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Italian Journal of Medicine ; 15(3):49, 2021.
Article in English | EMBASE | ID: covidwho-1567593


Background and Aim: In January 2021, vaccination against CoViD-19 was started in Italy. F. Miulli Regional Hospital, in Acquaviva delle Fonti (BA), has prepared a vaccination plan in order to cover the entire health care population which, starting from January 6, 2021, led to the vaccination of 1,700 subjects. Purpose of the study was to evaluate the impact of SARS-CoV-2 vaccination on healthcare personnel. Primary outcomes were: the number of infections detected after vaccination and hospitalizations for SARS-CoV-2 infection. Materials and Methods: Nasopharyngeal swabs were analyzed with reverse transcription-polymerase chain reaction techniques. Vaccination campaign was carried out in the period January-February 2021. The data were compared according to three periods: time 0: March-April 2020;time 1: October2020-January 2021;time 2 (post vaccine): February-April 2021. Results: The swabs analyzed were respectively: Time 0: 1.077;Time 1: 9.043;Time 2: 4.013. The positive tests and their percentage, relative to the swabs examined in the three times, are: Time 0: 17 cases (1.57%);Time 1: 137 cases (1.51%);Time 2: 15 cases (0.37%). Furthermore, none of the positive subjects at time 2 required hospitalization, compared to 3.2% of hospitalizations which occurred between time 0 and time 1. Conclusions: Vaccination against SARS-CoV-2 resulted in a 75.3% reduction in infections in vaccinated subjects and a 100% reduction in hospitalizations, indicating a high protective effect for both infection and disease expression.

Italian Journal of Medicine ; 14(SUPPL 2):109, 2020.
Article in English | EMBASE | ID: covidwho-984191


Background and Aim of the study: The COVID-19 pandemic israpidly spreading throughout the globe. Recent reports suggestthat 10-30% of SARS-CoV-2 infected patients are asymptomatic.Here, we reported the positive rate of COVID-19 tests supportedon RT-PCR, from March 14 to April 15 in General Hospital 'F. Miulli'(South of Italy). We observed a ~18% SARS-CoV-2 positive ratefrom 912 tests. Methods: The study was a retrospective study conducted in Regional General Hospital 'F. Miulli' (Acquaviva delle Fonti, BA), whichwas a chosen hospital for Covid-19 patients. The diagnosis ofCovid-19 was according to World Health Organization interim guidance and confirmed by RNA detection of the SARS-CoV-2 in onsiteclinical laboratory. Results: Nasopharyngeal swabs showed poor positive rate in 912cases, 163 out of 912 (17.9%) were positive by RT-PCR test withtheir respiratory specimens. Among this, 92.8% were positive forall the three target genes. Male had a higher positive rate than female in the total 912 cases. The male patients are 107, femaleare 56. The Positive Rate were significantly higher in male than infemale cases (p < 0.01). When we analyzed the positive rate according to age, we could see that positive rate increased from0.6% (age 18-30) to 25.0% (age >70) and 30.8% (age 50-59).Gender and age are two risk factors for SARS-CoV-2 infection.Conclusions: Therefore, consistent with other reports, we couldconclude that for suspect SARS-CoV-2 infection, positive percentage would be higher in male and old, but in Fever Clinics, genderwas not a risk factor.