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1.
14th International Conference on Cross-Cultural Design, CCD 2022 Held as Part of the 24th HCI International Conference, HCII 2022 ; 13312 LNCS:510-519, 2022.
Article in English | Scopus | ID: covidwho-1919663

ABSTRACT

The prevalence of depression and anxiety disorders has increased dramatically in the last two years due to the global COVID-19 epidemic, which leads to a shortage of traditional mental health care resources. To address these issues, we propose to use the digital, immersive, and private features of virtual reality technology to assist in the treatment of mental illness. We designed and completed a garden scene for virtual reality horticultural therapy based on the basic principles of traditional horticultural therapy. In order to study the effectiveness of the gardening scenario, we recruited 30 subjects to explore the effectiveness of mood regulation. A survey of a PANAS scale was conducted before and after the garden scene, and a user experience scale was presented to the subjects after the experiment. The ANOVA results showed that there were significant differences between anxious, distressed and self-loathing before and after the experiment. This demonstrates that virtual reality horticulture therapy has a mood-improving effect. In future works, we will improve the design of VR gardening scenarios and conduct more in-depth research on virtual reality horticulture therapy. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

2.
PubMed; 2021.
Preprint in English | PubMed | ID: ppcovidwho-333768

ABSTRACT

RATIONALE: Viral infection of the respiratory tract can be associated with propagating effects on the airway microbiome, and microbiome dysbiosis may influence viral disease. OBJECTIVE: To define the respiratory tract microbiome in COVID-19 and relationship disease severity, systemic immunologic features, and outcomes. METHODS AND MEASUREMENTS: We examined 507 oropharyngeal, nasopharyngeal and endotracheal samples from 83 hospitalized COVID-19 patients, along with non-COVID patients and healthy controls. Bacterial communities were interrogated using 16S rRNA gene sequencing, commensal DNA viruses Anelloviridae and Redondoviridae were quantified by qPCR, and immune features were characterized by lymphocyte/neutrophil (L/N) ratios and deep immune profiling of peripheral blood mononuclear cells (PBMC). MAIN RESULTS: COVID-19 patients had upper respiratory microbiome dysbiosis, and greater change over time than critically ill patients without COVID-19. Diversity at the first time point correlated inversely with disease severity during hospitalization, and microbiome composition was associated with L/N ratios and PBMC profiles in blood. Intubated patients showed patient-specific and dynamic lung microbiome communities, with prominence of Staphylococcus . Anelloviridae and Redondoviridae showed more frequent colonization and higher titers in severe disease. Machine learning analysis demonstrated that integrated features of the microbiome at early sampling points had high power to discriminate ultimate level of COVID-19 severity. CONCLUSIONS: The respiratory tract microbiome and commensal virome are disturbed in COVID-19, correlate with systemic immune parameters, and early microbiome features discriminate disease severity. Future studies should address clinical consequences of airway dysbiosis in COVID-19, possible use as biomarkers, and role of bacterial and viral taxa identified here in COVID-19 pathogenesis.

3.
Eur Rev Med Pharmacol Sci ; 26(6): 2201-2214, 2022 03.
Article in English | MEDLINE | ID: covidwho-1776800

ABSTRACT

Disruption of intracellular Ca2+ homeostasis plays an important role as an upstream pathology in Alzheimer's disease (AD), and correction of Ca2+ dysregulation has been increasingly proposed as a target of future effective disease-modified drugs for treating AD. Calcium dysregulation is also an upstream pathology for the COVID-19 virus SARS-CoV-2 infection and replication, leading to host cell damage. Clinically available drugs that can inhibit the disturbed intracellular Ca2+ homeostasis have been repurposed to treat COVID-19 patients. This narrative review aims at exploring the underlying mechanism by which lithium, a first line drug for the treatment of bipolar disorder, inhibits Ca2+ dysregulation and associated downstream pathology in both AD and COVID-19. It is suggested that lithium can be repurposed to treat AD patients, especially those afflicted with COVID-19.


