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1.
NeuroQuantology ; 20(11):1858-1865, 2022.
Article in English | EMBASE | ID: covidwho-2067333

ABSTRACT

Background: Fighting the Covid-19 pandemic is one of the global priorities now, and the most important type of pandemic control is vaccination. Pfizer-Biotech is considered one of the most important vaccines currently because of its high effectiveness in stimulating the immune system, despite limited data regarding the duration of the response and its side effects. The goal of this study is to assess the response ofSARS CoV-2 S1-RBD IgG andInterleukin-15 after 30 and 120days fromthe 2nd dose ofPfizer-BioNTech vaccine which applied on themedical college students at Diyala university. Methodology: This study began after the obtainment of the Medical College of the University of Diyala, the Medical College of Al-IraqiaUniversity, and the Iraqi Ministry of Health approvals . It continued from October 2021 until March 2022.A total of45 male and femaleparticipants from the College of Medicine( DiyalaUniversity)students who took thetwo doses of Pfizer-BioNTech and were divided into two groups: 1 month (30 days) and 4 months (120 days) after the full vaccination (two doses).A 5 ml of their blood was taken two times (30 days and 120 days after the 2nd dose of thePfizer-BioNTech vaccine) in the postgraduate laboratories inside the Diyala Medical College. A serological analysis to quantify IL-15 and SARS CoV-2 S1-RBD IgG has been done using BT LAB/ Bioassay Technology Laboratory/ Human Interleukin 15 ELISA Kit from CHINA andDiasino/ SARS CoV-2 S1-RBD IgG ELISA Kit/ CHINA respectively. All the lab work happened in the postgraduate laboratories inside the Diyala Medical College. Demographic information (Age and Gender) has been collected from the participants. These participants were split into two groups depending on the time after the 2nd of Pfizer-BioNTech vaccine dose (1 month and 4 months, respectively). STATISTICA (version 12 )and SPSS (version 26 ) were used to input, review and data analysis. Essential approaches of percentages and frequencies were used for qualitative variables, while, average and standard deviation were used for quantitative variables. For both IL-15 and SARS CoV-2 S1-RBD IgG, less than 0.05 of a P-value was considered considerable. Result(s): The ratio, according to gender, was (17.8: 82.2) while the age Average was (20.9 years old). The serum data of IL-15 and SARS-CoV-2 S1-RBD IgG levels after 1 month (30 days) and 4 months (120 days) were statistically non-parametric. Mann-Whitney test (Independent two samples), showeda considerabledrop(P<0.05) of IL-15as well as SARS CoV-2 S1-RBD IgGserum levels in the 4th-monthsgroup compared to the 1-monthgroup. Conclusion(s): Interleukin-15 and SARS CoV-2 S1-RBD IgG serum levels significantly droped after 120days of the 2nd dose of Pfizer-BioNTech vaccine. Copyright © 2022, Anka Publishers. All rights reserved.

2.
Biochemical and Cellular Archives ; 21(2):4005-4012, 2021.
Article in English | GIM | ID: covidwho-1755479

ABSTRACT

As of January, 2021, nearly 2-million deaths worldwide have been attributed to COVID-19, which is caused by SARS-CoV-2. Much of the mortality has been associated with a cytokine storm syndrome in patients admitted to hospital with COVID-19 pneumonia. The aims of this study are to estimate the severity of disease among patients from COVID-19 units in Diyala province and to estimate serum cytokines levels of interleukin-10, Interleukine-6 and Interferon gamma among studied patient groups. The data accumulated throughout this selective case control study which were extended from September 1st, 2020, to December 1st, 2020. A total of 176 human serum samples were collected, and subdivided into four groups moderate, sever, critical and control, each group comprised of 44 individuals. Analysis of data was carried out using the available statistical package of SPSS-20 (Statistical Packages for Social Sciences- version 20). The results revealed that the rate of infection with COVID-19 is higher in male (65.1%) than female (34.8%). The result of cytokines showed highly significant increase in the mean of interleukin-10 and interferon gamma and significant increase in interlukin-6 in patients with Covid-19 when compared to the control group, p-value = 0,000, p-value = 0.003, p-value = 0.016, respectively. The comparison of cytokine results among Covid-19 patients revealed that the Interleukin-10 showed significant increase in critical group when compared with moderate group p-value = 0.041, but don't showed any significant differences when compared the sever group with critical, and moderate groups p-value = 0.643 and p-value = 0.114, respectively. Interleukin-6 showed highly significant differences it is increased in critical group compared with moderate group and also increase compared to in severe group pvalue = 0.003, p-value = 0.013, respectively. While interleukin-6 showed no significant differences between severe and moderate groups p-value = 0.616. Interferon gamma showed no significant differences among moderate, severe and critical groups p-value = 0.527, p-value = 895, p-value = 447, respectively. In conclusions, there's a significant association in disease severity and elevated of circulating levels of cytokines Interleukine-10 and Interleukine-6, the rate of infection with COVID-19 is higher in male than female.

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