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1.
Asia Pac J Ophthalmol (Phila) ; 2022.
Article in English | PubMed | ID: covidwho-2018213

ABSTRACT

PURPOSE: This study aimed to summarize the latest literature on the trends and incidence of ocular trauma during the COVID-19 pandemic. DESIGN: Systematic review and meta-analysis. METHODS: A systematic literature search was conducted to identify the relevant literature. The search period was between January 1, 2020, and September 20, 2021. The incidence of overall and various types of ocular trauma during the COVID-19 pandemic and the control period was analyzed. The data from different studies were pooled. The odds ratio (OR) and 95% confidence interval (CI) were calculated. RESULTS: A total of 32 articles were included. After pooling the data from all included studies, the incidence of total and pediatric ocular trauma during the COVID-19 pandemic was 67.7% and 54.3% of those in the control period, respectively. However, the proportion of ocular trauma in eye emergency visits increased during the pandemic (OR, 95% CI: 1.46, 1.04-2.06). The proportion of domestic ocular trauma increased (OR, 95% CI: 3.42, 1.01-11.62), while ocular trauma related to sports and outdoor activities and occupational ocular trauma decreased (OR, 95% CI: 0.64, 0.09-4.29 and 0.18, 0.10-0.33, respectively). It was also reported that chemical injury caused by alcohol-based sanitizers, photokeratitis caused by ultraviolet lamps, and mechanical eye injury caused by masks increased during the COVID-19 pandemic. CONCLUSIONS: There was a reduction in overall eye injuries and substantial differences in the spectrum of ocular trauma during the COVID-19 pandemic. Proper health education and supervision should be strengthened to prevent ocular injuries related to COVID-19 preventive interventions.

2.
International Journal of Intelligent Systems ; 2022.
Article in English | Web of Science | ID: covidwho-2003600

ABSTRACT

It is urgent to identify the development of the Corona Virus Disease 2019 (COVID-19) in countries around the world. Therefore, visualization is particularly important for monitoring the COVID-19. In this paper, we visually analyze the real-time data of COVID-19, to monitor the trend of COVID-19 in the form of charts. At present, the COVID-19 is still spreading. However, in the existing works, the visualization of COVID-19 data has not established a certain connection between the forecast of the epidemic data and the forecast of the epidemic. To better predict the development trend of the COVID-19, we establish a logistic growth model to predict the development of the epidemic by using the same data source in the visualization. However, the logistic growth model only has a single feature. To predict the epidemic situation in an all-round way, we also predict the development trend of the COVID-19 based on the Susceptible Exposed Infected Removed epidemic model with multiple features. We fit the data predicted by the model to the real COVID-19 epidemic data. The simulation results show that the predicted epidemic development trend is consistent with the actual epidemic development trend, and our model performs well in predicting the trend of COVID-19.

3.
Chinese Journal of Pharmacology and Toxicology ; 35(8):561-574, 2021.
Article in Chinese | EMBASE | ID: covidwho-1896941

ABSTRACT

Since the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the number of SARS-CoV-2 infections has been increasing and health care is facing huge challenges. Innovative drug development in emergency and the development of new indications for the treatment of Coronavirus disease 2019 (COVID-19) on the market have become critical to finding effective drugs and optimal treatment options for COVID-19. The angiotensin converting enzyme 2 (ACE2) -inducing mechanism of SARS-CoV-2 invasion into host cells and the potential therapeutic targets based on SARS-CoV-2 and (or) host include RNA-dependent RNA polymerase, 3-chymotrypsin-like protease, papain like protease, Janus kinase, interleukine-6 and immune modulators etc. Based on the pharmacological mechanism mentioned above the clinical research and development of new indications and innovative drugs for the treatment of COVID-19 have achieved great progress, but no specific drugs have been found. Some traditional Chinese medicines can block the SARS-CoV-2 replication cycle, regulate human immune response and play an important role in the treatment of COVID-19. The new drugs for COVID-19 are undergoing Phase I clinical studies worldwide, and biologic drugs are gaining momentum, accounting for 67% of the total. The problems with the research and development of drugs for COVID-19 treatment in China include inadequate of biological safety laboratories, less research on SARS-CoV-2 reacting mechanisms, shortages of non-clinical cells and animal models, imperfect research platforms for quantitative pharmacological research and training systems of professionals and poor levels of informatization of drug clinical trials and sample detection. It is hoped that China can take this opportunity to improve the ability to develop new drugs in emergency and better protect human health.

