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1.
American Journal of Respiratory and Critical Care Medicine ; 205:2, 2022.
Article in English | English Web of Science | ID: covidwho-1880587
2.
American Journal of Respiratory and Critical Care Medicine ; 205:1, 2022.
Article in English | English Web of Science | ID: covidwho-1880450
4.
Journal of Managed Care and Specialty Pharmacy ; 27(4-A SUPPL):S128, 2021.
Article in English | EMBASE | ID: covidwho-1880081

ABSTRACT

BACKGROUND: Digital therapeutics (DTx) have grown in recent years in terms of market size and influence. Despite increasing interest, managed care organizations face barriers around DTx management. Disparate DTx coverage has led to unequal uptake and discrepancies around utilization management (UM) strategies. Thus, an unmet need exists for elucidating DTx coverage criteria and the evidence that shapes policy development. OBJECTIVE: To understand current DTx payer coverage policy patterns and anticipated future trends. METHODS: DTx medical policy research was conducted August to September 2020 using Canary Insights (Lakewood, CO). Following this surveillance, an online survey was fielded to payers from Xcenda's Managed Care Network. Respondents familiar with DTx were asked about DTx coverage, UM, policy criteria, and COVID-19 implications for DTx management. RESULTS: Fifty respondents (54% represent health plans, 26% pharmacy benefit managers, 20% integrated delivery network) completed the survey, and 88% evaluated ≥ 1 DTx in the past 12 to 18 months. Respondents reported that mobile apps (48%) and medication adherence platforms (40%) were the most reviewed and were expected to have the greatest increase in coverage demand over the next 12 to 18 months. Respondents indicated diabetes as the highest priority (66%) with the greatest impact in addressing unmet needs (52%). For UM, DTx coverage fell under medical benefit (41%) or was product dependent (43%). In evaluating DTx, clinical effectiveness (94%), safety (82%), and FDA-approved or cleared use (78%) were indicated as absolutely needed while clinical benefit (98%), peer-reviewed publications (94%), and return on investment (88%) were most useful for coverage decisions. The most cited rationale for either covering or denying DTx was evaluation of existing efficacy and safety data vs a lack of outcomes and cost data. For reauthorization, most respondents indicated documentation of positive clinical response (80%) and total cost of care reduction (71%) as requirements for re-authorization, while citing lack of long-term clinical data (73%) as the largest barrier for establishing re-authorization criteria, and 52% of respondents were interested in subscription-based or alternative pricing models for re-authorization. Respondents indicated that the COVID-19 pandemic has not impacted DTx coverage (58%), with no changes expected in the next 12 to 18 months (46%). CONCLUSIONS: Inconsistencies in DTx payer evaluation, coverage, and UM highlight the unmet need for establishing a standardized format for DTx appraisal.

5.
ICIC Express Letters, Part B: Applications ; 13(7):741-748, 2022.
Article in English | Scopus | ID: covidwho-1879766

ABSTRACT

Tourism activities have positive impact on individual’s emotions and can improve individual’s QOL (Quality of Life). To build sustainable tourism, resilience is required in difficult society such as COVID-19 pandemic era. One of resilience is “Bricolage” described by Levi-Strauss in “La Pensée Sauvage (The Savage Mind)”. In this research, we aim to discover Bricolage’s activities and how humans express their feelings under COVID-19. We classified Bricolage actions into three types: (type 1) Self-closed Bricolage actions, (type 2) One-directional Bricolage actions and (type 3) Mutual Bricolage actions. We implemented the collecting and analyzing system using tweets data in 2020 with the keyword “Tourism”. As a result, keywords of type 1 and type 2 are increasing, especially in conjunction with the first increasing peak of the number of infected people. For keywords of type 3, the increase was linked and was slightly behind in terms of the variation of keywords of type 1 and type 2. In addition, verbs of Bricolage activities were extracted by the 5-gram analysis in terms of the keywords of type 1 and synchronized with the increase trend in the number of infected people. This phenomenon shows social resilience with Bricolage is represented by people during COVID-19. © 2022, ICIC International. All rights reserved.

