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2.
2021 Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies: Demonstrations (Naacl-Hlt 2021) ; : 66-77, 2021.
Article in English | Web of Science | ID: covidwho-2068449

ABSTRACT

To combat COVID-19, both clinicians and scientists need to digest vast amounts of relevant biomedical knowledge in scientific literature to understand the disease mechanism and related biological functions. We have developed a novel and comprehensive knowledge discovery framework, COVID-KG to extract fine-grained multimedia knowledge elements (entities and their visual chemical structures, relations and events) from scientific literature. We then exploit the constructed multimedia knowledge graphs (KGs) for question answering and report generation, using drug repurposing as a case study. Our framework also provides detailed contextual sentences, subfigures, and knowledge subgraphs as evidence. All of the data, KGs, reports(1), resources, and shared services are publicly available(2).

4.
Journal of Urology ; 207(5):E596-E596, 2022.
Article in English | Web of Science | ID: covidwho-2068150
5.
American Journal of Transplantation ; 22(Supplement 3):420, 2022.
Article in English | EMBASE | ID: covidwho-2063366

ABSTRACT

Purpose: Extra-pulmonary organs from donors with SARS-CoV-2 detection during donor evaluation are not accepted by many centers due to theoretical concerns for productive infection and organ injury from COVID-related sequelae. We aimed to compare outcomes for kidney transplantation (KT) from donors with and without SAR-CoV-2 RNA detection, CoVD+ and CoVDneg, respectively. Method(s): We retrospectively reviewed donor data, recipient data and key outcomes for all adult CoVD+ KTs performed at our center between 2/1/2021 and 10/31/2021 and compared such data to all consecutive adult CoVDneg KTs during the same period. Organ selection was by protocol and excluded donors within the 1st 14 days of diagnosed symptomatic infection. No COVID-directed therapies were provided to CoVD+ KT recipients (KTRs). Vaccination was not required in early 2021. Result(s): There were 159 KTs, including 71 (44%) from 41 CoVD+'s with mean follow up 151d (range 35-291d). Of the 41 CoV+ donors, 16 (40%) died of COVID complications, mostly hypoxic respiratory failure, with 4 on VV ECMO. For those dying of COVID, the median time from first SARS-CoV2 RNA detection to donation was 28d (range 16-65). Compared to CoVneg donors, CoV+D's had lower KDPI (mean 31 v 43, mean difference -10.8, 95% CI -18.41 to -3.17, p=0.006), and were more likely DCD (OR 2.41, 95% CI 1.28-0.463, p=0.007). Having a CoV+ donor was not associated with delayed graft function (DGF). On multivariable analysis, CoVD+ was not associated with a higher serum creatinine (Cr) at 1, 3 or 6 months, but DCD was. There was 1 death (from pre-existing interstitial lung disease without SARS-CoV-2 detection from the lower airway) at 4 mo and 1 graft loss at 6 wk post-KT, both in the CoVD+ group. Neither of these KTR's donors had died of a COVID-related cause. Rejection occurred in 3 CoVD+ and 4 CoVneg KTRs. Six (3.7%) KTRs were diagnosed with COVID, all >3 mo post-KT, with 5/6 occurring >6 mo post-KT during peak periods of circulating virus. Conclusion(s): In a large series, kidney transplant outcomes from CoVD+s were similar to CoVDnegs up to 6 months post-transplant. CoVD+ KT recipients likely benefited from lower KDPI organs. We demonstrate safe and successful transplantation of CoVD+ kidneys outside of the peak period of symptomatic SARS-CoV-2 infection. (Figure Presented).