4.
Chinese Journal of Biologicals ; 34(6):699-703, 2021.
Article in Chinese | EMBASE | ID: covidwho-1894085

ABSTRACT

Objective To explore the application and safety of apheresis technology in collection of Coronavirus Disease 2019 (COVID-19) convalescent plasma (CP), and to analyze the quality characteristics of the plasma. Methods The general data of COVID-19 convalescent plasma (CP) donors, including gender, age, date of discharge or release from medical isolation, were collected based on informed consent. After physical examination, the CP was collected by apheresis technology with plasma separator, inactivated with methylene blue, and determined for severe acute respiratory symptom Coronavirus 2 (SARS-CoV-2) nucleic acid and specific antibody (RBD-IgG) against SARS-CoV-2. Results The collection process went well, and no serious adverse events related to plasma collection were reported during or after the collection. The average age of COVID-19 CP donors was 38 years (n = 933). The distributions of blood groups A, B, AB and 0 in RhD (+) COVID-19 CP were 33. 4%, 29. 2%, 10% and 27. 2% respectively. The plasma donation date was 18 d from the discharge date in average. All the test results of SARS-CoV-2 nucleic acid in CP were negative, while the proportion of plasma samples at SARS-CoV-2 antibody titer of more than 1: 160 was 92. 60%. Conclusion Apheresis technology was safe and reliable. The COVID-19 CP contained high titer antibody. Large-scale collection and preparation of inactivated plasma against SARS-CoV-2 played an important role in the treatment of COVID-19.

5.
5th International Conference on Education and E-Learning, ICEEL 2021 ; : 161-167, 2021.
Article in English | Scopus | ID: covidwho-1731326

ABSTRACT

Many universities have incorporated free and open-source software (FOSS) into undergraduate courses, though few research efforts have specifically investigated the interactions between undergraduates and real-world FOSS projects. In this paper, we present our experience of participating in the development of real-world FOSS projects, dealing with the challenges caused by COVID-19, and the feasibility of remote education with FOSS only. Our experience shows that undergraduates and FOSS projects can help each other well. Moreover, we summarize the strengths and weaknesses of the existing FOSS communities in attracting undergraduates and provide some suggestions. © 2021 Association for Computing Machinery.

6.
2021 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2021 ; : 3181-3184, 2021.
Article in English | Scopus | ID: covidwho-1722897

ABSTRACT

The COVID-19 pandemic has had a severe impact on humans' lives and and healthcare systems worldwide. How to early, fastly and accurately diagnose infected patients via multimodal learning is now a research focus. The central challenges in this task mainly lie on multi-modal data representation and multi-modal feature fusion. To solve such challenges, we propose a medical knowledge enriched multi-modal sequence to sequence learning model, termed MedSeq2Seq. The key components include two attention mechanisms, viz. intra-modal (Ia) and inter-model (Ie) attentions, and a medical knowledge augmentation mechanism. The former two mechanisms are to learn multi-modal refined representation, while the latter aims to incorporate external medical knowledge into the proposed model. The experimental results show the effectiveness of the proposed MedSeq2Seq framework over state-of-the-art baselines with a significant improvement of 1%-2%. © 2021 IEEE.

7.
Embase;
Preprint in English | EMBASE | ID: ppcovidwho-326764

ABSTRACT

The SARS-CoV-2 B.1.1.529 variant (Omicron) contains 15 mutations on the receptor-binding domain (RBD). How Omicron would evade RBD neutralizing antibodies (NAbs) requires immediate investigation. Here, we used high-throughput yeast display screening1,2 to determine the RBD escaping mutation profiles for 247 human anti-RBD NAbs and showed that the NAbs could be unsupervised clustered into six epitope groups (A-F), which is highly concordant with knowledge-based structural classifications3-5. Strikingly, various single mutations of Omicron could impair NAbs of different epitope groups. Specifically, NAbs in Group A-D, whose epitope overlap with ACE2-binding motif, are largely escaped by K417N, G446S, E484A, and Q493R. Group E (S309 site)6 and F (CR3022 site)7 NAbs, which often exhibit broad sarbecovirus neutralizing activity, are less affected by Omicron, but still, a subset of NAbs are escaped by G339D, N440K, and S371L. Furthermore, Omicron pseudovirus neutralization showed that single mutation tolerating NAbs could also be escaped due to multiple synergetic mutations on their epitopes. In total, over 85% of the tested NAbs are escaped by Omicron. Regarding NAb drugs, the neutralization potency of LYCoV016/LY-CoV555, REGN10933/REGN10987, AZD1061/AZD8895, and BRII-196 were greatly reduced by Omicron, while VIR-7831 and DXP-604 still function at reduced efficacy. Together, data suggest Omicron would cause significant humoral immune evasion, while NAbs targeting the sarbecovirus conserved region remain most effective. Our results offer instructions for developing NAb drugs and vaccines against Omicron and future variants.

