of donated plasma was 800 cc. Main Outcome and measures: Primary measure was the degree of clinical improvement among the COVID-19 patients who received CPT within 7 days. RESULTS: A total of 94 patients were enrolled who received CPT either within 7 days or after 7 days of hospitalization. 82 were severely ill and 12 were critically ill. The average age remained 58 years (±standard deviation 15.1 years). Male were 69% and 49% patients got cured while 51% died with case fatality rate 51%. Seventy-five percent deaths were above 45 years of age. The symptoms were dyspnea (55%), fever (52%), cough (46%), and loss of taste and smell (21%), and cyanosis (15%). The most common co-morbidities among the <40 years remained diabetes mellitus (21%) and asthma (14%). Among 40–60 years hypertension (56%), diabetes mellitus (39%) and among >60 years age group hypertension (57%), and chronic heart disease (24%) were reported. CPT within 7 days remained significant as compared with the CPT after 7 days with the number of days to cure (p=0.007) and ICU stay (p = 0.008) among severely ill cured cases. CONCLUSIONS: Among patients with COVID-19 and severe or critical illness, the use of CPT along with routine standard therapy resulted in a statistically significant improvement when administered within seven days of hospital admission. However, plasma transfusion, irrespective of days to transfusion may not help treat critically ill patients. The overall mean time to cure in severely ill patients was 15 days if CPT provided within 7 days with 65% cure rate. TRIAL REGISTRATION: Clinical Intervention identifier: MOHP_COVID-19_Ver1.1 registered April 2020.

2.
Construction Economics and Building ; 22(3):21-42, 2022.
Article in English | Scopus | ID: covidwho-2055995

ABSTRACT

Malaysia has seen the third wave of infection since the start of the global COVID-19 pandemic, with approximately 103 construction sites involving over 14,677 workers reported from April 2020 to February 2021. This has led to limited progress in construction projects or a complete halt, resulting in late project delivery. The purpose of this paper is to investigate the factors influencing the spread of COVID-19 and the strategies taken by the affected construction sites to mitigate the spread of the outbreak. The researchers adopted a case study approach with a multiple-case design and discusses the use of an in-depth interviewing method to collect rich data on the studied phenomenon. Data collected from three construction sites. The sites were mixed development projects in nature and provided in-depth, rigorous, and robust information. Based on the results, two categories of factors influencing the spread of COVID-19 were established. These are primary and secondary factors, such as workers’ mobilisation, uncontrolled movement of workers, and the limited practice of social distancing. Furthermore, evidence suggests that the strategies adopted to control the effects of the pandemic were a combination of government enforcement and initiatives taken by construction companies. This paper concludes that an early identification of the causes of the spread will enable appropriate implementation strategies to control the outbreak. This study is an attempt to present the experiences of one developing country as an example of a means of dealing with unexpected pandemics or other intractable diseases that can affect project delivery. © 2022 by the author(s).

3.
American Journal of Neuroradiology ; 43(8):1180-1183, 2022.
Article in English | EMBASE | ID: covidwho-2005845

ABSTRACT

This study aimed to assess the utility of DTI in the detection of olfactory bulb dysfunction in COVID-19-related anosmia. It was performed in 62 patients with COVID-19-related anosmia and 23 controls. The mean diffusivity and fractional anisotropy were calculated by 2 readers. The difference between the fractional anisotropy and mean diffusivity values of anosmic and control olfactory bulbs was statistically significant (P =.001). The threshold of fractional anisotropy and mean diffusivity to differentiate a diseased from normal olfactory bulb were 0.22 and 1.5, with sensitivities of 84.4% and 96.8%, respectively, and a specificity of 100%

4.
Open Access Macedonian Journal of Medical Sciences ; 9:1068-1075, 2021.
Article in English | EMBASE | ID: covidwho-1534294

