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1.
Frontiers in Psychology ; 13, 2022.
Article in English | Web of Science | ID: covidwho-2022868

ABSTRACT

Promoting the social integration of various groups provides a significant guarantee for China to achieve high-quality development. However, female workers, as the main force of the service industry, had suffered a greater occupational impact due to COVID-19 and loosened China's fertility policy in 2021. After female career interruption, the change in women's social roles and networks has aroused concern about their social integration. However, limited attention had been paid to female career interruption in existing studies about social integration. Therefore, this study developed a theoretical model to explore the relationship between female career interruption and social integration. An empirical test using data from the fourth Chinese Women's Social Status Survey of Hainan Province was applied to evaluate the hypotheses. The results indicate that there is a significantly negative correlation between female career interruption and social integration. And there is a difference among female career interrupters with different quantiles of social integration. Furthermore, the impact of human capital on the link between female career interruption and social integration depended on the type of new media use. When female career interrupters who use strong learning-oriented new media (such as learning about news, working/business, studying online, and investing/financial management) encounter human capital, the relationship between female career interruption and social integration is minimal. In contrast, this relationship is enhanced when female career interrupters who use strong amusing-oriented new media (such as online consumption, chatting, entertainment, and games) are confronted with human capital. Meanwhile, the results of quantile regression show that the secondary moderating effect of learning-oriented new media use gradually weakens with the rise of the quantile of female social integration. And so does amusing-oriented new media use. However, a moderating effect of human capital alone is not found.

2.
Front Pharmacol ; 13:779942, 2022.
Article in English | PubMed | ID: covidwho-2022832

ABSTRACT

Background: Although increasing clinical trials studying Shenfu injection (SFI) comprising panaxoside 0.8 mg/ml extracted from Panax ginseng C.A. Mey. and aconitine 0.1 mg/ml extracted from Aconitum carmichaeli Debeaux for elderly patients with severe pneumonia on biomarkers associated with COVID-19 progression are emerging, there is no evidence-based evaluation for the effect of SFI on elderly severe pneumonia. Objectives: To evaluate the effect of SFI on elderly patients with severe pneumonia providing hints for treating critical COVID-19, we conducted a systematic review and meta-analysis. Methods: Nine databases, namely, PubMed, EMBASE, Web of Science, Science Direct, Google Scholar, Wanfang, Chongqing VIP Database, CNKI, and SinoMed were used to search clinical trials reporting the effect of SFI as an adjuvant for elderly severe pneumonia on outcomes of interest. Primary outcomes were total effective rate, Acute Physiology and Chronic Health Evaluation (APACHE) II score, mortality, and safety. Secondary outcomes were predictors associated with COVID-19 progression. Duplicated or irrelevant articles with unavailable data were excluded. Cochrane Collaboration's tool was used to evaluate the risk of bias by two reviewers independently. All data were analyzed by Rev Man 5.4. Continuous variables were shown as weighted mean difference (WMD) or standard mean difference (SMD) with 95% confidence intervals (95% CI), whereas dichotomous data were calculated as the risk ratio (RR) with 95% CI. Results: We included 20 studies with 1, 909 participants, and the pooled data showed that compared with standard control, SFI could improve the total effective rate (RR = 1.25, 95% CI = 1.14-1.37, and n = 689), APACHE II score (WMD = -2.95, 95% CI = -3.35, -2.56, and n = 809), and predictors associated with COVID-19 progression (brain natriuretic peptide, creatine kinase, stroke volume, cardiac output, left ventricular ejection fraction, cardiac index, sE-selectin, von Willebrand factor, activated partial thromboplastin time, platelet counts, D-Dimer, procalcitonin, and WBC count). SFI may reduce mortality (RR = 0.52, 95% CI = 0.37-0.73, and n = 429) and safety concerns (RR = 0.29, 95% CI = 0.17-0.51, and n = 150) for elderly severe pneumonia. Conclusion: SFI as an adjuvant may improve the total effective rate, APACHE II score, gas exchange, and predictors associated with COVID-19 progression, reducing mortality and safety concerns for elderly patients with severe pneumonia.

