Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 20 de 60
Filter
2.
Cell Stem Cell ; 29(5):810-825.e8, 2022.
Article in English | ScienceDirect | ID: covidwho-1819607

ABSTRACT

Summary Trophoblast organoids derived from placental villi provide a 3D model system of human placental development, but access to first-trimester tissues is limited. Here, we report that trophoblast stem cells isolated from naive human pluripotent stem cells (hPSCs) can efficiently self-organize into 3D stem-cell-derived trophoblast organoids (SC-TOs) with a villous architecture similar to primary trophoblast organoids. Single-cell transcriptome analysis reveals the presence of distinct cytotrophoblast and syncytiotrophoblast clusters and a small cluster of extravillous trophoblasts, which closely correspond to trophoblast identities in the post-implantation embryo. These organoid cultures display clonal X chromosome inactivation patterns previously described in the human placenta. We further demonstrate that SC-TOs exhibit selective vulnerability to emerging pathogens (SARS-CoV-2 and Zika virus), which correlates with expression levels of their respective entry factors. The generation of trophoblast organoids from naive hPSCs provides an accessible 3D model system of the developing placenta and its susceptibility to emerging pathogens.

3.
Current Problems in Cardiology ; : 101236, 2022.
Article in English | ScienceDirect | ID: covidwho-1814290

ABSTRACT

Pulmonary hypertension is one of the difficult situations to treat. Complex pathophysiology, association of the multiple comorbidities make clinical scenario challenging. Recently it is being shown that patients who had recovered from COVID infection, are at risk of developing pulmonary hypertension. Studies on animals have been going on to find out newer treatment options. There are recent advancements in the treatment of pulmonary hypertension. Role of anticoagulation, recombinant fusion proteins, stem cell therapy are emerging as therapeutic options for affected patients. SGLT2 inhibitors have potential to have beneficial effects on pulmonary hypertension. Apart from the medical managements, advanced interventions are also getting popular. In this review article, the authors have discussed pathophysiology, recent advancement of treatments including COVID patients, and future aspect of managing pulmonary hypertension. We have highlighted treatment options for patients with sleep apnea, interstitial lung disease to discuss the challenges and possible options to manage those patients.

4.
EuropePMC; 2022.
Preprint in English | EuropePMC | ID: ppcovidwho-332053

ABSTRACT

Background To understand the impact of COVID-19 on implementation of the peer education programme of the National Adolescent Health Programme-Rashtriya Kishor Swasthya Karyakram;repurposing of the RKSK health workers and Peer Educators (PE) in COVID-19 response activities and;adolescents′ health and development issues. Methods Virtual in-depth interviews were conducted with stakeholders (n=31) (aged 15 to 54) engaged in the implementation of the peer education programme at state, district, block, and village levels in Madhya Pradesh and Maharashtra (India). These interviews were thematically coded and analysed to address the research objectives. Results Despite most peer education programme activities being stopped, delayed, or disrupted during the pandemic and subsequent lockdown, some communication networks previously established, helped facilitate public health communication regarding COVID-19 and RKSK, between health workers, peer educators, and adolescents. There was significant repurposing of RKSK health workers and Peer Educators’ role towards COVID-19 response-related activities. Peer educators, with support from health workers, were involved in disseminating COVID-19 information, maintaining migrant and quarantine records, conducting household surveys for finding COVID-19 active cases and providing essential items (grocery, sanitary napkins, etc.) to communities and adolescents. Conclusion Peer Educators with support from community health workers are able to play a crucial role in meeting the needs of the communities during a pandemic. There is a need to further engage, involve and build the skills of Peer Educators to support the health system. PEs can be encouraged by granting more visibility and incorporating their role more formally by paying them within the public health system in India.