ABSTRACT

AIM: We evaluated in this study the demographic and clinical characteristics of COVID-19 disease in the Egyptian population with special consideration for its mortality predictors. METHODS: About 8162 participants (mean age 48.7 ± 17.3 years, 54.5% males) with RT-PCR positive COVID-19 were included. The electronic medical records were reviewed for demographic, clinical, laboratory, and radiologic features. The primary outcome was the in-hospital mortality rate. RESULTS: The in-hospital mortality was 11.2%. There was a statistically significant strong association of in-hospital mortality with age >60-years-old (OR: 4.7;95% CI 4.1–5.4;p < 0.001), diabetes mellitus (OR: 4.6;95% CI 3.99–5.32;p <0.001), hypertension (OR: 3.9;95% CI 3.4–4.5;p < 0.001), coronary artery disease (OR: 2.7;95% CI 2.2–3.2;p < 0.001), chronic obstructive pulmonary disease (OR: 2.1;95% CI 1.7–2.5;p < 0.001), chronic kidney disease (OR: 4.8;95% CI 3.9–5.9;p < 0.001), malignancy (OR: 3.7;95% CI 2.3–5.75;p < 0.001), neutrophil-lymphocyte ratio >3.1 (OR: 6.4;95% CI 4.4–9.5;p < 0.001), and ground glass opacities (GGOs) in CT chest (OR: 3.5;95% CI 2.84–4.4;p < 0.001), respectively. There was a statistically significant moderate association of in-hospital mortality with male gender (OR: 1.6;95% CI 1.38–1.83;p < 0.001) and smoking (OR: 1.6;95% CI 1.3–1.9;p < 0.001). GGOs was reported as the most common CT finding (occurred in 73.1% of the study participants). CONCLUSION: This multicenter, retrospective study ascertained the higher in-hospital mortality rate in Egyptian COVID-19 patients with different comorbidities.

5.
Journal of Pediatric Infectious Diseases ; : 5, 2021.
Article in English | Web of Science | ID: covidwho-1087527

ABSTRACT

Objective The novel coronavirus disease 2019 (COVID-19) has made its worldwide spread since its outbreak in December 2019. Limited information is available about the epidemiology and clinical characteristics of COVID-19, especially in Africa and Egypt. Methods We aimed to study the clinical and epidemiological characteristics of COVID-19 in Egyptian children. This is an observational retrospective cohort study performed at two specialized COVID-19 isolation hospitals in Egypt. All admitted COVID-19 pediatric patients between March 20, 2020, and May 1, 2020, were included in the study. Discussion This study included 40 COVID-19 confirmed cases (mean age, 9.4 years), 67.5% were male, 85% were asymptomatic, and 15% had mild symptoms. There were no confirmed severe or critically ill cases among the patients. Conclusion COVID-19 runs in a benign course in Egyptian children with no mortality and no significant morbidity.

6.
Ain Shams Journal of Anesthesiology ; 12(1):9, 2020.
Article in English | Web of Science | ID: covidwho-975937

ABSTRACT

New corona virus disease COVID-19 is a pandemic outbreak viral infection that is highly contagious. The disease can affect any age groups. Majority of patients show mild or no symptoms. Immunocompromised patients and patients with co-morbidities are more vulnerable to have more aggressive affection with higher rate of complications. Thus, cancer patients carry a higher risk of infection. Diseased patient can transmit infection throughout the disease course starting from the incubation period to clinical recovery. All healthcare workers contacting COVID-19-positive patients are at great risk of infection, especially the anesthesiologists who can be exposed to high viral load during airway manipulation. In the National Cancer Institute of Egypt, we apply a protocol to prioritize cases where elective cancer surgeries that would not affect patient prognosis and outcome are postponed during the early phase and peak of the pandemic till reaching a plateau. However, emergency and urgent surgeries that can compromise cancer patient's life and prognosis take place after the proper assessment of the patient's condition. Aim This review aims to spot the management of cancer patients undergoing surgery during the COVID-19 pandemic in the National Cancer Institute, Egypt.

7.
Advances in Science, Technology and Engineering Systems ; 5(5):973-983, 2020.
Article in English | Scopus | ID: covidwho-954477

ABSTRACT

The Covid-19 is a pandemic issue that is causing widespread global disruption forcing lockdowns in many countries including Malaysia as an effort in disconnecting the virus from spreading. As an initiative, the Malaysia government has call for the Movement Control Order (MCO) as one of the lockdown alternatives starting on 18th March 2020. Due to that, the MCO has given a huge impact on Malaysia’s industries including the construction industry. Hence, to successfully deliver projects, time and cost become the essential component which in this current scenario, most of the on-going projects declined to deliver the project according to the time and cost as planned. Thus, this paper intends to explore the consequences of the Movement Control Order (MCO) towards project success. In getting an authentic data and fast feedback from the respondents during this current scenario, uses alternate methods as face to face interview is not encouraged. The interview sessions were held thru telephone conversation with 8 contractors in Klang Valley and Penang which randomly selected based on contractor listing in Malaysian Construction Industry Development Board (CIDB) website and content analysis are used to figure out the main consequences using Nvivo software. Results from the interviews found that the MCO has resulted in 6 main impacts consists of (1) regulation compliance;(2) safety;(3) additional time for project delivery;(4) increase in development cost;(5) limited human resources supplies;and (6) limited resource availability on-site. These shows the MCO has given the negative impact to the project success. This result is important for the government to ensure their awareness on the consequences of the MCO towards construction industry and facilitate the construction players to overcome the six factors mentioned in this paper. © 2020 ASTES Publishers. All rights reserved.

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