Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 20 de 101
Filter
Add filters

Document Type
Year range
1.
Pakistan Journal of Medical and Health Sciences ; 16(9):525-527, 2022.
Article in English | EMBASE | ID: covidwho-2164868

ABSTRACT

The aim of this descriptive case series was to determine the frequency of various gastrointestinal symptoms of the COVID-19 patients along with the respiratory symptoms. Secondary outcome was to determine the effect of various co-morbid conditions and various sign and symptoms on the length of hospital stay and outcome of disease Material: In this descriptive case series type study, carried out in the COVID ward in the Jinnah Hospital, Lahore, all patients diagnosed with COVID-19 by consultant physician in the out-patient department and ward were included. Written informed consent was taken from all the participants of the study after explaining the primary objective of the study. The study was carried out from 01-07-2019 to 31-12-2019. Primary objective of this study was to determine the various gastrointestinal symptoms of the COVID-19 patients along with the respiratory symptoms Results: Among the 386 patients enrolled in the study, 60% were male and 40% were female. Mean age of the patients was 54.14 SD 16.3 years, with around 71% cases of age above 45 years. Abdominal pain, anosmia and diarrhea were the most common GI complaints. Over all, 26% of the patients of COVID had GI symptoms. Conclusion(s): GI complaints such as anorexia, nausea, vomiting, diarrhea, and abdominal cramping have been documented in COVID-19 individuals even in the absence of respiratory problems. As a result, COVID-19 disease must be explored in individuals who have mostly GI complaints. Copyright © 2022 Lahore Medical And Dental College. All rights reserved.

2.
Abu Dhabi International Petroleum Exhibition and Conference 2022, ADIPEC 2022 ; 2022.
Article in English | Scopus | ID: covidwho-2162748

ABSTRACT

Reservoir surveillance and production optimization will remain at the forefront of company strategies in the new post-COVID19 environment. We anticipate that companies will focus more on producing assets and go the route of production enhancement rather than exploration. Accordingly, production logging will remain an important surveillance method in evaluating and strategizing production-optimization schemes pertaining to flow-characterization from reservoir-to-wellbore. This work is culmination of operational and technical excellence that enabled the revival of a loaded-up well through simultaneous lifting-and-logging technique. Conventionally, wireline is the preferred mode of conveyance for production-logging;however, well must be continuously flowing throughout acquisition timeframe. Kicking-off the well using nitrogen-lift and then bringing in wireline-unit for production-logging in Well A-4 was not feasible as previous attempts confirmed well to load-up in few hours post-offloading. Therefore, success of this project was heavily dependent on initial planning stage, which accounted for all available data including production-history, well-events, intervention-details, fluid analysis and well load-up behavior. Next, a multi-domain approach was adopted while bringing-out each domain from its silos and strategize collectively to simultaneously kickoff the well with nitrogen and acquire real-time downhole production-logging data through smart-coiled-tubing (CT). This was first implementation of concurrent lifting and logging operation in Pakistan. By deploying the approach mentioned above through smart CT (using optical-telemetry-link inside the CT-string coupled with downhole-assembly), synchronized lifting-and-logging operation was carried-out successfully. Well was observed to swiftly go back to load-up conditions post-kickoff;however, continuous well dynamics monitoring downhole enabled us to log perforated interval across multiple time domains. Well was activated through CT nitrogen-injection but depicted continuous loading tendency, which was captured downhole in form of flow-transients. Real-time job optimization ensured vigilant monitoring and selection of right-time to acquire meaningful zonal-contribution data for evaluation and diagnostic solutions. Finally, operational excellence was complemented through technical data analysis and interpretation, integrating passes data with transients and stationary measurements. Ultimately, acquired data analyzed using an integrated lens involving fluid velocities, downhole density, temperature, and water hold up data. Consequently, enabling us to decipher gas and water-entries on a zonal-basis across perforated sandstone reservoir. Copyright © 2022, Society of Petroleum Engineers.

