Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 8 de 8
Filter
1.
EcoMat ; 4(1), 2022.
Article in English | ProQuest Central | ID: covidwho-1591106

ABSTRACT

Direct solar vapor generation (SVG) provides a sustainable and eco‐friendly solution to the current global water scarcity challenges. However, existing SVG systems operating under natural sunlight suffer from low water yield and high energy requirement of vaporization. New materials with reduced latent heat of water vaporization are in urgent demand to boost SVG process. Herein, we propose a novel strategy to additively fabricate anisotropic hybrid 3D structure from photocurable thermoresponsive p(NIPAm‐co‐PEGDA) hydrogel on the top of PEGDA foam for SVG. The in‐situ post‐printing synthesis of iron oxide nanoparticles within the p(NIPAm‐co‐PEGDA) hydrogel on the top surface, thus introducing anisotropy, is achieved by adding metallic salt precursor into the printing solution. The as‐fabricated hydrogel composite structure exhibits superior light absorption properties and rapid capillary‐driven water transport through a 3D‐printed microchannel network within the hydrogel. As a result, our SVG device achieves an extraordinary water evaporation rate of 5.12 kg m−2 h−1 under one sun (1 kW/m2). The intrinsic water activation states, in addition to wettability modulation with temperature increase within p(NIPAm‐co‐PEGDA) hydrogel, plays a critical role in reducing the equivalent vaporization enthalpy and shifting the vaporization to relatively lower temperatures. The proposed hybrid SVG device is feasible, portable, and highly efficient, promising great potential for grand water‐energy nexus challenges.

2.
J Nanobiotechnology ; 19(1): 287, 2021 Sep 26.
Article in English | MEDLINE | ID: covidwho-1440936

ABSTRACT

Pancreatic cancer, at unresectable advanced stages, presents poor prognoses, which could be prevented by early pancreatic cancer diagnosis methods. Recently, a promising early-stage pancreatic cancer biomarker, extracellular vesicles (EVs) related glypican-1 (GPC1) mRNA, is found to overexpress in pancreatic cancer cells. Current mRNA detection methods usually require expensive machinery, strict preservation environments, and time-consuming processes to guarantee detection sensitivity, specificity, and stability. Herein, we propose a novel two-step amplification method (CHAGE) via the target triggered Catalytic Hairpin Assembly strategy combined with Gold-Enhanced point-of-care-testing (POCT) technology for sensitive visual detection of pancreatic cancer biomarker. First, utilizing the catalyzed hairpin DNA circuit, low expression of the GPC1 mRNA was changed into amplification product 1 (AP1, a DNA duplex) as the next detection targets of the paper strips. Second, the AP1 was loaded onto a lateral flow assay and captured with the gold signal nanoparticles to visualize results. Finally, the detected results can be further enhanced by depositing gold to re-enlarge the sizes of gold nanoparticles in detection zones. As a result, the CHAGE methodology lowers the detection limit of mRNA to 100 fM and provides results within 2 h at 37 °C. Furthermore, we demonstrate the successful application in discriminating pancreatic cancer cells by analyzing EVs' GPC1 mRNA expression levels. Hence, the CHAGE methodology proposed here provides a rapid and convenient POCT platform for sensitive detection of mRNAs through unique probes designs (COVID, HPV, etc.).

3.
BMC Infect Dis ; 20(1): 935, 2020 Dec 09.
Article in English | MEDLINE | ID: covidwho-967767

ABSTRACT

BACKGROUND: This study aims to investigate the comparative clinical characteristics of Covid-19 and non-Covid-19 patients. METHODS: Fifteen Covid-19 and 93 non-Covid-19 patients were included in RNA testing. All epidemiological and clinical data were collected and analyzed, and then comparative results were carried out. RESULTS: Covid-19 patients were older (46.40 ± 18.21 years vs 34.43 ± 18.80 years) and had a higher body weight (70.27 ± 10.67 kg vs 60.54 ± 12.33 kg, P < 0.05). The main symptoms that were similar between Covid-19 and non-Covid-19 patients, and Covid-19 patients showed a lower incidence of sputum production (6.67% vs 45.16%, P < 0.01) and a lower white-cell count (4.83 × 109/L vs 7.43 × 109/L) and lymphocyte count (0.90 × 109/L vs 1.57 × 109/L, P < 0.01). Although there were no differences, C-reactive protein and interleukin-6 were elevated in Covid-19 patients. The sensitivity and negative predictive value of CT images were 0.87 and 0.97, respectively. Covid-19 patients showed a higher contact history of Wuhan residents (80% vs 30.11%) and higher familial clustering (53.33% vs 8.60%, P < 0.001). Covid-19 patients showed a higher major adverse events (ARDS, 13.33%; death, 6.67%; P < 0.05). CONCLUSION: Our results suggested that Covid-19patients had a significant history of exposure and familial clustering and a higher rate of severe status; biochemical indicators showed lymphocyte depletion.