6.
Sustainability (Switzerland) ; 14(18), 2022.
Article in English | Scopus | ID: covidwho-2055362

ABSTRACT

In 2020, COVID-19 swept across the globe. To reduce the social harms caused by this public health event, nonprofit organizations (NPOs) cooperated with medical enterprises to produce reserves of emergency medical supplies. In practice, this cooperation was challenged by the different goals of NPOs and medical enterprises and the asymmetry of information between these parties. Enterprises are prone to irregularities or speculative behaviors that can result in insufficient production capacity during public health events, which increase disaster risks. Based on the principal–agent relationship of NPOs and enterprises, this study analyzed a game model between NPOs and enterprises under information asymmetry;constructed an incentive model for reserve emergency medical supply production capacity;and solved the optimal reward and punishment coefficients of NPOs, optimal effort level of enterprises, and benefits of disaster reduction. The study also verified the validity of the model using numerical examples and a sensitivity analysis. In taking up the findings of the study, this paper discusses the effects of several important exogenous variables on the optimal decision strategies of NPOs and enterprises and offers management-related insights for NPOs. © 2022 by the authors.

7.
J Hosp Infect ; 131: 1-11, 2022 Oct 03.
Article in English | MEDLINE | ID: covidwho-2049484

ABSTRACT

BACKGROUND: The arrival of the Delta variant of SARS-CoV-2 was associated with increased transmissibility and illness of greater severity. Reports of nosocomial outbreaks of Delta variant COVID-19 in acute care hospitals have been described but control measures varied widely. AIM: Epidemiological investigation of a linked two-ward COVID-19 Delta variant outbreak was conducted to elucidate its source, risk factors, and control measures. METHODS: Investigations included epidemiologic analysis, detailed case review serial SARS-CoV-2 reverse transcriptase-polymerase chain reaction (RT-PCR) testing of patients and healthcare workers (HCWs), viral culture, environmental swabbing, HCW-unaware personal protective equipment (PPE) audits, ventilation assessments, and the use of whole genome sequencing (WGS). FINDINGS: This linked two-ward outbreak resulted in 17 patient and 12 HCW cases, despite an 83% vaccination rate. In this setting, suboptimal adherence and compliance to PPE protocols, suboptimal hand hygiene, multi-bedded rooms, and a contaminated vital signs cart with potential fomite or spread via the hands of HCWs were identified as significant risk factors for nosocomial COVID-19 infection. Sudden onset of symptoms, within 72 h, was observed in 79% of all Ward 2 patients, and 93% of all cases (patients and HCWs) on Ward 2 occurred within one incubation period, consistent with a point-source outbreak. RT-PCR assays showed low cycle threshold (CT) values, indicating high viral load from environmental swabs including the vital signs cart. WGS results with ≤3 SNP differences between specimens were observed. CONCLUSION: Outbreaks on both wards settled rapidly, within 3 weeks, using a `back-to-basics' approach without extraordinary measures or changes to standard PPE requirements. Strict adherence to recommended PPE, hand hygiene, education, co-operation from HCWs, including testing and interviews, and additional measures such as limiting movement of patients and staff temporarily were all deemed to have contributed to prompt resolution of the outbreak.

8.
Journal of Internal Medicine of Taiwan ; 33(3):218-226, 2022.
Article in Chinese | Scopus | ID: covidwho-2025284

ABSTRACT

Covid-19 is associated with a higher risk of thrombotic complications, and prophylactic dose anticoagulants are recommended for hospitalized nonpregnant patients by international treatment guidelines. Whether the benefit and efficacy of using anticoagulants among Taiwanese patients remains uncertain, we aimed to evaluate the use of anticoagulants and to investigate the risk factors of the patients. 144 patients with confirmed SARSCoV-2 infection were admitted to a regional teaching hospital in Taipei, Taiwan between May, 2021 and July, 2021. We retrospectively collected these patients' data from electronic medical records. Descriptive statistics, independent t-test and Chi-square were applied for patients' characteristics and important factors. Medication use evaluation was performed through SOAP format for every patient by dedicated pharmacists. There were 29% patients receiving anticoagulants, 90% of the use were for Covid-19 thromboprophylaxis. Among these patients, old age, hypertension and diabetes have a high correlation with mortality and the use of anticoagulants. There was no medication related problem that remains unresolved, all patients were completely assessed. © 2022 Society of Internal Medicine of Taiwan. All rights reserved.