3.
Computational Approaches for Novel Therapeutic and Diagnostic Designing to Mitigate SARS-CoV2 Infection: Revolutionary Strategies to Combat Pandemics ; : 1-594, 2022.
Article in English | Scopus | ID: covidwho-2149171

ABSTRACT

Computational Approaches for Novel Therapeutic and Diagnostic Designing to Mitigate SARS-CoV2 Infection: Revolutionary Strategies to Combat Pandemics compiles information about various computational bioinformatic approaches that can help combat viral infection. The book includes working knowledge of various molecular docking and molecular dynamic simulation approaches that have been exploited for drug repurposing and drug designing purpose. In addition, it sheds light on reverse vaccinomics and immunoinformatic approaches for vaccine designing against SARS-CoV2 infection. This book is an essential resource for researchers, bioinformaticians, computational biologists, computational chemists and pharmaceutical companies who are working on the development of effective and specific therapeutic interventions and point-of-care diagnostic devices using various computational approaches. © 2022 Elsevier Inc. All rights reserved.

4.
Computational Approaches for Novel Therapeutic and Diagnostic Designing to Mitigate SARS-CoV2 Infection: Revolutionary Strategies to Combat Pandemics ; : 115-145, 2022.
Article in English | Scopus | ID: covidwho-2149123

ABSTRACT

The novel coronavirus infection (COVID-19) first reported in December 2019, has become serious global life-threatening disease that has created huge health care crises. Despite huge number of clinical trials for drug and vaccine, only few successful candidates are in market, which led to problem of demand and supply. The low- and middle-income countries faces major health crisis due to financial issues. Studies to search plant originated natural bioactive molecules for prophylactic and therapeutic of COVID-19 infection has gained considerable attention, due to their low-cost, easy availability and lesser side effects. Natural products and herbal medicine have long been known for their role in treating respiratory infections and many of them have been approved/under trial as drugs or over-the-counter food additives to lessen the symptoms. It is undisputable fact that herbal/natural molecules’ medicine is still a promising resource and used as precursor for drug discovery to search prospective prophylactic candidate against COVID-19. These bioactive compounds bind with potential therapeutic target of SARS-COV-2 such as ACE II, Spike protein, TMPRESS, RdRp, Main proteases and endoribonuclease and may prevent or at least slow down the SARS-CoV-2 infection. Therefore, several numbers of clinical trials have registered to investigate the potentials of natural product to halt disease progression. The main aim of present chapter is to discuss the potential role of natural molecules which can be used as therapeutic drugs for treatment of COVID-19 and thus helpful to curb down the mortality rate. © 2022 Elsevier Inc. All rights reserved.

5.
Computational Approaches for Novel Therapeutic and Diagnostic Designing to Mitigate SARS-CoV2 Infection: Revolutionary Strategies to Combat Pandemics ; : 357-378, 2022.
Article in English | Scopus | ID: covidwho-2149114

ABSTRACT

The emergence of mutagenic strains of severe acute respiratory syndrome-Coronavirus-2 (SARS-CoV-2) worst hit the world which already suffered from the Coronavirus disease-2019 (COVID-19) pandemic for 2 years. Due to recent advances in vaccinomics, many vaccine candidates are available but their efficacy against a mutant version of SARS-CoV-2 has remained uncertain. The immune-informatics-based reverse vaccinomic approaches have shown promising investigations recently for the development of cost-effective vaccinomics candidates in a very short period of time. The strategic vaccine development of selected epitopes using artificial intelligence for both B- and T-cells is a very crucial step in this process. This approach provides a highly effective and immunogenic vaccine that offers immunological safety against autoimmunity and other adverse effects over ethnicities, pregnant women, and vulnerable age groups. Several researchers have developed effective vaccine candidates using computational vaccinology and the immune-informatics approach. In this process, a unique peptide sequence of viral proteins such as Nucleocapsid, spike, envelope protein was identified by various in silico tools which are acting as immunological epitopes against TLRs, T-cells, and B-cells. While the conventional immunological vaccine studies take years for vaccine candidature, the immunoinformatics approach is a time-efficient way for the next generation research to study host-pathogen interactions and vaccine development. It is also cost-effective and leads to a better understanding of disease pathogenesis, diagnosis, and immunological response. Owing to the advantage of immunoinformatics-based vaccine approaches the present chapter aimed to discuss vaccine development using immunoinformatics approaches. Besides, the current challenges and future aspects have also been discussed herewith. © 2022 Elsevier Inc. All rights reserved.