5.
J Oral Maxillofac Surg Med Pathol ; 2022 Apr 04.
Article in English | MEDLINE | ID: covidwho-1773080

ABSTRACT

Introduction: Mucormycosis and Aspergillosis are opportunistic fungal infections causing significant morbidity and mortality. Post the outbreak of COVID-19, these fungal osteomyelitis have seen a global rise with few atypical presentations noted. Case report: Current case series reports three such atypical presentations of fungal osteomyelitis including mandibular fungal osteomyelitis in two patients, fungal osteomyelitis mimicking space infection in a middle aged male, and suspected mixed fungal osteomyelitis involving maxillary sinus. Aggressive surgical debridement was indicated along with institution of antifungal therapy (Liposomal Amphotericin B, and Posaconazole). The fungal osteomyelitis was successfully treated with surgical and medical management with no recurrence. Discussion: The injudicious use of corticosteroids in COVID-19 patients along with their immunocompromised status increases their susceptibility to opportunistic fungal osteomyelitis. Prompt and aggressive surgical intervention along with antifungal therapy is important after diagnosing fungal osteomyelitis, as a delay could increase the mortality rate considerably.

6.
Cureus ; 14(2): e22398, 2022 Feb.
Article in English | MEDLINE | ID: covidwho-1761144

ABSTRACT

INTRODUCTION: The serosurveillance of COVID-19 antibody levels and their difference between symptomatic and asymptomatic groups can help in understanding the immune status of the community and the factors affecting it. Hence, the study was undertaken to find the differences between these two groups with respect to antibodies level and other socio-demographic variables in the South Andaman district. METHODS: A population-based serosurveillance study covering more than 4,000 samples was carried out in the South Andaman district. The participants were selected by multistage cluster sampling. The venous blood samples were tested for IgG COVID-19 antibodies by Erba Lisa Elisa kit. RESULTS: 5.3% of total individuals (217) were symptomatic whereas 94.7% (3,872) were asymptomatic. The symptomatic individuals had lower antibodies (33.6%) as compared to asymptomatic individuals (40.1%) (p-value=0.059). In the age group of 31-45 years, antibody positivity in the asymptomatic group was significantly higher than in the symptomatic group (p-value 0.031). The antibody positivity was higher in moderate to severe cases who needed hospital admission. The antibody positivity was found similar in both the groups in front-line workers as well as in non-front-line workers (p-value=0.104, 0.274, respectively). CONCLUSION: The antibody positivity was higher in asymptomatic individuals as compared to symptomatic individuals, particularly in the age group of 31-45 years. The higher level of antibody positivity in asymptomatic individuals reflected a stronger immune response which led to no clinical manifestations. The antibody positivity was also found higher in moderate to severe cases undergoing hospital admission whereas antibodies positivity was found similar in front-line and non-front-line workers.

7.
J Clin Exp Hepatol ; 12(2): 390-397, 2022.
Article in English | MEDLINE | ID: covidwho-1751085

ABSTRACT

AIM: The severe acute respiratory syndrome coronavirus 2 outbreak resulted in severe health impact with the loss of many lives across the world. Pulmonary parenchyma suffers the most from the brunt of the infection. However, evidence suggested a systemic involvement during the course of illness. Information on morphological changes of the liver is sparse in the literature. We aimed to evaluate the pathological findings in the liver by minimally invasive autopsies. METHODS: Postmortem core biopsies of the liver obtained from patients who succumbed to coronavirus disease 2019 disease were studied. Demographic findings, comorbidities, and relevant laboratory tests were collected. Detailed histopathological changes were assessed. RESULTS: Liver function tests were available in 40 cases, and it was deranged in 80% cases. A spectrum of histological changes was observed. Macrovesicular steatosis and nonspecific portal inflammation of mild degree were the common morphological changes. Features suggestive of vascular alteration were noted in more than half of the cases. These included increased portal vein branches, irregular luminal dilation, and herniation of portal veins into the periportal hepatocytes. In addition, we observed morphological changes attributed to terminal shock-related changes. CONCLUSION: The present study results highlight that liver parenchyma changes may be related to multiple pathogenic mechanisms. The presence of vascular alteration in portal tracts suggests derangement of hepatic vasculature related to systemic hypercoagulable state induced by the viral infection. It remains to be established if the histological changes are related to direct viral insult or to the systemic response caused by the viral attack.