Subject(s)
COVID-19/blood , COVID-19/epidemiology , Disease Outbreaks , SARS-CoV-2/genetics , Adolescent , Adult , Body Weight , C-Reactive Protein/analysis , COVID-19/virology , China/epidemiology , Diagnostic Tests, Routine , Female , Humans , Incidence , Interleukin-6/blood , Lymphocyte Count , Male , Middle Aged , RNA, Viral/blood , RNA, Viral/genetics , Retrospective Studies , Young Adult
5.
Preprint | SSRN | ID: ppcovidwho-683

ABSTRACT

Background: ACE2 is a receptor for SARS-CoV-2 entry into cells. However, the related prognosis and possible immune mechanisms of ACE2 in UCEC and KIRafter SAR

6.
Open Access (OA) Online-First Publ Res Pap COVID-19 ; : 1-Sep, 2020.
Article | WHO COVID | ID: covidwho-602831

ABSTRACT

A review. Coronavirus disease 2019 has become a pandemic. The transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is strong, and the population is generally susceptible. The virus enters target cells via angiotensin-converting enzyme 2 as a cellular receptor. Spike protein is activated by serine protease TMPRSS2. The virus can cause damage to multiple organs, and there are currently no specific drugs for this virus. However, several assessments and studies have been carried out. At present, the epidemic situation in China has been effectively controlled. However,the number of infections abroad has increased rapidly. Therefore, the epidemic situation in foreign countries is still very serious. The global epidemic prevention and control work is facing huge challenges. In order to effectively prevent and treat coronavirus disease 2019, this article reviews the etiol., pathol. mechanism, pathol. manifestations, and development of therapeutic drugs for coronavirus disease 2019.

7.
Aging (Albany NY) ; 12(8): 6518-6535, 2020 Apr 27.
Article in English | MEDLINE | ID: covidwho-140657

ABSTRACT

Angiotensin-converting enzyme 2 (ACE2) is a member of the renin-angiotension system, however, the correlation between ACE2 and prognosis in UCEC (Uterine Corpus Endometrial Carcinoma) and KIRP (Kidney Renal Papillary Cell Carcinoma) is not clear. We analyzed the expression levels of ACE2 in the Oncomine and TIMER databases, the correlation between ACE2 and overall survival in the PrognoScan, GEPIA and Kaplan-Meier plotter databases. The correlation between ACE2 and immune infiltration level and the type markers of immune cells was investigated in TIMER database. A prognosis analysis based on the expression levels of ACE2 was further performed in related immune cells subgroup. The ACE2 promoter methylation profile was tested in the UALCAN database. In addition, we used GSE30589 and GSE52920 databases to elucidate the changes of ACE2 expression in vivo and in vitro after SARS-CoV infection. ACE2 was elevated in UCEC and KIRP, and high ACE2 had a favorable prognosis. The expression of ACE2 was positively correlated with the level of immune infiltration of macrophage in KIRP, B cell, CD4+T cell, neutrophil and dendritic cell immune infiltration levels in UCEC. ACE2 was significantly positively correlated with the type markers of B cells and neutrophils, macrophages in UCEC, while ACE2 in KIRP was positively correlated with the type markers of macrophages. High ACE2 expression level had a favorable prognosis in different enriched immune cells subgroups in UCEC and KIRP. And the promoter methylation levels of ACE2 in UCEC and KIRP were significantly reduced. What's more, we found that the expression of ACE2 decreased in vivo and in vitro after SARS-CoV infection. In conclusion, ACE2 expression increased significantly in UCEC and KIRP, elevated ACE2 was positively correlated with immune infiltration and prognosis. Moreover, tumor tissues may be more susceptible to SARS-CoV-2 infection in COVID-19 patients with UCEC and KIRP, which may worsen the prognosis.


Subject(s)
Betacoronavirus , Carcinoma, Renal Cell , Coronavirus Infections , Endometrial Neoplasms , Immunity, Cellular , Kidney Neoplasms , Pandemics , Peptidyl-Dipeptidase A/biosynthesis , Pneumonia, Viral , Angiotensin-Converting Enzyme 2 , Biomarkers, Tumor , COVID-19 , Carcinoma, Renal Cell/immunology , Carcinoma, Renal Cell/metabolism , Carcinoma, Renal Cell/mortality , Coronavirus Infections/immunology , Coronavirus Infections/metabolism , Endometrial Neoplasms/immunology , Endometrial Neoplasms/metabolism , Endometrial Neoplasms/mortality , Female , Humans , Kidney Neoplasms/immunology , Kidney Neoplasms/metabolism , Kidney Neoplasms/mortality , Pneumonia, Viral/immunology , Pneumonia, Viral/metabolism , Prognosis , SARS-CoV-2
8.
Psychiatry Res ; 288: 112992, 2020 06.
Article in English | MEDLINE | ID: covidwho-46087

ABSTRACT

The World Health Organization (WHO) has declared that the Corona Virus (COVID-19) has become a global pandemic. This study aimed to investigate the psychological symptoms of ordinary Chinese citizens during the Level I Emergency Response throughout China. From January 31 to February 2 2020, an online questionnaire, Symptom Checklist 90 (SCL-90) was designed, and differences in GSI T-scores among subgroups were examined by ANOVA. Based on a cut-off point of the GSI T-scores of 63, the overall sample was divided into high and low-risk groups. of the 1,060 participants investigated in China, more than 70% of them have moderate and higher level of psychological symptoms specifically elevated scores for obsessive compulsion, interpersonal sensitivity, phobic anxiety, and psychoticism. There were no significant differences between males and females. Those who were of over 50 years old, had an undergraduate education and below, were divorced or widowed, and agricultural workers had significantly more symptoms. However, significantly more minors and medical staff were in the high-risk group. These results show that COVID-19 has a significant adverse socio-psychological influence on ordinary citizens. Therefore, governments should equip psychological health departments and pay attention to the people who are in high-risk groups, providing psychological interventions and assistance.


Subject(s)
Coronavirus Infections/psychology , Emergencies , Mental Disorders , Mental Health , Pneumonia, Viral/psychology , Adolescent , Adult , Aged , Anxiety , Anxiety Disorders , Betacoronavirus , COVID-19 , China , Coronavirus Infections/epidemiology , Emergencies/psychology , Female , Humans , Male , Mental Disorders/epidemiology , Middle Aged , Occupations , Pandemics , Pneumonia, Viral/epidemiology , SARS-CoV-2 , Surveys and Questionnaires , Young Adult
SELECTION OF CITATIONS
SEARCH DETAIL
...