9.
Taiwan Journal of Public Health ; 41(1):96-104, 2022.
Article in Chinese | Scopus | ID: covidwho-2025280

ABSTRACT

Objectives: This study aimed to examine the relationship between family income loss and child health during the COVID-19 pandemic. Methods: Data for the analysis were obtained from the Taiwan Birth Cohort Study, a nationally representative sample of babies born in 2005, and 18, 024 caregivers participated in the survey as their children aged 15. In analysis, we first conducted descriptive analyses to test the correlation between socioeconomic variables and family income loss. We next assessed whether there was a gradient relationship between family income loss and child health using Cochran-Armitage trend test. Finally, multiple logistic regression was used to estimate the relationship between family income loss and child health. Results: Our findings indicated that (1) lower socioeconomic families were at a greater risk of suffering income loss during COVID-19;(2) children in the families experiencing a more severe loss of income had worse health, but the gradient relationship was not significant for those in higher income families;and (3) significantly higher risk of fair/poor health of children was found in the severe (OR: 1.3, 95% CI 1.2-1.5) and mild (OR: 1.2, 95% CI 1.1-1.3) income loss groups than in the no income loss group after adjustment for socioeconomic variables. Conclusions: Family income loss due to COVID-19 was significantly associated with child health inequality. To avoid widening the health gap, children in families experiencing financial impacts during the COVID-19 pandemic should be protected and supported, particularly those in lower socioeconomic groups. © 2022 Chinese Public Health Association of Taiwan. All rights reserved.

10.
Aerosol and Air Quality Research ; 22(10), 2022.
Article in English | Web of Science | ID: covidwho-2024889

ABSTRACT

To evaluate the difference in hazardous air pollutants in PM2.5 between reference method (National Institute of Environmental Analysis;NIEAA205) and high-volume air sampler (European standard:EN14907 and Japan method), we set up a sampling station on the campus of National Yang-Ming Chiao Tung University, northern Taiwan, during 2014-2015. Both vapor and solid phases of dioxins were collected using high-volume samplers, according to EN14907 and Japan method. The flow rate was set at 500 L min(-1) and 1000 L min(-1), respectively. To compare the difference with the high-volume air sampler, we simultaneously used the reference air sampler based on Taiwan NIEA A205.11C, at the flow rate of 16.7 L min(-1) (BGI PQ200-FRM). The mass concentrations of PM2.5 measured with NIEA A205, EN14907, and Japan method were 20.2 +/- 8.79, 25.4 +/- 10.5 and 28.6 +/- 13.9 mu g m(-3), respectively. The difference of the mass concentration of PM2.5 obtained from two different methods was lower than 3.9%. Moreover, the concentrations of PCDD/F between solid and vapor phases were 56.9-1,090 and 38.6-67.1 fg m(-3) via EN14907 and 51.1-1,150 and 18.4-81.8 fg m(-3) via Japan method, respectively. Obviously, there is no significant difference between these two samplers. Compared to the method of NIEA, high volume air sampling method not only provided equivalently good quality data but offer a higher sample quantity for analyzing the trace level chemical component of hazardous air pollutants and the toxicity in different areas.

11.
Comparative Research on Educational Policy Responses to the COVID-19 Pandemic: Eastern vs. Western Perspectives ; : 92-115, 2022.
Article in English | Scopus | ID: covidwho-2024488

ABSTRACT

During the COVID-19 pandemic, international higher education underwent significant changes. To maintain the operation of international education and ensure the continuity of students' education, the Chinese and Australian governments have introduced a set of emergency policies. This study unpacks the policies that relate to Chinese students enrolled in Australian universities. It also summarises the unique modes built in these two contexts and critically identifies their similarities and distinctions. Based on these findings, it proposes the concept, co-creation, and highlights the trend in international education. It suggests that a virtual geographical space in international education has emerged during the COVID-19 pandemic, where the immobility of students is accepted. The establishment of the space requires collaborative efforts from governments, social organisations, and universities. Hence, the future of higher education is more about innovation than recovery. © 2022, IGI Global.