8.
J Allergy Clin Immunol ; 2022 Mar 15.
Article in English | MEDLINE | ID: covidwho-1739828

ABSTRACT

BACKGROUND: Multisystem inflammatory syndrome in children (MIS-C) is a potentially life-threatening sequela of SARS-COV-2 infection characterized by hyperinflammation and multi-organ dysfunction. Though hyperinflammation is a prominent manifestation of MIS-C, there is limited understanding of how the inflammatory state of MIS-C differs from well characterized hyperinflammatory syndromes such as hemophagocytic lymphohistiocytosis (HLH). OBJECTIVES: To compare the qualitative and quantitative inflammatory profile differences between MIS-C, COVID-19 and HLH patients. METHODS: Clinical data abstraction from patient charts, T cell immunophenotyping and multiplex cytokine and chemokine profiling were performed for MIS-C, COVID-19 and HLH patients. RESULTS: We found that both MIS-C and HLH showed robust T cell activation, markers of senescence, and exhaustion along with elevated Th1 and pro-inflammatory cytokines such as IFN-γ, CXCL9, and CXCL10. In comparison, the amplitude of T cell activation and the levels of cytokines/chemokines were higher in HLH when compared to MIS-C. Distinguishing inflammatory features of MIS-C included elevation in Th2 inflammatory cytokines such as IL-4 and IL-13 and cytokine mediators of angiogenesis, vascular injury, and tissue repair such as VEGF-A and PDGF. Immune activation and hypercytokinemia in MIS-C resolved at follow-up. In addition, when these immune parameters were correlated with clinical parameters, CD8+ T cell activation correlated with cardiac dysfunction parameters such as BNP and troponin and inversely correlated with platelet count. CONCLUSION: Overall, this study characterizes unique and overlapping immunological features that help to define the hyperinflammation associated with MIS-C versus HLH.

9.
Cureus ; 14(1): e21618, 2022 Jan.
Article in English | MEDLINE | ID: covidwho-1716109

ABSTRACT

PURPOSE: This study was done to assess the extent of disability in coronavirus disease 2019 (COVID-19) survivors using the World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0). MATERIAL AND METHODS: This was a cross-sectional study with convenient sampling. Institutional ethical clearance was taken. Informed consent was taken from all patients. Disability assessment was done using WHODAS 2.0. All patients were initial reverse transcriptase-polymerase chain reaction (RT-PCR) positive for COVID-19. Patients with neuromuscular deficits or who were taking medication for psychiatric illness before getting infected with COVID-19 were excluded from the study. RESULTS: Fatigue followed by dyspnea was the most common reported symptom after three months of COVID-19 infection. COVID-19 survivors with fatigue or dyspnea had a more significant disability as compared to other patients. Females had a more significant disability when compared to males. We did not find any significant disability in COVID-19 survivors after three months of disease based on body mass index, hospitalization, diabetes, and oxygen requirements. CONCLUSION: COVID-19 survivors suffered from significant disability after three months of disease especially females and survivors with fatigue or dyspnea. Recognizing post-COVID-19 sequelae and the availability of rehabilitation services will be critical in preventing another public health crisis after acute COVID-19 infection.

