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2.
Journal of Urology ; 207(5):E528-E529, 2022.
Article in English | Web of Science | ID: covidwho-2068014
3.
Nursing Open ; 2022.
Article in English | Scopus | ID: covidwho-2013702

ABSTRACT

Aim: This study explored nursing students' eHealth literacy, lifestyle behaviours and COVID-19-related preventive behaviours and associated factors. Design: A cross-sectional comparative correlational study. Methods: Nursing students (n = 358) from a metropolitan area of South Korea were recruited for an online survey. The online questionnaire included: The eHealth Literacy Scale, the Health Promoting Lifestyle Profile-II and the COVID-19-related preventive behaviour scale. Results: COVID-19-related preventive behaviours correlated positively with satisfaction with one's major, time spent seeking health information online, eHealth literacy and lifestyle behaviours. Significant factors affecting COVID-19-related preventive behaviours were the following: being female (β = 0.194, p <.001), time spent seeking health information online (β = 0.114, p =.002), eHealth literacy (β = 0.167, p =.001) and lifestyle behaviours (β = 0.266, p <.001). Conclusions: Findings highlight the need to strengthen searching behaviours to access accurate health information online and reinforce eHealth literacy and health-promoting lifestyle behaviours to improve COVID-19 preventive behaviours among nursing students. © 2022 The Authors. Nursing Open published by John Wiley & Sons Ltd.

4.
Innovation in Aging ; 5:139-139, 2021.
Article in English | Web of Science | ID: covidwho-2011402
5.
Journal of Clinical Oncology ; 40(16), 2022.
Article in English | EMBASE | ID: covidwho-2009570

ABSTRACT

Background: Oral mucositis (OM) is a debilitating side effect of concomitant chemoradiotherapy (CRT) for head and neck cancer (HNC). EC-18 may effectively mitigate OM by minimizing the CRT-induced innate immune response. This Phase II, 2-stage trial evaluated safety, tolerability, and efficacy of EC- 18 in reducing the duration, incidence, and trajectory of severe OM (SOM) in HNC patients. Methods: Patients (n = 105) with pathologically confirmed oral cavity, oropharynx, hypopharynx, or nasopharynx squamous cell cancers who received intensity-modulated radiation therapy (IMRT;with ≥ 55 Gy on ≥ 2 oral sites) and weekly or tri-weekly cisplatin were studied. In Stage 1, 24 patients were randomized (n = 6 per arm) to receive 500, 1000, or 2000 mg of EC-18, or placebo. Following independent Data Safety Monitoring Board review, 81 patients in Stage 2 received EC-18 2000 mg (n = 41) or placebo (n = 40) throughout CRT. WHO OM grade was assessed twice weekly during IMRT and then once weekly for up to 6 weeks post-IMRT. The primary efficacy endpoint was duration of SOM during the active and short-term follow-up (STFU) periods in the compliant per-protocol population (PP). Much of Stage 2 was conducted during peak periods of the COVID-19 pandemic which measurably impacted patient compliance relative to test medication dosing and planned radiation. Consequently, to assess efficacy most accurately, the PP population was analyzed (with at least 4 weeks of study drug dosing, minimum cumulative radiation of 55 Gy, 80% study drug compliance in the first 28 days of dosing, and without using not-allowed-therapy). Results: Patient demographics and baseline characteristics were balanced between groups. Adverse events (AEs) were comparable amongst cohorts without drug-related severe AEs. In the PP, the median duration of SOM from baseline through STFU was 0 day in the EC-18 group (n = 22) v 13.5 days in the placebo group (n = 20). SOM incidence through STFU (45.5% v 70%) and opioid use (time to onset: 32.3 v 26.0 days;and duration: 32.8 v 37.5 days) favored EC-18 v placebo. Results of the covariates analyses suggested that EC-18 favorably impacted SOM incidence in patients who experienced SOM treated with weekly low-dose cisplatin (n = 26;37.5% v placebo 70.0%) and HPV+ tumors (n = 29;35.3% v placebo 66.7%;Table). One-year long-term follow-up for tumor outcomes is ongoing. Conclusions: EC-18 safely mitigated the development and the time course of SOM in CRT-treated HNC patients. In addition, EC-18 may provide substantial benefits to subpopulations of HPV+ HNC patients treated with low dose cisplatin.