12.
23rd International Conference on Artificial Intelligence in Education, AIED 2022 ; 13356 LNCS:453-457, 2022.
Article in English | Scopus | ID: covidwho-2013941

ABSTRACT

Students’ conversations in academic settings evolve over time and can be affected by events such as the COVID-19 pandemic. In this paper, we employ a Contextualized Topic Modeling technique to detect coherent topics from students’ posts in online discussion forums. We construct topic chains by connecting semantically similar topics across months using Word Mover’s Distance. Consistent academic discourse and contemporary events such as the COVID-19 outbreak and the Black Lives Matter movement were found among prominent topics. In later months, new themes around students’ lived experiences emerged and evolved into discussions reflecting the shift in educational experiences. Results revealed a significant increase in more general topics after the onset of pandemic. Our proposed framework can also be applied to other contexts investigating temporal topic trends in large-scale text data. © 2022, Springer Nature Switzerland AG.

13.
Psychol Med ; : 1-14, 2022 Jul 26.
Article in English | MEDLINE | ID: covidwho-2016465

ABSTRACT

BACKGROUND: The impact of the coronavirus disease 2019 (COVID-19) pandemic on mental health is still being unravelled. It is important to identify which individuals are at greatest risk of worsening symptoms. This study aimed to examine changes in depression, anxiety and post-traumatic stress disorder (PTSD) symptoms using prospective and retrospective symptom change assessments, and to find and examine the effect of key risk factors. METHOD: Online questionnaires were administered to 34 465 individuals (aged 16 years or above) in April/May 2020 in the UK, recruited from existing cohorts or via social media. Around one-third (n = 12 718) of included participants had prior diagnoses of depression or anxiety and had completed pre-pandemic mental health assessments (between September 2018 and February 2020), allowing prospective investigation of symptom change. RESULTS: Prospective symptom analyses showed small decreases in depression (PHQ-9: -0.43 points) and anxiety [generalised anxiety disorder scale - 7 items (GAD)-7: -0.33 points] and increases in PTSD (PCL-6: 0.22 points). Conversely, retrospective symptom analyses demonstrated significant large increases (PHQ-9: 2.40; GAD-7 = 1.97), with 55% reported worsening mental health since the beginning of the pandemic on a global change rating. Across both prospective and retrospective measures of symptom change, worsening depression, anxiety and PTSD symptoms were associated with prior mental health diagnoses, female gender, young age and unemployed/student status. CONCLUSIONS: We highlight the effect of prior mental health diagnoses on worsening mental health during the pandemic and confirm previously reported sociodemographic risk factors. Discrepancies between prospective and retrospective measures of changes in mental health may be related to recall bias-related underestimation of prior symptom severity.

14.
Innovation in Aging ; 5:1017-1018, 2021.
Article in English | Web of Science | ID: covidwho-2011855
15.
Journal of Clinical Oncology ; 40(16), 2022.
Article in English | EMBASE | ID: covidwho-2009641

