Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 20 de 31
Filter
1.
Front Psychiatry ; 13: 877595, 2022.
Article in English | MEDLINE | ID: covidwho-1952738

ABSTRACT

Background: People with dementia (PWD) are vulnerable to abrupt changes to daily routines. The lockdown enforced on the 23rd of March 2020 in the UK to contain the expansion of the COVID-19 pandemic limited opportunities for PWD to access healthcare services and socialise. The SOLITUDE study explored the potential long-term effects of lockdown on PWD's symptoms and carers' burden. Methods: Forty-five carers and 36 PWD completed a telephone-based assessment at recruitment (T0) and after 3 (T1) and 6 months (T2). PWD completed measures validated for telephonic evaluations of cognition and depression. Carers completed questionnaires on their burden and on PWD's health and answered a customised interview on symptom changes observed in the initial months of lockdown. Longitudinal changes were investigated for all outcome variables with repeated-measures models. Additional post hoc multiple regression analyses were carried out to investigate whether several objective factors (i.e., demographics and time under social restrictions) and carer-reported symptom changes observed following lockdown before T0 were associated with all outcomes at T0. Results: No significant changes were observed in any outcomes over the 6 months of observations. However, post hoc analyses showed that the length of social isolation before T0 was negatively correlated with episodic and semantic memory performance at T0. Carers reporting worsening of neuropsychiatric symptoms and faster disease progression in PWD also reported higher burden. Moreover, carer-reported worsening of cognitive symptoms was associated with poorer semantic memory at T0. Conclusion: PWD's symptoms and carers' burden remained stable over 6 months of observation. However, the amount of time spent under social restrictions before T0 appears to have had a significant detrimental impact on cognitive performance of patients. In fact, carer-reported cognitive decline during social isolation was consistent with the finding of poorer semantic memory, a domain sensitive to progression in Alzheimer's disease. Therefore, the initial stricter period of social isolation had greater detrimental impact on patients and their carers, followed then by a plateau. Future interventions may be designed to maintain an optimal level of social and cognitive engagement for PWD in challenging times, to prevent abrupt worsening of symptoms and associated detrimental consequences on patients' carers.

2.
Frontiers in microbiology ; 13, 2022.
Article in English | EuropePMC | ID: covidwho-1904976

ABSTRACT

An effective and rapid diagnosis has great importance in tackling the ongoing COVID-19 pandemic through isolation of the infected individuals to curb the transmission and initiation of specialized treatment for the disease. It has been proven that enhanced testing capacities contribute to efficiently curbing SARS-CoV-2 transmission during the initial phases of the outbreaks. RT-qPCR is considered a gold standard for the diagnosis of COVID-19. However, in resource-limited countries expenses for molecular diagnosis limits the diagnostic capacities. Here, we present interventions of two pooling strategies as 5 sample pooling (P-5) and 10 sample pooling (P-10) in a high-throughput COVID-19 diagnostic laboratory to enhance throughput and save resources and time over a period of 6 months. The diagnostic capacity was scaled-up 2.15-folds in P-5 and 1.8-fold in P-10, reagents (toward RNA extraction and RT-qPCR) were preserved at 75.24% in P-5 and 86.21% in P-10, and time saved was 6,290.93 h in P-5 and 3147.3 h in P-10.

3.
Frontiers in psychiatry ; 13, 2022.
Article in English | EuropePMC | ID: covidwho-1863999

ABSTRACT

Background People with dementia (PWD) are vulnerable to abrupt changes to daily routines. The lockdown enforced on the 23rd of March 2020 in the UK to contain the expansion of the COVID-19 pandemic limited opportunities for PWD to access healthcare services and socialise. The SOLITUDE study explored the potential long-term effects of lockdown on PWD’s symptoms and carers’ burden. Methods Forty-five carers and 36 PWD completed a telephone-based assessment at recruitment (T0) and after 3 (T1) and 6 months (T2). PWD completed measures validated for telephonic evaluations of cognition and depression. Carers completed questionnaires on their burden and on PWD’s health and answered a customised interview on symptom changes observed in the initial months of lockdown. Longitudinal changes were investigated for all outcome variables with repeated-measures models. Additional post hoc multiple regression analyses were carried out to investigate whether several objective factors (i.e., demographics and time under social restrictions) and carer-reported symptom changes observed following lockdown before T0 were associated with all outcomes at T0. Results No significant changes were observed in any outcomes over the 6 months of observations. However, post hoc analyses showed that the length of social isolation before T0 was negatively correlated with episodic and semantic memory performance at T0. Carers reporting worsening of neuropsychiatric symptoms and faster disease progression in PWD also reported higher burden. Moreover, carer-reported worsening of cognitive symptoms was associated with poorer semantic memory at T0. Conclusion PWD’s symptoms and carers’ burden remained stable over 6 months of observation. However, the amount of time spent under social restrictions before T0 appears to have had a significant detrimental impact on cognitive performance of patients. In fact, carer-reported cognitive decline during social isolation was consistent with the finding of poorer semantic memory, a domain sensitive to progression in Alzheimer’s disease. Therefore, the initial stricter period of social isolation had greater detrimental impact on patients and their carers, followed then by a plateau. Future interventions may be designed to maintain an optimal level of social and cognitive engagement for PWD in challenging times, to prevent abrupt worsening of symptoms and associated detrimental consequences on patients’ carers.