6.
Journal of General Internal Medicine ; 37:S287, 2022.
Article in English | EMBASE | ID: covidwho-1995798

ABSTRACT

BACKGROUND: The intersection of the opioid overdose epidemic and COVID-19 pandemic has prompted major regulatory changes to ease access to medications for opioid use disorder via telemedicine. We examined the impact of COVID-19-related health care changes on access to buprenorphine (BUP) by age, gender, insurance category, and prescriber specialty using a nationwide longitudinal prescription database. METHODS: We used an interrupted time series design with IQVIA LRx, a longitudinal database with >90% of all prescriptions dispensed in the US. The study timeline included BUP prescriptions from 52 weeks before (2/23/19- 2/21/20) to 52 weeks after (3/28/20-4/2/21) the initial pandemic period (2/22/ 20-3/27/20). The outcome of interest was total milligrams (MG) of BUP available per week nationwide. We used the CMS NPI database to assign prescriber specialty. Segmented regression was used to estimate relative changes in BUP prescribing at 1, 26, and 52 weeks post- initial-pandemic period compared to the expected baseline trend. We also evaluated treatment disruptions (a gap of 28 days) in previously stable patients, defined as ≥6 months of BUP prescriptions without a treatment disruption. RESULTS: A total of 31,801,061 prescriptions were included. The number of patients with an active BUP prescription was increasing in the 52 weeks prepandemic (trend: 1252 pat./wk.) and increased significantly in the 1st week post- initial-pandemic period (level change: 25786, p<0.001). The total MG BUP dispensed increased at 1, 26, and 52 weeks compared to the expected baseline trend (5.3% [4.9, 5.7], 3.3% [2.8, 3.8], 1.2% [0.48, 1.9]), as did the mean days supplied (9.3% [8.7, 9.9], 4.9% [4.3, 5.5], 6.3% [5.4, 7.3]). Stablytreated patients saw a significant decrease in treatment disruptions at 52 weeks post-initial-pandemic period (-28.4% [-33.7, -23.0]) compared to the expected baseline trend. Older age groups (40+) experienced an increase inMG BUP at 52 weeks (40-49: 4.9 [3.9, 5.9];50-64: 3.0 [0.75, 5.2];65+: 4.5 [3.4, 5.6]), while people aged 18-29 saw a significant decrease in MG BUP (-16.5 [-24.1, -8.8]). Men retained a significant increase in MG BUP compared to women at 52 weeks (1.7% [1.0, 2.4] v 0.5% [-0.34, 1.3]). People with Medicaid had a significant increase in MG BUP at 52 weeks (9.6% [7.7, 11.6]) while people paying with cash (-10.1 [-12.3, -7.9]) and commercial insurance (-4.6 [-5.7, -3.4]) saw significant decreases compared to the expected baseline trend. APPs, compared to physician specialties, had a notable increase in MG BUP dispensed at 1, 26, and 52 weeks (10.0 [8.8, 11.2], 7.1 [5.9, 8.4], 2.8 [0.13, 5.4]). CONCLUSIONS: In the year after the initial COVID-19 pandemic period, patients received longer prescriptions of BUP and overall increased total MG BUP. Stably-treated patients experienced fewer treatment disruptions. Regulatory changes around BUP prescribing may have helped patients maintain access to MOUD during the pandemic.

7.
2022 IEEE International Conference on Communications Workshops, ICC Workshops 2022 ; : 361-366, 2022.
Article in English | Scopus | ID: covidwho-1973476