3.
Front Med (Lausanne) ; 9:988133, 2022.
Article in English | PubMed | ID: covidwho-2022785

ABSTRACT

PURPOSE: The purpose of this study was to investigate the hotspots and research trends of ophthalmology research. METHOD: Ophthalmology research literature published between 2017 and 2021 was obtained in the Web of Science Core Collection database. The bibliometric analysis and network visualization were performed with the VOSviewer and CiteSpace. Publication-related information, including publication volume, citation counts, countries, journals, keywords, subject categories, and publication time, was analyzed. RESULTS: A total of 10,469 included ophthalmology publications had been cited a total of 7,995 times during the past 5 years. The top countries and journals for the number of publications were the United States and the Ophthalmology. The top 25 global high-impact documents had been identified using the citation ranking. Keyword co-occurrence analysis showed that the hotspots in ophthalmology research were epidemiological characteristics and treatment modalities of ocular diseases, artificial intelligence and fundus imaging technology, COVID-19-related telemedicine, and screening and prevention of ocular diseases. Keyword burst analysis revealed that "neural network," "pharmacokinetics," "geographic atrophy," "implementation," "variability," "adverse events," "automated detection," and "retinal images" were the research trends of research in the field of ophthalmology through 2021. The analysis of the subject categories demonstrated the close cooperation relationships that existed between different subject categories, and collaborations with non-ophthalmology-related subject categories were increasing over time in the field of ophthalmology research. CONCLUSIONS: The hotspots in ophthalmology research were epidemiology, prevention, screening, and treatment of ocular diseases, as well as artificial intelligence and fundus imaging technology and telemedicine. Research trends in ophthalmology research were artificial intelligence, drug development, and fundus diseases. Knowledge from non-ophthalmology fields is likely to be more involved in ophthalmology research.

4.
Frontiers in Bioengineering and Biotechnology ; 10, 2022.
Article in English | Web of Science | ID: covidwho-2022647

ABSTRACT

Drug addiction is a serious problem globally, recently exacerbated by the COVID-19 pandemic. Glial cell-derived neurotrophic factor (GDNF) is considered a potentially effective strategy for the treatment of addiction. Previous animal experiments have proven that GDNF has a good therapeutic effect on drug addiction, but its clinical application is limited due to its poor blood-brain barrier (BBB) permeability. Low-frequency focused ultrasound, combined with microbubbles, is a non-invasive and reversible technique for locally-targeted BBB opening. In the present study, magnetic resonance imaging-guided low-frequency focused ultrasound, combined with GDNF microbubbles, was used to target BBB opening in the ventral tegmental area (VTA) region. The effects of GDNF on morphine-induced conditioned place preference (CPP) and acute withdrawal symptoms in rats after a partially opened BBB were evaluated by behavioral observation. Western blot was used to detect changes in tyrosine hydroxylase (TH) expression levels in the VTA region after different treatments, and high performance liquid chromatography was used to detect the changes in monoamine neurotransmitter content. The results showed that ultrasound combined with GDNF microbubbles targeted and opened the BBB in the VTA region, and significantly increased GDNF content, destroyed morphine-induced CPP, and reduced the withdrawal symptoms of morphine addiction in rats. Furthermore, the up-regulation of TH expression and the increase of norepinephrine and dopamine content induced by morphine were significantly reversed, and the increase of 5-hydroxytryptamine content was partially reversed. Therefore, ultrasound combined with GDNF microbubbles to target and open the BBB can effectively increase the content of central GDNF, thus playing a therapeutic role in morphine addiction. Our study provides a new approach to locally open the BBB and target delivery of neurotrophic factors, such as GDNF, to treat brain diseases like addiction.

5.
J Biomed Sci ; 29(1):68, 2022.
Article in English | PubMed | ID: covidwho-2021289

ABSTRACT

The novel coronavirus disease (COVID-19) pandemic remains a global public health crisis, presenting a broad range of challenges. To help address some of the main problems, the scientific community has designed vaccines, diagnostic tools and therapeutics for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The rapid pace of technology development, especially with regard to vaccines, represents a stunning and historic scientific achievement. Nevertheless, many challenges remain to be overcome, such as improving vaccine and drug treatment efficacies for emergent mutant strains of SARS-CoV-2. Outbreaks of more infectious variants continue to diminish the utility of available vaccines and drugs. Thus, the effectiveness of vaccines and drugs against the most current variants is a primary consideration in the continual analyses of clinical data that supports updated regulatory decisions. The first two vaccines granted Emergency Use Authorizations (EUAs), BNT162b2 and mRNA-1273, still show more than 60% protection efficacy against the most widespread current SARS-CoV-2 variant, Omicron. This variant carries more than 30 mutations in the spike protein, which has largely abrogated the neutralizing effects of therapeutic antibodies. Fortunately, some neutralizing antibodies and antiviral COVID-19 drugs treatments have shown continued clinical benefits. In this review, we provide a framework for understanding the ongoing development efforts for different types of vaccines and therapeutics, including small molecule and antibody drugs. The ripple effects of newly emergent variants, including updates to vaccines and drug repurposing efforts, are summarized. In addition, we summarize the clinical trials supporting the development and distribution of vaccines, small molecule drugs, and therapeutic antibodies with broad-spectrum activity against SARS-CoV-2 strains.