4.
Sens Int ; 3: 100180, 2022.
Article in English | MEDLINE | ID: covidwho-1852065

ABSTRACT

A major threat that has surrounded human civilization since the beginning of the year 2020 is the outbreak of coronavirus disease 2019 (COVID-19). It has been declared a pandemic by the World Health Organization and significantly affected populations globally, causing medical and economic despair. Healthcare chains across the globe have been under grave stress owing to shortages of medical equipments necessary to address a pandemic. Furthermore, personal protective equipment supplies, mandatory for healthcare staff for treating severely ill patients, have been in short supply. To address the necessary requisites during the pandemic, several researchers, hospitals, and industries collaborated to meet the demand for these medical equipments in an economically viable manner. In this context, 3D printing technologies have provided enormous potential in creating personalized healthcare equipment, including face masks, face shields, rapid detection kits, testing swabs, biosensors, and various ventilator components. This has been made possible by capitalizing on centralized large-scale manufacturing using 3D printing and local distribution of verified and tested computer-aided design files. The primary focus of this study is, "How 3D printing is helpful in developing these equipments, and how it can be helpful in the development and deployment of various sensing and point-of-care-testing (POCTs) devices for the commercialization?" Further, the present study also takes care of patient safety by implementing novel 3D printed health equipment used for COVID-19 patients. Moreover, the study helps identify and highlight the efforts made by various organizations toward the usage of 3D printing technologies, which are helpful in combating the ongoing pandemic.

5.
Hosp Top ; : 1-8, 2022 May 10.
Article in English | MEDLINE | ID: covidwho-1830375

ABSTRACT

The study was carried out to explore the attitude and perception of observers involved in monitoring of doffing through Real Time Remote Audio-Visual aided (RT-RAVA), the first well-sophisticated surveillance system. A 21-item online-survey proforma was used to collect the data amongst 150 nursing personnel. 3/4th of the participants strongly agreed that they helped in reducing the doffing errors through RT-RAVA doffing. 97.3% perceived that the system is highly effective in reducing the infection during doffing. There was significant correlation between attitude and perception of the observers. The system was perceived as highly effective and was recommended for doffing.

6.
Acta Neuropsychiatr ; : 1-6, 2022 Apr 04.
Article in English | MEDLINE | ID: covidwho-1773882

ABSTRACT

OBJECTIVE: Social distancing to limit COVID-19 transmission has led to extensive lifestyle changes, including for people with dementia (PWD). The aim of this study, therefore, was to assess the impact of lockdown on the mental health of PWD and their carers. METHODS: Forty-five carers of PWD completed a telephone interview during the baseline assessment of the SOLITUDE study to gather information on life conditions and changes in symptoms of PWD during lockdown. Associations between changes in symptoms of PWD and carers' concerns and mental health were investigated. RESULTS: About 44% of carers experienced anxiety and irritability and reported changes in behavioural and cognitive symptoms in PWD. These changes were associated with worse carers' mental health and concerns about faster disease progression (χ2 = 13.542, p < 0.001). CONCLUSION: COVID-19-related social isolation has had a negative impact on patients' and carers' mental health. Potential long-term neurocognitive consequences require further investigation.

