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Pediatric Infection and Vaccine ; 29(3):125-130, 2022.
Article in Korean | EMBASE | ID: covidwho-2293424
Pediatric Infection and Vaccine ; 29(3):125-130, 2022.
Article in Korean | Scopus | ID: covidwho-2254967
J Frailty Aging ; 12(2): 150-154, 2023.
Article in English | MEDLINE | ID: covidwho-2265890


BACKGROUND: Frailty is associated with mortality in older adults hospitalized with COVID-19, yet few studies have quantified healthcare utilization and spending following COVID-19 hospitalization. OBJECTIVE: To evaluate whether survival and follow-up healthcare utilization and expenditures varied as a function of claims-based frailty status for older adults hospitalized with COVID-19. DESIGN: Retrospective cohort study. PARTICIPANTS: 136 patients aged 65 and older enrolled in an Accountable Care Organization (ACO) risk contract at an academic medical center and hospitalized for COVID-19 between March 11, 2020 - June 3, 2020. MEASUREMENTS: We linked a COVID-19 Registry with administrative claims data to quantify a frailty index and its relationship to mortality, healthcare utilization, and expenditures over 6 months following hospital discharge. Kaplan Meier curves and Cox Proportional Hazards models were used to evaluate survival by frailty. Kruskal-Wallis tests were used to compare utilization. A generalized linear model with a gamma distribution was used to evaluate differences in monthly Medicare expenditures. RESULTS: Much of the cohort was classified as moderate to severely frail (65.4%), 24.3% mildly frail, and 10.3% robust or pre-frail. Overall, 27.2% (n=37) of the cohort died (n=26 during hospitalization, n=11 after discharge) and survival did not significantly differ by frailty. Among survivors, inpatient hospitalizations during the 6-month follow-up period varied significantly by frailty (p=0.02). Mean cost over follow-up was $856.37 for the mild and $4914.16 for the moderate to severe frailty group, and monthly expenditures increased with higher frailty classification (p <.001). CONCLUSIONS: In this cohort, claims-based frailty was not significantly associated with survival but was associated with follow-up hospitalizations and Medicare expenditures.

COVID-19 , Frailty , Aged , Humans , United States/epidemiology , Health Expenditures , Medicare , Frail Elderly , Retrospective Studies , Delivery of Health Care , Academic Medical Centers
Chemical Engineering Journal ; 454, 2023.
Article in English | Web of Science | ID: covidwho-2232352


In recent decades, biomedical sensors based on surface-enhanced Raman spectroscopy (SERS), which reveals unique spectral features corresponding to individual molecular vibrational states, have attracted intensive attention. However, the lack of a system for precisely guiding biomolecules to active hotspot regions has impeded the broad application of SERS techniques. Herein, we demonstrate the irreversible active engineering of three-dimensional (3D) interior organo-hotspots via electrochemical (EC) deposition onto metal nanodimple (ECOMD) platforms with viral lysates. This approach enables organic seed-programmable Au growth and the spontaneous bottom-up formation of 3D interior organo-hotspots simultaneously. Because of the net charge effect on the participation rate of viral lysates, the number of interior organo-hotspots in the ECOMDs increases with increasingly positive polarity. The viral lysates embedded in the ECOMDs function as both a dielectric medium for field confinement and an analyte, enabling the highly specific and sensitive detection of SARS-CoV-2 lysates (SLs) at concentrations as low as 10-2 plaque forming unit/mL. The ECOMD platform was used to trace and detect the SLs in human saliva and diagnose of the delta-type SARS-CoV-2 in clinical environments;the results indicate that the proposed platform can provide point-of-care diagnoses of infectious diseases.

Pediatric Infection and Vaccine ; 29(3):125-130, 2022.
Article in Korean | EMBASE | ID: covidwho-2228917


For the extended duration of the coronavirus disease 2019 (COVID-19) pandemic, reports emerged that mother-to-child transmission rates were low. However, the pandemic protocols including strict isolation, testing for severe acute respiratory syndrome coronavirus 2, and negative pressure isolation remained in Korea. Recently, the guideline for the management of neonates born to mothers with COVID-19 have been revised based on guidelines in other countries. Here, we introduce this newly developed guideline and review the foreign guidelines that were used for reference. Copyright © 2022 The Korean Society of Pediatric Infectious Diseases.

Journal of the Architectural Institute of Korea ; 38(7):139-150, 2022.
Article in Korean | Scopus | ID: covidwho-2030267
Journal of Institute of Control, Robotics and Systems ; 28(9):804-810, 2022.
Article in Korean | Scopus | ID: covidwho-2025124
Journal of the Korean Ophthalmological Society ; 63(7):625-629, 2022.
Article in Korean | Web of Science | ID: covidwho-1979029
Korean Journal of Dermatology ; 59(8):581-586, 2021.
Article in Korean | Scopus | ID: covidwho-1918674
Ieee Access ; 9:164503-164509, 2021.
Article in English | Web of Science | ID: covidwho-1583826
Pediatric Infection and Vaccine ; 28(1):1-6, 2021.
Article in Korean | EMBASE | ID: covidwho-1224345
Journal of the American Geriatrics Society ; 69(SUPPL 1):S129, 2021.
Article in English | EMBASE | ID: covidwho-1214843