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Journal of Pediatric Infectious Diseases ; 2022.
Article in English | EMBASE | ID: covidwho-1956443


Objective: Multisystem inflammatory syndrome in children (MIS-C) is a hyperinflammatory syndrome associated with multiorgan damage that occurs following coronavirus disease 2019 (COVID-19). Research on clinical and laboratory findings, and imaging studies, aiming to predict the progression to severe disease state is limited. This study recruited patients with MIS-C who presented with mild or severe symptoms from a single center in Turkey and evaluated factors related to their symptoms. Methods: This retrospective study included 25 pediatric patients with mild and severe presentations of MIS-C. We explored the differences in demographic and clinical data on clinical severity to understand their possible diagnostic and prognostic values. Results: Patients with MIS-C had cardiovascular symptoms (68%), gastrointestinal symptoms (64%), dermatologic/mucocutaneous findings (64%), lung involvement (36%), and neurological symptoms (16.0%). About 45.1% of patients with MIS-C had manifestations that overlapped with Kawasaki disease. Eleven patients (44%) were admitted to the intensive care unit, and one (4%) patient died. Grouping based on clinical severity did not differ statistically in terms of gender, age, height, weight, body mass index, and duration of hospital stay. Procalcitonin and ferritin levels correlated with disease severity. The receiver operating characteristic curve for D-dimer gave the highest value of area under the curve, among other biomarkers. The cutoff value for D-dimer was determined as more than 6780. Conclusions: Although COVID-19 is usually mild in children, some can be severely affected, and clinical severity in MIS-C can differ from mild to severe multisystem involvement. This study shows that procalcitonin, ferritin, and D-dimer levels may give us information about disease severity.

Southern Clinics of Istanbul Eurasia ; 31(Suppl. 1):48-51, 2020.
Article in Turkish | CAB Abstracts | ID: covidwho-1264699


Coronavirus disease 2019 (COVID-19) was first reported in December 2019 from Wuhan-China. The disease has spread over the World in a few months. On 11 March 2020, it was declared as pandemic by the World Health Organization (WHO). COVID-19 usually causes mild upper respiratory disease or pneumonia. In general, COVID-19 seems to be a less aggressive disease in children compared to adults. Ninety percent of pediatric cases have asymptomatic, mild or moderate disease. Despite several published pediatric reports, the epidemiological, clinical patterns and the treatment approach in pediatric patients with COVID-19 are still uncertain. In this review, we aimed to summarize the epidemiology, clinical course and the diagnosis of COVID-19 in children.

Guncel Pediatri ; 19(1):9-14, 2021.
Article in English | Scopus | ID: covidwho-1210303


Introduction:Vitamin D is known as a vitamin but also it acts as a prohormone and has many functions. The aim of this study is to investigate the vitamin D levels in pediatric patients with COVID-19. Materials and Methods: A retrospective study was performed in a tertiary education and research hospital in Istanbul, Turkey during the period of Marcht o April 2020. Children diagnosed with symptomatic COVID-19 infection were included in the study. Demographic, clinical and laboratory findings were recorded from patient charts retrospectively. All patients investigated for vitamin D levels. Control group consists of healthy children admitted to pediatric outpatient units for routine check-up in the same season.Thirty children with COVID-19 and 82 healthy children included in this study were compared due to 25-OH vitamin D levels. Results: The median age of COVID-19 positive patients was 11.8 (1.8-17.6) years and the median age of control group was 12.7 (1-16.4) years old. There were 15 (50%) females and 15 (50%) males in infected group and there were 39 (47.5%) females and 43 (52.5%) males control group. Age and gender did not differ among the groups. Median vitamin D level in COVID-19 positive group was 8.9 ng/ml (342 ng/ml) and 18.5 ng/ml (9-40.7 ng/ml) in control group. We detected significantly lower vitamin D values in COVID19(+) group when compared with control group (p<0.001). CT was performed 19 patients in COVID-19 positive group and viral pneumonia was detected in 12(63%) of 19. pneumonia (+) group a 17.4-years-old female patient and a 13.1-years-old male patient had low phosphorus levels by age (2.2 and 2.4 mg/dl). Both of them needed high flow oxygen therapy. None of the other cases needed oxygen therapy. Conclusions: This is the first study to date has measured vitamin D levels in children with COVID-19 in Turkey. We detected significantly lower vitamin D values in COVID-19(+) hospitalized children. © 2021, Galenos. All rights reserved.