10.
EuropePMC; 2021.
Preprint in English | EuropePMC | ID: ppcovidwho-318590

ABSTRACT

Background: Bloodstream infections (BSIs) are emerging cause of significant morbidity and mortality in severe Corona virus disease (Covid-19). We aimed to assess the prevalence, clinical profile and outcome of BSIs in critically ill Covid-19 disease. Material: and Methods: This was a single-centre retrospective study conducted at a tertiary care hospital in Western India. All the patients (age >18 years) with reverse-transcription polymerase chain reaction (RT-PCR) confirmed Covid-19 pneumonia admitted in Covid intensive care unit (ICU) between September 2020 to February 2021 were included. Hospital electronic records were searched for demographic data, time of bloodstream infection since admission, clinical profile, antimicrobial resistance pattern and clinical outcome of all patients who developed BSIs. Results: : Out of 750 patients admitted in Covid ICU, 8.5% developed secondary BSIs. All severe Covid-19 pneumonia patients developed BSIs succumbed to illness. The major proportion of BSIs were gram-negative pathogens (53/64, 82.8%). Acinetobacter baumannii was the commonest isolate followed by Klebsiella pneumoniae (32.8% and 21.9% respectively). Multidrug-resistance microorganisms (MDRO) were found in 57.8% of the cases. The majority of MDRO belonged to K. pneumoniae and Enterococcus groups. The proportion of gram-negative bacteria resistant to carbapenems was 47.2% (25/53). Conclusion: BSIs in severe Covid-19 patients carries a substantial mortality, which is a cause for concern. Timely initiation of empirical antibiotics and prompt de-escalation are vital to improve the outcome. At the same time, strict compliance of infection control practices should be accomplished to reduce the occurrence of MDRO.

11.
EuropePMC; 2021.
Preprint in English | EuropePMC | ID: ppcovidwho-308491

ABSTRACT

The surge of variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) is a global concern to public health as the mutations in the genome may alter the virulence of the virus, which poses a challenge to manage the disease. The virus depends on RNA dependent RNA polymerases [RdRp(s)] and its associated non-structural proteins for replication. Therefore, RdRp is a target of antiviral drugs. Several mutations in RdRp in SARS-CoV2 from all over the world have been identified. Some of the mutations are known to alter the RdRp structure. This may have an implication on the effectiveness of the drugs being approved for combating the disease. Therefore, we believe elaborate studies are necessary to identify and characterize mutations in RdRp with respect to drug binding ability. Herein, using molecular docking, we have studied the interaction of the approved drug, Ledipasvir, with wild type and different mutant RdRps to gain mechanistic insights into structural changes which can affect the drug binding and may be responsible for drug resistance. We observed a change in the binding energy of ledipasvir with wild type and mutant polymerases. Further, deviation in the orientation of the drug was observed in the case of mutants in comparison to wild type RdRp. These findings suggest that it is of utmost importance to study RdRp mutants to assess drug resistance.

12.
EuropePMC; 2021.
Preprint in English | EuropePMC | ID: ppcovidwho-314636

ABSTRACT

The present study was performed to model a COVID-19 spread and stabilization constraints for the regional people of Madhya Pradesh, India, at the mid-time of the lockdown period. A novel mathematical model was developed to predict the number of days required to break the virus spread chain based on the chain breaking concept of the virus carriers. This model has predicted the very accurate COVID-19 results at a mid-time of the lockdown period. Unfortunately, a good recovery rate was not achieved in Madhya Pradesh as expected by the model to stop the chain of virus spread. Thus, this novel model failed to predict the COVID-19 spread for a large duration. Nevertheless, this novel model has much potential to model the other parallel situations similar to COVID-19 spread.

13.
EuropePMC; 2020.
Preprint in English | EuropePMC | ID: ppcovidwho-313885

ABSTRACT

Vitamin D has generated interest in the context of COVID-19 pandemic. Some authorities believe that it is beneficial;others think that without proven deficiency it should not be administered. The results of clinical trial are still awaited. Therefore nothing regarding the matter is conclusively known. In this context we believe that selocalcitol, a Vitamin D analogue if administered via inhalational route, has the potential to prevent SARS-CoV2 infection. The basis of this idea is presented here.