6.
Health SA Gesondheid ; 27, 2022.
Article in English | Scopus | ID: covidwho-2144067

ABSTRACT

Background: Vaccination falls within the scope of practice of a pharmacist and the coronavirus disease 2019 pandemic has seen an increase in pharmacies providing vaccination services. These vaccines are not without risk of allergic reactions and anaphylaxis. The available guidelines for the management of anaphylaxis include the administration of intravenous (IV) fluids. However, IV administration does not fall within the scope of practice of a pharmacist. A gap was identified in the availability of guidelines for the management of anaphylaxis without the use of IV fluid administration. Aim: This review aimed to address this gap by describing the mechanisms of allergic reactions and anaphylaxis and developing an algorithm to assist pharmacy personnel to manage these within the scope of practice. Methods: The authors used the recommendations for developing guidelines. Results: The availability of anaphylaxis guidelines and clinical studies catering for anaphylaxis and allergy management by pharmacists was deficient, thus the review modified the available management guidelines to align the management of allergy and anaphylaxis within the scope of a pharmacist. The items required for the management were also identified and listed as items that form part of the emergency tray in the pharmacy. Conclusion: The review designed algorithms based on the available literature to assist pharmacy personnel to manage allergy and anaphylaxis within the relevant scope of practice. The review also lists the equipment needed for an emergency tray. Contribution: This review serves to offer guidance for the management of allergy and anaphylaxis in a pharmacy setting. © 2022. The Authors. Licensee: AOSIS.

7.
SAGE Open ; 12(4), 2022.
Article in English | Scopus | ID: covidwho-2108690

ABSTRACT

The incorporation of mobile phones is persistent in the development of language learning, particularly in the EFL context. The present investigation aims to determine the impact of mobile-assisted language learning (MALL) applications on developing “learners” grammar proficiency. The current study employed a quantitative research method to explore MALL-assisted feedback in a WhatsApp group during the group chat. 60 Saudi male EFL learners, randomly assigned to the control and experimental group. Participants in the Experimental group practiced grammar in WhatsApp chat, whereas the same material was sent to the control group on Blackboard. The data was gathered by administering pre and post-test of grammar proficiency. Descriptive statistics and ANCOVA were used to analyze the data. The study’s findings exhibited that WhatsApp group practice and feedback positively impacted learners’ performance. © The Author(s) 2022.

8.
2022 IEEE Symposium on Industrial Electronics and Applications, ISIEA 2022 ; 2022.
Article in English | Scopus | ID: covidwho-2052038

ABSTRACT

The rapid advancement of social networks and the convenience of internet availability have accelerated the rampant spread of false news and rumors on social media sites. Amid the COVID-19 epidemic, this misleading information has aggravated the situation by putting people's mental and physical lives in danger. To limit the spread of such inaccuracies, identifying the fake news from online platforms could be the first and foremost step. In this research, the authors have conducted a comparative analysis by implementing five transformer-based models such as BERT, BERT without LSTM, ALBERT, RoBERTa, and a Hybrid of BERT & ALBERT in order to detect the fraudulent news of COVID-19 from the internet. COVID-19 Fake News Dataset has been used for training and testing the models. Among all these models, the RoBERTa model has performed better than other models by obtaining an F1 score of 0.98 in both real and fake classes. © 2022 IEEE.