ABSTRACT

Location fingerprinting based on Received Signal Strength Indicator (RSSI) has become a mainstream indoor localization technique due to its advantage of not requiring the installation of new infrastructure and the modification of existing devices, especially given the prevalence of Wi-Fi-enabled devices and the ubiquitous Wi-Fi access in modern buildings. The use of Artificial Intelligence (AI)/Machine Learning (ML) technologies like Deep Neural Networks (DNNs) makes location fingerprinting more accurate and reliable, especially for large-scale multi-building and multi-floor indoor localization. The application of DNNs for indoor localization, however, depends on a large amount of preprocessed and deliberately-labeled data for their training. Considering the difficulty of the data collection in an indoor environment, especially under the current epidemic situation of COVID-19, we investigate three different methods of RSSI data augmentation based on Multi-Output Gaussian Process (MOGP), i.e., by a single floor, by neighboring floors, and by a single building;unlike Single-Output Gaussian Process (SOGP), MOGP can take into account the correlation among RSSI observations from multiple Access Points (APs) deployed closely to each other (e.g., APs on the same floor of a building) by collectively handling them. The feasibility of the MOGP-based RSSI data augmentation is demonstrated through experiments using a recently-published work based on Recurrent Neural Network (RNN) indoor localization model and the UJIIndoorLoc, i.e., the most popular publicly-available multi-building and multi-floor indoor localization database;the RNN model trained with the UJIIndoorLoc database, augmented by using the whole RSSI data of a building in fitting an MOGP model (i.e., by a single building), outperforms the other two augmentation methods and reduces the mean three-dimensional positioning error from 8.62 m to 8.42 m in comparison to the RNN model trained with the original UJIIndoorLoc database. © 2022 IEEE.

8.
IEEE International Electron Devices Meeting (IEDM) ; 2021.
Article in English | Web of Science | ID: covidwho-1927525

ABSTRACT

Semiconductors, amongst one of the most important innovations of the 20th century, have played a pivotal role in the creation of a digitalized, modern industrial society. The global pandemic caused by COVID-19 has further accelerated the already ongoing transition towards a digital economy, and created many new opportunities for the semiconductor industry. It is true that certain concerns about the industry's ability to sustain its growth trajectory do exist, with some believing that Moore's law is no longer valid. As such, it is of paramount importance and also timely that our community comes together to courageously stand up to the challenges at hand, and takes action in a coordinated and concerted manner to advance further for many generations to come.

9.
International Economic Journal ; : 20, 2022.
Article in English | Web of Science | ID: covidwho-1915392

ABSTRACT

In this paper, we examine the extent to which a government's response to a pandemic affects election outcomes. Using detailed data on South Korea's 21st legislative election, held in April 2020 during the COVID-19 pandemic, we find that a candidate of the ruling Democratic Party was less preferred in electoral districts where the COVID-19 infection rate was higher. We also find that the South Korean government's successful control of the disease contributed significantly to the overwhelming victory of the ruling party against the leading opposition party. Specifically, our counterfactual analysis predicts that each party would have taken 129 and 102 of the 231 constituency seats considered in the analysis, respectively, had the COVID infection rate been the same as the OECD average during the election period. Given that the observed result was 147 to 84, this implies that 18 electees of the ruling party would have lost to the candidates of the leading opposition party, which in turn would have granted the opposition party the ability to block any attempt by the ruling party to fast-track debatable bills.

10.
Journal of Urology ; 207(SUPPL 5):e528-e529, 2022.
Article in English | EMBASE | ID: covidwho-1886515

ABSTRACT

INTRODUCTION AND OBJECTIVE: During the pandemic, hypogonadal return patients required remote treatment without inperson evaluation. Consequently, patients undergoing testosterone therapy transitioned to telehealth in order to maintain therapeutic testosterone levels. Patients were instructed to obtain laboratory testing;compliance fell solely on patient motivation over the course of the pandemic. The purpose of this study was to determine the compliance rates over an 8-month period and identify risk factors for non-compliance. The question remained whether, among other confounders, the distance from the patient to a clinic or patient maturity (age) influenced these rates of non-compliance. METHODS: A retrospective chart review was performed on all hypogonadal patients (n=326) seen virtually as an established patient for continued testosterone therapy. All orders were sent to the nearest lab. Patients were instructed to complete a hypogonadal panel prior to filling their medication and were referred to the site nearest to their homes. RESULTS: The patients were divided into groups with regards to compliance. They were then grouped by radial distance to the nearest lab location. The groups were defined by the distances of <20 miles, 20-30 miles, and >30 miles to the nearest Clinical Pathology Lab (CPL). There was no significant difference (p >0.05) amongst groups in lab compliance by distance. The overall compliance was 32.2% with similar age distribution in compliant versus non-compliant (44.3 vs. 44.7) patients. The attached map demonstrates patient distribution;the average distance to a lab was 16.07 miles. CONCLUSIONS: Giving more autonomy may strengthen our relationships with patients in shared decision-making when it comes to their care. Unfortunately, it is now seen that compliance with routine blood work will require in person visit or restriction of medication until labs have been drawn and results received. While telemedicine offers a service to some patients, the importance of routine monitoring may be lost with this system. If properly regulated, this type of care may be a valuable service but requires close surveillance.