7.
EuropePMC; 2020.
Preprint in English | EuropePMC | ID: ppcovidwho-322001

ABSTRACT

It was shown that the human ACE2 is the receptor of recent coronavirus SARS-CoV-2 and variation in this gene may affect the susceptibility of a population. Therefore, we have analysed whole genome data of World populations focusing South Asia. Genetically, South Asians are more related with the West Eurasian populations rather than East Eurasians. Whereas, for this gene, unexpectedly South Asians are more closer to East Eurasians rather than West Eurasians. The phylogenetic analysis suggested that the majority of South Asian haplotypes are shared with the East Eurasians in the background of two unique event polymorphisms which are responsible for this attraction. The second SNP rs2285666 has marked difference among South Asian vs European/American. Hence, it is highly likely that among the South Asians, the host susceptibility to the novel coronavirus SARS-CoV-2 will be more similar to East/Southeast Asians rather than the Europeans.

8.
EuropePMC; 2020.
Preprint in English | EuropePMC | ID: ppcovidwho-321682

ABSTRACT

Background: Few studies have focused on exploring the clinical characteristics and outcomes of COVID-19 in older patients. We conducted this systematic review and meta-analysis to have a better understanding of the clinical characteristics of older COVID-19 patients. Methods: A systematic search of PubMed and Scopus was performed from December 2019 to May 3rd, 2020. Observational studies including older adults (age ≥60 years) with COVID-19 infection and reporting clinical characteristics or outcome were included. Primary outcome was assessing weighted pooled prevalence (WPP) of severity and outcomes. Secondary outcomes were clinical features including comorbidities and need of respiratory support. Result: 46 studies with 13,624 older patients were included. Severe infection was seen in 51% (95% CI– 36-65%, I 2 - 95%) patients while 22% (95% CI– 16-28%, I 2 - 88%) were critically ill. Overall, 11% (95% CI– 5-21%, I 2 - 98%) patients died. The common comorbidities were hypertension (48%, 95% CI– 36-60% I 2 - 92%), diabetes mellitus (22%, 95% CI– 13-32%, I 2 - 86%) and cardiovascular disease (19%, 95% CI – 11-28%, I 2 - 85%). Common symptoms were fever (83%, 95% CI– 66-97%, I 2 -91%), cough (60%, 95% CI– 50-70%, I 2 - 71%) and dyspnoea (42%, 95% CI– 19-67%, I 2 - 94%). Overall, 84% (95% CI– 60-100%, I 2 - 81%) required oxygen support and 21% (95% CI– 0-49%, I 2 - 91%) required mechanical ventilation. Majority of studies had medium to high risk of bias and overall quality of evidence was low for all outcomes. Conclusion: Approximately half of older patients with COVID-19 have severe infection, one in five are critically ill and one in ten die. More high quality evidence is needed to study outcomes in this vulnerable patient population and factors affecting these outcomes.

9.
The Researchers' International Research Journal ; 6(3):72-73, 2020.
Article in English | ProQuest Central | ID: covidwho-1689638
10.
Indian J Med Res ; 2022 Feb 10.
Article in English | MEDLINE | ID: covidwho-1687169

ABSTRACT

BACKGROUND & OBJECTIVES: : The safety of the ChAdOx1 nCoV-19 vaccine is a cause of concern for many who have been vaccinated. The people have multiple concerns and fear regarding the adverse events of the vaccine. Thus, this study was undertaken to establish the safety profile of ChAdOx1 nCoV-19 Corona Virus Vaccine (Recombinant) among the healthcare professionals. METHODS: : This was a descriptive cross-sectional survey. After taking clearance from the institutional ethics committee 1500 healthcare professionals, who had their vaccination in the past two weeks were selected. They were provided with an online survey proforma regarding adverse events following immunization (AEFIs) of COVID-19 vaccine developed using google forms with an informed consent form affixed to it. RESULTS: : A total of 1036 individuals participated in the study. The mean and median (inter quartile range) age of the participants was 37.7 ±11.25 and 35 (29-46) yr, respectively. Of these, 52.1 per cent were female, 29.3 per cent were doctors, 33.4 per cent were nurses and 9.5 per cent were paramedical staff. Forty six per cent participants experienced one or more minor AEFIs such as pain, tenderness, redness, etc. at the injection site. Fatigue (31.75%), generalized feeling of unwell (28.57%), muscle pain (23.16%) and fever (21.71%) were the most commonly reported systemic AEFIs followed by headache (20.07%), dizziness (10.03%) and joint pains (15.25%). Most of them experienced these AEFIs within 24 h of the first dose of administration. About 42 per cent of the participants took oral antipyretics/analgesics for managing the AEFIs. INTERPRETATION & CONCLUSIONS: : ChAdOx1 nCoV-19 Corona Virus Vaccine was found to be associated with mild local and systemic AEFIs that were more common after the first dose as compared to the second dose. There adverse events could be dealt with oral over-the-counter medications, with no requirement of hospitalization.