ABSTRACT

Background: Prognosis of COVID-19 is poor in the setting of immunosuppression. Casirivimab/imdevimab (REGEN-COV), bamlanivimab, and sotrovimab are investigational monoclonal antibodies (MoAbs) authorized for treatment of mild/moderate COVID-19 for patients (pts) 12 years or older and who are at high-risk for progression to severe COVID-19. These neutralizing antibodies, against SARS-CoV-2 spike proteins, have been shown to decrease risk of progression to severe disease. Recipients of allogeneic stem cell transplants (allo-SCT) or chimeric antigen T cell therapy (CAR T cell) represent a high risk population. However, treatment outcomes with these MoAbs in these pts are not well described. Methods: This retrospective study included 33 consecutive adult pts who developed mild/moderate COVID-19 and received anti-spike SARS-CoV-2 MoAbs between December 2020 and November 2021. Allo-SCT (N=27) or CAR T cell (N=6) recipients were included, and outcomes were analyzed separately. Pts received REGEN-COV (N=19), bamlanivimab (N=11), or sotrovimab (N=1), missing (N=2). Results: In the allo-SCT cohort (N=27), median age at time of COVID-19 was 55 (23-76) years. Median time from allo-SCT to COVID-19 was 31 (22-64) months. Two pts received CAR T-cell therapy prior to allo-SCT. Diagnoses included leukemia or myeloid diseases (82%), lymphoma (11%), or myeloma (7%). Transplant characteristics are summarized (Table). Thirteen pts were vaccinated against SARS-CoV-2 prior to breakthrough COVID-19. Events considered included hospitalization due to COVID- 19, disease progression, or death from any cause. The 6-month event-free and overall survivals were 81% and 91%, respectively. In the CAR T cell recipients cohort (N=6), 4 pts received axicabtagene ciloleucel for diffuse large B-cell or follicular lymphoma and 2 received brexucabtagene autoleucel for mantle cell lymphoma. The median follow-up was 8 (1-11) months. Two pts received autologous SCT prior to COVID-19. Median time from CAR T cell therapy to COVID-19 was 10 (3-24) months. Three pts were vaccinated prior to COVID-19. Only 1 pt was hospitalized due to severe COVID- 19 requiring mechanical ventilation leading to death. Conclusions: These results show a potential benefit of MoAbs in high-risk pts, namely allo-SCT or CAR T cell recipients. Future studies should evaluate the role of prophylactic use MoAbs in these populations. A comparative analysis with a matched control cohort (who did not receive MoAbs) will be provided at the meeting.

16.
Annals of the Rheumatic Diseases ; 81:210-211, 2022.
Article in English | EMBASE | ID: covidwho-2009170

ABSTRACT

Background: Interleukin-6 (IL-6) is elevated in patients with active polymyalgia rheumatica (PMR) and is associated with disease activity, relapse and severity. Clinical trials with IL-6 receptor (IL-6R) inhibitors in PMR showed higher remission rates and reduced glucocorticoid (GC) use vs GC alone.1-4 Objectives: The SAPHYR study (NCT03600818) assessed the efficacy and safety of sarilumab (SAR), a fully human anti IL-6Rα monoclonal antibody, with a 14 week (wk) GC taper in patients with steroid resistant active PMR who fared on ≥7.5 mg/day prednisone or equivalent. Methods: Patients were randomized (1:1) to 52 wks of treatment with SAR 200 mg every 2 wks (Q2W) + 14 wk GC tapered regimen (SAR arm) OR placebo Q2W + 52 wk GC tapered regimen (comparator arm). The primary endpoint was the proportion of patients achieving sustained remission at wk 52, defned as disease remission by wk 12, absence of disease fare, CRP normalization from wks 12 to 52 and adherence to the per protocol GC taper from wks 12 to 52. Results: The study was terminated early due to protracted recruitment timelines during the COVID-19 pandemic, resulting in 118 of the intended 280 patients recruited between Oct 2018 and Jul 2020, and 117 were treated (SAR n=59, comparator n=58). The demographics were balanced;patients were primarily female, Caucasian, and a median age of ~70 years (Table 1). Overall, 78 patients completed the treatment (SAR n=42;comparator n=36). Primary reasons for treatment discontinuation were adverse events (AEs;SAR n=7, comparator n=4) and lack of efficacy (SAR n=4, comparator n=9). Sustained remission rate was signifcantly higher in the SAR arm vs the comparator arm (28.3% vs 10.3%;P=0.0193). Results of a sensitivity analysis excluding CRP from the sustained remission defnition was consistent with the primary analysis (31.7% vs 13.8%;P=0.0280). All sustained remission components favored SAR (Figure 1). Patients in the SAR arm were 44% less likely to have a fare after achieving clinical remission vs the comparator arm (16.7% vs 29.3%;HR 0.56;95% CI 0.35-0.90;P=0.0158). The comparator arm required more additional GCs vs the SAR arm, mainly due to PMR fare (median difference in actual and expected cumulative dose 199.5 mg vs 0.0 mg;P=0.0189). The cumulative GC toxicity index scores numerically favored SAR but the difference was not statistically signifcant. PMR activity scores improved in the SAR arm vs the comparator arm (LS mean-15.57 vs-10.27, nominal P=0.0002). Patient reported outcomes (eg, physical and mental health component scores, disability index, etc) favored SAR (Figure 1). Incidence of treatment-emergent AEs (TEAEs) was numerically higher in the SAR arm vs the comparator arm (94.9% vs 84.5%) and included neutropenia (15.3%) and arthralgia (15.3%) in the SAR arm, and insomnia (15.5%) in the comparator arm. Conversely, the frequency of serious AEs was higher in the comparator arm vs the SAR arm (20.7% vs 13.6%). No deaths were reported. Conclusion: SAR + 14 wk GC taper demonstrated signifcant efficacy vs the comparator arm in steroid refractory PMR patients, including clinically meaningful improvement in quality of life. Safety was consistent with the known safety profile of SAR.