11.
American Journal of Respiratory and Critical Care Medicine ; 205:2, 2022.
Article in English | English Web of Science | ID: covidwho-1881057
13.
12th International Conference on ICT Convergence (ICTC) - Beyond the Pandemic Era with ICT Convergence Innovation ; : 1205-1207, 2021.
Article in English | Web of Science | ID: covidwho-1853461

ABSTRACT

This paper discusses the system for visual assistance assistant non-face-to-face activity assistance services to help blind and blind people with visual information during their daily lives. We would like to provide a limited number of helpers to help more people through non-face-to-face services. In addition, we would like to minimize the mutual anxiety between the blind and the helper in offline face-to-face activities due to pandemics such as COVID-19. The proposed system uses raspberry pie-based optician aids and WebRTC streaming technology to help visually impaired people check videos taken through aids in real time through streaming and translate videos. In addition, by allowing voice calls to be made so that visually impaired people can communicate well in situations where they ask for help, the visually impaired can only receive help at the moment they need it in real time. This is expected to contribute to the efficient use of time and manpower to assist more visually impaired people. As a follow-up study, we would like to study how the function of spectacle-type aids can be added to assist blind people in doing more activities independently.

14.
Embase; 2022.
Preprint in English | EMBASE | ID: ppcovidwho-333275

ABSTRACT

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron subvariant BA.2 has spread in many countries, replacing the earlier Omicron subvariant BA.1 and other variants. Here, using a cell culture infection assay, we quantified the intrinsic sensitivity of BA.2 and BA.1 compared with other variants of concern, Alpha, Gamma, and Delta, to five approved-neutralizing antibodies and antiviral drugs. Our assay revealed the diverse sensitivities of these variants to antibodies, including the loss of response of both BA.1 and BA.2 to casirivimab and of BA.1 to imdevimab. In contrast, EIDD-1931 and nirmatrelvir showed a more conserved activities to these variants. The viral response profile combined with mathematical analysis estimated differences in antiviral effects among variants in the clinical concentrations. These analyses provide essential evidence that gives insight into variant emergence’s impact on choosing optimal drug treatment.

15.
PubMed; 2022.
Preprint in English | PubMed | ID: ppcovidwho-332928

ABSTRACT

During COVID-19 pandemic, mutations of SARS-CoV-2 produce new strains that can be more infectious or evade vaccines. Viral RNA mutations can arise from misincorporation by RNA-polymerases and modification by host factors. Analysis of SARS-CoV-2 sequence from patients showed a strong bias toward C-to-U mutation, suggesting a potential mutational role by host APOBEC cytosine deaminases that possess broad anti-viral activity. We report the first experimental evidence demonstrating that APOBEC3A, APOBEC1, and APOBEC3G can edit on specific sites of SARS-CoV-2 RNA to produce C-to-U mutations. However, SARS-CoV-2 replication and viral progeny production in Caco-2 cells are not inhibited by the expression of these APOBECs. Instead, expression of wild-type APOBEC3 greatly promotes viral replication/propagation, suggesting that SARS-CoV-2 utilizes the APOBEC-mediated mutations for fitness and evolution. Unlike the random mutations, this study suggests the predictability of all possible viral genome mutations by these APOBECs based on the UC/AC motifs and the viral genomic RNA structure. One-sentence summary: Efficient Editing of SARS-CoV-2 genomic RNA by Host APOBEC deaminases and Its Potential Impacts on the Viral Replication and Emergence of New Strains in COVID-19 Pandemic.