9.
Intelligent Automation and Soft Computing ; 35(3):3641-3658, 2023.
Article in English | Scopus | ID: covidwho-2030637

ABSTRACT

The coronavirus (COVID-19) is a lethal virus causing a rapidly infec-tious disease throughout the globe. Spreading awareness, taking preventive mea-sures, imposing strict restrictions on public gatherings, wearing facial masks, and maintaining safe social distancing have become crucial factors in keeping the virus at bay. Even though the world has spent a whole year preventing and curing the disease caused by the COVID-19 virus, the statistics show that the virus can cause an outbreak at any time on a large scale if thorough preventive measures are not maintained accordingly. To fight the spread of this virus, technologically developed systems have become very useful. However, the implementation of an automatic, robust, continuous, and lightweight monitoring system that can be efficiently deployed on an embedded device still has not become prevalent in the mass community. This paper aims to develop an automatic system to simul-taneously detect social distance and face mask violation in real-time that has been deployed in an embedded system. A modified version of a convolutional neural network, the ResNet50 model, has been utilized to identify masked faces in peo-ple. You Only Look Once (YOLOv3) approach is applied for object detection and the DeepSORT technique is used to measure the social distance. The efficiency of the proposed model is tested on real-time video sequences taken from a video streaming source from an embedded system, Jetson Nano edge computing device, and smartphones, Android and iOS applications. Empirical results show that the implemented model can efficiently detect facial masks and social distance viola-tions with acceptable accuracy and precision scores. © 2023, Tech Science Press. All rights reserved.

10.
Female Pelvic Medicine and Reconstructive Surgery ; 28(6):S112-S113, 2022.
Article in English | EMBASE | ID: covidwho-2008715

ABSTRACT

Introduction: A shift in the practice of medicine to include telemedicine modalities has been gaining momentum, being accelerated even further by the current pandemic. There is a paucity of data regarding patient-perceived barriers to telemedicine in urogynecology patients, a unique and complex population, In a previous study at our institution, we found that conversion to telemedicine in FPMRS during the first 11 weeks of the COVID-19 related shut-down was very low. Objective: The aim of this study is to understand patient-perceived barriers to telemedicine and examine why some patients did not convert to telemedicine. Methods: This was a qualitative study using both a questionnaire and one-onone semi-structured interviews with patients from our institution's urogynecology practice who were scheduled for appointments from March 17th through June 9th, 2020, a time period when our office was closed to meet social distancing guidelines. Informed consent was obtained verbally and interpretation services were used when necessary. All interviews were recorded, transcribed, and coded by two readers. The data was analyzed in a 3-phase coding process and the manifest context analysis method was used to analyze, summarize and refine interview data. Inductive codes were then applied to text fragments. A codebook was developed through serial discussions and triangulated amongst the research team. The codebook was saturated at 30 interviews and the final six interviews were cross-referenced to confirm findings. Results: 36 interviews were conducted. Participants represented a wide age range (39 to 75 years), with 30.6% of participants ranging in age between 45 and 54 years. 66.7% of patients stated English was their preferred language. While some patients (25%) recalled being offered a virtual visit, others reported that this option was not offered (44.4%) or were unsure (19.4%). The majority of participants reported having a smartphone (97.2%). Codes from interviews were organized into four categories (Table 1). Three themes were identified: (1) Patients seemed amenable to telemedicine, yet there was reservation about the use of this modality for FPMRS specific patients. The participants felt concerned with the inability for physicians to examine them, and seemed to equate physical evaluation and diagnostic testing with an optimal experience. (2) The majority of participants felt comfortable using the technology and had minimal concerns regarding costs of cellular data or access to internet connectivity. Although some participants voiced reservations with this technological advancement, most seemed agreeable to using telemedicine in some capacity in the future. (3) There was a willingness to forgo certain comforts of in-person visits, in order to preserve safety, especially given simplicity and ease of accessibility. However, the overarching perception was that telemedicine could lend itself to be more impersonal, and should be used for more straightforward and follow-up visits. Conclusions: While there are certain challenges to incorporating telemedicine into urogynecology practice, many of our patients felt that tele-visits were practical and helpful. However, the concern for loss of human touch and testing obviates that the desire for in-person visits remains. Further patient education and development of systems to streamline telemedicine practices will help those who remain hesitant (Table Presented).

