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Klimik Dergisi ; 35(3):179-185, 2022.
Article in Turkish | EMBASE | ID: covidwho-2081563


Objectives: The probability of detecting viral and atypical agents in pneumonia patients has increased with the molecular methods used in recent years. We aimed to investigate pneumonia pathogens in endotracheal aspiration samples (ETA) of patients with severe community-acquired (CAP), hospital-acquired pneumonia (HAP), and ventilator-asso-ciated pneumonia (VAP) by multiplex polymerase chain reaction (m-PCR) and culture method. Method(s): A prospective study was performed between December 2019 and October 2020. Patients 18 years and older with pneumonia followed in ICU on the mechanical ventilator were included. COVID-19 patients were excluded. Patients were grouped as CAP, HAP, and VAP. Two ETA samples were obtained from patients within 48 hours of the pneumonia diagnosis. Respiratory pathogens were investigated in samples by viral-bacterial m-PCR and bacterial culture methods. Result(s): 74 patients were included in the study. m-PCR of ETA samples achieved pathogen detection in 87.8% of patients compared with 58.1% with culture methods. The most common pathogen detected by m-PCR was Streptococcus pneumoniae in both CAP and HAP patients and Klebsiella spp. in VAP patients. The most common pathogen isolated by culture was Staphylococcus aureus in both CAP and HAP patients and Klebsiella spp. in VAP patients. Atypical pneumonia pathogens were positive for 14.9% of the patients. Atypical pathogens were recovered from 28.5% of CAP patients and 23.1% of HAP patients. Viruses constituted all of the atypical pathogens recovered from HAP patients. No atypical pathogen was found in VAP patients. Conclusion(s): In this study, S. pneumoniae was the most common pathogen detected with m-PCR, and S. aureus and Kleb-siella spp. were the most common pathogens detected with culture. Determination of microbial etiology of lower respiratory tract samples by molecular methods for diagnosing severe CAP and HAP may be beneficial in terms of treatment. Copyright © 2022, DOC Design and Informatics Co. Ltd.. All rights reserved.

Medical Science ; 26(121):8, 2022.
Article in English | Web of Science | ID: covidwho-1812228


Background: The lack of an effective antiviral treatment in the COVID 19 pandemic is increasing the importance of vaccines day by day. Materials and Methods: The study was scheduled between October 1, 2021 and January 7, 2022. COVID-19 PCR negative cases, cases whose vaccine information could not be reached, and cases under 18 years of age were excluded from the study. The cases in the service and the ICU, the cases that died and did not die during the follow-up in the ICU, and the vaccinated and unvaccinated cases were compared among themselves by dividing them into two groups. Results: The mean age, presence of comorbid conditions, length of stay, time elapsed after the last dose of vaccine and some laboratory values were found to be higher in ICU cases than in cases hospitalized in the service. The mean age and intubation rate were higher in the patients who died in the ICU compared to the survivors. The intubation rate was higher and the length of stay in the ICU was longer in unvaccinated cases compared to vaccinated cases. Conclusion: in our study, it was determined that the COVID 19 vaccines reduced the hospitalization of the patients in the early age groups, the length of stay in the ICU, and the admission to intubation. The reason for the significant difference in terms of mortality was thought to be due to the excess of comorbid conditions and higher average age in vaccinated cases.