16.
INFORMS International Conference on Service Science, ICSS 2020 ; : 329-342, 2022.
Article in English | Scopus | ID: covidwho-1750468

ABSTRACT

Advanced metering infrastructure (AMI) is an integrated system of smart meters, communication networks, and data management systems. The AMI allows the automatic and remote measurement and monitoring of energy consumption. It also provides important information for the management of peak demand and energy consumption and costs. Pohang University of Science Technology (POSTECH) has developed its own AMI and an IT platform called Open Innovation Big Data Center (OIBC) to store and share various data collected in the campus. In this work, we describe the AMI and the OIBC platform equipped with various sensors and systems for measuring, storing, calling, and monitoring data. Data are collected from seven buildings with different characteristics. We installed 266 sensors at the buildings, including 188 EnerTalk and Biz, 18 plugin, and 60 high-sampling sensors. The sensors collect electricity consumption data in real time, and users can visualize and download the data through the OIBC platform. In this work, we present analysis results of the collected data. The results show that the amounts of electricity consumed by campus buildings are different depending on various factors, including building size, occupant type and their behaviors, and building use. We also compare the amounts of electricity consumed before and after the COVID-19 outbreak. The information extracted can be used to improve the satisfaction of students and faculty as well as the efficiency of electricity management. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

17.
Open Forum Infectious Diseases ; 8(SUPPL 1):S341, 2021.
Article in English | EMBASE | ID: covidwho-1746518

ABSTRACT

Background. Patients with COVID-19 infection at highest risk for poor outcomes include immunocompromised patients, such as solid organ transplant (SOT) recipients. Monoclonal antibody (mAb) infusions were developed to promote passive immunity. Analysis of the first 200 patients who received SARS-CoV-2 mAb at our hospital showed a 27 % absolute reduction in hospitalization and emergency department (ED) visits. Understanding the role of SARS-CoV-2 mAb therapy in management of the SOT population is likely to inform decision making for these patients. Methods. We conducted a retrospective chart review of SOT patients diagnosed with COVID-19 who received mAb therapy between 11/18/20 and 04/26/21. Patients were excluded if they were < 18 years of age or if they weighed < 40 kg. We compared those patients who were hospitalized or visited the ED within 29 days of mAb therapy to those who recovered without further visits to our hospital. Results. A total of 50 SOT patients receiving mAb therapy were included in this analysis. Bamlanivimab was given to 33 patients, while 9 patients received bamlanivimab/ etesevimab and 8 patients received casirivimab/imdevimab. Twelve (24 %) patients were hospitalized or visited the ED within 29 days of mAb therapy;38 patients did not. These 2 groups did not significantly differ by age, gender, body mass index, time from SOT, or other risk factors for severe COVID-19 illness per FDA Emergency Use Authorization guidance. Both groups were primarily made up of kidney transplant recipients (66.7 % and 68.4 %, respectively). Significantly more patients in the hospitalization/ ED group were receiving antimetabolites as part of their immunosuppression (IS) regimen prior to COVID-19 diagnosis (100 % vs 68.4 %, p = 0.047). Patients in the hospitalization/ED group received mAbs within a median of 6 days (IQR 3.8) of symptom onset compared to 4 days (IQR 4) (p = 0.006). Conclusion. SOT recipients were more likely to be hospitalized or visit the ED due to COVID-19 after mAb if they were receiving antimetabolite IS or received mAb later after symptom onset. These data stress the importance of early mAb administration in all SOT patients, particularly in those on antimetabolite therapy.