6.
BMC Med Educ ; 22(1):668, 2022.
Article in English | PubMed | ID: covidwho-2021277

ABSTRACT

BACKGROUND: Conducting on-site, hands-on training during the Coronavirus disease 2019 (COVID-19) pandemic has been challenging. We conducted a before and after interventional study to estimate the efficacy of a new remote hands-on training model for improving the trainees' tracheal intubation competency using optical stylets. METHODS: Residents or physicians in anesthesiology apartment who have not received the nominated training in tracheal intubation using optical stylets were enrolled. The 4-week training course contains theoretical knowledge along with preclinical and clinical training of optical stylets techniques. Competency of intubation using optical stylets on patients with normal airways was evaluated according to an assessment tool with a maximum score of 29 points based on video recording pre-post training performance. Pre-post questionnaires measured theoretical knowledge and self-efficacy. RESULTS: Twenty-two participants were included (8 females, 14 men, mean age of 33.5 years). The total score of intubation competency was significantly improved after training from 14.6±3.7 to 25.3±2.6 (P < 0.0001). The scores of three subitems (anatomical identification, hand-eye coordination, and optimized intubation condition) were all significantly increased after training (P < 0.0001). The total percentage of correct answers in the multiple-choice questionnaire increased from 58.2%±8.2% before training to 85.2%±7.2% shortly after training (P < 0.0001). In addition, the self-efficacy score was significantly increased from 2.5±1.2 to 4.4±0.6 (P < 0.0001). CONCLUSIONS: The new remote and progressively advanced hands-on training model improved the competency of intubation using optical stylets under the COVID-19 pandemic.

7.
Atmospheric Environment ; 289, 2022.
Article in English | Web of Science | ID: covidwho-2014913

ABSTRACT

Nitrogen dioxide (NO2) is an important target for monitoring atmospheric quality. Deriving ground-level NO2 concentrations with much finer resolution, it requires high-resolution satellite tropospheric NO2 column as input and a reliable estimation algorithm. This paper aims to estimate the daily ground-level NO2 concentrations over China based on machine learning models and the TROPOMI NO2 data with high spatial resolution. In this study, four tree-based algorithm machine learning models, decision trees (DT), gradient boost decision tree (GBDT), random forest (RF) and extra-trees (ET), were used to estimate ground-level NO2 concentrations. In addition to considering many influencing factors of the ground-level NO2 concentrations, we especially introduced simplified temporal and spatial information into the estimation models. The results show that the extra-trees with spatial and temporal information (ST-ET) model has great performance in estimating ground-level NO2 concentrations with a cross-validation R-2 of 0.81 and RMSE of 3.45 mu g/m(3) in test datasets. The estimated results for 2019 based on the ST-ET model achieves a satisfactory accuracy with a cross-validation R-2 of 0.86 compared with the other models. Through time-space analysis and comparison, it was found that the estimated high-resolution results were consistent with the ground observed NO2 concentrations. Using data from January 2020 to test the prediction power of the models, the results indicate that the ST-ET model has a good performance in predicting ground-level NO2 concentrations. Taking four ground-level NO2 concentrations hotspots as examples, the estimated ground-level NO2 concentrations and ground-based observation data during the coronavirus disease (COVID-19) pandemic were lower compared with the same period in 2019. The findings offer a solid solution for accurately and efficiently estimating ground-level NO2 concentrations by using satellite observations, and provide useful information for improving our understanding of the regional atmospheric environment.

