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1.
Journal of Drug Delivery and Therapeutics ; 12(4-s):101-111, 2022.
Article in English | CAB Abstracts | ID: covidwho-2056786

ABSTRACT

In-silico Computer-Aided Drug Design (CADD) often comprehends virtual screening (VS) of datasets of natural pharmaco-active compounds for drug discovery protocols. Plant Based Natural Products (PBNPs) still, remains to be a prime source of pharmaco-active compounds due to their unique chemical structural scaffolds and functionalities with distinct chemical characteristic feature from natural source that are much acquiescent to drug metabolism and kinetics. In the Post-COVID-Era number of publications pertaining to PBNPs and publicly accessible plant based natural product databases (PBNPDBs) has significantly increased. Moreover, PBNPs are important sources of inspiration or starting points to develop novel therapeutic agents. However, a well-structured, indepth ADME/Tox profile of PBNPs has been limited or lacking for many of such compounds, this hampers the successful exploitation of PBNPs by pharma industries. Absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties play key roles in the discovery/ development of drugs, pesticides, food additives, consumer products, and industrial chemicals. In the present study, ADMET-informatics of Tetradecanoic Acid (Myristic Acid) from ethyl acetate fraction of Moringa oleifera leaves to predict drug metabolism and pharmacokinetics (DMPK) outcomes has been taken up. This work contributes to the deeper understanding of Myristic acid as major source of drug from commonly available medicinal plant - Moringa oleifera with immense therapeutic potential. The data generated herein could be useful for NP based lead generation programs.

2.
Journal of Drug Delivery and Therapeutics ; 11(5-s):77-84, 2021.
Article in English | CAB Abstracts | ID: covidwho-1603047

ABSTRACT

Quercetin (3,3',4',5,7-Pentahydroxyflavone) is the one among the bioactive secondary metabolite (BASM) in neem seed of Azadirachta indica A. Juss. Quercetin (Que) and its derivatives hold promising pharmacological effects. Antidiabetic, anti-inflammatory, antioxidant, antimicrobial, anti-Alzheimer's, antiarthritic, cardiovascular, and wound-healing effects of Que have been extensively investigated, recently lot of work has been carried out on its anticancer activity against different cancer cell lines. Recently, in silico/in vitro studies have demonstrated that Que interferes with different stages of coronavirus entry and replication cycle (PLpro, 3CLpro, and NTPase/helicase). Due to its pleiotropic effects in human health and disease and lack of systemic toxicity, Que and its derivatives could be tested for their efficacy on human target system in future clinical trials. In the present study, an attempt has been made to evaluate the physicochemical, druggable properties of Que from A. indica to prospect its ADMET properties.

3.
International Journal of Pharmaceutical Research ; 13(3):1237-1245, 2021.
Article in English | EMBASE | ID: covidwho-1308608

ABSTRACT

Background Coronavirus Disease 2019 (COVID-19) has been designated a worldwide public health emergency, impacting individuals all over the world. Objectives The goal of this study was to evaluate health care workers Awareness, Attitudes and Practices (KAP) regarding the 2019 Coronavirus Disease (COVID-2019) pandemic in Kerala. Methods A cross-sectional study was carried out among health care workers (n=388) in Kerala over 6 months. The questionnaire was divided into 5 parts, part 1demographic information, and next 3 parts evaluated knowledge (10 questions), attitude, (10 questions) and practice (9 questions). Part 5 obtained access to health care workers' mental well-being. The data was subjected to Chi-square analysis and Pearson’s correlation;95% confidence interval (CI) was calculated and p<0.05 was recognised statistically significant. Results A total of 388 HCWs (response rate: 88.78 %) completed the survey out of 437 participants;72 % (n=1279) were female, 40.46 % (n=157) were aged 31-40 years, and most were nurses (n=258, 66.49 %). A large percentage of HCWs had strong Knowledge, positive Attitude and good Practice towards COVID-19. Participants Demographics were not correlated with knowledge attitude and practice level towards Covid-19 but Pearson analysis indicated that there is a positive correlation between knowledge and attitude (p=0.016). Conclusions. The HCW’s of Kerala have excellent Knowledge, Attitude and Practice towards COVID-19. It is suggest that government and Health Care department should conduct regular seminars and practice sessions regarding COVID-19 which would empower the HCW’s against COVID-19.

4.
International Journal of Pharmaceutical Research ; 12:3010-3015, 2020.
Article in English | EMBASE | ID: covidwho-891793

ABSTRACT

Background: COVID-19 pandemic has triggered panic attacks as its deadly footprint had transmitted across the globe. Although Kerala became the first Indian state to encounter COVID-19, it had notched up the best recovery rates and low mortality rates. Objective: To investigate the level of knowledge and perception of the Keralites about COVID-19 and to explore the barriers involved to curb its transmission. Methods: A cross-sectional web-based survey was conducted in Keralites during April and May, 2020 to obtain the responses regarding the knowledge, attitude and practices towards COVID-19 based on a standardized questionnaire. Chi-Square test, Kruskal-Wallis test and Spearman's one-tailed test were employed in statistical data analysis using Graph pad prism. Results: The overall correct rate on knowledge assessment was 59.2%. Chi-Square test exhibited a noteworthy association between the different levels of knowledge and demographic characteristics (P < 0.0001). Kruskal-Wallis test analyzed the variation of different levels of knowledge with districts (P < 0.0018). High knowledge was the vital predictor for the low mortality and best recovery rate as analyzed by Spearman's one-tailed test (alpha level < 0.5, P = 0.0297). Conclusion: Exploring deeper insights and the latest updates on COVID-19 will pave for eradicating the barriers faced while managing the crisis. We concluded that the Keralites demonstrated good knowledge, optimistic attitude and safer practices towards COVID-19 and its subsequent lockdown period.

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