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Journal of Pharmaceutical Sciences and Research ; 13(12):661-665, 2021.
Article in English | EMBASE | ID: covidwho-1766679


Calling Covid-19 a viral disease would be an understatement. The worldwide impact this pandemic has caused in every sphere of human life is remarkable and so is the pace at which treatment modalities and immunisation agents were formulised for it. More so, the severe complications of this disease can be devastating and fatal, therefore a number of pharmaceutical agents have been studied that have shown response in the critically ill. This article throws light upon how melatonin can be a safe and effective adjuvant pharmaceutical agent against Covid-19. Melatonin is one of the hormones that controls the bodily clock, which in turn has a crucial role to play in the pathogenesis of Covid-19. Yoga asanas can also aid in suppressing the aggravated immune response and inflammatory process in this disease. Anxiety due to the disease itself and other social factors related to it, is another reason for disturbed sleep and hence poor immune response in alleviating the effects of Covid-19.

Nephrology Dialysis Transplantation ; 36(SUPPL 1):i467, 2021.
Article in English | EMBASE | ID: covidwho-1402477


BACKGROUND AND AIMS: Asymptomatic maintenance hemodialysis patients with SARS-COV-2are missed with pre-dialysis screening without testing. The possible ideal strategy of testing each patient before each shift with RT-PCR was not feasible. We aimed to study the effectiveness of fortnightly screening with RT-PCR for SARSCoV-2 in curbing transmission. METHOD: Between July 1, 2020, and September 30, 2020, all 273 patients receiving hemodialysis were subjected to fortnightly testing for SARS-Cov-2 in the unit to detect asymptomatic patients. The cost and effectiveness of universal testing in preventing transmission were analyzed using Susceptible-Infectious-Removed (SIR) modeling assuming R0 of 2.2. RESULTS: Of 273 MHD patients, 55 (20.1%) got infected with SARS-CoV-2 over three months. Six (10.9%) were symptomatic, and 49 (89.1%) asymptomatic at the time of testing. Six (10.9%) asymptomatic patients develop symptoms later;and 43 (78.2%) remained asymptomatic. A total of 7(6.1%) HCWs also tested positive for the virus. With an assumption of R0 2.2 and isolation of symptomatic patients only, all 273 patients could have been affected by September 30, 2020;with the isolation of both symptomatic patients and those testing positive after pre-dialysis screen, only 52 (19%) infections could have been prevented. However, at the end of the study period, 218 (80%) patients remained uninfected of SARS-CoV-2. Fortnightly universal testing is cost-effective, and SIR modeling proved effective in preventing person-to-person transmission. CONCLUSION: Repeated universal testing in maintenance hemodialysis patients detected 89% of asymptomatic SARS-CoV-2 patients over three months and appeared to be an effective strategy to prevent person-to-person transmission in the dialysis unit.