8.
FEBS Open Bio ; 25:25, 2022.
Article in English | MEDLINE | ID: covidwho-2013287

ABSTRACT

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been spreading globally for over two years, causing serious contagious disease and incalculable damage. The introduction of vaccines has slowed the spread of SARS-CoV-2 to some extent, but there remains a need for specific and effective treatment. The high chemical diversity and safety profiles of natural products make them a potential source of effective anti-SARS-CoV-2 drugs. Cotton plant is one of the most important economic and medical crops, and is the source of a large number of antiviral phytochemicals. In this work, we used SARS-CoV-2 main protein (Mpro ) as the target to identify potential anti-SARS-CoV-2 natural products in cotton. An in vitro assay showed that of all cotton tissues examined, cotton flower extracts (CFs) exhibited optimal inhibitory effects against Mpro . We proceeded to use the CF metabolite database to screen natural Mpro inhibitors by combining virtual screening and biochemical assays. We identified that several CF natural products, including astragalin, myricitrin and astilbin, significantly inhibited Mpro with half-maximal inhibitory concentrations (IC50s) of 0.13 muM, 10.73 muM and 7.92 muM, respectively. These findings may serve as a basis for further studies into the suitability of cotton as a source of potential therapeutics for SARS-CoV-2.

10.
Innovation in Aging ; 5:688-688, 2021.
Article in English | Web of Science | ID: covidwho-2011850
11.
Innovation in Aging ; 5:140-140, 2021.
Article in English | Web of Science | ID: covidwho-2011849
12.
Innovation in Aging ; 5:141-141, 2021.
Article in English | Web of Science | ID: covidwho-2011848
13.
Chinese Journal of Pharmaceutical Biotechnology ; 29(3):320-325, 2022.
Article in Chinese | EMBASE | ID: covidwho-2010559

ABSTRACT

Heparin is a kind of glycosaminoglycan drug with a complex structure, which is a mixture of polysaccharides with different chain lengths composed of hexuronic acid, aminohexose and its derivatives.Hexuronic acids are L-aduronic acid and D-glucuronic acid, aminohexose is α -D-glucosamine, and the modification of derivatives includes sulfation and acetylation.As a natural biomacromolecule, heparin has a variety of biological activities.It has been discovered for more than a hundred years and has good anticoagulant effect, which is clinically the first choice for anticoagulant and prevention and treatment of thromboembolic diseases.It has been discovered that there are more than one hundred functional proteins that interact with heparin.Heparin can bind to a variety of proteins and exert a variety of biological activities such as anticoagulant, anti-inflammatory, antiviral, and anti-tumor. The anticoagulant mechanism of heparin has been explained in detail, but its anti-inflammatory, antiviral, anti-tumor and other non-anticoagulant biolo-gical activities are still under extensive research, and these activities also have the potential to be developed into new drugs and new materials.Derivatives which with low anticoagulant activity and high antiangiogenic activity have been developed.In addition, sepsis-induced coagulopathy was common in patients with severe pneumonia caused by COVID-19 during the global outbreak of novel coronavirus epidemic.Heparin is effective in improving coagulation disorders and is likely to provide a better prognosis in patients with severe pneumonia.Due to its better biological activity, it also has potential applications in the field of new materials, such as being a cross-linking agent in the formation of hydrogels, and as a surface modifier of nanoparticles. This article consists of five parts, through which the author will first review the pharmacological activities of heparin in anticoagulation, anti-inflammatory and anti-tumor activities, then introduce the application of heparin in the new coronavirus, and finally give an overview of the application of heparin in new materials.

14.
Immunotherapy ; 2022.
Article in English | MEDLINE | ID: covidwho-2009820

ABSTRACT

In the past decade, the emergence of biologics targeting human cytokine networks has advanced a new era in atopic dermatitis therapy. Dupilumab, in particular, the most widely studied and used IL-4/IL-13 inhibitor, has been considered a milestone in the treatment of patients with moderate-to-severe atopic dermatitis. In addition to the IL-4 and IL-13 pathways, many other cytokines and receptors have been newly targeted as therapeutic options. In this review, the authors provide an overview of the approved and tested biologics and JAK inhibitors for the treatment of atopic dermatitis, including their advantages and limitations.