11.
European heart journal ; 43(Suppl 1), 2022.
Article in English | EuropePMC | ID: covidwho-1999073

ABSTRACT

Funding Acknowledgements Type of funding sources: Private company. Main funding source(s): Beximco Pharmaceutical Limited, Bangladesh OnBehalf Cardiology Study Group (Bangladesh) Background The fact that SAARS-Cov2 virus enters cells through ACE2 receptors and the Renin-Angiotensin-Aldosterone System Inhibitors (RAASi) upregulate the ACE2 receptors, there was speculation that use of RAASi may lead increased cellular entry of the virus.  There was a pause for a brief period of the use of RAASi in COVID 19 patients. But clinically the speculation has been found to be incorrect. Different professional societies come up with the assertion to continue to use RAASi. As the hesitancy among the clinicians appears to continue and there is no first hand data regarding the safety of the use of RAASi in Bangladeshi population, the study was undertaken to evaluate the safety of RAASi in COVID 19 patients. Aims & Methods This study was a prospective, observational multi-center study to evaluate the outcome of COVID-19 patients receiving RAAS inhibitors. Adult Hypertensive patients (age ≥18 years) with diagnosed COVID-19 confirmed by RT-PCR test who have a history of taking either ACE inhibitor/ARB or any other anti-hypertensive medication. Evaluation of outcome was assessed by rate of hospitalization, requirement of oxygen therapy, requirement of high flow nasal cannula, admission to ICU and mortality between two groups. All statistical analyses were performed using SPSS for Windows, version 20.0 (SPSS Inc., Chicago, IL, USA). Results We collected data from 147 Covid-19 positive patients confirmed by RT-PCR. Among them, 117 (79.6%) had a history of taking RAAS inhibitor and 30 had history of taking other antihypertensive medications. Of them, two-third patients had more than 50 years of age and more than half of the patients had overweight or obesity. Other than hypertension they had several comorbidities such as Diabetes Mellitus (45.4%), Ischemic Heart Diseases (35.4%), Asthma or COPD (15%) etc. Rate of hospitalization had no statistical difference between RAAS inhibitor group and other hypertensive group (48.7% vs 46.70% respectively;p-value - 0.841). There was no statistical difference between two groups in terms of requirement of oxygen therapy (p-value - 0.297), High Flow Nasal Cannula (p-value - 0.430), intensive care unit (p-value - 0.194) and death (p-value – 0.383) also. Almost half and one-third of the patients had persistence of symptoms even after 14 days and 28 days respectively. Fatigue, cough, breathlessness, loss of appetite and taste were the most common symptoms among those. Conclusion In our study we found that RAAS inhibitor treatment had no adverse effect on the outcome of COVID-19 patients compared with other antihypertensive drugs. Patients may continue receiving ACEIs and ARBs for the treatment of any indication for RAASi without an increased risk of worse outcomes.

12.
International Journal of Health Sciences ; 6:15128-15139, 2022.
Article in English | Scopus | ID: covidwho-1989160

ABSTRACT

Education is a prerequisite for the development, prosperity of an individual, society, and nation at large. Education is an important means to enhance knowledge, character building and behavior modification. It accelerates the process of social change, adaptation, and accommodation with the environment. It helps to develop creative and critical minds and enables them to think, analyze and reflect from varied perspectives. It enables learners to reconstruct the experiences and draw meaningful conclusions to understand their immediate surroundings in a better way. Thus, to realize the goals of education, we must address the quality concern of education. As mentioned in the sustainable development goals that recognize the role of good quality education in developing countries. (SDGs- 4) “Ensure inclusive and equitable quality education and promote lifelong learning opportunities for all”. © International Journal of Health Sciences.All right reserved.

