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1.
Journal of Advanced Biotechnology and Experimental Therapeutics ; 3(Special Issue 4):76-96, 2020.
Article | WHO COVID | ID: covidwho-1209789

ABSTRACT

Coronaviruses are endemic in humans and infections typically mild, such as the common cold Still, the cross-species transmission has produced some unusually ICLE virulent strains which now causing viral pneumonia, in severe cases, even acute respiratory distress syndrome and death SARS-CoV-2 is the most threatening issue which leads the world to an uncertainty alongside thousands of regular death scenes An effective vaccine to cure this virus is not yet available, so it requires concerted efforts at various scales The viral Main Protease controls coronavirus replication and is a proven drug discovery target for SARS-CoV-2 Comprehensive computational study e g , molecular docking and ADMET (absorption, distribution, metabolism and excretion) profiling were employed to predict the efficacy of medicinal plant-based bioactive compounds against SARS-CoV-2 MPP Paritaprevir and lopinavir-previously approved viral main protease inhibitors were used as standards for comparison MPP was docked with 90 phytochemical compounds, and the screening revealed that four compounds (azadirachtin,-12 5 kcal/mol;rutin,-9 kcal/mol;theaflavin,-9 kcal/mol;astragalin,-8 8 kcal/mol) showed the highest binding affinity than the controls paritaprevir and lopinavir (-8 7 and-7 9 kcal/mol, respectively) Comparative structural analysis of protein-inhibitor complexes revealed that the compounds have intense interaction with the vital catalytic residue His-41 and Cys-145 Furthermore, the pharmaco-kinetics and drug-likeness properties of the antiviral phytochemicals suggested that the compounds do not have any considerable detrimental effects and can be considered potential drug candidates against SARS-CoV-2 These compounds can be further explored for in vitro experimental validation against SARS-CoV-2 © 2020, Bangladesh Society for Microbiology, Immunology and Advanced Biotechnology All rights reserved

2.
Cureus ; 13(3):3, 2021.
Article | WHO COVID | ID: covidwho-1200343

ABSTRACT

Multiple neurological complications, including Guillain-Barre syndrome (GBS), have been reported in association with the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak GBS has well-known associations with viruses such as influenza, human immunodeficiency virus, Zika, severe acute respiratory syndrome, Middle East respiratory syndrome, Epstein-Barr virus, and cytomegalovirus Till date, there have been around 50 distinct published cases of GBS occurring concurrently or shortly after SARS-CoV-2 infection This report describes the case of a 53-year-old male who presented with bilateral extremity paresthesias two weeks after a positive SARS-CoV-2 test His symptoms were originally thought to be due to underlying diabetic peripheral neuropathy, but as they progressed, he was eventually diagnosed with SARS-CoV-2-associated GBS Though GBS may not be a common sequelae of SARS-CoV-2 infection, the prevalence of diabetes mellitus-associated peripheral neuropathy is high enough to warrant awareness and prompt recognition of neurological symptoms that deviate from the baseline in individuals with recent, confirmed SARS-CoV-2 infection