17.
International Journal of Gerontology ; 16(3):180-185, 2022.
Article in English | Web of Science | ID: covidwho-1988400

ABSTRACT

Since December 2019, the emergence of coronavirus disease 2019 (COVID-19) has had a major impact worldwide. This emerging virus does not only affect the respiratory system but also affects the nervous system. Cerebrovascular events have been reported as complications of COVID-19. In this review article, we summarized the epidemiology, stroke subtype, characteristics, laboratory findings, pathophysiology, risk factors and treatment of stroke in COVID-19 patients by reviewing case reports and cohort studies. On the other hand, sporadic adverse events such as systemic thromboembolism and stroke have been reported after COVID-19 vaccination. Herein, we reviewed the literature to elucidate the association between COVID-19 vaccines and stroke with the aim of assisting clinical decisions and giving people greater confidence in receiving vaccines. Copyright (c) 2022, Taiwan Society of Geriatric Emergency & Critical Care Medicine.

18.
Cancer Research ; 82(12), 2022.
Article in English | EMBASE | ID: covidwho-1986496

ABSTRACT

Objective: Screening with low-dose CT (LDCT) effectively reduces mortality from lung cancer. Elective imaging procedures, including lung cancer screening (LCS) LDCT exams, were paused during the height of the COVID-19 pandemic at our institution to conserve healthcare resources and minimize risk as we learned how to mitigate the spread of COVID-19. We aimed to investigate the short-term impact of this COVID-related screening pause on patient participation and adherence to LCS. Methods: We analyzed data of 5133 LDCT screening exams performed at our institution from 2961 patients who were aged 50-80 at each screen between July 31, 2013 and Dec 30, 2020. Independent t-test, Pearson's chi-square and Fisher's exact tests were used to compare monthly average number of LDCTs, on-time adherence rates (i.e., completion of recommended or more invasive follow-up within 15, 9, 5, and 3 months for Lung-RADS 1/2, 3, 4A, and 4B/4X, respectively), percentages of positive screens (Lung-RADS 3 and 4), and lung cancer diagnoses across pre- (July 31, 2013 ∼ Mar 18, 2020), during (Mar 19, 2020 ∼ May 19, 2020), and post-COVID screening pause (May 20, 2020 and after) periods. Results: As expected, compared with the pre-COVID screening pause, there was a significant decrease in monthly average number of LDCTs during the COVID screening pause period (total monthly mean ± sd: pre 55±28 vs during 17±1, p<0.05;new patient monthly mean ± sd: pre 34±16 vs during 6±2, p<0.05). However, a surge in LCS activities was observed after the COVID screening pause period (total: during 17±1 vs post 89±10, p<0.05;new: during 6±2 vs post 42±8, p<0.05), surpassing monthly means in the pre-COVID period (total: pre 55±28 vs post 89±10, p<0.05;new: pre 34±16 vs post 42±8, p<0.05). Overall on-time adherence decreased in the post-COVID period as opposed to the pre-COVID period (p<0.05). There were no significant changes in the percent of positive screens across the three periods (p>0.05). Among the 88 patients diagnosed with lung cancers, 76 diagnoses were made before COVID, 12 diagnoses were made after the COVID pause, and no lung cancer diagnoses were made during the COVID screening pause period. There were no significant differences in terms of the rate of lung cancer (pre 2.9% vs post 1.9%, p>0.05) and the percent of advanced lung cancers (pre 20% vs post 0%, p>0.05) during the two periods. Conclusion: The rate of LCS exams performed at our institution declined during the early days of the COVID-19 pandemic, as elective exams were paused. Once screening resumed, we experienced a surge in the rate of LCS that surpassed pre-COVID rates. Although there were no significant changes in the percentages of positive screens and lung cancer diagnoses shortly after the COVID screening pause period, long-term follow-up is needed to monitor these trends. Additionally, interventions may be needed to improve rates of patients' timely adherence to LCS follow-up recommendations, which decreased in the post-COVID period.

