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1.
J Formos Med Assoc ; 120(12): 2186-2190, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1198883

ABSTRACT

We presented the clinical course and immune responses of a well-controlled HIV-positive patient with COVID-19. The clinical presentation and antibody production to SARS-CoV-2 were similar to other COVID-19 patients without HIV infection. Neutralizing antibody reached a plateau from 26th to 47th day onset but decreased on 157th day after symptoms.


Subject(s)
COVID-19 , HIV Infections , Antibodies, Neutralizing , Antibodies, Viral , Enzyme-Linked Immunosorbent Assay , HIV Infections/complications , Humans , Immunoglobulin G , SARS-CoV-2
2.
J Formos Med Assoc ; 120(5): 1269-1273, 2021 May.
Article in English | MEDLINE | ID: covidwho-728694

ABSTRACT

Until now, there are no approved treatment against COVID-19. Hydroxychloroquine (HCQ) was hypothesized to be active against SARS-CoV2 via antiviral and anti-inflammatory effect; however, HCQ for COVID-19 in clinical use remained debating. In this preliminary report, we presented six patients with mild to moderate COVID-19. They were treated with HCQ for 14 days from the day of COVID-19 diagnosis. Serial viral load from respiratory specimens were performed every other day. Cytokine profile was checked before HCQ initiation and on the 14th day of HCQ treatment. All patients receiving HCQ completed 14-day course without complication. Among the six patients, the mean duration from symptom onset to last detectable viral load was 34 ± 12 days, which was similar to those without specific treatment in previous reports. Low level of interferon-gamma was noted in all patients of different stage of infection and three patients had elevation of IL-17 level. Prolonged virus shedding is still observed regardless HCQ. The impact of HCQ on cytokine kinetics remained unclear; however, IL-17 could be an inflammatory marker for disease status monitor and a potential therapeutic target.


Subject(s)
COVID-19 , Hydroxychloroquine , Antiviral Agents/therapeutic use , COVID-19/drug therapy , COVID-19 Testing , Cytokines , Humans , Kinetics , RNA, Viral , SARS-CoV-2 , Treatment Outcome , Viral Load
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