11.
Alzheimers Dement ; 17 Suppl 7: e053813, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1664364

ABSTRACT

BACKGROUND: Social isolation and loneliness are both known to exert detrimental effects on mental health and cognitive functioning, as well as on medial temporal lobe volume in older adults. Reduced social interactions have also been found to increase the risk of cognitive decline and dementia in older people. Since restrictions to social contacts have been imposed to tackle the current Coronavirus Disease 2019 (COVID-19) pandemic, this study aims to investigate the long-term impact of the resulting social isolation on people with mild dementia and their carers. METHOD: This study has been implemented using a multi-centre longitudinal observational design to monitor mental health (9-item Patient Health Questionnaire and Neuropsychiatric Inventory Questionnaire), cognitive performance (telephone Mini-Mental State Examination and Telephone Assessment of Cognitive Function) and quality of life (Quality of Life in Alzheimer's Disease) of patients with mild dementia due to neurodegenerative aetiologies, as well as carers' burden (12-item Zarit Burden Interview). Additionally, a structured interview is included to assess the potential impact of social isolation on everyday functioning of patients and carers. Participants are assessed telephonically at three time-points: baseline and two follow-ups after 3 and 6 months. RESULT: Six centres across the UK have confirmed capacity and capability to recruit up to eighty participants. Between September and December 2020, twenty-nine participants have been recruited across different sites and completed the baseline assessment. Moreover, nine participants have already completed the 3-month follow-up. CONCLUSION: This study (predicted completion date: July 2021) is expected to provide valuable insights into the potential long-term consequences of lockdown measures on people with dementia and their carers. Moreover, it will enable the identification of potential risk/protective factors for decline in mental health and cognition due to extensive changes in patients' social environment. Findings from the SOLITUDE study may inform preventative and management strategies for decline in mental function targeting people with dementia, who may be the most affected by social isolation and loneliness.

12.
Educ Inf Technol (Dordr) ; : 1-23, 2021 Nov 15.
Article in English | MEDLINE | ID: covidwho-1536321

ABSTRACT

Nowadays, internet technology plays a vital role in all the fields of our daily lives ranging from the world economy, professional careers, higher education, and almost all the spheres that are deeply impacted. In the current situation, due to COVID19, the dependence on the Internet for almost everything, including learning, getting daily needs, etc., is heavily dependent on the Internet. Online learning is made possible by the Internet, and today most students, educators, researchers are leveraging online learning platforms to enhance their knowledge at their own pace. Generally, the quality of the E-learning courses is evaluated with the help of the courses' review and rating mechanisms. In the present context, review systems are centralized, storing highly valuable information at one location and are liable to manipulation, hacking, and tampering. In this paper, the Blockchain-based Online Education Content Ranking system is proposed for an online review and ranking system that offers a decentralized trustworthy system, ensuring the integrity of the rating and the independence and integrity of content reviews by Subject Matter Experts (SME).

13.
Education and information technologies ; : 1-23, 2021.
Article in English | EuropePMC | ID: covidwho-1515913

ABSTRACT

Nowadays, internet technology plays a vital role in all the fields of our daily lives ranging from the world economy, professional careers, higher education, and almost all the spheres that are deeply impacted. In the current situation, due to COVID19, the dependence on the Internet for almost everything, including learning, getting daily needs, etc., is heavily dependent on the Internet. Online learning is made possible by the Internet, and today most students, educators, researchers are leveraging online learning platforms to enhance their knowledge at their own pace. Generally, the quality of the E-learning courses is evaluated with the help of the courses’ review and rating mechanisms. In the present context, review systems are centralized, storing highly valuable information at one location and are liable to manipulation, hacking, and tampering. In this paper, the Blockchain-based Online Education Content Ranking system is proposed for an online review and ranking system that offers a decentralized trustworthy system, ensuring the integrity of the rating and the independence and integrity of content reviews by Subject Matter Experts (SME).