8.
Chinese General Practice ; 24(34):4306-4311, 2021.
Article in Chinese | Scopus | ID: covidwho-1600053

ABSTRACT

Background: Among the regions in China, Shanghai has took the lead in proposing the establishment of fever alertness clinics in community health centers. As a component of the epidemic control and prevention system, fever alertness clinics assume the role of containing an epidemic at the primary level. The Public Health Preparedness Clinic(PHPC) is a branch of Singapore's sound public health system. Objective: To compare fever alertness clinics of Shanghai and Singapore's PHPCs, then put forward suggestions to improve the construction of Shanghai's fever alertness clinics. Methods: This study was carried out from December 2020 to April 2021. For studying Shanghai's fever alertness clinics, policy documents analysis, literature review and field survey were used. Besides, interviews were also used, which were conducted in two rounds, separately for managers and healthcare workers who were selected from a random sample of three fever alertness clinics(one in the central urban area, one in the outer suburb and one in the urban fringe) of Shanghai. Guided by different outlines, the interviews for the two groups were aimed to collect their perspectives of the organizational structure, setting, operation, and management of fever alertness clinics. For studying Singapore's PHPCs and relevant practice, literature review was used. Results: The number and density of PHPC in Singapore are higher than those in Shanghai fever alertness clinic. Shanghai has higher standards for setting up fever alertness clinic, but PHPCs in Singapore has a higher entry threshold. Shanghai fever alertness clinic have more specific treatment procedures and standardization. Singapore's PHPC system is more prominent in terms of subsidies for epidemic prevention and protection of medical staff. Conclusion: The construction of Singapore's PHPCs needs longer preparation time, and the government is responsible for setting standards, admittance approval, planning and layout using the top-down approach, so the development of PHPCs shows higher homogeneity and meticulousness. In contrast, the construction of fever alertness clinics in Shanghai started late, showing higher personalized and localized characteristics. Copyright © 2021 by the Chinese General Practice.

9.
Nano Biomedicine and Engineering ; 13(3):225-228, 2021.
Article in English | EMBASE | ID: covidwho-1403981

ABSTRACT

The novel coronavirus pneumonia, a global pandemic disease named as coronavirus disease 2019, has caused enormous losses on the health and economies of people all over the world, while there is still a lack of quick and sensitive diagnostic method and effective therapy. Developing rapid diagnostic method for coronavirus disease 2019 has become exceptional urgent. Herein we report a rapid diagnostic method for the novel coronavirus through monitoring the volatile biomarkers in human exhaled breath. The breath volatile biomarkers are derived from the metabolism of novel coronavirus, including acetoin, 2,4,6-trimethylpyridine, 3-methyl tridecane, tetradecane, isooctyl alcohol, pentadecane, hexadecane, 1-methylene-1H-indene. By comparing the types and concentrations of the volatile biomarkers in human exhaled breath combined with SERS sensor, we could distinguish between the healthy person and the patients with coronavirus disease 2019. This work confirms that various volatile organic compounds metabolized by novel coronavirus can be employed for rapidly screening of patients with coronavirus disease 2019, and has broad application prospects in the prevention and control of the epidemic.