Subject(s)
Alzheimer Disease , COVID-19 , Alzheimer Disease/drug therapy , Alzheimer Disease/metabolism , COVID-19/drug therapy , Humans , Lithium/therapeutic use , Lithium Compounds/therapeutic use , SARS-CoV-2
4.
Acm Transactions on Management Information Systems ; 12(4):20, 2021.
Article in English | Web of Science | ID: covidwho-1691236

ABSTRACT

The outbreak of COVID-19 has caused huge economic and societal disruptions. To fight against the coronavirus, it is critical for policymakers to take swift and effective actions. In this article, we take Hong Kong as a case study, aiming to leverage social media data to support policymakers' policy-making activities in different phases. First, in the agenda setting phase, we facilitate policymakers to identify key issues to be addressed during COVID-19. In particular, we design a novel epidemic awareness index to continuously monitor public discussion hotness of COVID-19 based on large-scale data collected from social media platforms. Then we identify the key issues by analyzing the posts and comments of the extensively discussed topics. Second, in the policy evaluation phase, we enable policymakers to conduct real-time evaluation of anti-epidemic policies. Specifically, we develop an accurate Cantonese sentiment classification model to measure the public satisfaction with anti-epidemic policies and propose a keyphrase extraction technique to further extract public opinions. To the best of our knowledge, this is the first work which conducts a large-scale social media analysis of COVID-19 in Hong Kong. The analytical results reveal some interesting findings: (1) there is a very low correlation between the number of confirmed cases and the public discussion hotness of COVID-19. Themajor public concern in the early stage is the shortage of anti-epidemic items. (2) The top-3 anti-epidemic measures with the greatest public satisfaction are daily press conference on COVID-19 updates, border closure, and social distancing rules.

5.
American Journal of Translational Research ; 13(6):6191-6199, 2021.
Article in English | EMBASE | ID: covidwho-1445159

ABSTRACT

The aim of this study was to evaluate factors affecting the recurrence of positive RT-PCR results. By performing a retrospective analysis, we evaluated the clinical data of recurrent positive coronavirus disease 2019 (COVID-19) patients in multiple medical institutions in Wuhan. We recruited COVID-19 patients who were hospitalized from January 1 to March 10, 2020, in three tertiary hospitals in Wuhan, met the discharge criteria and received at least one additional nucleic acid test before leaving the hospital. According to the RT-PCR results, patients were split into a recurrent positive group (RPos group) and a nonrecurrent positive group (non-RPos group). Clinical characteristics, therapeutic schedules and antibody titers were compared between the two groups. AI-assisted chest high-resolution computed tomography (HRCT) technology was applied to investigate pulmonary inflammatory exudation and compare the extent of lung areas with different densities. This study involved 122 COVID-19 patients. There were no significant differences in age, sex, preexisting diseases, clinical symptoms, clinical classification, course of disease, therapeutic schedules or serum-specific antibodies between the two groups. A higher proportion of patients who showed pulmonary inflammatory exudation on HRCT scans were recurrent positive at the time of discharge than other patients (81.6% vs 13.7%, P < 0.01). In addition, the degree of pulmonary fibrosis was higher in the RPos group than in the non-RPos group (P < 0.05). Subpleural exudation at the peripheral edge of the lung and extensive pulmonary fibrosis at the time of discharge represent risk factors for the recurrence of COVID-19.

6.
22nd IEEE International Conference on High Performance Computing and Communications, 18th IEEE International Conference on Smart City and 6th IEEE International Conference on Data Science and Systems, HPCC-SmartCity-DSS 2020 ; : 393-400, 2020.
Article in English | Scopus | ID: covidwho-1228676

ABSTRACT

Nowadays, the information about COVID-19 is spreading widely on social networks while rumors about it are also propagating quickly. When users receive two opposing opinions, they are more likely to accept the information with greater impact. Therefore, there is an urgent need to clarify rumors. Given the cost Ctotal, the rumor clarifying problem aims to find a seed set with at most k users such that the total number of the users influenced by positive information can be maximized. In this paper, we propose a Cost-Randomized Greedy algorithm called CRG to solve the rumor clarifying problem. It runs in O((n-r)mC{total}), where n, m and r are the number of nodes, edges and the initial rumor nodes, respectively. Extensive contrast experiments on online networks show that our algorithm is much more efficient than the state-of-The art methods. © 2020 IEEE.