14.
Urban Clim ; 40: 101013, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1483005

ABSTRACT

Novel Coronavirus disease has affected almost all the countries; which leads to the pandemic, impacting adversely on environment. The impact on environment during pre-and during lockdowns needs an attention to correlate the pollutants from industrial emissions and other factors. Therefore, the current study demonstrates the changes in fine particulate matter PM2.5, PM10 and effect on air quality during lockdown. The highest reduction was observed in lockdown I (25 March - 14 April) as compared to others lockdowns (between 15 April and 31st May 2020) due to the complete shutdown of industrial, transport, and construction activities. A significant reduction in PM2.5 and PM10 from 114.27 µg/m3 and 194.48 µg/m3 for pre-lockdown period to 41.41 µg/m3 and 86.81 µg/m3 for lockdown I was observed. The levels of air quality index fall under satisfactory category for lockdown I whereas satisfactory to moderate category for other lockdowns. The present study revealed a strong correlation between PM2.5 and PM10 levels during the pre-lockdown period (0.71) and through lockdown IV (0.76), which indicate that change in the PM10 level influences the PM2.5 level greatly. The findings of the present study could be scaled up nationwide and might be useful in formulating air pollution reduction policies in the future.

15.
EClinicalMedicine ; 38: 101025, 2021 Aug.
Article in English | MEDLINE | ID: covidwho-1397307

ABSTRACT

BACKGROUND: Immunosuppression and comorbidities increase the risk of severe coronavirus disease-2019 (COVID-19) in solid organ transplant (SOT) recipients. The outcomes of COVID-19 in liver transplant (LT) recipients remain unclear. We aimed to analyse the outcomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in LT recipients. METHODS: The electronic databases were searched for articles published from 1 December 2019 to 20 May 2021 with MeSH terms COVID-19, SARS-CoV-2, and liver transplantation. Studies reporting outcomes in more than 10 LT recipients were included for analysis. LT vs non-LT patients with COVID-19 infection were compared for all-cause mortality, which was the primary outcome studied. We also evaluated the relation between the timing of COVID-19 infection post-LT (< one year vs > one year) and mortality. FINDINGS: Eighteen articles reporting 1,522 COVID-19 infected LT recipients were included for the systematic review. The mean age (standard deviation [SD]) was 60·38 (5·24) years, and 68·5% were men. The mean time (SD) to COVID-19 infection was 5·72 (1·75) years. Based on 17 studies (I2 = 7·34) among 1,481 LT recipients, the cumulative incidence of mortality was 17·4% (95% confidence interval [CI], 15·4-19·6). Mortality was comparable between LT (n = 610) and non-LT (n = 239,704) patients, based on four studies (odds ratio [OR], 0·8 [0·6-1·08]; P = 0·14). Additionally, there was no significant difference in mortality between those infected within one year vs after one year of LT (OR, 1·5 [0·63-3·56]; P = 0·35). The cumulative incidence of graft dysfunction was 2·3% (1·3-4·1). Nearly 23% (20·71-25) of the LT patients developed severe COVID-19 infection. Before infection, 71% and 49% of patients were on tacrolimus and mycophenolate mofetil, respectively. Immunosuppression was modified in 55·9% (38·1-72·2) patients after COVID-19 infection. INTERPRETATION: LT and non-LT patients with COVID-19 have a similar risk of adverse outcomes.

16.
EClinicalMedicine ; 38: 101025, 2021 Aug.
Article in English | MEDLINE | ID: covidwho-1313062

ABSTRACT

BACKGROUND: Immunosuppression and comorbidities increase the risk of severe coronavirus disease-2019 (COVID-19) in solid organ transplant (SOT) recipients. The outcomes of COVID-19 in liver transplant (LT) recipients remain unclear. We aimed to analyse the outcomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in LT recipients. METHODS: The electronic databases were searched for articles published from 1 December 2019 to 20 May 2021 with MeSH terms COVID-19, SARS-CoV-2, and liver transplantation. Studies reporting outcomes in more than 10 LT recipients were included for analysis. LT vs non-LT patients with COVID-19 infection were compared for all-cause mortality, which was the primary outcome studied. We also evaluated the relation between the timing of COVID-19 infection post-LT (< one year vs > one year) and mortality. FINDINGS: Eighteen articles reporting 1,522 COVID-19 infected LT recipients were included for the systematic review. The mean age (standard deviation [SD]) was 60·38 (5·24) years, and 68·5% were men. The mean time (SD) to COVID-19 infection was 5·72 (1·75) years. Based on 17 studies (I2 = 7·34) among 1,481 LT recipients, the cumulative incidence of mortality was 17·4% (95% confidence interval [CI], 15·4-19·6). Mortality was comparable between LT (n = 610) and non-LT (n = 239,704) patients, based on four studies (odds ratio [OR], 0·8 [0·6-1·08]; P = 0·14). Additionally, there was no significant difference in mortality between those infected within one year vs after one year of LT (OR, 1·5 [0·63-3·56]; P = 0·35). The cumulative incidence of graft dysfunction was 2·3% (1·3-4·1). Nearly 23% (20·71-25) of the LT patients developed severe COVID-19 infection. Before infection, 71% and 49% of patients were on tacrolimus and mycophenolate mofetil, respectively. Immunosuppression was modified in 55·9% (38·1-72·2) patients after COVID-19 infection. INTERPRETATION: LT and non-LT patients with COVID-19 have a similar risk of adverse outcomes.