3.
Nutrition Clinique et Metabolisme ; 35(1):37-37, 2021.
Article | WHO COVID | ID: covidwho-1188925

ABSTRACT

L'épidémie de coronavirus-2 du syndrome respiratoire aigu sévère (SRAS-CoV-2), à l'origine de la maladie à coronavirus 2019 (COVID-19), présente une menace importante et urgente pour la santé mondiale Cette infection virale alarmante, déclarée pandémique par l'OMS en février 2020, a entraîné des millions de patients infectés et des milliers de morts dans le monde Au Maroc, malgré les efforts fournis par les autorités, le SRAS-CoV-2 continue de se propager et constitue un fardeau de morbidité et de mortalité L'objectif de cette étude est de décrire les caractéristiques cliniques des patients marocains COVID-19 et d'établir la relation entre des symptômes cliniques spécifiques, à savoir l'agueusie et/ou l'anosmie, avec ces caractéristiques Nous avons réalisé une étude transversale descriptive et non interventionnelle analysant les données de 108 patients admis à la clinique VINCI, Casablanca (Maroc) La base de données porte sur 39 paramètres comprenant des caractéristiques épidémiologiques, des mesures anthropométriques et des analyses biologiques La moyenne d'âge des patients était de 43,35 ± 15,75 ans avec une sex-ratio de 1 :1 L'indice de masse corporelle moyen des patients était de 25,54 ± 4,66 kg/m2 La majorité des patients présentaient au moins une comorbidité et parmi les 75 % des cas symptomatiques, environ 50 % présentaient au moins trois symptômes à savoir : fièvre (40,7 %), toux (39,8 %), myalgie (28,7 %) et anosmie et/ou agueusie (20,4 %) À partir des analyses biologiques, nous avons remarqué une lymphopénie et une élévation des taux de protéine C réactive et du lactate déshydrogénases chez 24,1 %, 36,1 % et 35,2 % des sujets, respectivement Une perturbation des marqueurs de la fonction hépatique a été observée dans 15,7 % des cas Pour les autres paramètres d'hémostase, des taux élevés de prothrombine et de plaquettes ont été rapportés respectivement chez 14,6 % et 14,8 % des patients Les comparaisons liées à la présence d'anosmie et/ou d'agueusie n'ont pas montré de différence pour les caractéristiques démographiques et anthropométriques, alors qu'une possibilité de différence significative a été révélée pour certains paramètres biologiques, en particulier les taux de lymphocytes, de D-dimère et de troponine Cette étude fournit des résultats significatifs qui seront utilisés non seulement pour compléter les études précédentes menées au Maroc afin de reprendre la situation épidémiologique par rapport à d'autres pays, mais aussi pour améliorer la qualité du diagnostic des patients COVID-19 en identifiant tous les symptômes de la maladie et pour une meilleure compréhension de ses résultats cliniques [ABSTRACT FROM AUTHOR] Copyright of Nutrition Clinique et Metabolisme is the property of Elsevier B V and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission However, users may print, download, or email articles for individual use This abstract may be abridged No warranty is given about the accuracy of the copy Users should refer to the original published version of the material for the full abstract (Copyright applies to all Abstracts )

4.
Pakistan Journal of Pharmaceutical Sciences ; 34(1):345-352, 2021.
Article | WHO COVID | ID: covidwho-1187261

ABSTRACT

SARS-CoV-2, a new world coronavirus belonging to class Nidovirales of Coronaviridae family causes COVID-19 infection which is the leading cause of death worldwide Currently there are no approved drugs and vaccines available for the prevention of COVID-19 infection, although couples of immunizations are being tested in clinical trials However, the present efforts are focused on computational vaccination technique for evaluating candidates to design multi-epitope-based vaccine against pathogenic mechanism of novel SARS-COV-2 Based on recent published evidence, we recognized spike glycoprotein and envelope small membrane protein are the potential targets to combat the pathogenic mechanism of SARS-CoV-2 Similarly, in the present study we identified epitope of both B and T cell associated with these proteins Extremely antigenic, conserve, immunogenic and nontoxic epitope of B and T cell of Spike protein are WPWYVWLGFI, SRVKNLNSSEGVPDLLV whereas the CWCARPTCIK and YCCNIVNVSL are associated with envelope small membrane protein were selected as potential candidate for vaccine designing These epitopes show virtuous interaction with HLAA0201 during molecular docking analysis Under simulation protocol the predicted vaccine candidates show stability Collectively, this work provides novel potential candidates for epitope-based vaccine designing against COVID-19 infection

5.
ACS Pharmacology and Translational Science ; 2021.
Article | WHO COVID | ID: covidwho-1182796

ABSTRACT

For the first time, it is shown that severe COVID-19 associated genes (CCR2, DPP9, HSPA1L, TYK2, OAS1, ACE2, and TMPRSS2) were also upregulated in the brain tissue of chronic alcoholics It is proposed that chronic alcohol abuse should be considered as an important factor in COVID-19-associated neurological complications © 2021 American Chemical Society

6.
Infectious Diseases in Clinical Practice ; 29(2):E129-E130, 2021.
Article | WHO COVID | ID: covidwho-1173264
8.
Journal of Cell Signaling ; 2(1):63-79, 2021.
Article | WHO COVID | ID: covidwho-1151295