13.
IDS Bulletin ; 53(3):129-152, 2022.
Article in English | Scopus | ID: covidwho-1988752

ABSTRACT

People with disabilities are often excluded from research, which may be exacerbated during the ongoing Covid-19 pandemic. This article provides an overview of key challenges, opportunities, and strategies for conducting disability-inclusive research during the pandemic, drawing on the experience of research teams working across ten countries on disability-focused studies. It covers adaptations that are relevant across the project lifecycle, including maintaining ethical standards and safeguarding;enabling active participation of people with disabilities;adapting remote research data collection tools and methods to meet accessibility, feasibility, and acceptability requirements;and promoting inclusive and effective analysis and dissemination. While this article is focused on adaptations during the pandemic, it is highly likely that the issues and strategies highlighted here will be relevant going forward, either in similar crises or as the world continues to move towards greater digital communication and connectedness. © 2022 The Authors, IDS Bulletin © Institute of Development Studies and Crown Copyright 2022.

14.
International Journal of Computer Science and Network Security ; 22(5):531-538, 2022.
Article in English | Web of Science | ID: covidwho-1979861

ABSTRACT

The purpose of this study is to evaluate learners' perceptions of using mobile devices for learning during COVID-19 in Saudi Arabia, with a particular focus on university students. Several educational institutions have set policies and procedures to adopt an e-learning environment by employing various potential methods for a smooth transition from classroom to online instruction to avoid disturbing the teaching and learning process. This study was conducted by implementing a survey method on 116 students to determine learners' perceptions of adopting mobile phones as a type of education. This survey found that the majority of university students have a favorable attitude toward m - learning. This study established that m-learning is exceptionally beneficial for remedying study gaps during this COVID-19 pandemic period. The findings will assist education decision-makers and educational establishments in incorporating m - learning technology throughout the system, in which social media could indeed significantly improve the teaching-learning activities. The results also suggest that M - learning may support learners in filling in study gaps during the COVID-19 disease outbreak timespan.

15.
International Journal of Climatology ; 2022.
Article in English | Scopus | ID: covidwho-1958811

ABSTRACT

Asia is one of the continents where aerosol levels are comparatively higher across the world. India and Sri Lanka are some of the regions in the South Asian continent where pollution is increasing rapidly due to the rise in industrialization. The present study investigated the interactions between atmospheric aerosol and cloud microphysical properties and their spatial, temporal, and seasonal variation at local and regional scales during 2000–2020 using remotely sensed data sets in south India and Sri Lanka. High values (>0.5) of annual mean aerosol optical depth (AOD) were detected over southern India. On the other hand, lower values (0.2) were detected over Sri Lanka. In terms of seasonality, a high level of AOD was registered in both southern India and Sri Lanka during the premonsoon and monsoon periods. The angstrom exponent (AE412-470) revealed the dominance of fine-mode particles during winter and the postmonsoon, generally from biomass burning and industrial activities. The long-term analysis exhibited an increasing trend of atmospheric aerosol concentration over southern India and Sri Lanka. Interestingly, there was a decrease in AOD during the year 2020;the reduction in anthropogenic activities in the region was attributed to the COVID-19 lockdown, hence less accumulation of pollutants in the atmosphere. AOD showed a positive correlation with cloud effective radius over the western areas along with the Indian Ocean, north, southeast, and southern end of India, while negatively correlated with high AOD areas such as northeast of the study domain. The AOD and cloud optical depth were positively correlated over continental areas, while negative correlations were notable over the Indian Ocean around Sri Lanka, implying heterogeneities of aerosol's effect on cloud microphysical properties over the study area. Finally, the results from wind circulation and backward air mass trajectories reveal higher concentrations of fine-mode particles associated with the continent, whereas coarse-mode particles originate from the oceans. © 2022 Royal Meteorological Society.