15.
Virol J ; 19, 2022.
Article in English | PMC | ID: covidwho-2009431

ABSTRACT

Background: Rapid and accurate detection of SARS-CoV-2 infection is the cornerstone of prompt patient care. However, the reliability of the antigen rapid diagnostic test (Ag-RDT) in the diagnosis of SARS-CoV-2 infection remains inconclusive. Methods: We conducted a field evaluation of Ag-RDT performance during the Shanghai Coronavirus disease 2019 (COVID-19) quarantine and screened 7225 individuals visiting our Emergency Department. 83 asymptomatic SARS-CoV-2 (+) individuals were enrolled in the current study. Simultaneously, Ag-RDT was performed to evaluate its testing performance. Results: For the Ag-RDT(−) cases, the average cycle threshold (Ct) values of the N gene were 27.26 ± 4.59, which were significantly higher than the Ct value (21.9 ± 4.73) of the Ag-RDT(+) individuals (p < 0.0001). The overall sensitivity of Ag-RDT versus that of RT-PCR was 43.37%. The Ag-RDT(+) individuals regarding the N gene’s Ct value were 16 cases in the < 20 range, 12 in 20–25, 5 in 25–30, and 3 in 30–35. The corresponding sensitivity was 84.21%, 52.17%, 21.74% and 16.67%, respectively. Meanwhile, sampling had a straight specificity of 100% regardless of the Ct value. Conclusions: The Ag-RDT were extremely sensitive in asymptomatic COVID-19 individuals with a Ct value < 20.

16.
J Inflamm (Lond) ; 19, 2022.
Article in English | PMC | ID: covidwho-2009409

ABSTRACT

Background: Angiotensin-converting enzyme 2 (ACE2) has been reported to be the main receptor for SARS-CoV-2 infection of host cells. Understanding the changes in bronchoalveolar epithelial cells after SARS-CoV-2 infection of host cells and the intercellular communication relationship between these epithelial cell changes and immune cells is of great significance for the development of therapeutic methods. Methods: We explored the single-cell RNA sequence (scRNA-seq) of cells infected with bronchoalveolar lavage fluid (BaLF) of patients with different severities of SARS-CoV-2 and healthy people. Results: We found 11 clusters of epithelial cells in the BaLF, and they were derived from the S group. In the S group, the proportion of cells with positive ACE2 expression was relatively high. ACE2 was relatively more expressed in epithelial cell clusters 1, 3, and 7. Clusters 4 and 5 represented the original state, and there were two differentiation directions: one was cluster 2, and the others were clusters 1, 3, and 6. Cluster 7 was the intermediate state. Clusters 1, 3, 6, and 7 had high similarities (> 0.9), and their main signaling pathways focused on inflammatory activation and immune response. Cluster 2 was relatively specific and was up-regulated in differential genes that were mainly related to apoptosis. The ligand-receptor expression pattern of TNFRSF10D-TNFSF10 showed a special inter-cell regulatory relationship between epithelial cell cluster 2 and macrophages. Conclusion: This study revealed the changes in epithelial cells derived from alveolar lavage fluid after SARS-CoV-2 infection and the communication relationship with other immune cells.

17.
Heliyon ; 8(9):e10473, 2022.
Article in English | PMC | ID: covidwho-2007720

ABSTRACT

Metabolic reprogramming is a distinctive characteristic of SARS-CoV-2 infection, which refers to metabolic changes in hosts triggered by viruses for their survival and spread. It is current urgent to understand the metabolic health status of COVID-19 survivors and its association with long-term health consequences of infection, especially for the predominant non-severe patients. Herein, we show systemic metabolic signatures of survivors of non-severe COVID-19 from Wuhan, China at six months after discharge using metabolomics approaches. The serum amino acids, organic acids, purine, fatty acids and lipid metabolism were still abnormal in the survivors, but the kynurenine pathway and the level of itaconic acid have returned to normal. These metabolic abnormalities are associated with liver injury, mental health, energy production, and inflammatory responses. Our findings identify and highlight the metabolic abnormalities in survivors of non-severe COVID-19, which provide information on biomarkers and therapeutic targets of infection and cues for post-hospital care and intervention strategies centered on metabolism reprogramming.