19.
Dermatologica Sinica ; 40(2):67-70, 2022.
Article in English | EMBASE | ID: covidwho-1957509

ABSTRACT

With the rapid outbreak of the coronavirus disease 2019 (COVID-19) pandemic, considerable concerns about the safety of systemic treatments of immune-mediated dermatologic disorders has been raised by dermatologists and their patients. We aimed to perform a rapid review of latest American and European guidelines on the use of systemic treatments in patients with immune-mediated dermatologic disorders and confirmed COVID-19 infection and to provide recommendations to inform practice. Based on the current limited guidelines and evidence, systemic corticosteroids should not be abruptly discontinued and the lowest effective dose should be continued. Systemic immunosuppressants (including methotrexate, cyclosporine, azathioprine, cyclophosphamide, and leflunomide), biologics, and sulfasalazine should be withheld in patients with confirmed COVID-19 infection. Whether to continue Janus kinase inhibitors should be determined following a shared decision-making process between dermatologists and patients after considering patients' medical conditions and risk for severe COVID.

20.
14th International Conference on Cross-Cultural Design, CCD 2022 Held as Part of the 24th HCI International Conference, HCII 2022 ; 13311 LNCS:480-496, 2022.
Article in English | Scopus | ID: covidwho-1941429

ABSTRACT

The modern economic era is experience-oriented, with pleasure generated through perceptual experiences to create an enjoyable process and more sales. Under the influence of the coronavirus-19 (COVID-19) pandemic, people have begun to pursue a sense of ritual and to focus on their emotion, which has enhanced the connection between brands and consumers. The new emphasis on enhancing consumer experiences illustrates how incorporation of ritual and cultural imagery have become a means through which fashion brands can distinguish themselves from global competitors. Although international fashion weeks are now being hosted through virtual catwalks, these shows lack face-to-face interactions and a sense of on-site ritual. Therefore, many have proposed that the COVID-19 era fashion industry should be redesigned to ensure shows maintain a strong sense of ritual that enables audiences to transform their perceptions through a cultivated atmosphere to experience pleasure and satisfaction. In the present study, we explored the incorporation of cultural experiences into fashion curation to identify modern design focuses for fashion curation. We also analyzed the shows of different brands participating in the fashion weeks and discussed whether incorporation of ritual in the design of the shows affected their experiential value and audience satisfaction. Our conclusions were as follows: 1. use of ritual in designing fashion shows was effective, 2. ritual in the design of fashion shows increased participants’ satisfaction with the show and its experiential value. Future studies should integrate design practice into our proposed research framework to provide a reference for fashion curation and instruction to develop curators that meet the needs of the fashion industry. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

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