15.
Indian J Public Health ; 65(4): 422-424, 2021.
Article in English | MEDLINE | ID: covidwho-1603912

ABSTRACT

Guillain-Barré syndrome (GBS) is an acute inflammatory demyelinating disorder of the peripheral nerve. Different variants of GBS can produce a wide array of symptoms among which motor weakness, areflexia without bladder-bowel involvement are commonly encountered. ChAdOx1 nCoV-19 is a recombinant Corona Virus Vaccine and it is incorporated into India's coronavirus disease-2019 (COVID-19) vaccination program. Few rare instances of serious neurological complications have been reported following COVID-19 vaccination. Our case received 2 dose of COVID-19 vaccine. After receiving 1st dose he had rapid onset of ascending paralysis without any sensory and bladder bowel involvement. He received Intra Venous Immuno Globulin and Injection prednisolone for 5 days. Following that his lower limb weakness resolved rapidly but there was no improvement in upper limb weakness. Nerve conduction study showed demyelinating etiology and along with clinical features, it was appeared to be a case of GBS. However, more evidence is needed before establishing the causal relationship between COVID-19 vaccines and GBS.


Subject(s)
COVID-19 , Guillain-Barre Syndrome , COVID-19 Vaccines , Guillain-Barre Syndrome/chemically induced , Humans , India , Male , SARS-CoV-2 , Vaccination
16.
J Mycol Med ; 32(2): 101238, 2021 Dec 25.
Article in English | MEDLINE | ID: covidwho-1586952

ABSTRACT

OBJECTIVE: To evaluate the outcome of patients with ROCM (Rhino-orbito-cerebral mucormycosis) following their medical and surgical management. MATERIALS AND METHODS: It is a prognostic study based in a tertiary care center in North-Western India. Patients who developed ROCM post COVID-19 infection from 1st September 2020 to 30th June 2021 were included in this study. Surgical debridement and administration of antifungal therapy was done for the post-COVID-19 ROCM patients. Disease progression and survival was studied up to 5 months of follow-up in the second wave. RESULTS: A total of 145 ROCM patients were included. The mean age at presentation, male: female ratio was 48.2 years and 2:1 respectively. As per our proposed new staging system and treatment strategy, the majority of patients belonged to stage II (31.72%) and stage III (31.03%). On a follow-up period of 5 months, 26 (18%) patients have lost their life and rest of the patients are on strict follow-up. CONCLUSION: ROCM is an extremely aggressive fungal infection which rapidly became an epidemic following the COVID-19 pandemic. The diverse and unique presentation led us to evolve a new strategy to classify and manage these patients.

17.
Phytomed Plus ; 2(1): 100206, 2022 Feb.
Article in English | MEDLINE | ID: covidwho-1586869

ABSTRACT

Background: Glycyrrhiza glabra L. (G. glabra) commonly known as liquorice is one of the highly exploited and utilized medicinal plant of the world. Since ancient times liquorice is considered as an auspicious and valuable traditional medicine across the world for treatment of various ailments. Method: Several electronic online scientific databases such as Science Direct, PubMed, Scopus, Scifinder, Google Scholar, online books and reports were assessed for collecting information. All the collected information was classified into different sections to meet the objective of the paper. Results: The electronic database search yielded 3908 articles from different countries. Out of them one ninety-eight articles published between 1956 and 2021 were included, corresponding to all detailed review on G. glabra and research on anti-inflammatories, antivirals and immunomodulatory through pre-clinical and clinical models. From all selective area of studies on G. glabra and its bioactive components it was established (including molecular mechanisms) as a suitable remedy as per the current requirement of pandemic situation arise through respiratory tract infection. Conclusion: Different relevant studies have been thoroughly reviewed to gain an insight on utility of liquorice and its bioactive constituents for anti-inflammatories, antivirals and immunomodulatory effects with special emphasized for prevention and treatment of COVID-19 infection with possible mechanism of action at molecular level. Proposed directions for future research are also outlined to encourage researchers to find out various mechanistic targets and useful value added products of liquorice in future investigations.