18.
Infectious Diseases and Therapy ; 2022.
Article in English | EMBASE | ID: covidwho-2007310

ABSTRACT

Introduction: This study explored circulating pneumoproteins in the diagnosis, severity, and prognosis of COVID-19 by meta-analysis. Methods: We searched five databases and other sources until December 16, 2021. Standardized mean difference (SMD) and 95% confidence interval (CI) were the overall outcomes. RevMan 5.3, Stata 16, and Meta-DiSc 1.4 were utilized for pooled analysis. Results: A total of 2432 subjects from 26 studies were included. Patients with COVID-19 had higher circulating KL-6, SP-D, and SP-A levels (SMD 1.34, 95% CI [0.60, 2.08];SMD 1.74, 95% CI [0.64, 2.84];SMD 3.42, 95% CI [1.31, 5.53], respectively) than healthy individuals. Circulating SP-D levels were not significantly different in survivors and non-survivors (SMD − 0.19, 95% CI [− 0.78, 0.40]). Circulating KL-6, SP-D, and RAGE levels in patients with mild to moderate COVID-19 were significantly lower (SMD − 0.93, 95% CI [− 1.22, − 0.65];SMD − 1.32, 95% CI [− 2.34, − 0.29];SMD − 1.17, 95% CI [− 2.06, − 0.28], respectively) than in patients with severe COVID-19. Subgroup analysis suggested that country and total number may be related to the heterogeneity when analyzing SP-D in patients with mild to moderate vs. severe COVID-19. The meta-analysis of diagnostic accuracy including KL-6 for severity, KL-6 for mortality, and SP-D for severity demonstrated that they all had limited diagnostic value. Conclusion: Therefore, circulating pneumoproteins (KL-6, SP-D, and RAGEs) reflect the diagnosis, severity, and prognosis of COVID-19, and follow-up studies are still needed.

19.
Viruses ; 14(9):1872, 2022.
Article in English | MDPI | ID: covidwho-2006215

ABSTRACT

Beyond their pulmonary disease, many COVID-19 patients experience a complex constellation of characteristics, including hyperinflammatory responses, autoimmune disorders, and coagulopathies. However, the pathogenesis of these aspects of COVID-19 is obscure. More than 90% of people are latently infected with the lymphotropic herpesviruses Epstein–Barr Virus (EBV) and/or Human Herpesvirus-6 (HHV-6). Some of the inflammatory features of COVID-19 resemble clinical syndromes seen during EBV and HHV-6 infection, and these latent viruses can be reactivated by inflammatory mediators. We hypothesized that EBV and HHV-6 reactivation might be a common feature of early COVID-19, particularly in patients with more inflammation. We tested for EBV and HHV-6 reactivation in 67 patients acutely hospitalized with COVID-19 using previously validated quantitative PCR assays on the plasma. In our cohort, we found that 15/67 (22.4%) patients had detectable EBV and 3/67 (4.5%) had detectable HHV-6. This frequency of activation is somewhat more than the frequency reported for some healthy cohorts, such as blood donors and other healthy control cohorts. There was no association between EBV or HHV-6 and markers indicative of more inflammatory disease. We conclude that EBV and HHV-6 activation at about day 7 of hospitalization occurred in a modest fraction of our cohort of COVID-19 patients and was not associated with high levels of inflammation. In the modest fraction of patients, EBV and HHV-6 reactivation could contribute to some features of acute disease and pre-disposition to post-acute sequelae in a subset of patients.

20.
PLoS ONE [Electronic Resource] ; 17(8):e0273150, 2022.
Article in English | MEDLINE | ID: covidwho-2002321

ABSTRACT

OBJECTIVE: To examine the clinical characteristics of patients with asymptomatic novel coronavirus disease 2019 (COVID-19) and compare them with those of patients with mild disease. DESIGN: A retrospective cohort study. SETTING: Multiple medical centers in Wuhan, Hubei, China. PARTICIPANTS: A total of 3,263 patients with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection between February 4, 2020, and April 15, 2020. MAIN OUTCOME MEASURES: Patient demographic characteristics, medical history, vital signs, and laboratory and chest computed tomography (CT) findings. RESULTS: A total of 3,173 and 90 patients with mild and moderate, and asymptomatic COVID-19, respectively, were included. A total of 575 (18.2%) symptomatic patients and 4 (4.4%) asymptomatic patients developed the severe illness. All asymptomatic patients recovered;no deaths were observed in this group. The median duration of viral shedding in asymptomatic patients was 17 (interquartile range, 9.25-25) days. Patients with higher levels of ultrasensitive C-reactive protein (odds ratio [OR] = 1.025, 95% confidence interval [CI], 1.01-1.04), lower red blood cell volume distribution width (OR = 0.68, 95% CI 0.51-0.88), lower creatine kinase Isoenzyme(0.94, 0.89-0.98) levels, or lower lesion ratio (OR = 0.01, 95% CI 0.00-0.33) at admission were more likely than their counterparts to have asymptomatic disease. CONCLUSIONS: Patients with younger ages and fewer comorbidities are more likely to be asymptomatic. Asymptomatic patients had similar laboratory characteristics and longer virus shedding time than symptomatic patients;screen and isolation during their infection were helpful to reduce the risk of SARS-CoV-2 transmission.

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