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Asian Pacific Journal of Tropical Medicine ; 15(11):479-484, 2022.
Article in English | GIM | ID: covidwho-2163868


Objective: To determine post-discharge mortality and associated factors of the first-wave multicenter Turkish Thoracic Society (TTD)-TURCOVID study.

European Respiratory Journal ; 58:2, 2021.
Article in English | Web of Science | ID: covidwho-1705016
Flora Infeksiyon Hastaliklari Ve Klinik Mikrobiyoloji Dergisi ; 26(2):238-248, 2021.
Article in Turkish | Web of Science | ID: covidwho-1524408


Introduction: COVID-19 can cause acute respiratory failure, metabolic acidosis, coagulopathy, septic shock, and death in older adults. The timely identification of at-risk patients will facilitate early intensive care intervention. Therefore, this study aimed to investigate the prognostic factors of COVID-19 in geriatric patients, a group shown to have higher mortality risk. Materials and Methods: A total of 61 patients over 65 years of age with presumed COVID-19 were included in the study. Patients' demographic characteristics, chest computed tomography findings at admission, biomarkers such as neutrophil/lymphocyte ratio (NLR), hemoglobin (g/dL), platelet count (109/L), alanine aminotransferase (ALT) (U/L), aspartate aminotransferase (AST) (U/L), total bilirubin (mg/dL), direct bilirubin (mg/dL), lactate dehydrogenase (LDH) (U/L), creatine kinase (CK) (U/L), blood urea nitrogen (BUN) (mg/dL), creatinine (mg/dL), albumin (mg/dL), D-dimer (ng/mL), ferritin (ng/mL), troponin (ng/mL), C-reactive protein (CRP) (mg/L), and procalcitonin (PCT) (ng/mL), complications during follow-up, and treatments received were recorded retrospectively from patient files and electronic records. Results: Mean age was 71.13 +/- 7.68 years, and 32 (52.5%) of the patients were males. During hospitalization, 18 patients (29.5%) were admitted to the intensive care unit and 10 (16.4%) died. Non-surviving patients were significantly older. Mean admitting NLR, LDH, CK, BUN, creatinine, troponin, D-dimer, CRP, and procalcitonin values were higher and mean albumin level was lower among the non-surviving patients. A Cox regression model based on variables associated with significantly prolonged hospital length of stay showed that highest NLR during follow-up was an independent risk factor for mortality and increased the risk of death by 10.67 times (95% Confidence Interval: 1.183-96.309) (p= 0.035). Conclusion: Highest NLR was found to be an independent risk factor for mortality and was associated with a 10-fold higher risk of death. Close monitoring and comprehensive treatment are required to reduce mortality in these patients.

Flora ; 26(3):410-418, 2021.
Article in Turkish | EMBASE | ID: covidwho-1478356


Introduction: To date, over 165 million people have been infected in the COVID-19 pandemic caused by the novel coronavirus SARS-CoV-2 which emerged in Wuhan, China in December 2019. This study examined the relation between serum monocyte chemoattractant protein-1 and surfactant protein-A levels and the clinical course and prognosis of COVID-19. Materials and Methods: The study included a total of 108 subjects. Those in the patient group (n= 88) were diagnosed with COVID-19 using real-time PCR analysis of nasopharyngeal swab samples and treated in the Pulmonary Diseases Intensive Care Unit and the Infectious Diseases Department between March 24 and May 20. The control group (n= 20) included asymptomatic healthcare workers whose real-time PCR results during routine COVID-19 screening in our hospital were negative. Results: The COVID-19 patient group had significantly higher monocyte chemoattractant protein-1 and SP-A levels compared to the control group (p= 0.001, p= 0.001). Patients who developed macrophage activation syndrome had significantly higher monocyte chemoattractant protein-1 and surfactant protein-A levels than those who did not both at admission (p= 0.001, p= 0.001) and on day 5 of treatment (p= 0.05, p= 0.04). Similarly, monocyte chemoattractant protein-1 and surfactant protein-A levels were significantly higher in patients who developed acute respiratory distress syndrome compared to those who did not at both time points (p= 0.001 for all). Both parameters were significantly higher in non-surviving COVID-19 patients compared to survivors (p= 0.001 for both). Conclusion: Monocyte chemoattractant protein-1 and surfactant protein-A are on opposing sides of the inflammatory balance, and SP-A may be a pneumoprotein of importance in the presentation, course, prognosis, and possibly the treatment of COVID-19 in the future.