7.
Huanjing Kexue Xuebao/Acta Scientiae Circumstantiae ; 41(4):1173-1183, 2021.
Article in Chinese | Scopus | ID: covidwho-1215754

ABSTRACT

During the novel coronavirus (COVID-19) lock down from 31st January to 2nd February, a regional atmospheric PM2.5 pollution episode had arosed concerns of society in Guangxi. Based on Nanning as an sampling site, Monitor for Aerosols and Gases in Ambient Air (MARGA), particulate LiDAR, surface meteorological and environmental data, satellite remote sensing data and modeled HYSPLIT4 trajectory were used to analyze the cause of PM2.5 pollution. According to the air quality sub-index, the observation durations were classified as the superior period, the fine period and the polluted period. The results indicated that K+ and Cl- concentrations closely related to biomass burning (BB) increased significantly during the polluted period. The average concentrations of K+ and Cl- in polluted period were 3.6 and 17.0 times higher than those corresponding figures of the superior period. The total concentration of eight water-soluble ions accounted for about 30% of PM2.5 in all three periods. The total concentration of three secondary water-soluble ions accounted for 83.33%~89.18% of the total concentration of eight ions. The high proportion of secondary inorganic components was related to the secondary transformation promoted by BB. The variation trends of proportion and levels of secondary water-soluble ions were not consistent, which was not only attributed to the emission characteristics of straw combustion, but also related to the formation mechanism and main influencing factors of different secondary inorganic ions. Straw burning spots were centralized around Nanning city during the fine period. The accumulation of direct emissions of particulate and gaseous pollutants caused by open burning of straw during the fine period under decreased boundary layer height, increased humidity and low wind speed were the main causes for atmospheric PM2.5 pollution in Nanning. During the polluted period, there was no obvious vertical transmission process of particulate matter in Nanning. The near ground was mainly affected by the southward airflow from the Beibu Gulf of Guangxi and Guangdong coastal, which indicated the regional pollution transmissions were insignificant. © 2021, Science Press. All right reserved.

8.
Eur Rev Med Pharmacol Sci ; 25(7): 3136-3144, 2021 04.
Article in English | MEDLINE | ID: covidwho-1194855

ABSTRACT

OBJECTIVE: Disruption of intracellular Ca2+ homeostasis via excessive and pathological Ca2+ release from the endoplasmic reticulum (ER) and/or sarcoplasmic reticulum (SR) through ryanodine receptor (RyRs) Ca2+ channels play a critical role in the pathology of systemic inflammatory response syndrome (SIRS) and associated multiple organ dysfunction syndrome (MODS) in sepsis or septic shock. Dantrolene, a potent inhibitor of RyRs, is expected to ameliorate SIRS and MODS and decrease mortality in sepsis or septic shock patients. This review summarized the potential mechanisms of therapeutic effects of dantrolene in sepsis or septic shock at molecular, cell, and organ levels and provided suggestions and strategies for future clinical studies.