6.
Asia-Pacific Journal of Research in Early Childhood Education ; 16(2):275-291, 2022.
Article in English | Scopus | ID: covidwho-1879691

ABSTRACT

The purpose of this study was to gain an understanding of the experiences and perceptions of distance learning among early childhood pre-service teachers in Korea during the COVID-19 pandemic, which has been spreading worldwide since early 2020. A total of 196 early childhood pre-service teachers with experience in distance learning participated in the survey, and the results of the survey are as follows. While early childhood pre-service teachers perceived a difference between face-to-face (inperson) classes and distance learning, they expressed a high willingness to take part in distance learning in the post-COVID-19 era. Convenience and usefulness were mentioned as key advantages of distance learning, while difficulties in interaction and concentration were emphasised as disadvantages. To improve the quality of distance learning in the future, they suggested that students should increase participation, while instructors should strengthen their distance learning-related capabilities and universities should enhance support through system development. The implications of this study were discussed based on these results. © 2022. by THE PACIFIC EARLY CHILDHOOD EDUCATION RESEARCH ASSOCIATION

7.
Eur Rev Med Pharmacol Sci ; 26(10): 3760-3770, 2022 May.
Article in English | MEDLINE | ID: covidwho-1876425

ABSTRACT

OBJECTIVE: This meta-analysis aims to assess the susceptibility to and clinical outcomes of COVID-19 in autoimmune inflammatory rheumatic disease (AIRD) and following AIRD drug use. MATERIALS AND METHODS: We included observational and case-controlled studies assessing susceptibility and clinical outcomes of COVID-19 in patients with AIRD as well as the clinical outcomes of COVID-19 with or without use of steroids and conventional synthetic disease-modifying antirheumatic drugs (csDMARDs). RESULTS: Meta-analysis including three studies showed that patients with AIRD are not more susceptible to COVID-19 compared to patients without AIRD or the general population (OR: 1.11, 95% CI: 0.58 to 2.14). Incidence of severe outcomes of COVID-19 (OR: 1.34, 95% CI: 0.76 to 2.35) and COVID-19 related death (OR: 1.21, 95% CI: 0.68 to 2.16) also did not show significant difference. The clinical outcomes of COVID-19 among AIRD patients with and without csDMARD or steroid showed that both use of steroid (OR: 1.69, 95% CI: 0.96 to 2.98) or csDMARD (OR: 1.35, 95% CI: 0.63 to 3.08) had no effect on clinical outcomes of COVID-19. CONCLUSIONS: AIRD does not increase susceptibility to COVID-19, not affecting the clinical outcome of COVID-19. Similarly, the use of steroids or csDMARDs for AIRD does not worsen the clinical outcome.


Subject(s)
Antirheumatic Agents , Autoimmune Diseases , COVID-19 , Rheumatic Diseases , Antirheumatic Agents/therapeutic use , COVID-19/drug therapy , Humans , Incidence , Rheumatic Diseases/drug therapy , Rheumatic Diseases/epidemiology
8.
2022 CHI Conference on Human Factors in Computing Systems, CHI 2022 ; 2022.
Article in English | Scopus | ID: covidwho-1874723

ABSTRACT

The COVID-19 pandemic has forced workers around the world to switch their working paradigms from on-site to video-mediated communication. Despite the advantages of videoconferencing, diverse circumstances have prevented people from focusing on their work. One of the most typical problems they face is that various surrounding factors distract them during their meetings. This study focuses on conditions in which remote workers are distracted by factors that disturb, interrupt, or restrict them during their meetings. We aim to explore the various problem situations and user needs. To understand users' pain points and needs, focus group interviews and participatory design workshops were conducted to learn about participants' troubled working experiences over the past two years and the solutions they expected. Our study provides a unified framework of distracting factors by which to understand causes of poor user experience and reveals valuable implications to improve videoconferencing experiences. © 2022 ACM.

9.
2022 CHI Conference on Human Factors in Computing Systems, CHI 2022 ; 2022.
Article in English | Scopus | ID: covidwho-1874707

ABSTRACT

Deaf and Hard-of-Hearing (DHH) users face accessibility challenges during in-person and remote meetings. While emerging use of applications incorporating automatic speech recognition (ASR) is promising, more user-interface and user-experience research is needed. While co-design methods could elucidate designs for such applications, COVID-19 has interrupted in-person research. This study describes a novel methodology for conducting online co-design workshops with 18 DHH and hearing participant pairs to investigate ASR-supported mobile and videoconferencing technologies along two design dimensions: Correcting errors in ASR output and implementing notification systems for influencing speaker behaviors. Our methodological findings include an analysis of communication modalities and strategies participants used, use of an online collaborative whiteboarding tool, and how participants reconciled differences in ideas. Finally, we present guidelines for researchers interested in online DHH co-design methodologies, enabling greater geographically diversity among study participants even beyond the current pandemic. © 2022 ACM.

