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Journal of Bacteriology and Virology ; 51(3):89-102, 2021.
Article in English | Scopus | ID: covidwho-1538679


The ongoing coronavirus disease-2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus-2. COVID-19 severity is related to the cytokine storm phenomenon, which is amplified by pro-inflammatory cytokines and chemokines;it may cause extensive pulmonary damage. Among these cytokines, interleukin (IL)-17, produced mainly by T helper 17 (Th17) cells, is responsible for the immunopathological responses present in acute respiratory distress syndrome. This review discusses the roles of IL-17 and Th17 responses in the pathophysiology of COVID-19. Dysregulated Th17-responses, linked to various risk factors, may contribute to pathological inflammation through the amplification of multiple inflammatory cytokines and chemokines, as well as augmentation of neutrophil infiltration in the lungs of severe COVID-19 patients. A more detailed understanding of the roles of Th17 responses, as well as the mechanisms underlying altered IL-17 production and signaling, may improve therapeutic strategies for severe or critically ill COVID-19 patients by targeting the IL-17 pathway. © 2021 Journal of Bacteriology and Virology.

Academic Journal of Second Military Medical University ; 41(10):1142-1147, 2020.
Article in Chinese | Scopus | ID: covidwho-971176


Epidemic infectious diseases have become a major threat to public health safety. This paper reviews the previous researches and analyzes the psychological impact of infectious disease outbreak on medical staff, patients and the public, exploring the risk and protective factors of adverse psychological reactions, so as to provide references for future research and counseling after coronavirus disease 2019 outbreak. It is suggested that multi-center and large-scale follow-up investigation is needed, and more attention needs to be paid on influences of stigma and public opinion on internet and the change of positive psychological quality after the epidemic outbreak. Moreover, the research results of risk and protective factors should be fully used in psychological intervention. © 2020 Second Military Medical University Press. All rights reserved.