10.
Chinese General Practice ; 24(25):3184-3189, 2021.
Article in Chinese | Scopus | ID: covidwho-1395303

ABSTRACT

Background: Since the outbreak of COVID-19, the ability to manage public health emergencies in mega-cities has been put on the policy agenda, and the role of primary care in public health system is critical. Objective: To explore the status, problems and challenges of practical exploration of Shanghai's primary care in responding to COVID-19, providing policy recommendations and decision-making basis for improving the public health emergency system. Methods: From June to September 2020, a qualitative study was conducted using group interviews with administrators and healthcare professionals selected from 10 representative community health centers(CHCs) in suburban, fringe and urban areas in Shanghai's 5 districts for exploring major tasks shouldered by the CHCs, organizational structure of the CHCs, actual tasks performed by the CHCs, internal collaboration, major problems in service delivery during the pandemic, and recommendations, and with directors, as well as professionals responsible for information, healthcare management and quality control, public emergency management and infectious disease containment selected from health commissions and centers for disease control and prevention in the districts, for exploring the functions and roles of CHCs during the pandemic and their weaknesses in anti-pandemic actions, anti-pandemic supports from health commissions and centers for disease control and prevention for CHCs, and ideas about actions of primary care in pandemic and non-pandemic periods. The interviews with individuals from three kinds of affiliations were guided using different types of semi-structured outlines developed by our research team. Results: The interviews revealed that during the pandemic, the CHCs gave emergency responses to COVID-19, participated in regional collaboration for COVID-19 containment, delivered in-hospital COVID-19 screening and triage services while providing routine medical services, and continued to offer family doctor services. Four issues were found to be addressed: insufficient healthcare resources and workers, insufficient services targeting psychological influence of COVID-19, unsatisfied internal coordination and multi-departmental management, and lack of appropriate mechanisms incentivizing healthcare workers and invigorating primary care. Conclusion: In view of the challenges in fighting COVID-19 faced by primary care, it is recommended to take actions on the basis of appropriately balancing the delivery of routine primary care services and public health services, and tasks during pandemic and non-pandemic periods, and appropriately coordinating with higher level departments, as well as developing incentive programs according to the local conditions as a supplement for the government programs. Copyright © 2021 by the Chinese General Practice.

11.
Asia Pacific Journal of Marketing and Logistics ; 2021.
Article in English | Scopus | ID: covidwho-1281925

ABSTRACT

Purpose: To alleviate the effects of coronavirus disease 2019 (COVID-19) on the economy, Taiwan introduced a stimulus package in the form of triple stimulus vouchers. Despite intense promotion to opt for the vouchers in digital form, Taiwanese public overwhelmingly chose the paper form. This study considers the reasons that influenced their decision comfort in choosing paper rather than digital vouchers based on two categories: rational (promotion depth and ease of use) and behavioral economics factors (analysis paralysis, mental accounting related to ease of tracking expenses, social influence and payment habits). Design/methodology/approach: Partial least squares (PLS) method was utilized to analyze survey information obtained from 183 individuals who chose paper vouchers. Findings: Individuals consider rational and behavioral economic factors in their perception of decision comfort while choosing paper over digital vouchers. Decision comfort is driven more by behavioral economics than rational factors such as ease of use. Interestingly, analysis paralysis related to paper vouchers has the greatest impact, but it positively influences decision comfort, indicating that Taiwanese people view paper vouchers as a safe haven in the midst of uncertainties and information overload. Therefore, when designing public policies or promotional campaigns, possible behavior outcomes should be considered from both rational and behavioral economic perspectives. Originality/value: This study provides insights into the dynamics of how individuals arrive at their decision of opting paper vouchers over digital ones and offers theoretical contributions related to system adoption and behavioral economics. © 2021, Emerald Publishing Limited.

12.
13th ACM SIGCHI Symposium on Engineering Interactive Computing Systems, EICS 2021 ; : 6-11, 2021.
Article in English | Scopus | ID: covidwho-1280489

ABSTRACT

Mental health conditions pose a major challenge for individuals, healthcare systems and society-and the COVID-19 pandemic has likely worsened this issue. According to the Mental Health Foundation of New Zealand, one in five people will develop a serious mood disorder, including depression, at some time in their life. Co-designed solutions to increase resilience and well-being in young people have specifically been recognised as part of the National Suicide Prevention Strategy and the New Zealand Health Strategy. Virtual Reality (VR) in mental health is an innovative field. Recent studies support the use of VR technology in the treatment of anxiety, phobia, and pain management. However, there is little research on using VR for supporting, treating and preventing depression. There is also very little work done in offering an individualised VR experience to improve mental health. In our earlier work, we presented iVR, a novel individualised VR experience for enhancing peoples' self-compassion, and in the long run, their mental health, and described its design and architecture. In this paper, we outline the results of a feasibility study conducted recently. Most participants believed introducing elements of choice within iVR enhanced their user experience and that iVR had the potential to enhance people's self-compassion. We also approached seven mental health professionals for feedback, who felt that introducing elements of choice within iVR would increase their knowledge of clients. Our contribution can pave the way for large-scale efficacy testing, clinical use, and cost-effective delivery of intelligent individualised VR technology for mental health therapy in future. © 2021 ACM.