10.
BMJ Open ; 12(Suppl 1):A14-A15, 2022.
Article in English | ProQuest Central | ID: covidwho-1874569

ABSTRACT

BackgroundThe COVID-19 pandemic has created challenges and led to the massive closure of in-person CPR trainings globally. We developed a mobile application-based real-time CPR training solution named HEROS-Remote, which combines instructors, learners, training contents, and CPR feedback in just one app. In this study, we investigated the usability, acceptability, and feasibility of the HEROS-Remote CPR training solution among community lay people.MethodFrom August to November 2021, HEROS Remote pilot study was conducted in Seoul, Korea. During the study period, 164 learners participated in 22 HEROS-Remote sessions. Before the training, CPR training material, including Little Anne QCPR manikin, was delivered to the individual learner. After one-hour chest compression-only HEROS Remote online training, the learners participated in-depth survey on their experiences of HEROS Remote online training.ResultsA total 152 learners (92.7%) responded to the survey. Overall, 88.1% of the learners were satisfied with the HEROS Remote training and 85.5% responded that they would recommend online training to others. Majority of the learners (37.3% strongly agree;41.3% agree) also agreed with the easiness of using the HEROS Remote app. Manikin delivery service was highly satisfactory (97%). However, major challenge for this online solution was that the quality of the training highly depended on internet connectivity.ConclusionThis study provides evidence of the feasibility and acceptability of a novel online, real-time CPR training solution. Further research is needed to investigate the effectiveness of online CPR training versus face-to-face training.Conflict of interestSYJK, HM, TSB are employees of Laerdal Medical.FundingSeoul Metropolitan Government.

11.
Electrochimica Acta ; 422, 2022.
Article in English | Scopus | ID: covidwho-1873023

ABSTRACT

We present an open source, fully wireless potentiostat (the “NanoStat”) for applications in electrochemistry, sensing, biomedical diagnostics, and nanotechnology, based on only 2 integrated circuit chips: A digital microcontroller with integrated on board WiFi and file/web server hardware/software, and an analog front end. This versatile platform is fully capable of all modern electrochemisty assays, including cyclic voltammetry, square wave voltammetry, chronoamperometry, and normal pulse voltammetry. The user interface is a web browser connected over http. All the code (firmware, HTML5, JavaScript) is hosted by the NanoStat itself without the need for any additional software. The total size is 4×40×20 mm and battery operation for 6 h is demonstrated, possible to extend to weeks or months in sleep mode. We anticipate that the applications of this could be very broad, from biomedical sensing in the clinic, to remote monitoring of unattended “motes”, to even possibly sensing aerial pathogens such as COVID in large public spaces without the need for anything other than a web browser for remote monitoring from anywhere in the world. Finally, we propose to use this software suite as a basis (kernel) of a fully open source, general purpose, web based electrochemistry software suite, ed from the hardware, which we call “OpenEChem”. © 2022

12.
Multiple Sclerosis Journal ; 28(1_SUPPL):75-75, 2022.
Article in English | Web of Science | ID: covidwho-1866013
13.
Internal Medicine Journal ; 52:31-31, 2022.
Article in English | Web of Science | ID: covidwho-1865946
14.
Embase; 2021.
Preprint in English | EMBASE | ID: ppcovidwho-337383

ABSTRACT

Sotrovimab (VIR-7831) and VIR-7832 are dual action monoclonal antibodies (mAbs) targeting the spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Sotrovimab and VIR-7832 were derived from a parent antibody (S309) isolated from memory B cells of a 2003 severe acute respiratory syndrome coronavirus (SARS-CoV) survivor. Both mAbs contain an “LS” mutation in the Fc region to prolong serum half-life. In addition, VIR-7832 encodes an Fc GAALIE mutation that has been shown previously to evoke CD8+ T-cells in the context of an in vivo viral respiratory infection. Sotrovimab and VIR-7832 neutralize wild-type and variant pseudotyped viruses and authentic virus in vitro. In addition, they retain activity against monoclonal antibody resistance mutations conferring reduced susceptibility to previously authorized mAbs. The sotrovimab/VIR-7832 epitope continues to be highly conserved among circulating sequences consistent with the high barrier to resistance observed in vitro. Furthermore, both mAbs can recruit effector mechanisms in vitro that may contribute to clinical efficacy via elimination of infected host cells. In vitro studies with these mAbs demonstrated no enhancement of infection. In a Syrian Golden hamster proof-of concept wildtype SARS-CoV-2 infection model, animals treated with sotrovimab had less weight loss, and significantly decreased total viral load and infectious virus levels in the lung compared to a control mAb. Taken together, these data indicate that sotrovimab and VIR-7832 are key agents in the fight against COVID-19.