16.
Pakistan Journal of Medical and Health Sciences ; 16(6):337-339, 2022.
Article in English | EMBASE | ID: covidwho-1939795

ABSTRACT

Objective: To determine the pattern of coagulation profile and their association with mortality in COVID-19 patients. Study Design: Retrospective descriptive study Place and Duration of Study: Makkah, Saudi Arabia from 2nd March 2020, to 2nd July 2020. Methodology: One thousand, nine hundred and twenty three conceded COVID-19 patients affirmed with polymerase chain response testing were included. Results: Patients' average age was 58.7±2.75 years. Patients drop was observed 6.4% in the survivor group as compared to 0.8% in the non-survivor group with a significant (p=0.000) association with mortality. Prolonged PT/INR was observed in 16% of patients, having a significant association (P=0.003) with mortality. APTT was prolonged in 29.4% of patients, and a comparison of APTT levels between the survivor and non-survivor groups showed a significant difference (p=0.002. A higher fibrinogen level was seen in 23.2% of patients with a significant (p=0.001). Conclusion: Severe COVID-19 infection is related to coagulopathy that is related to the destitute condition of hospitalized patients. Early and consistent evaluation of the coagulation profile along the disease course can help to treat and prevent disease morbidity and mortality in the hospital setting.

17.
Pakistan Journal of Medical and Health Sciences ; 16(6):264-266, 2022.
Article in English | EMBASE | ID: covidwho-1939790

ABSTRACT

Objective: To find out the effects of remdesivir on the body weight of treated albino rats and its testes Study Design: Experimental Place & Duration of study: At the Anatomy Department of Baqai Medical University Karachi, from August 2021-February 2022 Material & Method: The research was undertaken to record the body weight and its testes in Albino Wistar rats treated by antiviral agent remdesivir. This drug is also recommended for the treatment of Covid-19. The albino rats were divided into 4 groups as A, B, C & D. In each group having 6 Albino Wistar rats. Group A was untreated i.e. control group while group B, C & D were treated by intraperitoneal injection with low, Intermediate and high doses of Remdesivir respectively for 10 consecutive days. A paired sample t-test was performed to determine changes in body weights before and after provision of drugs. The one-way ANOVA was conducted to compare the difference of body weight and relative weight of testes amongst all four groups. Results: The mean body weight of group A before giving any treatment was 173.10±3.42 g & after sterile saline injection intraperitoneally without the drug was 173.48±3.46 g & the difference between the two was insignificant. The mean body weight albino rats before giving any treatment to group B was 178.24±1.78 g, in group C was 174.33±2.49 g & in group D was 173.76±3.22 g. After treatment with intraperitoneal remdesivir with low, intermediate and high doses given to the rats, the mean body weight of group B, C & D was 179.88±1.87 g,177.17±2.41 g and 176.44±3.15 g respectively and the difference between the two means was highly significant (p=0.0001). The mean relative weight of tetes of rat in group A=0.713 ± 8.56 g, B=0.717 ± 15.83 g, C=0.716 ± 14.18 g and D=0.705 ± 4.15 g. There was no statistically significant difference found in the overall relative weight changes of testes amongst four groups (p=0.876). Conclusion: It has been concluded from this study that the mean body weight of animal treated with remdesivir increased significantly while weight of the testes did not affect significantly but in high dose the relative weight of testes decreases. In high dose this drug should be used cautiously as it can affect germ cells present in the testes.