ABSTRACT

The outbreak of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has led to coronavirus disease-19 (COVID-19);a pandemic disease that has resulted in devastating social, economic, morbidity and mortality burdens SARS-CoV-2 infects cells following receptor-mediated endocytosis and priming by cellular proteases Following uptake, SARS-CoV-2 replicates in autophagosome-like structures in the cytosol following its escape from endolysosomes Accordingly, the greater endolysosome pathway including autophagosomes and the mTOR sensor may be targets for therapeutic interventions against SARS-CoV-2 infection and COVID-19 pathogenesis Naturally existing compounds (phytochemicals) through their actions on endolysosomes and mTOR signaling pathways might provide therapeutic relief against COVID-19 Here, we discuss evidence that some natural compounds through actions on the greater endolysosome system can inhibit SARS-CoV-2 infectivity and thereby might be repurposed for use against COVID-19

9.
Proc. - IEEE Int. Conf. Mach. Learn. Appl., ICMLA ; : 1402-1409, 2020.
Article | WHO COVID | ID: covidwho-1142803

ABSTRACT

Trust in predictions made by machine learning models is increased if the model generalizes well on previously unseen samples and when inference is accompanied by cogent explanations of the reasoning behind predictions In the image classification domain, generalization can be assessed through accuracy, sensitivity, and specificity Explainability can be assessed by how well the model localizes the object of interest within an image However, both generalization and explainability through localization are degraded in scenarios with significant overlap between classes We propose a method based on binary expert networks that enhances the explainability of image classifications through better localization by mitigating the model uncertainty induced by class overlap Our technique performs discriminative localization on images that contain features with significant class overlap, without explicitly training for localization Our method is particularly promising in real-world class overlap scenarios, such as COVID-19 and pneumonia, where expertly labeled data for localization is not readily available This can be useful for early, rapid, and trustworthy screening for COVID-19 © 2020 IEEE

10.
Medical Forum Monthly ; 32(1):140-144, 2021.
Article in English | WHO COVID | ID: covidwho-1106853

ABSTRACT

Objective: To assess the accuracy of high-resolution computed tomography of chest for diagnosis of pneumonia related to corona virus disease taking Reverse transcription polymerase chain reaction as gold standard Study Design: Cross Sectional survey Place and Duration of Study: This study was conducted at the Jinnah Medical Diagnostic Center, Sialkot Pakistan, for 6 months from 1st April 2020- 30th September 2020 Materials and Methods: 200 patients were included with symptoms of coronavirus pneumonia were included HRCT chest was done and findings were recorded Then RT-PCR assays was applied and findings were recorded Patients were labeled as positive or negative Data was analyzed using SPSS v 20 Diagnostic accuracy of HRCT Chest was calculated taking RT-PCR as gold standard Results: The mean age of patients was 35 69 ± 12 95 years There were 103 (51 5%) males and 97 (49 5%) females On HRCT Chest, 121 (60 5%) had ground glass appearance and 108 (54%) had consolidation The sensitivity of HRCT Chest was 70 1%, specificity was 60 3%, positive and negative predictive values were was 79 3% and 48 1% and diagnostic accuracy was 67% Conclusion: HRCT Chest is highly accurate to diagnose the COVID-19 in symptomatic patients and can replace RT-PCR which is expensive than HRCT Chest and not readily available in all set-ups

11.
Clin Exp Allergy ; 51(1): 159-194, 2021 Jan.
Article in English | MEDLINE | ID: covidwho-1109492
12.
Asia-Pacific Journal of Business Administration ; 2021.
Article in English | WHO COVID | ID: covidwho-1105076

ABSTRACT

Purpose: A sudden shift of work from the office to home amid global lockdown demands exploration of factors that facilitate or obstruct remote working and their impact on practical and psychological outcomes for the employee when individual mandatorily telecommutes full-time with no prior experience of the same Based on job demands and resources model (JD-R), the present study explores the role of certain job demands and resources on negative and positive outcomes through mediating role of strain and well-being, respectively Design/methodology/approach: A data sample of 371 IT sector employees was collected and confirmatory factor analysis model was run to assess the model fit indices, convergent and divergent validities of the data While proposed hypotheses of the study were tested using structural equations modeling (SEM) technique Findings: It was found that workload pressure, task interdependence, professional isolation and family interference in work lead to exhaustion and further stress, whereas the presence of autonomy and schedule flexibility and sufficient technology resources improve employee work-life balance and further better productivity and performance and job satisfaction Improved well-being was also found to reduce stress for full-time telecommuters Practical implications: This study provides implications that will help in doing away with exhaustion and stress for employees and ensure business continuity in emergencies like COVID-19 pandemic Originality/value: There are no past instances of mandatory full-time telecommuting arrangement by organizations, and researchers never had the opportunity to study it This research, based on the JD-R model provides for the first time empirical insights into the experiences of mandatory full-time telecommuting during COVID-19 induced lockdown © 2021, Emerald Publishing Limited