17.
BMC Geriatr ; 21(1): 321, 2021 05 19.
Article in English | MEDLINE | ID: covidwho-1236541

ABSTRACT

BACKGROUND: Few studies have focused on exploring the clinical characteristics and outcomes of COVID-19 in older patients. We conducted this systematic review and meta-analysis to have a better understanding of the clinical characteristics of older COVID-19 patients. METHODS: A systematic search of PubMed and Scopus was performed from December 2019 to May 3rd, 2020. Observational studies including older adults (age ≥ 60 years) with COVID-19 infection and reporting clinical characteristics or outcome were included. Primary outcome was assessing weighted pooled prevalence (WPP) of severity and outcomes. Secondary outcomes were clinical features including comorbidities and need of respiratory support. RESULT: Forty-six studies with 13,624 older patients were included. Severe infection was seen in 51% (95% CI- 36-65%, I2-95%) patients while 22% (95% CI- 16-28%, I2-88%) were critically ill. Overall, 11% (95% CI- 5-21%, I2-98%) patients died. The common comorbidities were hypertension (48, 95% CI- 36-60% I2-92%), diabetes mellitus (22, 95% CI- 13-32%, I2-86%) and cardiovascular disease (19, 95% CI - 11-28%, I2-85%). Common symptoms were fever (83, 95% CI- 66-97%, I2-91%), cough (60, 95% CI- 50-70%, I2-71%) and dyspnoea (42, 95% CI- 19-67%, I2-94%). Overall, 84% (95% CI- 60-100%, I2-81%) required oxygen support and 21% (95% CI- 0-49%, I2-91%) required mechanical ventilation. Majority of studies had medium to high risk of bias and overall quality of evidence was low for all outcomes. CONCLUSION: Approximately half of older patients with COVID-19 have severe infection, one in five are critically ill and one in ten die. More high-quality evidence is needed to study outcomes in this vulnerable patient population and factors affecting these outcomes.


Subject(s)
COVID-19 , Aged , Cough , Fever , Humans , Respiration, Artificial , SARS-CoV-2
18.
J Clin Transl Hepatol ; 9(2): 276-278, 2021 Apr 28.
Article in English | MEDLINE | ID: covidwho-1232705
20.
Am J Transplant ; 21(6): 2279-2284, 2021 06.
Article in English | MEDLINE | ID: covidwho-1052266

ABSTRACT

COVID-19 (coronavirus disease 2019) has impacted solid organ transplantation (SOT) in many ways. Transplant centers have initiated SOT despite the COVID-19 pandemic. Although it is suggested to wait for 4 weeks after COVID-19 infection, there are no data to support or refute the timing of liver transplant after COVID-19 infection. Here we describe the course and outcomes of COVID-19-infected candidates and healthy living liver donors who underwent transplantation. A total of 38 candidates and 33 potential living donors were evaluated from May 20, 2020 until October 30, 2020. Ten candidates and five donors were reverse transcriptase-polymerase chain reaction (RT-PCR) positive for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pretransplant. Four candidates succumbed preoperatively. Given the worsening of liver disease, four candidates underwent liver transplant after 2 weeks due to the worsening of liver disease and the other two candidates after 4 weeks. Only one recipient died due to sepsis posttransplant. Three donors underwent successful liver donation surgery after 4 weeks of COVID-19 infection without any postoperative complications, and the other two were delisted (as the candidates expired). This report is the first to demonstrate the feasibility of elective liver transplant early after COVID-19 infection.


Subject(s)
COVID-19 , Liver Transplantation , Organ Transplantation , Humans , Pandemics , SARS-CoV-2 , Transplant Recipients
SELECTION OF CITATIONS
SEARCH DETAIL