18.
Computers, Materials and Continua ; 73(2):2591-2618, 2022.
Article in English | Scopus | ID: covidwho-1934991

ABSTRACT

The COVID-19 pandemic has triggered a global humanitarian disaster that has never been seen before. Medical experts, on the other hand, are undecided on the most valuable treatments of therapy because people ill with this infection exhibit a wide range of illness indications at different phases of infection. Further, this project aims to undertake an experimental investigation to determine which treatments for COVID-19 disease is the most effective and preferable. The research analysis is based on vast data gathered from professionals and research journals, making this study a comprehensive reference. To solve this challenging task, the researchers used the HF AHP-TOPSIS Methodology, which is a well-known and highly effective Multi-Criteria Decision Making (MCDM) technique. The technique assesses the many treatment options identified through various research papers and guidelines proposed by various countries, based on the recommendations of medical practitioners and professionals. The review process begins with a ranking of different treatments based on their effectiveness using the HF-AHP approach and then evaluates the results in five different hospitals chosen by the authors as alternatives. We also perform robustness analysis to validate the conclusions of our analysis. As a result, we obtained highly corroborative results that can be used as a reference. The results suggest that convalescent plasma has the greatest rank and priority in terms of effectiveness and demand, implying that convalescent plasma is the most effective treatment for SARS-CoV-2 in our opinion. Peepli also has the lowest priority in the estimation. © 2022 Tech Science Press. All rights reserved.

19.
Journal of Integrated Care ; : 21, 2022.
Article in English | Web of Science | ID: covidwho-1927502

ABSTRACT

Purpose The purpose of this study is to understand virtual care use (e.g. telephone and video visits) during the COVID-19 pandemic across three hospital-based ambulatory clinics (i.e. mental health, renal and respiratory care) and to describe associated patient and provider experiences. Design/methodology/approach A mixed-methods convergent study was conducted including quantitative electronic medical records data on virtual care use, electronic surveys assessing domains of experience (e.g. satisfaction, acceptance and technology use) among patient and providers and semi-structured interviews exploring the associated barriers and facilitators of virtual care adoption. Findings Virtual care adoption rates and relative modality use (telephone vs video) varied across specialty clinics. Mental health clinics) showed the greatest use of virtual care and greater use of video over telephone, as compared to renal and respiratory care, where telephone was used almost exclusively. Patients and providers reported an overall good satisfaction and acceptance of virtual care (60-72%) across clinics, but commonly observed barriers (technical problems, behavioral adaptations needed and inequity) persisted. Good value propositions, tech support and the presence of early adopters who can support others in workflow re-design and highlight value propositions of virtual care were listed as adoption facilitators. Originality/value The study provides a unique opportunity to compare the rate of virtual care adoption before and during the COVID-19 pandemic across distinct specialties that operate within the same organizational and political setting. This study showed that the nature of the condition (e.g. mental health conditions) and the characteristics of the users (e.g. younger patients) may drive models of care with higher rate of video use. Focusing on removing common barriers, like providing tech support and ensuring equitable access to patients, continues to be important even in the context of high virtual care adoption rates during the pandemic.

20.
Rawal Medical Journal ; 47(2):262-264, 2022.
Article in English | EMBASE | ID: covidwho-1925316

ABSTRACT

Objective: To identify the current practice parameters and apprehensions of medical fraternity. Methodology: This cross sectional survey was conducted by using online Google forms. A total of 119 participants completed the form and were included in the analysis. Brief questionnaire constituted of nine questions to explore current crisis and future apprehensions about non-COVID-19 patients. SPSS version 23 was used for data analysis. Results: Among 119 participants, majority (77%) were from Pakistan. Medicine and allied were in the highest number (67%) followed by surgical colleagues (18%). Around 41% reported to close their clinical services during pandemic and 69% started providing online services, including those (36%) who were providing both i.e. face-to-face and online. A significant number of physicians (72%) believed that non-COVID patients were suffering these days and around (76%) apprehended that patient’s health may have deteriorated due to lack of care. Conclusion: Care of non-COVID patients has compromised and immediate actions are needed to halt further decline. A separate place of care for COVID-19 patients, utilization of technology, home visits and gradual opening of OPDs with strict SOP compliance is needed.

SELECTION OF CITATIONS
SEARCH DETAIL