13.
Cureus ; 13(1):12, 2021.
Article in English | WHO COVID | ID: covidwho-1060213

ABSTRACT

Purpose To study the spectrum of chest dual-energy computed tomography (DECT) imaging findings in severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) or COVID-19 infected Indian patients and classify them on the basis of the Radiological Society of North America CT classification Method A total of 110 reverse transcription-polymerase chain reaction (RT-PCR)-positive patients (subjects) in which noncontrast chest DECT was done in our COVID-19 care center (CCC) were enrolled in this study The prevalence of various abnormalities of lung parenchyma due to SARS-COV-2 and their distribution with extent was recorded Various types of lung parenchyma abnormalities due to COVID-19 were evaluated in all patients Data were analyzed and various prevalent abnormalities were calculated as a percentage for each type All the cases were also sorted into four major groups on the basis of the Radiological Society of North America CT classification of COVID patients Result Among the total 110 patients that were enrolled in this study, 80 (72 7%) were males and 30 (27 3%) were females with a mean age of 40 5 +/- 7 years (range 24-84) Out of this, we observed that 59 (53 6%) cases had abnormalities of lung parenchyma and were designated as DECT positive, whereas 51 (46 3%) cases had completely normal DECT Only 14 (12 7%) of the patients (cases) presented with dyspnoea, 10 (9%) had hyperpnoea, whereas 12 (10 8%) had other associated comorbidities Among the patients having abnormal DECT findings, multilobar (86%), bilateral lung field involvement (72 8%) with the ascendancy of peripheral and posterior distribution was most commonly noted With respect to the different types of opacities noted in various patients, we found that ground-glass opacity (GGO) was the common abnormality found in almost all cases for the greatest part Pure GGO was reported in 16 (28%), GGO admixed with a crazy-paving pattern were elicited in 17 (28 8%) and GGO mixed with consolidation was noted in 25 (42 3%) cases Thirty-eight (64 4%) cases were having peri-lesional or intra-lesional segments or involving a small segment enlargement of the pulmonary vessel Among the cases showing DECT positivity, the typical pattern on the basis of the Radiological Society of North America (RSNA) classification was noted in 71 2% of cases, whereas the atypical pattern was found in 1 2% percent of cases and the intermediate type was depicted in 25 4% percent of cases Forty-six point three percent (46 3%) of the total cases that were enrolled in the study were grouped as the no pneumonia category Conclusion The result of this study proved that the maximum number of RT-PCR-positive COVID-19 patients had mild symptoms and few comorbidities with normal chest DECT and fell under the no pneumonia category of the RSNA CT classification of COVID patients However, out of the remaining patients, the majority of patients had GGO on DECT as a typical finding mixed with other patterns in a bilateral distribution and peripheral predominance A preponderance of patients presented with the typical appearance of pneumonia followed by an intermediate type

14.
Clinical and Experimental Allergy ; 51(1):160-160, 2021.
Article in English | WHO COVID | ID: covidwho-1037811
15.
European Journal of Molecular and Clinical Medicine ; 7(3):2845-2870, 2020.
Article in English | WHO COVID | ID: covidwho-1001209

ABSTRACT

The recent deadly outbreak of Novel coronavirus (2019-COVID) associated with human to human transmission and severe human infection has been recently reported from the city of Wuhan in Hubei province in China and gradually the number of infected people around the globe increased in fatality ratio This study aims to identify the historical background of the coronavirus family that is already affected the civilization and animals This study will overview the overall literature published on the Coronavirus and vaccination development with nature of viruses For that, the Scopus database and web of science database is selected to analyse the published literature The research methodology is followed by the strict screening process of the PRISMA statement framework (2015) for the screening and quality assessment Final 93 studies are included for the systematic literature review The most important and critical part of the study is about the classification of the past literature on the topic of coronavirus severe acute respiratory syndrome coronavirus (SARS), Middle East Respiratory Syndrome Coronavirus (MERS), bovine coronavirus, canine coronavirus and feline coronavirus are the major classifications discuss in the literature This study contributes to the literature by providing an elaboration of a descriptive mapping of the existing literature on the studies of Coronavirus pandemic that is a greater challenge for humanity in the current circumstances Finally, the future of the world after the 2019-COVID is more challenging and important for vaccination development and health care sector © 2020 Ubiquity Press All rights reserved