Subject(s)
COVID-19/drug therapy , Calcium Channel Blockers/therapeutic use , Dantrolene/therapeutic use , Sepsis/drug therapy , COVID-19/metabolism , Calcium/metabolism , Drug Repositioning , Endoplasmic Reticulum/metabolism , Humans , Mortality , Multiple Organ Failure , Ryanodine Receptor Calcium Release Channel/metabolism , SARS-CoV-2 , Sarcoplasmic Reticulum/metabolism , Sepsis/metabolism , Shock, Septic/drug therapy , Shock, Septic/metabolism
9.
Eur Rev Med Pharmacol Sci ; 24(19): 10228-10238, 2020 10.
Article in English | MEDLINE | ID: covidwho-890958

ABSTRACT

Dantrolene, an FDA approved drug to treat malignant hyperthermia and muscle spasm, has been demonstrated to inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mediated toxicity of host cells. Ryanodine receptor overactivation and associated disruption of intracellular Ca2+ homeostasis play important roles in SARS-CoV-2 infection and replication of host cells. Dantrolene, as an inhibitor of RyRs, is expected to ameliorate these detrimental effects of SARS-CoV-2 in host cells. Additionally, dantrolene has also been shown to inhibit multiple cell or organ damage induced by hypoxia/ischemia, mitochondria damage, oxidative stresses, inflammation, impairment of autophagy and apoptosis, etc., which are often the causes of severity and mortality of COVID-19 patients. We have repurposed that dantrolene has a high potential at treating COVID-19 patients and reducing its morbidity and mortality.


Subject(s)
COVID-19/drug therapy , COVID-19/metabolism , Calcium/metabolism , Dantrolene/therapeutic use , Drug Repositioning , Homeostasis/drug effects , Humans , Muscle Relaxants, Central/therapeutic use , Pandemics
10.
World J Urol ; 39(9): 3151-3160, 2021 Sep.
Article in English | MEDLINE | ID: covidwho-754593

ABSTRACT

PURPOSE: Contemporary, original research should be utilised to inform guidelines in urology relating to the COVID-19 pandemic. This comprehensive review aimed to: identify all up-to-date original publications relating to urology and COVID-19, characterise where publications were from, and outline what topics were investigated. METHODS: This review utilised a search strategy that assessed five electronic databases, additional grey literature, and global trial registries. All current published, in-press, and pre-print manuscripts were included. Eligible studies were required to be original research articles of any study design, reporting on COVID-19 or urology, in any of study population, intervention, comparison, or outcomes. Included studies were reported in a narrative synthesis format. Data were summarised according to primary reported outcome topic. A world heatmap was generated to represent where included studies originated from. RESULTS: Of the 6617 search results, 48 studies met final inclusion criteria, including 8 pre-prints and 7 ongoing studies from online registries. These studies originated from ten countries according to first author affiliation. Most studies originated from China (n = 13), followed by Italy (n = 12) and USA (n = 11). Topics of the study included pathophysiological, administrative, and clinical fields: translational (n = 14), COVID-19-related outcomes (n = 5), urology training (n = 4), telemedicine (n = 7), equipment and safety (n = 2), urology in general (n = 4), uro-oncology (n = 3), urolithiasis (n = 1), and kidney transplantation (n = 8). CONCLUSION: This review has outlined available original research relevant to COVID-19 and urology from the international community. This summary may serve as a guide for future research priorities in this area.


Subject(s)
Biomedical Research , COVID-19 , Kidney Transplantation , Medical Oncology , Publishing , Urology , Biomedical Research/methods , Biomedical Research/organization & administration , COVID-19/epidemiology , COVID-19/prevention & control , Global Health , Humans , Kidney Transplantation/methods , Kidney Transplantation/trends , Medical Oncology/methods , Medical Oncology/trends , Publishing/statistics & numerical data , Publishing/trends , SARS-CoV-2 , Telemedicine/methods , Urology/methods , Urology/trends
11.
J. Risk Financial Manag. 2020, 13, 22. ; 13(2):22, 2020.
Article | WHO COVID | ID: covidwho-158

ABSTRACT

Recently, a novel coronavirus pneumonia (2019–nCoV) outbreak occurred in Wuhan, China, rapidly spreading first to the whole country, and then globally, causing widespread concern. From the perspectives of early warning and identification of risk, risk monitoring, and analysis, as well as risk management and handling, we propose corresponding solutions and recommendations, which include institutional cooperation, and to inform national and international policy-makers.

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