15.
12th International Conference on ICT Convergence (ICTC) - Beyond the Pandemic Era with ICT Convergence Innovation ; : 20-24, 2021.
Article in English | Web of Science | ID: covidwho-1853457

ABSTRACT

The coronavirus disease (COVID-19) highlighted our daily lives recently and caused panic over the world. In parallel, artificial intelligence contributes to presenting solutions to cease the spread of the virus by offering robust deep learning models for disease detection in chest X-ray images, despite the limited data available and the quality of its distribution as we face the problem of imbalanced data often in this kind of classification. To manage this issue, many techniques were presented recently that aim to make the distribution of the dataset homogeneous, increase the accuracy of the CNN models and obtain a correct classification. This work suggests a study of different techniques of handling the imbalanced data for the chest X-ray image classification when using distinct pre-trained CNN models. The results were unrelated depending on the approach used and the trained model.

16.
International Review of Financial Analysis ; 80:11, 2022.
Article in English | Web of Science | ID: covidwho-1851325

ABSTRACT

This paper examines whether the investment of Korean business group ("chaebol") affiliated firms behaved differently from that of non-chaebol firms in response to the COVID-19 outbreak. I show that chaebol firms cut back investment to a lesser degree than similar non-chaebol firms. Chaebol firms with higher-than-industry-median market-to-book ratios invested more and experienced less decline in their stock prices, while I do not find such relationships for non-chaebol firms. This paper provides evidence that chaebol internal capital markets helped mitigate the negative effects of the pandemic on firm investment and value.

18.
Journal of Current Southeast Asian Affairs ; 2022.
Article in English | Scopus | ID: covidwho-1846753

ABSTRACT

We examine the Thai government's politicised COVID-19 containment strategies, which have been challenged by Thai protesters. Although we use securitisation theory as an explanatory framework, we argue that researchers using this theory can explain the issues only if they simultaneously use social-conflict theory to explain the interactions between securitising actors and their audiences. By supplementing securitisation theory with social-conflict theory, we have found that the roles of securitising actors and audiences are not fixed. In our case study of Thailand, the Thai government and protesters have played two roles simultaneously: the role of a securitising actor and the role of an audience. This finding suggests that successful securitisation is impermanent;that is, it is subject to change over time. Securitisation may be successful, but the success can only be temporary because as new actors or resources enter the picture, the previously successful securitisation will, at some point, diminish. © The Author(s) 2022.

19.
2022 zh Conference on Human Factors in Computing Systems, zh EA 2022 ; 2022.
Article in English | Scopus | ID: covidwho-1846570

ABSTRACT

Motivated by the outbreak of COVID-19, museums have increased interests in online museum and online museum education. This study presents a way to use AI image synthesis technology for online art education guided by a constructivist design approach. An experiment was conducted to empirically test the effectiveness of AI-based art education in the online museum context. A total of 83 participants visited one of 3 different web-based art museums (i.e., AI image synthesis not applied vs. AI image synthesis applied with given photos vs. AI image synthesis applied with self-uploaded photos). Those who experienced the online museum with synthesized images using self-uploaded photos reported a higher level of motivation and satisfaction and to experience in a more constructivist way compared to other conditions. © 2022 ACM.

20.
Embase; 2021.
Preprint in English | EMBASE | ID: ppcovidwho-335728

ABSTRACT

There is strong evidence for brain-related abnormalities in COVID-191-13. It remains unknown however whether the impact of SARS-CoV-2 infection can be detected in milder cases, and whether this can reveal possible mechanisms contributing to brain pathology. Here, we investigated brain changes in 785 UK Biobank participants (aged 51-81) imaged twice, including 401 cases who tested positive for infection with SARS-CoV-2 between their two scans, with 141 days on average separating their diagnosis and second scan, and 384 controls. The availability of pre-infection imaging data reduces the likelihood of pre-existing risk factors being misinterpreted as disease effects. We identified significant longitudinal effects when comparing the two groups, including: (i) greater reduction in grey matter thickness and tissue-contrast in the orbitofrontal cortex and parahippocampal gyrus, (ii) greater changes in markers of tissue damage in regions functionally-connected to the primary olfactory cortex, and (iii) greater reduction in global brain size. The infected participants also showed on average larger cognitive decline between the two timepoints. Importantly, these imaging and cognitive longitudinal effects were still seen after excluding the 15 cases who had been hospitalised. These mainly limbic brain imaging results may be the in vivo hallmarks of a degenerative spread of the disease via olfactory pathways, of neuroinflammatory events, or of the loss of sensory input due to anosmia. Whether this deleterious impact can be partially reversed, or whether these effects will persist in the long term, remains to be investigated with additional follow up.

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