16.
Journal of Clinical and Diagnostic Research ; 14(12):14-16, 2020.
Article in English | WHO COVID | ID: covidwho-994205

ABSTRACT

Pirfenidone has been approved for the treatment of Idiopathic pulmonary fibrosis due to its anti-fibrotic activity It has been shown to have anti-inflammatory and antioxidant properties apart from being an anti-fibrotic agent Cytokine storm, severe inflammation and oxidative stress leading to acute respiratory distress syndrome and multi organ failure are factors causing mortality in patients of COVID-19 This article reports two cases of 35 years and 60 years old male patients of COVID-19, those were diagnosed by real time Polymerase Chain Reaction (PCR) using nasopharyngeal samples They were started on pirfenidone 400mg bd, later increased to 600mg tds along with empirical antibiotics, dexamethasone, supplemental oxygen and non-invasive ventilator support Both the patients improved and were discharged Both the patients were followed by telemedicine after 1 week, did not require oxygen at rest and were comfortable at rest in contrast to earlier complains Thus, the authors conclude that pirfenidone can be a possible cure for COVID-19 patients, larger trials are required to confirm its efficacy

17.
Open Access Macedonian Journal of Medical Sciences ; 8(T1):314-324, 2020.
Article in English | WHO COVID | ID: covidwho-993658

ABSTRACT

Coronavirus disease (COVID)-19 outbreak was the first time experienced in Wuhan City, China, at the end of December 2019 which spreads rapidly in China and then worldwide approximately all countries of America, Europe, Australia, and Asia including Bangladesh There are more than 1,039,135 mortalities and 35,207,771 people have been affected globally until October 4, 2020, and the figure is still increasing The global information on the COVID-19 case was collected from a reliable database (worldometers info) and domestic information was taken from the government circulating websites and analyzed Different steps have been taken to control the COVID-19 worldwide Even with few resources, Bangladesh also has taken rigorous measures such as designed special hospitals, laboratories, quarantine facilities, social distance awareness campaigns, and lockdown to control the spreading of the virus As Bangladesh is an overpopulated country and vast population lives under the poverty line, it was difficult to maintain a strict lockdown to curb the COVID-19 In this study, we have focused the government efforts to combat this deadly pneumonia and presented recent situations and challenges of Bangladesh We compiled general treatments, COVID-19 specific treatments, and antiviral treatments should be prescribed in fighting COVID-19 We suggest certain nutritional elements and natural products which can boost up the immunity of individuals and protect from the infection of this virus The review was undertaken to synopsis the recent conditions, challenges of Bangladesh arise after the COVID-19 pandemic and summarize certain possible intervention options for management of COVID-19

18.
Front Pharmacol ; 11:594487, 2020.
Article in English | WHO COVID | ID: covidwho-979031

ABSTRACT

The outbreak of the novel coronavirus disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome CoronaVirus-2 (SARS-CoV-2) requires urgent clinical interventions Crucial clinical needs are: 1) prevention of infection and spread of the virus within lung epithelia and between people, 2) attenuation of excessive lung injury in Advanced Respiratory Distress Syndrome, which develops during the end stage of the disease, and 3) prevention of thrombosis associated with SARS-CoV-2 infection Adenosine and the key adenosine regulators adenosine deaminase (ADA), adenosine kinase (ADK), and equilibrative nucleoside transporter 1 may play a role in COVID-19 pathogenesis Here, we highlight 1) the non-enzymatic role of ADA by which it might out-compete the virus (SARS-CoV-2) for binding to the CD26 receptor, 2) the enzymatic roles of ADK and ADA to increase adenosine levels and ameliorate Advanced Respiratory Distress Syndrome, and 3) inhibition of adenosine transporters to reduce platelet activation, thrombosis and improve COVID-19 outcomes Depending on the stage of exposure to and infection by SARS-CoV-2, enhancing adenosine levels by targeting key adenosine regulators such as ADA, ADK and equilibrative nucleoside transporter 1 might find therapeutic use against COVID-19 and warrants further investigation

