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1.
QJM ; 116(3): 161-180, 2023 Mar 27.
Article in English | MEDLINE | ID: covidwho-2293833

ABSTRACT

Corona Virus Disease 2019 (COVID-19) has caused several pandemic peaks worldwide due to its high variability and infectiousness, and COVID-19 has become a long-standing global public health problem. There is growing evidence that severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) frequently causes multi-organ injuries and more severe neurological manifestations. Therefore, increased awareness of possible neurological complications is beneficial in preventing and mitigating the impact of long-term sequelae and improving the prognostic outcome of critically ill patients with COVID-19. Here, we review the main pathways of SARS-CoV-2 neuroinvasion and the potential mechanisms causing neurological damage. We also discuss in detail neurological complications, aiming to provide cutting-edge basis for subsequent related basic research and clinical studies of diagnosis and treatment.


Subject(s)
COVID-19 , Nervous System Diseases , Humans , COVID-19/complications , SARS-CoV-2 , Nervous System Diseases/etiology , Nervous System Diseases/therapy
2.
Sleep Med ; 101: 50-57, 2022 Oct 23.
Article in English | MEDLINE | ID: covidwho-2237055

ABSTRACT

OBJECTIVE: To explore the impact of the COVID-19 pandemic on the sleep-wake patterns of preschool children. METHODS: A cohort of preschoolers established before the COVID-19 pandemic was invited to participate in this study. Data including children's demographics, their own and parental sleep-wake patterns, physical activities, and screen time were collected through an online questionnaire from August to September 2020. A comparison was made on the collected data from the same cohort of children before and during the pandemic. RESULTS: The cohort which was established before the pandemic consisted of 3720 preschoolers. For this current study, 642 (17%) participated, and 497 (13%) children who fulfilled the eligibility criteria were included in the final analysis. They showed a delay in their bedtime and wake time on both weekdays and weekends with a 15-30 min increase in nocturnal sleep duration. However, with a reduction in nap time, the average daily sleep duration was shortened by 16.3 ± 64.3 min (p < 0.001) and 27.5 ± 72.9 min (p < 0.001) during weekdays and weekends, respectively. Screen time was increased while outdoor activity duration was decreased. Parental sleep/wake times were also delayed with an increase in sleep duration. Children's sleep habits were associated with screen time and parental sleep/wake patterns. CONCLUSION: Despite school suspension during the COVID-19 pandemic, preschoolers were not sleeping longer. Screen time and parental sleep/wake patterns were the major factors driving the preschoolers' sleep habits. Health education is required to control screen time in children and to promote sleep hygiene among all family members.

3.
Acta Medica Mediterranea ; 38(1):585-595, 2022.
Article in English | Scopus | ID: covidwho-1699165

ABSTRACT

Objective: This study mainly to explore the effect of comprehensive treatment in Hangzhou (China) on cognitive function of attention network in patients with nasopharyngeal carcinoma. Methods: Patients with locally advanced nasopharyngeal carcinoma who were initially diagnosed as the pre-treatment group were collected as the pre-treatment group in Hangzhou (China), and the patients who were reexamined within more than half a year after treatment were the post-treatment group. All patients received behavioral tests of attention network cognitive function. The processing efficiency of three sub-networks (executive control network, alertness system and orientation network) of cognitive function of patients' attention network was compared horizontally. Results: After treatment, the score and ratio of processing efficiency of executive control network in the group after treatment were significantly lower than those in the group before treatment, while the scores and score ratios of alertness system and oriented network processing efficiency did not change significantly. Conclusion: After treatment, the processing efficiency of the alert system and orientation network of NPC patients did not change significantly in Hangzhou (China), but the processing efficiency of the executive control network was improved. Conclusion: We determined that the pneumococcal vaccine, which is mainly administered in family medicine centers, has a positive effect on the course of COVID-19, and adult immunization should be given importance in every period. © 2022 A. CARBONE Editore. All rights reserved.

4.
Journal of Medicinal Chemistry ; 30:30, 2021.
Article in English | MEDLINE | ID: covidwho-1210153

ABSTRACT

Hexameric structure formation through packing of three C-terminal helices and an N-terminal trimeric coiled-coil core has been proposed as a general mechanism of class I enveloped virus entry. In this process, the C-terminal helical repeat (HR2) region of viral membrane fusion proteins becomes transiently exposed and accessible to N-terminal helical repeat (HR1) trimer-based fusion inhibitors. Herein, we describe a mimetic of the HIV-1 gp41 HR1 trimer, N3G, as a promising therapeutic against HIV-1 infection. Surprisingly, we found that in addition to protection against HIV-1 infection, N3G was also highly effective in inhibiting infection of human beta-coronaviruses, including MERS-CoV, HCoV-OC43, and SARS-CoV-2, possibly by binding the HR2 region in the spike protein of beta-coronaviruses to block their hexameric structure formation. These studies demonstrate the potential utility of anti-HIV-1 HR1 peptides in inhibiting human beta-coronavirus infection. Moreover, this strategy could be extended to the design of broad-spectrum antivirals based on the supercoiling structure of peptides.

5.
Zhonghua Yan Ke Za Zhi ; 56(6): 433-437, 2020 Jun 11.
Article in Chinese | MEDLINE | ID: covidwho-742857

ABSTRACT

This article was published ahead of print on the official website of Chinese Journal of Ophthalmology on April 16,2020. Objective: To screen for novel coronavirus related conjunctivitis among patients with coronavirus disease 2019. Methods: Prospective series case study. Eighty-one patients diagnosed as coronavirus disease 2019 in Guangxi Zhuang Autonomous Region People's Hospital were enrolled with ophthalmological consultation and screening for novel coronavirus related conjunctivitis, including the inquiring of eye symptoms and checking for conjunctivitis-related signs. Novel coronavirus nucleic acid testing of conjunctival swabs was performed on patients with clinical manifestations of conjunctivitis. Results: Only 3 of the 81 patients (3.70%) complained of eye discomfort, which appeared on day 16.67±9.29 after the diagnosis of coronavirus disease 2019. The eye signs were not typical of viral conjunctivitis. Novel coronavirus nucleic acid tests of conjunctival swabs were negative in both eyes. There was no evidence to support the diagnosis of novel coronavirus related conjunctivitis. The remaining 78 patients showed no clinical symptoms or signs of conjunctivitis. Conclusions: The occurrence of novel coronavirus related conjunctivitis may be low in patients with coronavirus disease 2019.(Chin J Ophthalmol, 2020, 56: 433-437).


Subject(s)
Conjunctivitis/virology , Coronavirus Infections/prevention & control , Pandemics/prevention & control , Pneumonia, Viral/prevention & control , Betacoronavirus , COVID-19 , China , Humans , Prospective Studies , SARS-CoV-2
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