18.
Journal of Korean Ophthalmological Society ; 63(2):126-133, 2022.
Article in Korean | Scopus | ID: covidwho-1742192

ABSTRACT

Purpose: To analyze the change in the weekly incidence of epidemic keratoconjunctivitis (EKC) per 1,000 outpatients during the coronavirus disease 2019 (COVID-19) pandemic by comparing the mean weekly proportion of EKC of 2020 with that from 2016 to 2019. Methods: Using data from the Korea Disease Control and Prevention Agency for 2016-2020, we analyzed the weekly proportion of EKC per 1,000 outpatients. The data were also analyzed according to age, semester and vacation periods, region, and social distancing stages. For the Daegu data, we also analyzed the effects of social distancing in an area. Results: The mean weekly proportion of EKC per 1,000 outpatients in 2020 was lower than in previous years for all ages (2016-2019 19.77 ± 7.17 , 2020 7.28 ± 2.97 ;p 0.001). During the semester, the mean difference between 2016-2019 and 2020 was significant, particularly for preschool children. In Daegu, the weekly proportion of EKC per 1,000 outpatients during the extra 12-18 weeks of social distancing was significantly lower (2016-2019, 18.78 ± 6.61 ;2020, 8.94 ± 2.92 ;p 0.001). Conclusions: The public health interventions implemented during the COVID-19 outbreak not only reduced the prevalence of COVID-19 but also reduced the prevalence of EKC. Therefore, maintaining hygiene principles and standard precautions may help prevent EKC. © 2022 Korean Ophthalmological Society (KOS). All rights reserved.

19.
Journal of business and psychology ; : 1-24, 2022.
Article in English | EuropePMC | ID: covidwho-1710720

ABSTRACT

Despite demonstrating high levels of academic and professional competence, Asians are underrepresented in leadership roles in North America. The limited research on this topic has found that Asian Americans are perceived by others as poorer leaders than White Americans due to perceptions that Asians lack the ideal traits of a Western leader (i.e., agentic) relative to White Americans. However, we contend that, in addition to poorly activating ideal leader traits, Asian Americans may strongly activate ideal follower traits (e.g., industrious and reliable), and being seen as a good follower may pigeonhole Asian Americans in non-managerial roles. Across 4 studies, our findings generally supported our arguments regarding the activation of ideal follower traits and lack of activation of ideal leader traits for Asian American workers. However, compared to their majority group counterparts, we found some unexpected evidence for a more favorable view of Asian Americans as leaders, which was primarily driven by the greater activation of ideal follower traits (i.e., industry and good citizen) among Asian American workers. Yet, we uncover an important boundary condition in that these “good follower” advantages did not accrue when observers experienced threat—revealing how the benefits of so-called positive stereotypes of Asian American workers are context dependent. Supplementary Information The online version contains supplementary material available at 10.1007/s10869-022-09794-3.

20.
24th International Conference on Interactive Collaborative Learning, ICL 2021 ; 390 LNNS:23-28, 2022.
Article in English | Scopus | ID: covidwho-1704891

ABSTRACT

IDEEA program provides a platform for academia and industry to meet, exchange ideas, foster collaboration and make new friendships. The IDEEA program, which started in 2019, is on its third year this year. The purpose of this program is for students to find solutions of innovative designs or strategies as potential answers to a given set of requirements. Engineering design tasks for specific purpose drones have been carried out for the past two years, but this year, the development of future mobility was selected as the subject. In order to gain an in-depth understanding of future automobile using C (Connected), A (Autonomous), S (Shared), and E (Electric) as the keywords, 215 engineering and design students from 26 universities around the world form 16 teams. In addition, despite the Covid 19 pandemic environment, various online tools are being used to efficiently cooperate globally. The contents of this project are to design, model, and package an innovative future mobility design and engineering concept. In November of 2020, the program was launched with a general announcement of this year’s assignments. In December, team composition started, and the entire student team formation was completed and the collaboration started in March. It was easier for students to focus on conducting the project during “the team collaboration phase 1”, when all universities around the world were offering classes. The teams had to select a megacity. Then they would develop ideas and define concepts for the future mobility, appropriate for their selected metropolitan area. The midterm presentation took place on May 14th, and the purpose of this presentation was to determine how well cooperation among participating students have been progressing. Students will carry out user-needs research, industrial design and the engineering specifications and develop a “soft” precision mock-up and a CAD model of their final solution. They will present a series of development processes and their virtual mock up on the final presentation, scheduled to be on July 26–27. The IDEEA program faces many challenges due to the wide variety of the participating universities, different majors, semester starting dates and media restrictions in different countries. At the same time, the challenges of the global student teams form the foundation for an important teaching content of the course. The students can experience the collaborative work of engineers and designers in developing real world products in advance. This program will give recommendations for implementing an international, multidisciplinary collaboration course. A structured approach will be documented regarding the organization and project design, the team initiation, teaching concept and the project outcome in terms of quality of the delivered results as well as the learning success of the students. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

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