19.
Journal of SAFOG ; 12(4):243-244, 2020.
Article in English | WHO COVID | ID: covidwho-972684

ABSTRACT

Background: The coronavirus disease-2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global public health emergency Physiological and mechanical changes in pregnancy increase susceptibility to infections in general, particularly when the cardiorespiratory system is affected, and encourage rapid progression to respiratory and heart failure in the gravida Case description: We present a case report of 30-year-old primigravidae with 36 5 weeks by date and 37 week by scan with diagnosed preeclampsia 2 weeks back on medication with 11 × 10 4 × 10 9 cm single intramural anterior wall fibroid with breech presentation COVID nasopharyngeal sample reported as SARS-CoV-2 real-time PCR positive The patient was started on medication defining the Stage 1 Group A Asymptomatic Category Chest X-ray showed mild bilateral pulmonary infiltrates On Day 6 of admission, the patient went in labor, and hence was taken for emergency LSCS in view of primigravidae with breech with preeclampsia with fibroid with PROM under spinal anesthesia with all precautions Intraoperatively, the LSCS was uneventful Postoperatively 6 hours postpartum, the patient developed sudden onset breathlessness NYHA Grade 4, with saturation of 56%, and patient was intubated and shifted to ICU Chest X-ray revealed viral pneumonia, and further 2D ECHO was suggestive of cardiomyopathy Conclusion: We suggest an echocardiogram in pregnant women with coronavirus disease 2019 pneumonia, in particular those necessitating oxygen or those who are critically ill Clinical significance: Viral myocarditis and cardiomyopathy have been reported in nonpregnant COVID-19 patients Information on COVID-19 in pregnancy is currently limited No specific literature is available of viral cardiomyopathy reported in pregnant women with COVID-19 infection © The Author(s) 2020

20.
Frontiers in Physiology ; 11, 2020.
Article in English | WHO COVID | ID: covidwho-970863

ABSTRACT

Background: The epidemic of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), causing coronavirus disease 2019 (COVID-19), presents a significant and urgent threat to global health This alarming viral infection, declared as pandemic by the WHO in February 2020, has resulted millions of infected patients and thousands of deaths around the world In Morocco, despite the efforts made by the authorities, the SARS-CoV-2 continues to spread and constitutes a burden of morbidity and mortality The objective of this study is to describe clinical characteristics of COVID-19 Moroccan patients and to establish the relationship between specific clinical symptoms, namely ageusia and/or anosmia, with these characteristics Methods: We performed a descriptive, non-interventional cross-sectional study analyzing data from 108 patients admitted to the VINCI clinic, Casablanca (Morocco) The database includes 39 parameters including epidemiological characteristics, anthropometric measurements and biological analyzes Results: The average of age of the patients was 43 80 ± 15 75 years with a sex ratio of 1:1 The mean body mass index of the patients was 25 54 ± 4 63 Kg/m2 The majority of patients had, at least, one comorbidity and among 75% symptomatic patients, about 50% had, at least, three symptoms namely, fever (40 7%), cough (39 8%), myalgia (28 7%), and anosmia and/or ageusia (20 4%) From biological analyzes, we noticed lymphopenia and an elevated protein C reactive and lactate dehydrogenases levels in 24 1, 36 1, and 35 2% of patients, respectively A disturbance in liver function markers was observed in 15 7% of cases For the other hemostasis parameters, high levels of prothrombin and platelets were reported in 14 6 and 14 8% of patients, respectively Comparisons related to the presence of anosmia and/or ageusia did not show any difference for demographic and anthropometric characteristics, while a possibility of a significant difference was revealed for certain biological parameters, particularly the levels of lymphocytes, D-dimer and troponin Conclusion: This study provides significant findings that will be used not only to supplement previous studies carried out in Morocco in order to resume the epidemiological situation in comparison with other countries, but also to improve the quality of the diagnosis of COVID-19 patients by identifying all the symptoms of the disease and better understanding its clinical outcomes © Copyright © 2020 Benkirane, Heikel, Laamiri, Bouziani, Lahmam, Al-Jawaldeh, El Haloui, Ennibi, Akhtar-Khan, El Fahime, Obtel, Barkat and Aguenaou

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