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1.
EuropePMC; 2021.
Preprint in English | EuropePMC | ID: ppcovidwho-315485

ABSTRACT

Purpose: To explore the role of chronic liver disease (CLD) in COVID-19. Methods: : A total of 1,439 consecutively hospitalized patients with COVID-19 from one large medical center in the United States from March 16, 2020 to April 23, 2020 were retrospectively identified. Clinical characteristics and outcomes were compared between patients with and without CLD. Postmortem examination of liver in 8 critically ill COVID-19 patients was performed. Results: : There was no significant difference in the incidence of CLD between critical and non-critical groups (4.1% vs 2.9%, p=0.259), or COVID-19 related liver injury between patients with and without CLD (65.7% vs 49.7%, p=0.065). Postmortem examination of liver demonstrated mild liver injury associated central vein outflow obstruction and minimal to moderate portal lymphocytic infiltrate without evidence of CLD. Conclusion: Patients with CLD were not associated with a higher risk of liver injury or critical/fatal outcomes. CLD was not a significant comorbid condition for COVID-19.

2.
Sci Rep ; 11(1): 11734, 2021 06 03.
Article in English | MEDLINE | ID: covidwho-1258596

ABSTRACT

To explore the role of chronic liver disease (CLD) in COVID-19. A total of 1439 consecutively hospitalized patients with COVID-19 from one large medical center in the United States from March 16, 2020 to April 23, 2020 were retrospectively identified. Clinical characteristics and outcomes were compared between patients with and without CLD. Postmortem examination of liver in 8 critically ill COVID-19 patients was performed. There was no significant difference in the incidence of CLD between critical and non-critical groups (4.1% vs 2.9%, p = 0.259), or COVID-19 related liver injury between patients with and without CLD (65.7% vs 49.7%, p = 0.065). Postmortem examination of liver demonstrated mild liver injury associated central vein outflow obstruction and minimal to moderate portal lymphocytic infiltrate without evidence of CLD. Patients with CLD were not associated with a higher risk of liver injury or critical/fatal outcomes. CLD was not a significant comorbid condition for COVID-19.


Subject(s)
COVID-19/epidemiology , Liver Diseases/epidemiology , Acute Lung Injury/epidemiology , Acute Lung Injury/pathology , Aged , COVID-19/mortality , Chronic Disease , Comorbidity , Female , Humans , Liver Diseases/pathology , Liver Function Tests , Male , Middle Aged , Proportional Hazards Models , United States/epidemiology
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