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2.
Front Psychol ; 12: 806756, 2021.
Article in English | MEDLINE | ID: covidwho-1662619

ABSTRACT

The COVID-19 pandemic severely hit small and micro-businesses. In the face of the impact of the pandemic, how to help entrepreneurs, especially small- and micro-businesses that are more sensitive to the impact of the pandemic, make decisions to reduce losses has become an issue worth paying attention to. From the perspective of personality approach, this article studied openness, which is the strongest predictor of entrepreneurial performance among the big five personality traits, and explored the impact of entrepreneurs' openness on entrepreneurial performance during the COVID-19 pandemic, as well as the inconsistent mediating role of strategic decision comprehensiveness on entrepreneurial performance. An online questionnaire survey was conducted among 238 entrepreneurs of small- and micro-businesses when China was recovering from the pandemic and starting to resume work and production (February 18 - February 26, 2020). Entrepreneurial performance during the COVID-19 pandemic was measured by comparing the business conditions before and after the pandemic. The results showed that entrepreneurs' openness positively impacted strategic decision comprehensiveness and entrepreneurial performance during the COVID-19 pandemic. Among the two competing hypotheses proposed by summarizing previous research, the results supported that strategic decision comprehensiveness negatively affected entrepreneurial performance. It indicated that entrepreneurs who tend to collect and analyze information extensively and then make decisions during the pandemic could not seize opportunities and improve their entrepreneurial performance. The results further supported that strategic decision comprehensiveness was an inconsistent mediator between openness and entrepreneurial performance, showing that entrepreneurs with low openness can also reduce the loss of entrepreneurial performance during the pandemic by making incomplete but rapid strategic decisions. This study found that the openness of entrepreneurs had a positive impact on strategic decision comprehensiveness for the first time and provided more empirical evidence for the negative effect of strategic decision comprehensiveness on entrepreneurial performance in the context of information uncertainty and unanalyzable situations. The inconsistent mediating effect of strategic decision comprehensiveness revealed in this study also has practical significance for helping entrepreneurs make correct decisions to reduce the losses caused by the pandemic.

3.
Int Immunopharmacol ; 101(Pt B): 108254, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1549846

ABSTRACT

With the outbreak and rapid spread of COVID-19, the world health situation is unprecedentedly severe. Systemic lupus erythematosus (SLE) is a common autoimmune disease, which can cause multiple organ damage. Numerous studies have shown that immune factors have important roles in the pathogenesis of both COVID-19 and SLE. In the early stages of COVID-19 and SLE pathogenesis, IFN-α expression is frequently increased, which aggravates the virus infection and promotes SLE development. In addition, increased IL-6 levels, caused by different mechanisms, are observed in the peripheral blood of patients with severe COVID-19 and SLE, stimulating a series of immune cascades that lead to a cytokine storm, as well as causing B cell hyperfunction and production of numerous of antibodies, aggravating both COVID-19 and SLE. In this review, we explore the background immunopathological mechanisms in COVID-19 and SLE and analyze the advantages and disadvantages of commonly used SLE drugs for patients with COVID-19, to optimize treatment plans for patients with SLE who develop COVID-19.


Subject(s)
COVID-19/drug therapy , COVID-19/immunology , Interferon-alpha/immunology , Interleukin-6/immunology , Lupus Erythematosus, Systemic/immunology , SARS-CoV-2 , Animals , Humans , Lupus Erythematosus, Systemic/drug therapy
4.
Journal of Southwest Minzu University Natural Science Edition ; 46(4):354-369, 2020.
Article in Chinese | GIM | ID: covidwho-1372327

ABSTRACT

This study was to combine network pharmacology with molecular docking technology, and the purpose was to explore the potential pharmacodynamic substances of Ma-Xing-Shi-Gan decoction in the treatment of COVID-19 and to predict the mechanism. Firstly, the main active components and targets were screened using TCMSP database, and Cytoscape software was used to construct the "active component-target" network. The Uniprot database and Genecards database were used to obtain the target protein genes and disease targets respectively, and the common targets were uploaded to STRING database to construct the core network of protein interaction to screen out the core targets. GO functional enrichment analysis and KEGG pathway analysis were performed using DAVID database. Finally, molecular docking software was used to dock and screen the key active components and therapeutic targets. The results showed that Ma-Xing-Shi-Gan decoction contained multiple active ingredients acting on multiple targets, and played a role in the treatment of COVID-19 through multiple pathways such as inflammatory pathways, suppression of cytokine storms, and immune regulation.

5.
Journal of Southwest Minzu University Natural Science Edition ; 46(2):141-160, 2020.
Article in Chinese | GIM | ID: covidwho-1350786

ABSTRACT

The novel coronavirus(2019-nCoV) induced acute pneumonia is classified as "wet poison epidemic" in traditional Chinese medicine(TCM). With the development of the epidemic situation, several preventive and therapeutic procedures of TCM against the novel coronavirus-infected pneumonia have been issued by the National Health Commission and the State Administration of TCM according to the local climate characteristics, human population quality, and patient clinical performance. Recently, the epidemic situation in China has been gradually under effective control, and TCM has shown clear efficacy in the prevention and treatment of COVID-19. The authors systematically summarized the prevention and treatment programs of TCM for 2019-nCoV pneumonia published in 23 provinces and municipalities of China, and then analyzed the medication rules, explored the therapeutic advantages and characteristic functions of TCM in the prevention and treatment of 2019-nCoV pneumonia, and provided some useful suggestions for the diagnosis and treatment of 2019-nCoV pneumonia.

7.
Dermatol Ther ; 33(6): e14472, 2020 Nov.
Article in English | MEDLINE | ID: covidwho-894746

ABSTRACT

During COVID-19 outbreak hospitals were congested and infliximab was interrupted. Thus, we performed this observational study to understand the consequent burden of complications in these special cluster of psoriatic patients. We followed up 56 psoriatic patients who were receiving Infliximab treatment by telephone. The majority of patients had lesions exacerbation, accompanied by anxiety emotion. It is suggested that reserving common drugs for psoriasis at home is necessary. Besides, telemedicine should be advocated as a main medical visit mode during the outbreak of COVID-19.


Subject(s)
COVID-19 , Dermatologic Agents/therapeutic use , Health Services Accessibility , Infliximab/therapeutic use , Psoriasis/drug therapy , Telemedicine , Adult , Dermatologic Agents/supply & distribution , Drug Substitution , Female , Humans , Male , Middle Aged , Psoriasis/diagnosis , Psoriasis/immunology , Treatment Outcome
8.
Stat Biopharm Res ; 12(4): 451-460, 2020 Oct 01.
Article in English | MEDLINE | ID: covidwho-727004

ABSTRACT

Many clinical trials of treatments for patients hospitalised for COVID-19 use an ordinal scale recommended by the World Heath Organisation. The scale represents intensity of medical intervention, with higher scores for interventions more burdensome for the patient, and highest score for death. There is uncertainty about use of this ordinal scale in testing hypotheses. With the objective of assessing the power and Type I error of potential endpoints and analyses based on the ordinal scale, trajectories of the score over 28 days were simulated for scenarios based closely on results of two trials recently published. The simulation used transition probabilities for the ordinal scale over time. No one endpoint was optimal across scenarios, but a ranked measure of trajectory fared moderately well in all scenarios. Type I error was controlled at close to the nominal level for all endpoints. Because not tied to a particular population with regard to baseline severity, the use of transition probabilities allows plausible assessment of endpoints in populations with configurations of baseline score for which data is not yet published, provided some data on the relevant transition probabilities are available. The results could support experts in the choice of endpoint based on the ordinal scale.

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