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Clinical Research in Cardiology ; 110(2):292-301, 2021.
Article | WHO COVID | ID: covidwho-1064474


AIMS: During the COVID-19 pandemic, hospital admissions for cardiac care have declined However, effects on mortality are unclear Thus, we sought to evaluate the impact of the lockdown period in central Germany on overall and cardiovascular deaths Simultaneously we looked at catheterization activities in the same region METHODS AND RESULTS: Data from 22 of 24 public health-authorities in central Germany were aggregated during the pandemic related lockdown period and compared to the same time period in 2019 Information on the total number of deaths and causes of death, including cardiovascular mortality, were collected Additionally, we compared rates of hospitalization (n = 5178) for chronic coronary syndrome (CCS), acute coronary syndrome (ACS), and out of hospital cardiac arrest (OHCA) in 26 hospitals in this area Data on 5,984 deaths occurring between March 23, 2020 and April 26, 2020 were evaluated In comparison to the reference non-pandemic period in 2019 (deaths: n = 5832), there was a non-significant increase in all-cause mortality of 2 6% [incidence rate ratio (IRR) 1 03, 95% confidence interval (CI) 0 99-1 06;p = 0 16] Cardiovascular and cardiac mortality increased significantly by 7 6% (IRR 1 08, 95%-CI 1 01-1 14;p = 0 02) and by 11 8% (IRR 1 12, 95%-CI 1 05-1 19;p < 0 001), respectively During the same period, our data revealed a drop in cardiac catherization procedures CONCLUSION: During the COVID-19-related lockdown a significant increase in cardiovascular mortality was observed in central Germany, whereas catherization activities were reduced The mechanisms underlying both of these observations should be investigated further in order to better understand the effects of a pandemic-related lockdown and social-distancing restrictions on cardiovascular care and mortality

Journal of Veterinary Internal Medicine ; 34 (1):371-372, 2020.
Article | WHO COVID | ID: covidwho-824922


Feline coronavirus (FCoV) infection is very common in multi-cat households It has been proposed that cats with higher antibody titres are more likely to shed FCoV in their faeces Aim of the study was to determine a possible correlation between FCoV serum antibody titres and faecal FCoV shedding Four faecal samples from 72 cats originating from 18 German catteries were examined for FCoV by quantitative reverse transcriptase polymerase chain reaction (RT-PCR) Serum antibody titres were determined by immunofluorescence assay There was a weak positive correlation between height of antibody titre and mean faecal virus load (Spearman r = 0 3394;P = 0 0035) Antibody titres were significantly higher if cats shed FCoV more frequently (Kruskal Wallis test P = 0 0042) Twenty-two cats were RT-PCRnegative in all four faecal samples Those cats had significantly lower antibody titres than cats shedding continuously (in all four samples) (Dunn's test;P 0 05) When analysing FCoV-shedding cats (shedding at least once), cats that were FCoV RT-PCR-positive continuously in all four samples had significantly higher antibody titres (Mann-Whitney U test P = 0 0026) and significantly higher mean faecal virus loads (Mann-Whitney U test P = 0 0383) than cats that were FCoV RT-PCRpositive in only one, two, or three samples Eight cats had no detectable antibodies but were shedding FCoV Height of antibody titre was correlated to faecal virus load Chronic FCoV shedders had higher antibody titres and shed more virus This knowledge can be of importance for the management of FCoV infection in multi-cat environments However, measurement of serum antibodies cannot replace faecal RT-PCR