13.
Aging-Us ; 13(8):10853-10865, 2021.
Article in English | Web of Science | ID: covidwho-1250435

ABSTRACT

Because SARS-COV2 entry into cells is dependent on angiotensin converting enzyme 2 (ACE2) and angiotensin converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) increase ACE2 activity, the safety of ACEI/ARB usage during the coronavirus disease 2019 (COVID-19) pandemic is a controversial topic. To address that issue, we performed a meta-analysis following The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Searches of the Embase, MEDLINE, PubMed, and Cochrane Library databases identified 16 case-control studies examining the effect of ACEI/ARB on the incidence of COVID-19 and its severity. ACEI/ARB usage was associated with an increased risk of COVID-19 morbidity (odds ratio (OR) 1.20, 95% confidence interval (CI) 1.07-1.33, P=0.001) among the general population but not in a hypertensive population (OR 1.05, 95% CI 0.90-1.21, P=0.553). ACEI/ARB usage was not associated with an increased risk of COVID-19 morbidity (coefficient 1.00, 95% CI 1.00-1.00, P=0.660) when we adjusted for hypertension in the general population. ACEI/ARB usage was also not associated with an increased risk of severe illness (OR 0.90, 95%CI 0.55-1.47, P=0.664) or mortality (OR 1.43, 95%CI 0.972.10, P=0.070) in COVID-19 patients. Our meta-analysis revealed that ACEI/ARB usage was not associated with either the increased risk of SARS-COV2 infection or the adverse outcomes in COVID-19 patients.

14.
Fudan University Journal of Medical Sciences ; 48(2):176-181, 2021.
Article in Chinese | Scopus | ID: covidwho-1196057

ABSTRACT

Objective: To investigate and analyze the epidemiological characteristics of a cluster of coronavirus disease 2019 (COVID-19) spread by a super spreader in Taizhou, Zhejiang Province, and provide reference for prevention and control of COVID-19. Methods: The field epidemiological investigation was conducted to investigate the confirmed cases and close contacts;the data were analyzed with descriptive method. Chi-squared test was used to compare the differences of attack rates among close contacts. Results: A total of 23 epidemiological related cases were identified, including 20 confirmed cases and 3 asymptomatic infection cases. Thirteen (56.52%) were males, ten (43.48%) were females, and the median age was 51 years old with the range of 30 to 70 years old. The second generation case firstly developed symptoms on Jan 19th and was confirmed on Jan 30th, 2020.The first generation cases were from Wuhan and the last case was confirmed on Feb 3rd, 2020.The epidemic spread to the fifth generation with a total attack rate of 6.07% (21/346), among which the third generation case was a super spreader who directly transmitted to 12 subsequent cases with a significantly higher attack rate than other cases (27.27% vs. 2.98%, χ2=39.754, P<0.001). Conclusion: The expansion of the epidemic can be attributed to the lack of timely control of imported personnel from high risk regions, the lacking awareness of novel infectious diseases at the early stage of the epidemic and the appearance of the super spreader. To form a normalized prevention mechanism, it is necessary to improve the alertness of novel infectious diseases among medical staffs and the masses, implement prevention and control strategies in time. © 2021, Editorial Department of Fudan University Journal of Medical Sciences. All right reserved.