18.
Transplant Direct ; 8(1): e1255, 2022 Jan.
Article in English | MEDLINE | ID: covidwho-1575040

ABSTRACT

Background: COVID-19-associated mucormycosis (CAM) is a recently emerging entity. There is a lack of reports of CAM in organ transplant recipients. Methods: We conducted a multicenter (n = 18) retrospective research in India during November 2020 to July 2021. The purpose of this study was to explore the clinical spectrum, outcome and risk factors for mortality of CAM in kidney transplant recipients (KTRs). Results: The incidence of CAM was 4.4% (61/1382 COVID-19-positive KTRs) with 26.2% mortality. The median age of the cohort was 45 (38-54) y. Twenty (32%) were not hospitalized and 14 (22.9%) were on room air during COVID-19. The proportion of postdischarge CAM was 59.1%, while concurrent CAM was reported in 40.9%. The presentation of CAM was 91.8% rhino-orbital-cerebral mucormycosis and 8.2% pulmonary with 19.6% and 100% mortality, respectively. In the univariable analysis, older age, obesity, difficulty of breathing, high-flow oxygen requirement, and delay in starting therapy were significantly associated with mortality. In the multivariable logistic regression analysis, patients requiring high-flow oxygen therapy [odds ratio (95% confidence interval) = 9.3 (1.6-51); P = 0.01] and obesity [odds ratio (95% confidence interval) = 5.2 (1-28); P = 0.05] was associated with mortality. The median follow-up of the study was 60 (35-60) d. Conclusions: We describe the largest case series of CAM in KTRs. Morality in pulmonary CAM is extremely high. Severe COVID-19 pose extra risk for the development of CAM and associated mortality. Our report will help in better understanding the conundrum and management of CAM.

19.
Bhatnagar, Tarun, Chaudhuri, Sirshendu, Ponnaiah, Manickam, Yadav, Pragya, Sabarinathan, R.; Sahay, Rima, Ahmed, Faheem, Aswathy, S.; Bhardwaj, Pankaj, Bilimale, Anil, Muthusamy, Santhosh Kumar, Logaraj, M.; Narlawar, Uday, Palanivel, C.; Patel, Prakash, Rai, Sanjay, Saxena, Vartika, Singh, Arvind, Thangaraj, Jeromie Wesley Vivian, Agarwal, Ashwini, Alvi, Yasir, Amoghashree, Ashok, P.; Babu, Dinesh, Bahurupi, Yogesh, Bhalavi, Sangita, Behera, Priyamadhaba, Biswas, Priyanka Pandit, Charan, Jaykaran, Chauhan, Nishant Kumar, Chetak, K. B.; Dar, Lalit, Das, Ayan, Deepashree, R.; Dhar, Minakshi, Dhodapkar, Rahul, Dipu, T. S.; Dudeja, Mridu, Dudhmal, Manisha, Gadepalli, Ravisekhar, Garg, Mahendra Kumar, Gayathri, A. V.; Goel, Akhil Dhanesh, Gowdappa, Basavana, Guleria, Randeep, Gupta, Manoj Kumar, Islam, Farzana, Jain, Mannu, Jain, Vineet, Jawahar, Lanord Stanley, Joshi, Rajendra, Kant, Shashi, Kar, Sitanshu Sekhar, Kalita, Deepjyoti, Khapre, Meenakshi, Khichar, Satyendra, Kombade, Sarika Prabhakar, Kohli, Sunil, Kumar, Abhinendra, Kumar, Anil, Kumar, Deepak, Kulirankal, Kiran, Leela, K. V.; Majumdar, Triparna, Mishra, Baijayantimala, Misra, Puneet, Misra, Sanjeev, Mohapatra, Prasanta Raghab, Murthy, Narayana, Nyayanit, Dimpal, Patel, Manish, Pathania, Monika, Patil, Savita, Patro, Binod Kumar, Jalandra, Ramniwas, Rathod, Pragati, Shah, Naimesh, Shete, Anita, Shukla, Deepak, Shwethashree, M.; Sinha, Smita, Surana, Ashish, Trikha, Anjan, Tejashree, A.; Venkateshan, Mahalingam, Vijaykrishnan, G.; Wadhava, Sarita, Wig, Naveet, Gupta, Nivedita, Abraham, Priya, Murhekar, Manoj.
EuropePMC; 2021.
Preprint in English | EuropePMC | ID: ppcovidwho-294258

ABSTRACT

Background: India introduced BBV152/Covaxin and AZD1222/Covishield vaccines from January 2021. We estimated effectiveness of these vaccines against severe Coronavirus disease 2019 (COVID-19) among individuals aged >=45 years.<br><br>Methods: We did a multi-centric, hospital-based, case–control study between May and July 2021. Cases were severe COVID-19 patients and controls were COVID-19 negative individuals from 11 hospitals. Vaccine effectiveness (VE) was estimated for full (2 doses ≥14days) and partial (1 dose ≥21 days) vaccination;duration between two vaccine doses and against the Delta variant. We used a random effects logistic regression model to calculate adjusted odds ratios (aOR) with 95% CI after adjusting for relevant known confounders.<br><br>Findings: We enrolled 1,143 cases and 2,541 controls. The VE of full vaccination was 80% (95% CI: 73%-86%) with AZD1222/Covishield and 69% (95% CI: 54%-79%) with BBV152/Covaxin. The VE was highest for a gap of 6-8 weeks between two doses of AZD1222/Covishield (92%, 95% CI: 82%-96%) and BBV152/Covaxin (92%, 95% CI: 26%-99%). The VE estimates were similar against the Delta strain and sub-lineages.<br><br>Interpretation: BBV152/Covaxin and AZD1222/Covishield were effective against severe COVID-19 among the Indian population during the period of dominance of highly transmissible Delta variant in second wave of pandemic. An escalation of two-dose coverage with COVID-19 vaccines is critical to control the pandemic in the country.<br><br>Funding Information: Indian Council of Medical Research<br><br>Declaration of Interests: None to declare. <br><br>Ethics Approval Statement: We obtained written informed consent from all the participants or their legally authorized representatives. Study procedures were approved by the Institutional Human Ethics Committees of all participating institutions.<br><br>

20.
Healthcare (Basel) ; 9(12)2021 Dec 08.
Article in English | MEDLINE | ID: covidwho-1554930

ABSTRACT

Long-term coronavirus disease 2019 (long-COVID) refers to persistent symptoms of SARS-CoV-2 (COVID-19) lingering beyond four weeks of initial infection. Approximately 30% of COVID-19 survivors develop prolonged symptoms. Communities of color are disproportionately affected by comorbidities, increasing the risk of severe COVID-19 and potentially leading to long-COVID. This study aims to identify trends in health disparities related to COVID-19 cases, which can help unveil potential populations at risk for long-COVID. All North Carolina (NC) counties (n = 100) were selected as a case study. Cases and vaccinations per 1000 population were calculated based on the NC Department of Health and Human Services COVID-19 dashboard with reports current as of 8 October 2021, which were stratified by age groups and race/ethnicity. Then, NC COVID-19 cases were correlated to median household income, poverty, population density, and social vulnerability index themes. We observed a negative correlation between cases (p < 0.05) and deaths (p < 0.01) with both income and vaccination status. Moreover, there was a significant positive association between vaccination status and median household income (p < 0.01). Our results highlight the prevailing trend between exacerbated COVID-19 infection and low-income/under-resourced communities. Consequently, efforts and resources should be channeled to these communities to effectively monitor, diagnose, and treat against COVID-19 and potentially prevent an overwhelming number of long-COVID cases.

SELECTION OF CITATIONS
SEARCH DETAIL