15.
Nano Biomedicine and Engineering ; 12(4):325-330, 2020.
Article in English | EMBASE | ID: covidwho-993983

ABSTRACT

The novel coronavirus disease (COVID-19) is breaking out and spreading rapidly around the world. There is an urgent need for an accurate and rapid detection method to quickly find infected patients and asymptomatic carriers in order to prevent the spread of the severe acute respiratory syndrome coronavirus [SARS-CoV-2]. In this paper, we designed a test strip which used the principle of double antigen sandwich. Fe3O4 magnetic nanobeads are firstly coupled with specific antibodies, and the S protein of the new coronavirus is used as the coating antigen to capture specific antibodies against the new coronavirus, which is used to detect the virus nucleoprotein of specific antibodies in clinical samples. At the same time, Fe3O4 magnetic nanobeads have unique magnetic properties, which can be used to generate different types of detection signals and simplify the detection process. These results can be judged by color changes and magnetic changes at the test and control lines. Compared with the traditional method, this test strip of Fe3O4 magnetic nanobeads has high sensitivity and can qualitatively detect samples within 15 minutes. The magnetic performance of the magnetic nanobeads can be used to improve the sensitivity of the strip in our further research and product development.

16.
Nano Biomedicine and Engineering ; 12(4):321-324, 2020.
Article in English | EMBASE | ID: covidwho-993982

ABSTRACT

The new coronavirus SARS-CoV-2 has become a global pandemic, which has had a huge impact on the lives of people around the world and has caused huge impacts and losses on global economic development. To now, there is still no effective drug or therapy against coronavirus. A large number of studies have shown that vaccines are the ultimate weapon to eliminate major infectious diseases. The development of new vaccines against new coronaviruses is the best way to prevent new coronavirus infections. In this study, we developed a new vaccine against the new coronavirus by combining our self-developed nano adjuvant loaded with carnosine graphene oxide adjuvant with loaded with CpG molecule and RBD protein antigen. Our results showed that this vaccine can produce high titer anti-SARS-CoV-2 RBD antibody neutralizing SARS-CoV-2 in mice within 2 weeks.

17.
Nano Biomedicine and Engineering ; 12(4):316-320, 2020.
Article in English | EMBASE | ID: covidwho-993981

ABSTRACT

The SARS-CoV-2 isothermal amplification detection kits based on loop-mediated isothermal amplification (LAMP) were developed and evaluated on three types samples of SARS-CoV-2. The kits included enzyme reaction mixtures and chromogenic agents. After the isothermal amplification reactions were completed, the reaction results were judged by using the chromogenic agents to determine whether SARS-CoV-2 exists in the samples to be tested. The detection kits have the advantages of convenient operation, fast detection speed and high sensitivity up to 1 copy of virus particles per reaction, which can speed up the detection speed of suspected cases, and avoid the missing detection problems caused by the low detection sensitivity.

18.
Nano Biomedicine and Engineering ; 12(4):311-315, 2020.
Article in English | EMBASE | ID: covidwho-993980

ABSTRACT

The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a public health emergency of international concern. Real-time reverse transcription-polymerase chain reaction (RT-PCR) is widely used as the gold standard method for the diagnosis of SARS-CoV-2 infection. However, the reliability of current real-time RT-PCR assays is questioned due to some false-negative reports. In this study, we improved the real-time RT-PCR method based on three target regions (ORF1ab, E, and N) of SARS-CoV-2. Results showed that real-time RT-PCR assays herein could complete detection within one hour after viral RNA preparation and had high sensitivity down to 5 copies of viral RNA. In addition, six clinical specimens were detected to evaluate the availability of this method. Among them, four samples were 3-plex SARS-CoV-2 positive and two were negative by real-time RT-PCR. The sensitivity was 100% (4/4), and specificity was 100% (2/2). These results demonstrate that we develop a rapid and high-sensitive real-time RT-PCR method for SARS-CoV-2 detection, which will be a powerful tool for COVID-19 identification and for monitoring suspected patients.

19.
Nano Biomedicine and Engineering ; 12(4):306-310, 2020.
Article in English | EMBASE | ID: covidwho-993979

ABSTRACT

To combat the COVID-19 pandemic, serologic lateral flow immunoassays are required to facilitate accurate diagnosis of SARS-CoV-2 infection and confirmation of molecular results. This study evaluated sensitivity of two different designs of colloidal gold serologic tests (antigen based total antibody test and antibody based IgG test) by using residual serum samples from patients who were evaluated for SARS-CoV-2 infection status by polymerase chain reaction (PCR). The results showed 100% specificity for both tests, while when testing of 16 positive patients, the data showed 90% sensitivity for total antibody test and 30% for IgG test. This study demonstrates high diagnostic accuracy for anti-SARS-CoV-2 total antibody tests and will facilitate further development and selection of serological assays.

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